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| Effect of directional drug penetration combined with Fuke Qianjin Capsules in the treatment of pelvic inflammatory disease with damp heat stasis type#br# |
| WANG Qun1 LUO Mingyan2 |
1.Department of Gynaecology, Xindu Hospital of Traditional Chinese Medicine, Sichuan Province, Chengdu 610000, China;
2.Department of Obstetrics and Gynecology, Western Theater General Hospital, Sichuan Province, Chengdu 610000, China |
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Abstract Objective To investigate the effect of directional drug penetration combined with Fuke Qianjin Capsules in the treatment of pelvic inflammatory disease (PID) with damp heat stasis type. Methods A total of 91 PID patients with damp heat stasis type who were admitted to Xindu Hospital of Traditional Chinese Medicine from January 2019 to October 2020 were selected. They were divided into control group (45 cases, Fuke Qianjin Capsules + conventional treatment) and study group (46 cases, directional drug penetration + Fuke Qianjin Capsules + conventional treatment) by random number table method. The clinical efficacy, traditional Chinese medicine symptom score, serum inflammatory factors (interleukin-6[IL-6], IL-2, tumor necrosis factor-α [TNF-α], and high-sensitivity C-reactive protein [hs-CRP]), hemorheology index (plasma viscosity, low shear whole blood viscosity, fibrinogen, high shear whole blood viscosity, and hematocrit), pelvic effusion depth, pelvic inflammatory mass diameter were compared between two groups; the incidence of adverse reactions during treatment was observed. Results The total effective rate of study group was higher than that of control group (P < 0.05). After treatment, the scores of lower abdominal pain, lumbosacral pain, prolonged menstrual period, increased menstrual volume, and mental fatigue in two groups were lower than those before treatment, and study group was lower than control group (P < 0.05). After treatment, the levels of serum IL-6, IL-2, TNF-α, and hs-CRP of two groups were lower than those before treatment, and study group was lower than control group (P < 0.05). After treatment, the plasma viscosity, low shear whole blood viscosity, fibrinogen, high shear whole blood viscosity, and hematocrit of two groups were lower than those before treatment, and study group was lower than control group (P < 0.05). After treatment, the pelvic effusion depth and pelvic inflammatory mass diameter in two groups were lower than those before treatment, and study group was lower than control group (P < 0.05). There were no serious adverse reactions in two groups during treatment. Conclusion Directional drug penetration combined with Fuke Qianjin Capsules has good clinical efficacy in the treatment of PID with damp heat stasis type patients, which can reduce inflammatory reaction, improve hemorheology, relieve clinical symptoms with high safety.
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