健脾补肾法治疗艾滋病患者的临床效果

Abstract
Figure/Table
References (28)
Related Citation (15)

Download: PDF (695 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To observe the clinical effect of the method of invigorating spleen and tonifying kidney on acquired immunodeficiency syndrome patients. Methods A total of 32 acquired immunodeficiency syndrome patients with incomplete immune reconstitution and deficiency of spleen and kidney in Wuhan Infectious Disease Hospital from January 2017 to December 2020 were selected as research subjects, and they were divided into treatment group and control group according to random number table method, with 16 cases in each group. Sixteen patients in the treatment group were treated with highly active anti-retroviral therapy (HAART) + Jianpi Bushen Mianjian Granules, and sixteen patients in the control group were treated with HAART+Jianpi Bushen Mianjian Granule Simulation Agents. Both groups were treated for 48 weeks. The liver and kidney function, traditional Chinese medicine symptom and sign score, Karofsky score and immunological indexes of the two groups were observed before and after treatment. Results There was no significant difference in liver and kidney function between the two groups after treatment and before treatment (P ＞ 0.05). After treatment, the scores of traditional Chinese medicine symptoms and signs in the two groups were lower than those before treatment, and which in the treatment group were lower than those in the control group (P ＜ 0.05). After treatment, the Karofsky score in the treatment group was higher than that before treatment, and that in the treatment group was higher than that in the control group (P ＜ 0.05). After treatment, the proportion of CD4+CD45RA+T cells and the ratio value of CD4+CD45RA+T cells to CD4+CD45RO+T cells in the treatment group were higher than those before treatment, and those in the treatment group were higher than those in the control group (P ＜ 0.05). After treatment, the proportion of CD4+CD45RO+T cells in the treatment group was lower than that before treatment, and that in the treatment group were higher than the control group (P ＜ 0.05). Conclusion Invigorating spleen and tonifying kidney method has a good safety in the treatment of acquired immunodeficiency syndrome patients with incomplete immune reconstitution and deficiency of spleen and kidney, improving the quality of life of patients, improving the immune function of the body, showing a good synergistic effect.

Key words： Invigorating spleen and tonifying kidney method Highly active anti-retroviral therapy Acquired immunodeficiency syndrome Incomplete immune reconstitution.

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	WANG Yinglin1 LIU Jianzhong1 XIAO Mingzhong1 NI Wei1 CHEN Yao1 YU Xiaoli2 YUN Fan3 KE Jingwen3

Cite this article:

WANG Yinglin1 LIU Jianzhong1 XIAO Mingzhong1 NI Wei1 CHEN Yao1 YU Xiaoli2 YUN Fan3 KE Jingwen3. Clinical effect of the method of invigorating spleen and tonifying kidney on acquired immunodeficiency syndrome patients#br#[J]. 中国医药导报, 2022, 19(2): 112-116.

URL:

https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I2/112

[1] 中华中医药学会防治艾滋病分会.HIV感染者中西医协同治疗专家共识[J].中医学报，2020，35（3）：551-554.
[2] 中华中医药学会防治艾滋病分会，广西中医药大学附属瑞康医院，广东省广州市第八人民医院，等.艾滋病免疫功能重建不良中西医协同治疗专家共识[J].中医学报，2020，35（2）：281-284.
[3] 中华中医药学会防治艾滋病分会.艾滋病中医诊疗指南[J].中医报，2014，29（5）：617-620.
[4] 卫生部传染病标准专业委员会.艾滋病和艾滋病病毒感染诊断标准[J].中国艾滋病性病，2012，18（5）：354-356.
[5] 国家中医药管理局中医药防治艾滋病工作组织协调小组办公室，中国中医药研究院艾滋病中医药防治中心.11省中医药治疗艾滋病项目临床技术培训资料[Z].2005：4.
[6] Sultana ZZ，Hoque FU，Beyene J，et al. HIV infection and multidrug resistant tuberculosis：a systematic review and meta-analysis [J]. BMC Infect Dis，2021，21（1）：51-55.
[7] 杨玉琪，瞿广城，陆中云，等.扶正抗毒丸联合HAART治疗艾滋病免疫重建不全的临床疗效分析[J].中医药导报，2020，26（10）：66-68.
[8] 马玉青，桑锋，许向前，等.细胞焦亡—中医药调节HIV/AIDS免疫功能作用机制研究新位点[J].中华中医药杂志，2020，35（6）：2974-2976.
[9] 赵银龙.益气扶正解毒散联合高效抗病毒逆转录疗法治疗HIV/AIDS患者50例[J].西部中医药，2020，33（4）：112-114.
[10] 咸庆飞，刘颖，邹雯，等.温肾健脾颗粒对HAART后免疫重建不全艾滋病患者T淋巴细胞亚群的作用研究[J].中国中医基础医学杂志，2019，25（10）：1391-1392，1455.
[11] 王超楠，程东岩，王健，等.黄芪及复方黄芪制剂双向免疫调节作用研究进展[J].中华中医药学刊，2021，39（5）：126-129.
[12] 李雪琴，李科，秦雪梅，等.多糖的结构解析方法研究进展[J].山西医科大学报，2021，52（3）：380-387.
[13] 曹磊，平芬，韩书芝，等.大株红景天在不同系统疾病中的应用进展[J].河北医药，2020，42（4）：608-612.
[14] 李畅，陈菲菲，杨艳君，等.淫羊藿多糖组成分析及其免疫调节作用研究[J].中国中药杂志，2021，5（25）：306.
[15] 艾拉旦·麦麦提艾力，李洋，姚军，等.管花肉苁蓉多糖水提物的分离及免疫活性研究[J].中国药房，2021，32（12）：1479-1484.
[16] 郑昆，钟肖飞，张华.艾叶挥发油类成分及其药理作用的研究进展[J].中国实验方剂学杂志，2020，26（18）：224-234.
[17] Yang G，Jiao L. Research Progress of Traditional Chinese Medicine in Prevention and Treatment of AIDS [J]. Proceedings of Anticancer Research，2020，4（4）：21-23.
[18] 宋晓漫，李文林，杨丽丽，等.常用药食两用中药免疫增强作用研究进展[J].河南中医，2021，41（8）：1271-1276.
[19] Li X，Li H，Li C，et al. Traditional Chinese Medicine Can Improve the Immune Reconstruction of HIV/AIDS Patients [J]. AIDS Res Hum Retroviruses，2020， 36（4）：258-259.
[20] 翟旭楠，刘永武，张娜，等.刺五加多糖对小鼠免疫功能的影响[J].中医药信息，2020，37（6）：42-45.
[21] 黄青，李丽媛，刘晴晴，等.灵芝多糖和猪苓多糖及其复方的免疫调节作用研究进展[J].食品科学，2020，41（17）：275-282.
[22] 焦艳梅，施明，徐若男，等.艾滋病临床免疫基础及转化应用研究[J].中国艾滋病性病，2019，25（9）：877-881.
[23] 张斌，苏中静.T细胞受体信号转导中的CD45亚型的研究进展[J].解剖学研究，2021，43（1）：82-85.
[24] 宋玉丽，冯辉.干细胞样记忆性CD4＋T细胞与临床疾病的研究进展[J].国际免疫学杂志，2020，43（5）：564-568.
[25] 张亚兰，郑海潮，卫晓丽，等.HAART对HIV/AIDS患者T淋巴细胞活化及CD4＋CD45RA＋T细胞亚群的影响[J].中华微生物学和免疫学杂志，2020，40（7）：518-522.
[26] 许海芬.HIV患者CD4+T淋巴细胞检测结果与抗病毒治疗的效果[J].中国医药指南，2020，18（21）：71-72.
[27] 刘尹正泽，肖寒，梁欣，等.外周血淋巴细胞计数在艾滋病患者HAART治疗中的变化及其对疗效的影响[J].中国医药科学，2021，11（11）：20-23.
[28] 黄妙琳，梁均和，邹健祺，等.226例HIV-1抗体阳性者WB带型及首次CD4+T淋巴细胞检测结果分析[J].皮肤性病诊疗学杂志，2021，28（1）：12-14，18.