儿童腺病毒肺炎及呼吸道合胞病毒肺炎的临床特征分析

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Abstract Objective To analyze the clinical characteristics of adenovirus (ADV) and respiratory syncytial virus (RSV) infection in hospitalized children with pneumonia, and to provide reference for clinical diagnosis and treatment. Methods Retrospective analysis from January to December 2019, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology of the clinical data of children with simple ADV pneumonia and simple RSV pneumonia, including general situation, clinical manifestations, early course of laboratory examination and imaging examination, severe or very severe pneumonia, respiratory support, and hospital stay. Results Among 102 cases of pneumonia, 36 cases were simple ADV pneumonia and 66 cases were simple RSV pneumonia. There was no significant difference in gender between two groups (P > 0.05). The age of onset in ADV group was significantly higher than that in RSV group (P < 0.05). There was statistical significance in onset seasons between two groups (P < 0.05). The course of heat of ADV group was longer than that of RSV group, the proportion of fever ≥39.0℃ was higher than that of RSV group, the incidence of expectoration, moist rale, and wheezing sound were lower than those of RSV group, and the differences were statistically significant (P < 0.05). There was no significant difference in the incidence of gasping and inspiratory three concave sign between two groups (P > 0.05). There was no significant difference in white blood cell count between two groups (P > 0.05). The percentage of neutrophil, C-reactive protein level, and the proportion of procalcitonin > 0.1 ng/ml in ADV group were higher than those in RSV group; the percentage of lymphocytes was lower than that in RSV group, and the differences were statistically significant (P < 0.05). There were no significant differences in lung imaging and imaging improvement rate after treatment between two groups (P > 0.05). There were no extremely severe pneumonia in both groups; there were no significant differences in the incidence of severe pneumonia between two groups (P > 0.05). There were no significant differences in oxygen rate, non-invasive respiratory support rate and hospital stay between two groups (P > 0.05). Conclusion ADV pneumonia should be considered in infants and preschool children with high fever, lung auscultation with only moist rale, neutrophil percentage, C-reactive protein and procalcitonin significantly increased, while RSV pneumonia should be considered in infants with obvious wheezing sound.

Key words： Children Adenovirus Respiratory syncytial virus Pneumonia

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	YANG Yan1 ZHANG Yang2 HUANG Juan1 ZHAN Xiaoyun1 ZHAO Alan1 WU Bei1 LU Yinghong1▲

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YANG Yan1 ZHANG Yang2 HUANG Juan1 ZHAN Xiaoyun1 ZHAO Alan1 WU Bei1 LU Yinghong1▲. Clinical characteristics of adenovirus pneumonia and respiratory syncytial virus pneumonia in children#br#[J]. 中国医药导报, 2022, 19(2): 80-83,103.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I2/80

[1] 李素芳，袁永红，田军.病毒性肺炎患儿的病原学及细胞免疫功能分析研究[J].中华医院感染学杂志，2015，25（6）：1278-1280.
[2] 黄艳智，孙利伟，刘宇奇，等.618例小儿重症社区获得性肺炎病原谱及临床特点分析[J].中国小儿急救医学，2021，28（2）：111-115.
[3] 国家卫生健康委员会，国家中医药管理局.儿童腺病毒肺炎诊疗规范（2019年版）[J].传染病信息，2019，32（4）：293-298.
[4] Heim A. Adenovirus infections [J]. Monatsschr Kinderheilkd，2020：1-9.
[5] Fu Y，Tang Z，Ye Z，et al. Human adenovirus type 7 infection causes a more severe disease than type 3 [J]. BMC Infect Dis，2019，19（1）：36.
[6] 梅小娟，林剑.120例小儿病毒性肺炎的临床特征及影响因素分析[J].中国妇幼保健，2020，35（1）：72-74.
[7] 国家呼吸系统疾病临床医学研究中心，中华医学会儿科学分会呼吸学组，中国医师协会呼吸医师分会儿科呼吸工作委员会，等.儿童呼吸道合胞病毒感染诊断、治疗和预防专家共识[J].中华实用儿科临床杂志，2020（4）：241-242.
[8] Kalergis AM，Soto JA，Galvez N，et al. Pharmacological management of human respiratory syncytial virus infection [J]. Expert Opin Pharmacother，2020，21（18）：2293-2303.
[9] Greber UF，Flatt JW. Adenovirus Entry：From Infection to Immunity [J]. Annu Rev Virol，2019，6（1）：177-197.
[10] 陈媛媛.重症呼吸道合胞病毒肺炎82例临床特点分析[J].中国小儿急救医学，2021，28（7）：621-624.
[11] 中华人民共和国国家健康委员会，国家中医药局.儿童社区获得性肺炎诊疗规范（2019年版）[J].中华临床感染病杂志，2019，12（1）：6-13.
[12] 郭仁铭，林海，陈伟莉.福州地区2018—2019年儿童腺病毒肺炎流行病学和临床特征研究[J].海峡预防医学杂志，2020，26（6）：98-100.
[13] 林静，陈志敏.儿童腺病毒性肺炎与呼吸道合胞病毒肺炎的研究进展[J].实用临床医学，2020，21（3）：95-98.
[14] Lim JU，Choi JY，Jeong HJ，et al. Comparison of clinical characteristics and inflammatory cytokines between hypoxemic and non-hypoxemic human adenovirus 55 pneumonia [J]. J Thorac Dis，2020，12（8）：4044-4056.
[15] Pettersson U. Encounters with adenovirus [J]. Ups J Med Sci，2019，124（2）：83-93.
[16] 赵明奇，连广琬，朱冰，等.婴幼儿病毒性肺炎病原学与外周血淋巴细胞亚群变化的研究[J].中华医院感染学杂志，2011，21（12）：2398-2400.
[17] Seidenberg J. Respiratory syncytial virus [J]. Internist（Berl），2019，60（11）：1146-1150.
[18] 郑海涛，任献青，闫永彬，等.人呼吸道合胞病毒感染对机体Th1、Th2影响的研究进展[J].病毒学报，2020，36（4）：719-725.
[19] Yoon JS，Kim HH，Lee Y，et al. Cytokine induction by respiratory syncytial virus and adenovirus in bronchial epithelial cells [J]. Pediatr Pulmonol，2007，42（3）：277-282.
[20] Chen RF，Lee CY. Adenoviruses types，cell receptors and local innate cytokines in adenovirus infection [J]. Int Rev Immunol，2014，33（1）：45-53.
[21] 刘又宁，解立新.感染相关生物标志物临床意义解读专家共识[J].中华结核和呼吸杂志，2017，40（4）：243-257.
[22] 刘华柱，张欢，杨建波.C反应蛋白、降钙素原及铁蛋白水平在急性胰腺炎患者中的变化及意义[J].国际检验医学杂志，2021，42（17）：2128-2131.
[23] 赵登峰，徐慧，陈恒，等.不同类型病原体感染社区获得性肺炎临床与影像特征及转归[J].中华医院感染学杂志，2021，31（18）：2768-2772.
[24] 王贺新，王正，郑瑞，等.病毒性肺炎影像学诊断研究现状[J].武警后勤学院学报：医学版，2021，30（3）：77-84.
[25] 林创兴，谢志伟，林广裕，等.儿童社区获得性肺炎合并肺不张的病毒性病原学研究[J].汕头大学医学院学报，2017，30（1）：34-35.