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2021 Vol. 18, No. 3
Published: 2021-01-25
 
 
4 Effect of modified decoction Ⅱ of ectopic pregnancy on apoptosis of endoplasmic reticulum stress JNK signaling pathway in HTR-8/SVneo cells
JIAN Yongnan1 ZHENG Wenlan2
Objective To research modified decoction Ⅱ of ectopic pregnancy to nourish the effect of cell apoptosis based on the endoplasmic reticulum stress JNK signaling pathway. Methods Thirty-six female SD rats weighing 180-220 g were divided into six groups by random number table method, each with six rats, namely the negative control group (equal volume of normal saline in the dose of medium traditional Chinese medicine), low, medium and high dose traditional Chinese medicine  group (12, 24 and 48 g/[kg·d]), Western medicine group (equal volume of normal saline in the dose of medium traditional Chinese medicine + 7.775 mg/kg Methotrexate), Chinese and Western medicine combination group (24 g/kg+7.775 mg/kg Methotrexate). Blood samples were collected and serum was separated eight days after treatment with traditional Chinese medicine and once after administration of Western medicine. After different groups of drug-containing serum were cultured with HTR-8/SVneo cells for 24 hours respectively, Western blot was used to detect the protein expressions of IRE1α, TRAF2, ASK1, JNK1, JNK2, p-JNK and quantitative real-time PCR (qRT-PCR) was used to detect the mRNA expressions of IRE1α, TRAF2, ASK1, JNK1, JNK2. In addition, cells not treated with serum were used as blank control group to exclude interference caused by complex serum composition. Results Compared with the blank control group, the expression levels of IRE1α, TRAF2, ASK1, JNK1, JNK2 and p-JNK proteins and the expression levels of IRE1α, TRAF2, ASK1, JNK1 and JNK2 mRNA in the negative control group showed no significant changes (P ＞ 0.05). Compared with the negative control group, the expression levels of JNK1 and JNK2 proteins in the traditional Chinese medicine dose groups, the Western medicine group and the Chinese and Western medicine combination group showed no significant changes (P ＞ 0.05), while the expression levels of IRE1α, TRAF2, ASK1, p-JNK proteins, and the expression levels of IRE1α, TRAF2, ASK1, JNK1 and JNK2 mRNA were all increased, with statistically significant differences (all P ＜ 0.05). The expression levels of IRE1α, TRAF2, p-JNK proteins and the expression levels of IRE1α, TRAF2, JNK1 and JNK2 in the high dose traditional Chinese medicine group were higher than those in the low and medium dose traditional Chinese medicine groups, and the differences were statistically significant (all P ＜ 0.05). The expression levels of IRE1α, ASK1, p-JNK proteins and the expression levels IRE1α, ASK1 and JNK1 mRNA in the medium dose traditional Chinese medicine group were higher than those in the low dose traditional Chinese medicine group, and the differences were statistically significant (all P ＜ 0.05). Compared with the high dose traditional Chinese medicine group, the expression levels of IRE1α, ASK1, p-JNK proteins and IRE1α, JNK1 mRNA in the Western medicine group and the Chinese and Western medicine combination group were increased, and the differences were statistically significant (all P ＜ 0.05). Compared with the Western medicine group, the expression levels of IRE1α protein and IRE1α, ASK1, JNK1 and JNK2 mRNA in the Chinese and Western medicine combination group showed no significant changes, and the differences were not statistically significant (P ＞ 0.05). ASK1 protein expression was increased, while TRAF2, p-JNK protein expression and TRAF2 mRNA expression were decreased, with statistically significant differences (all P ＜ 0.05). Conclusion The modified decoction Ⅱ of ectopic pregnancy can cause excessive endoplasmic reticulum stress and activate the JNK signaling pathway, leading to cell apoptosis, and possible relevance dose.
2021 Vol. 18 (3): 4-8,16 [Abstract] ( 543 ) HTML (1 KB)  PDF (708 KB)  ( 128 )
9 Basic research on potential substances of Zukamu Granules for treatment of corona virus disease 2019
FAN Chenyang1 MA Xuan1,2 JI Zhihong1 LI Keao1 LI Zhijian3
Objective To explore the potential material basis of Zukamu Granules in the treatment of corona virus disease 2019 (COVID-19) through network pharmacology and molecular docking techniques. Methods The chemical constituents and targets of ten medicinal herbs in Zukamu Granules were retrieved from China national knowledge infrastructure and traditional Chinese medicine systems pharmacology database and analysis platform (TCMSP) database. GeneCards and NCBI databases were used to obtain the COVID-19 targets, the corresponding Genes of the targets were searched in the UniProt database, Cytoscape3.7.2 was used to construct the network of herb-ingredient-target-disease, and the gene ontology (GO) enrichment analysis and kyoto encyclopedia of genes and genomes pathway (KEGG) pathway analysis were performed on the targets using the Bioconductor biological information software package. The predicted core ingredients were docking with the novel coronavirus 3CL hydrolase (SARS-CoV-2 3CL hydrolase) and the angiotensin converting enzyme Ⅱ (ACE2) respectively. Results The herb-ingredient-target-disease network consisted of 114 ingredients and 50 targets. There were 1876 items obtained by GO enrichment analysis (P ≤ 0.05), including 1754 biological process, 33 cell components and 89 molecular functions. There were 155 signal pathways obtained by KEGG pathway analysis (P ≤ 0.05). The binding energies of quercetin, kaempferol, luteolin and other components in the Zukamu Granules with SARS-COV-2 3CL hydrolase and ACE2 enzyme were all less than -5.0 kJ/mol. Conclusion Quercetin, kaempferol, luteolin and other components in Zukamu Granules can act on multiple signaling pathways by binding with SARS-CoV-2 3CL hydrolase and ACE2 enzyme, thus playing a therapeutic role on COVID-19.
2021 Vol. 18 (3): 9-16 [Abstract] ( 486 ) HTML (1 KB)  PDF (2885 KB)  ( 87 )
17 Experimental study on the optimized prescription of Danggui Shaoyao San against chronic pelvic inflammation
LIU Min WANG Xiaoyan JIA Ruilin REN Cunxia
Objective To observe the effects of the optimized composition of Danggui Shaoyao San combined with the Mongolian medicine Chipaozi on serum inflammatory factors and histopathology in chronic pelvic inflammatory disease (CPID) model rats. Methods Seventy female SD rats were randomly divided into seven groups, including normal group, model group, high, medium, and low-dose Xinfang group, Jingangteng group, and Mongolian medicine Chipaozi group with 10 cases in each group. The CPID model was reproduced by the method of bacterial planting and mechanical damage, and medication was administered four weeks later. The high, medium, and low-dose groups of the new prescription were given by intragastric administration at 19.74, 9.87 g/kg, and 4.93 g/kg, respectively. The Jingangteng group and the Mongolian medicine Chipaozi group were given by oral administration at 0.63 g/kg and 1.04 g/kg. The material was taken two weeks after the administration. Enzyme-linked immunosorbent assay (ELISA) was used to determine serum tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and IL-10 levels in rats in each group. The changes of rat uterine tissue under a microscope was observed and the pathology was scored. Results Compared with the normal group, the uterine pathology score of the model group was significantly increased, and the difference was highly statistically significant (P ＜ 0.01). The pathological score of Jingangteng group, high and medium Xinfang group were lower than that of model group, and the differences were statistically significant (P ＜ 0.05). Compared with the model group, the levels of IL-10 in the high and medium-dose Xinfang groups were increased, while the levels of IL-1β and TNF-α in the high, medium and low-dose Xingfang groups were decreased, and the differences were statistically significant (P ＜ 0.05). Compared with Jingangteng group, the content of TNF-α in the high and medium-dose Xinfang groups were decreased, and the differences were statistically significant (P ＜ 0.05). Compared with the Mongolian medicine Chipaonzi group, IL-10 in the high and medium-dose Xinfang groups were increased and IL-1β were decreased, and the differences were statistically significant (P ＜ 0.05). Conclusion The optimized prescription of Danggui Shaoyao San can counteract the abnormal expression of inflammatory cytokines in CPID model rats and improve the local pathological environment of model rats. The new prescription can promote the recovery of immune function by regulating the levels of TNF-α, IL-1β and IL-10 inflammatory factors, thereby exerting an active therapeutic effect on CPID model rats.
2021 Vol. 18 (3): 17-20 [Abstract] ( 316 ) HTML (1 KB)  PDF (790 KB)  ( 138 )
21 High throughput microarray analysis of Lncrna-mRNA co-expression network in intrahepatic cholangiocarcinoma
TANG Jintian1 WANG Ruibin2 WANG Boqing1▲
Objective To explore the co-expression network of long non coding RNA (lncRNA)-messenger RNA (mRNA) in intrahepatic cholangiocarcinoma, and to analyze the function of the differentially expressed lncrnas. Methods From January to June 2017, fresh tissue sample of five patients with cholangiocarcinoma  who were resected by hepatobiliary surgery in the Affiliated Cancer Hospital, Xinjiang Medical University were selected. High throughput microarray technology was used to analyze the mRNA and lncRNA differential expression profiles, and to construct the lncRNA-mRNA co-expression network. Top 1 lncRNA with significant difference was selected for mRNA co-expression screening, GO analysis and Pathway analysis. In addition, Top1 lncRNA and its co-expression mRNA were verified in other 30 specimens of intrahepatic cholangiocarcinoma. Results When the screening threshold was P ≤ 0.05 and log2 | Fold Change（FC）| ≥1, 475 differential genes were obtained, including 213 up-regulated mRNA and 262 down regulated mRNA; 438 differential lncRNA were obtained, including 131 up-regulated lncRNA and 307 down regulated lncRNA. Top1 lncRNA was screened as carbamoyl phosphate synthase I-intron transcript 1 (CPS1-IT1). GO analysis and Pathway analysis showed that CPS1-IT1 was associated with 20 biological processes and two cellular functions, involving eight cell signaling pathways. Conclution The mRNA and lncRNA in intrahepatic cholangiocarcinoma form a complex co-expression network and participate in many important biological processes.
2021 Vol. 18 (3): 21-25 [Abstract] ( 264 ) HTML (1 KB)  PDF (974 KB)  ( 62 )
26 Relationship between T-bet/GATA-3 ratio in peripheral blood mononuclear cells and tidal breathes lung function and Th1/Th2 cell balance in recurrent wheezing infants
CHEN Guohua1 HUANG Weimin2 PAN Zhiwei1 BAI Jun1
Objective To investigate the relationship between T-bet/GATA-3 ratio in peripheral blood mononuclear cells and tidal breathes lung function and helper T lymphocyte (Th) 1/ Th2 cell balance of infants with recurrent wheezing. Methods A total of 120 infants with recurrent wheezing who were followed up in Foshan Maternal and Child Health Hospital Affiliated to the First Clinical Medical College of Southern Medical University from January 2018 to December 2019 as wheezing group and 60 healthy infants with healthy physical examination during the same period as control group. T-bet/GATA-3 ratio, tidal breathes lung function parameters, Th1/Th2 and other indexes between two groups were compared, and the correlation between T-bet/GATA-3 ratio and tidal breathes lung function parameters and Th1/Th2 were analyzed. Results T-bet and T-bet/GATA-3 ratio in wheezing group were significantly lower than those in control group, while GATA-3 was significantly higher than that in control group (P < 0.01). Respiratory rate (RR), tidal breathes peak expiratory flow (PTEF) in wheezing group were significantly higher than those in control group, while the tidal volume (VT), peak time ratio (TPTEF/TE) and peak volume ratio (VPEF/VE) were significantly lower than those in control group (P < 0.01). Th1, Th1/Th2 and γ-interferon (IFN-γ) in wheezing group were significantly lower than those in control group, while Th2 and interleukin-4 (IL-4) were significantly higher than those in control group (P < 0.01). Pearson correlation analysis showed that T-bet/GATA-3 ratio was positively correlated with VT, TPTEF/TE, Th1/Th2 (r = 0.741, 0.567, 0.762, P < 0.01), and negatively correlated with RR (r = -0.717, P < 0.01). Conclusion T-bet/GATA-3 ratio in peripheral blood mononuclear cells of infants with recurrent wheezing is decreased, and it is closely related to the tidal breathes lung function and Th1/Th2 cell-mediated immune imbalance, which may provide a new idea for the diagnosis and treatment of recurrent wheezing infants.
2021 Vol. 18 (3): 26-29,34 [Abstract] ( 207 ) HTML (1 KB)  PDF (795 KB)  ( 112 )
30 Effect of cyclooxygenase inhibitor NS-398 combined with Oxaliplatin on growth inhibition and apoptosis induction of HeLa cells in cervical cancer
WANG Jing1 JIN Yan2 DONG Shanglin3 WU Xin4
Objective To explore the effect of cyclooxygenase inhibitor NS-398 combined with Oxaliplatin (L-OHP) on growth inhibition and apoptosis induction of HeLa cells in cervical cancer. Methods HeLa cells were cultured in vitro. CCK-8 method was used to detect the inhibitory effect of different concentrations of NS-398 (0, 30, 60 μmol/L) and L-OHP (0.0, 2.5, 5.0, 10.0 mg/L) on HeLa cells alone or in combination. HeLa cells were divided into: control group, NS-398 group (60 μmol/L), L-OHP group (10 mg/L) and combined group (NS-398 60 μmol/L+L-OHP 10 mg/L). The morphological changes of HeLa cells were observed by inverted microscope. The apoptosis of HeLa cells was observed by Rhodamine staining, and the early apoptosis rate of HeLa cells was detected by flow cytometry. The ladder strip was detected by DNA agarose gel electrophoresis. Results CCK-8 analysis showed that compared with untreated group, the cell growth inhibition rate in NS-398 single drug group and L-OHP single drug group were higher; growth inhibition rate in combined group was higher than that in NS-398 single drug group and L-OHP single drug group (all P ＜ 0.01). The cells in control group were in good condition, with fusiform shape, adherent growth, clear cell edges and intact cell membrane. In NS-398 group, the volume of cells shrank and became round, granular substances appeared in the cytoplasm, and a small number of cells fell off from the bottom of the bottle and floated in the culture medium. The cells of L-OHP group lost their normal morphology and shrank, and dead cells could be seen in the culture medium. A large number of dead cells and cell debris could be seen in the culture medium of the combined group, with only a few cells sticking to the bottom of the bottle, with different degrees of shrinkage, partial cell rupture, and cell contents overflow. Rodamine 123 staining result showed that, the control group had no fluorescence. The fluorescence intensity of NS-398 group, L-OHP group and combination group was enhanced, especially the combination group. The results of flow cytometry showed that the apoptosis rate of NS-398 group and L-OHP group were significantly higher than those of control group; the apoptosis rate of combined group was higher than that of NS-398 group and L-OHP group (all P ＜ 0.01). DNA electrophoresis showed that there were obvious ladder-like bands in combined group, while there were obvious dispersion phenomena in NS-398 group and L-OHP group. In control group, neither dispersion nor ladder band appeared. Conclution NS-398 can enhance the inhibitory effect of L-OHP on the growth of HeLa cells and induce apoptosis.
2021 Vol. 18 (3): 30-34 [Abstract] ( 330 ) HTML (1 KB)  PDF (798 KB)  ( 118 )
35 Progress in traditional Chinese medicine treatment of cardiogenic shock
YANG Geyan1 WANG Xiaolong2
Cardiogenic shock is one of the most common critical diseases in clinical practice. Even if treated with modern medical methods such as vasoactive drugs, positive inotropic drugs and mechanical assisted circulation, it still has a high mortality rate. Therefore, it is of great significance to actively explore more perfect methods to treat cardiogenic shock. Traditional Chinese medicine has traditional advantages in the treatment of cardiovascular diseases. A number of studies have shown that patients with cardiogenic shock can achieve better curative effects after combined with traditional Chinese medicine treatment, including reduced mortality in hospital, improved cardiac function and reduction of adverse drug reactions. To provide assistance for clinical intervention of cardiogenic shock with traditional Chinese medicine or integrated traditional Chinese and western medicine, this article searchs the relevant research literatures on the treatment of cardiogenic shock by traditional Chinese medicine, and summarizes from the aspects of traditional Chinese medicine understanding, etiology and pathogenesis, syndrome differentiation and the efficacy of traditional Chinese medicine intervention, etc. in cardiogenic shock.
2021 Vol. 18 (3): 35-38,47 [Abstract] ( 358 ) HTML (1 KB)  PDF (595 KB)  ( 89 )
39 Application progress of in situ tissue engineering technology to repair bone and cartilage injury
ZHANG Juntao1* YUE Chen2* TANG Yanfeng2 JIA Yudong2 LIU Youwen2
With the accelerating pace of life and the aggravation of the aging society, the incidence of bone and cartilage injury diseases is increasing. Traditional methods of treating bone and cartilage injuries have the disadvantages of long treatment time, poor curative effect and high cost. In order to better treat the disease, scholars put forward the concept of in situ tissue engineering technology. Through good scaffold materials and the regulation of its own microenvironment, under the guidance of cytokines, autologous seed cells (stem cells/progenitor cells) are recruited from the injured site to repair the damaged bone and cartilage, eliminating the need for traditional tissue engineering techniques. The required exogenous seed cells avoid the shortcomings of prolonged propagation of exogenous seed cells in vitro and possible immune rejection caused by implantation in the body, greatly shortening the treatment time and reducing the treatment failure rate. It has achieved remarkable results in the treatment of bone and cartilage injuries. By consulting the literature, this article summarizes and introduces the principles and clinical effects of in situ tissue engineering in the treatment of bone and cartilage injuries for reference.
2021 Vol. 18 (3): 39-42 [Abstract] ( 156 ) HTML (1 KB)  PDF (541 KB)  ( 59 )
43 Progress in neoadjuvant therapy of non-small cell lung cancer
SHI Hubo1 XU Yihui2
Lung cancer is a malignant tumor with the highest morbidity and mortality in the world, and non-small cell lung cancer (NSCLC) is the most common type. At present, chest CT is widely used in clinical and physical examinations, and more and more early lung cancers are found, but there are still more patients with advanced lung cancer. For patients with locally advanced NSCLC, postoperative adjuvant treatments, including radiotherapy and chemotherapy, immunotherapy, and targeted therapy have been shown to significantly improve the prognosis of patients. The latest research shows that the preoperative neoadjuvant treatment has good tolerance and treatment compliance, does not increase the risk of complications and death of surgery, and provides more opportunities for surgical treatment and reduces disease recurrence, while improves the overall cure rate. At the same time, the combined application trials of these neoadjuvant treatments are also underway, and the results are expected. This article discusses the effects of different neoadjuvant treatments for NSCLC, reviews its latest developments, and provides references for clinical research.
2021 Vol. 18 (3): 43-47 [Abstract] ( 499 ) HTML (1 KB)  PDF (555 KB)  ( 88 )
48 Research progress of Cervical Pain Granules in the treatment of cervical radiculopathy
FANG Shengjie1 ZHU Liguo1 WEI Xu2 SUN Kai1 WANG Xu1 SHI Bin3 YANG Shaofeng4
Cervical spondylotic radiculopathy (CR) is a common and frequent orthopedic disease, which belongs to the category of Bi syndrome in traditional Chinese medicine. The pathogenesis of CR is relatively complex and there is no unified conclusion. In recent years, the Chinese patent medicine CR, represented by the Cervical Pain Granules, has been widely used in clinical practice, the clinical and basic research of Cervical Pain Granules has attracted more and more attention. The single and combined use of Cervical Pain Granules has a good effect on relieving the clinical symptoms and signs of CR, however, basic research is rare. Through reviewing the existing studies, it was found that the main effects of the treatment of CR were anti-inflammatory, analgesic and promoting blood circulation and removing stasis. Based on the existing literature, this paper reviews the current status of pharmacodynamics and basic science research on the treatment of CR by Cervical Pain Granules in order to better apply in clinical treatment. However, the research on the mechanism of action of this prescription is limited, and the future research on the mechanism of this prescription will deepen the understanding of CR treatment under the guidance of “promoting blood circulation and removing blood stasis, promoting qi and relieving pain”, it is of great significance to further optimize the prescription drugs under this treatment, and provide reference for drug development and application.
2021 Vol. 18 (3): 48-51 [Abstract] ( 384 ) HTML (1 KB)  PDF (542 KB)  ( 68 )
52 Research on frailty assessment and nursing intervention in elderly patients with cardiovascular surgery
ZHANG Xiaohong1 MENG Li′na2 ZHANG Peipei3 LIU Yanhui1
Cardiovascular disease is one of the most common clinical diseases and surgery is the main clinical treatment. Frailty is a multidimensional syndrome refers to the decline of homeostasis reserve function, which is closely related to the growth of age. With age, frailty becomes common and widely associated with the outcome of cardiovascular surgery. There is a high incidence of frailty in patients with cardiovascular disease, with a high incidence of frailty and an increased risk of deterior ating health and mortality in those with frailty. Therefore, frailty is a indicator of poor prognosis in elderly patients with cardicvascular diease. However, there are fewer studies on frailty assessment and intervention in elderly patients undergoing cardiovascular surgery. This study summarized frailty assessment and intervention measures, so as to show the importance of frailty assessment in patients with cardiovascular disease.
2021 Vol. 18 (3): 52-54 [Abstract] ( 190 ) HTML (1 KB)  PDF (531 KB)  ( 83 )
55 Investigation and analysis of the ratio of urine microalbumin/urinary creatinine in adults in Suzhou community
CHEN Bei SHEN Dong WEN Jiangtao ZHU Hongnan ZHANG Changsong
Objective To investigate and analyze the distribution and abnormal rate of urinary microalbumin/urinary creatinine ratio (UACR) among adults in Suzhou community provide a theoretical basis for the prevention and treatment of chronic diseases. Methods The community adult residents filed in seven medical consortium communities in Suzhou High-tech Zone, Hengtang, Hu’guan, Yangshan, Zhenhu, Shishan, Tongan, and Dongzhu were selected from July 2017 to January 2020, while 14 350 cases were collected. All random urine microalbumin and urine creatinine values were detected, and the UACR value was calculated. The differences in the distribution of UACR in different age groups and genders, and the differences in the abnormal rates of UACR in different age groups and in different years were compared. Results Comparison of UACR values among different age groups showed statistically significant differences (P ＜ 0.05). Further pairwise comparisons, the UACR values of the 70 to 80 years old group and the ≥80 years old group were compared with other age groups, and the differences were statistically significant (P ＜ 0.05). The UACR level of women in the same age group were higher than that of men, and the differences were statistically significant (P ＜ 0.05). Comparison of UACR values of different genders and age groups showed statistically significant differences (P ＜ 0.05). Compared with the abnormal rate of UACR in different age groups, and the differences were statistically significant (P ＜ 0.05). Compared with the abnormal rate of UACR from 2017 to 2020, and the differences were statistically significant (P ＜ 0.05). Conclusion The distribution of UACR values is closely related to gender and age. The focus is on disease changes in people under 50 and over 70 in the region. At the same time, attention is paid to changes in data every year to strengthen the screening and prevention of early kidney damage.
2021 Vol. 18 (3): 55-58 [Abstract] ( 143 ) HTML (1 KB)  PDF (383 KB)  ( 59 )
59 Analysis of risk factors affecting middle-aged and elderly type 2 diabetes patients with DR
AN Yan GAO Jianqin GUO Caihong ZHU Wei
Objective To explore the risk factors that affect middle-aged and elderly type 2 diabetes patients with diabetic retinopathy (DR), and to provide a basis for the prevention of such complications in the clinic. Methods A total of 171 middle-aged and elderly patients diagnosed with type 2 diabetes and relatively complete data records from the Department of Endocrinology, Beijing Aerospace General Hospital from January to December 2018, were divided into DR group (56 cases) and control group (115 cases) according to whether they occurred DR. The age, body mass index (BMI), course of diabetes, triacylglycerol (TG), total cholesterol (TCHO), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), fasting blood glucose (FPG), glycosylated hemoglobin (HbA1c), blood uric acid (UA), urine microalbumin/creatinine (UMA) levels of two groups were collected to analyze. Results There were no significant difference in BMI, LDL-C and HDL-C between the two groups (P ＞ 0.05). The course of disease in the DR group was longer than that in the control group, while TG, TCHO, FPG, HbA1c, UA and UMA were higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). Logistic multivariate regression analysis showed that the course of diabetes (OR = 1.27, 95%CI: 1.11-1.45, P ＜ 0.05), TG (OR = 2.06, 95%CI: 1.30-3.25, P ＜ 0.05), HbA1c (OR = 2.92, 95%CI: 1.79-4.76, P ＜ 0.05) and UMA (OR = 1.00, 95%CI: 1.00-1.01, P ＜ 0.05) were independent risk factors for DR. Conclusion In middle-aged and elderly patients with type 2 diabetes, the course of diabetes, TG, HbA1c, and UMA are risk factors for DR.
2021 Vol. 18 (3): 59-61,66 [Abstract] ( 489 ) HTML (1 KB)  PDF (684 KB)  ( 78 )
62 Comparison of clinical effect of Febuxostat and Allopurinol in the treatment of KDIGO grade four to five chronic nephropathy with hyperuricemia
ZHANG Yiwen1 ZHANG Liyuan1▲ GUO Yibin2
Objective To investigate clinical effect of Febuxostat and Allopurinol in the treatment of KDIGO grade four to five chronic nephropathy (CKD) with hyperuricemia (HUA). Methods One hundred and thirty-four patients with CKD and HUA of KDIGO grade four to five admitted to the First People’s Hospital of Lianyungang City from August 2016 to January 2019 were selected and divided into allopurinol group and febuxostat group according to random number table method, with 67 cases in each group. The course of treatment was six months. The standard rate of serum uric acid (SUA) in the first to six months of treatment, adverse reaction, body mass index, systolic blood pressure, total cholesterol (TC), triglyceride, low density lipoprotein-cholesterol (LDL-C), SUA, blood urea nitrogen (BUN), serum creatinine (Scr), estimate glomerular filtration rate (eGFR) and 24 h urinary protein before and after treatment were compared between two groups. Results The standard rate of SUA in febuxostat group was higher than that in allopurinol group at one, two, three, four, five and six months after treatment, the differences were statistically significant (P < 0.05). Six months after treatment, the incidence rate of adverse reaction in febuxostat group was lower than that in allopurinol group, the difference was statistically significant (P < 0.05). After treatment, TC, LDL-C, SUA, BUN, Scr and 24 hours urinary protein in febuxostat group were lower than those before treatment and allopurinol group, and eGFR in febuxostat group was higher than that before treatment and allopurinol group, the differences were statistically significant (P < 0.05). After treatment, BUN in allopurinol group was significantly lower than that before treatment, the difference was statistically significant (P < 0.05). Conclusion Febuxostat can reduce the SUA level of CKD and HUA patients with grade four to five of KDIGO, reduce Scr and proteinuria, and improve renal function.
2021 Vol. 18 (3): 62-66 [Abstract] ( 141 ) HTML (1 KB)  PDF (552 KB)  ( 94 )
67 Clinical effect of ureteroscopic tumor resection in the treatment of upper urinary tract tumor
LEI Ruru ZHANG Xiaolin LIU Lijie CHEN Huai’an
Objective To study clinical effect of ureteroscopic tumor resection in the treatment of upper urinary tract tumor. Methods Ninety-six patients with upper urinary tract tumor admitted to the First Affiliated Hospital of Hebei North University from April 2014 to April 2016 were included and divided into two groups according to the random number table, 48 cases in each group. Control group were treated with traditional open surgery, and observation group were treated with ureteroscopic tumor resection. The operation, quality of life, pain and complications between two groups were observed. The patients were followed up for one, two, three years. Results The operation time, first anal exhaust time, extubation time and hospitalization time of observation group were shorter than those of control group, and the amount of bleeding of observation group was less than that of control group, the differences were statistically significant (P < 0.05). After operation, ADL score of two groups was higher than that before operation, and VAS of two groups was lower than that before operation, ADL score of observation group was higher than that of control group, and VAS of observation group was lower than that of control group (P < 0.05). The incidence rate of complication in observation group was lower than that in control group (P < 0.05). There was no significant difference in one, two, three year survival rate between two groups (P > 0.05). Conclusion The effect of ureteroscopic resection for upper urinary tract tumor is similar to that of open surgery, but with good postoperative care, it can significantly improve the quality of life, relieve pain, shorten the recovery time, and have high safety.
2021 Vol. 18 (3): 67-70 [Abstract] ( 172 ) HTML (1 KB)  PDF (531 KB)  ( 90 )
71 Changes of RDW and NLR levels and prognosis in patients with end-stage renal disease undergoing maintenance hemodialysis
SHEN Yang QIN Mingming ZHANG Hongxu
Objective To study the changes of red blood cell distribution width (RDW) and neutrophil/lymphocyte ratio (NLR) levels and prognosis in patients with end-stage renal disease (ESRD) undergoing maintenance hemodialysis. Methods Clinical data of 152 patients with ESRD who received maintenance hemodialysis (ESRD group) in the Second People’s Hospital of Anhui (“our hospital” for short) from May 2017 to October 2019 were retrospectively analyzed, and 100 healthy people who received physical examination in our hospital during the same period were selected as control group. According to the survival of patients with ESRD, ESRD group was divided into death group (n = 25) and survival group (n = 127). The gender, age, body mass index (BMI), hemoglobin (Hb), albumin (ALB), high-sensitivity C-reactive protein (hs-CRP), blood calcium (Ca), blood phosphorus (P), serum creatinine (Scr), RDW, neutrophil count, lymphocyte number and NLR were compared in each group. Results Hb, ALB and the number of lymphocyte in ESRD group were lower than those in control group, hs-CRP, Ca, P, Scr, RDW, the number of neutrophil and NLR in ESRD group were higher than those in control group (P < 0.05). The age, hs-CRP, Ca, P, RDW and NLR of death group were higher than those of survival group, and the proportion of primary diseases, Hb, ALB and the number of lymphocytes of death group were lower than those of survival group (P < 0.05). Logistic regression analysis showed that age, Hb, ALB, diabetic nephropathy, hs-CRP, Ca, P, RDW, lymphocyte number and NLR were risk factors for the prognosis of patients with ESRD (P < 0.05). Conclusion RDW and NLR levels in maintenance hemodialysis patients with ESRD are increased, and they are independent risk factors for prognosis.
2021 Vol. 18 (3): 71-74 [Abstract] ( 424 ) HTML (1 KB)  PDF (535 KB)  ( 46 )
75 The efficacy of transurethral plasmakinetic resection of prostate and transurethral selective green laser vaporization of prostate in the treatment of benign prostatic hyperplasia
HE Haibing QI Ping WANG Hao
Objective To study the efficacy of transurethral plasmakinetic resection of prostate (TUPKRP) and transurethral selective green laser vaporization of prostate (PVP) in the treatment of benign prostatic hyperplasia (BPH). Methods Eighty patients with BPH admitted to Ma’anshan Central Hospital of Anhui Province from January 2017 to March 2020 were selected and divided into observation group and control group according to random number table method, 40 cases in each group. Observation group was treated with PVP, and control group was treated with TUPKRP. The perioperative situation, urination, prostate volume, international prostate symptom score (IPSS), quality of life (QOL) score and the incidence rate of complication were compared between two groups. Results The intraoperative blood loss of observation group was less than that of control group, and operation time, postoperative bladder irrigation time, postoperative catheter indwelling time and hospitalization time of observation group were shorter than those of control group, the differences were statistically significant (P < 0.05). At three months after operation, the maximum urinary flow rate of two groups was larger than that before operation, the residual urine volume was less than that before operation, and the prostate volume was less than that before operation (P < 0.05). At three months after operation, IPSS and QOL scores of two groups were lower than those before operation, and the differences were statistically significant (P < 0.05). Total incidence rate of complication in observation group was lower than that in control group (P < 0.05). Conclusion TUPKRP and PVP have similar efficacy in the treatment of BPH, but PVP has less injury, faster postoperative recovery and lower incidence rate of complication, which is worthy for application and promotion.
2021 Vol. 18 (3): 75-78 [Abstract] ( 367 ) HTML (1 KB)  PDF (568 KB)  ( 32 )
79 Analysis of risk factors related to postoperative incision infection for closed tibial fractures with internal fixation
WANG Bin1 ZHANG Wenxian2 LIAO Minjie2 ZHANG Kun2 SU Qi3 LI Jialin3 YAN Qikai3 ZHAO Jianwei3
Objective To analyze and discuss the possible influencing factors of postoperative incision infection for closed tibial fracture, and to provide some scientific theoretical basis for clinical prevention and treatment of postoperative incision infection for closed tibial fracture. Methods The data of 397 patients with closed tibial fractures treated by surgical internal fixation and followed up in the Department of Orthopedics, Gansu Provincial Hospital of Traditional Chinese Medicine from January 2018 to October 2019 were retrospectively analyzed by using the hospital electronic medical record system. Single-factor and multi-factor statistical analysis were performed on patients’ data. Results A total of 397 patients were followed up for six to twelve months, including ten patients with postoperative incision infection. Age ≥60 years old, hospitalization days ≥two weeks, body mass index ≥28 kg/m2 , combined with basic diseases (diabetes mellitus, hypertension, hyperlipidemia), smoking, duration of surgery ≥two hours, general anesthesia, intraoperative blood loss ≥500 mL, not reasonable use of antibiotics, not using negative pressure drainage, the higher soft tissue injury classification, the closed tibial fracture internal fixation of postoperative incision infection rate increased, the differences were statistically significant (all P < 0.05). Among them, age≥60 years old (OR = 4.136, 95%CI: 1.144-14.951, P ＜ 0.05), obesity (OR = 4.949, 95%CI: 1.258-19.461, P < 0.05), combined diabetes mellitus (OR = 5.250, 95%CI: 1.449-19.027, P ＜ 0.05), duration of surgery ≥two hours (OR = 5.714, 95%CI: 1.398-23.357, P ＜ 0.05) were independent risk factors for postoperative incision infection, while rational use of antibiotics (OR = 0.128, 95%CI: 0.025-0.668, P ＜ 0.05) and using negative pressure drainage (OR = 0.184, 95%CI: 0.039-0.877, P ＜ 0.05) during the whole perioperative period were independent protective factors for postoperative incision infection. Conclusion Postoperative incision infection is related to many factors in the whole perioperative period. Enough attention should be paid to in clinical work and positive prevention measures should be taken accordingly to reduce the postoperative incision infection rate of closed tibial fracture and finally achieve the goal of health medicine.
2021 Vol. 18 (3): 79-83 [Abstract] ( 418 ) HTML (1 KB)  PDF (663 KB)  ( 21 )
84 Clinical observation of modified Stoppa and ilioinguinal approach for the acetabular fractures
CHEN Dong1 ZHU Feng2 GONG Jie1 DI Dechun3 WANG Dechao4
Objective To observe the clinical value of modified Stoppa and ilioinguinal approach in the treatment of acetabular fractures. Methods A total of 72 patients with acetabular fractures admitted to Suzhou Xiangcheng People’s Hospital, Jiangsu Province from May 2014 to September 2018 were selected as the study subjects, and they were divided into observation group and control group by random number table method, with 36 cases in each group. The control group was treated with ilioinguinal approach for fracture reduction, while the observation group was treated with modified Stoppa approach for fracture reduction. The operative time, intraoperative bleeding volume, incision length and hospitalization time were recorded. Matta imaging assessment criteria and Matta function score criteria were used to evaluate the reduction quality and hip function of the two groups at two months after operation, respectively. The levels of interleukin-6 (IL-6), C-reactive protein (CRP) and procalcitonin (PCT) in the serum of the two groups were measured one day before operation and one week after operation. The occurrence of lateral femoral cutaneous nerve injury, sciatic nerve injury, incision infection and traumatic arthritis were calculated. Results The operation time, intraoperative bleeding volume, incision length and hospitalization time in the observation group were lower than those in the control group, the differences were statistically significant (all P ＜ 0.05). There was no statistically significant difference between the two groups in satisfaction rate of reduction and excellent rate of hip joint function (P ＞ 0.05). The postoperative serum levels of IL-6, CRP and PCT in the two groups were all higher than those before surgery, and the differences were statistically significant (all P ＜ 0.05). The postoperative serum levels of IL-6, CRP and PCT in the observation group were all lower than those in the control group, and the differences were statistically significant (all P ＜ 0.05). The incidence of adverse reactions in the observation group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion The modified Stoppa approach has the same efficacy as the ilioinguinal approach in the operation of hip fracture patients, but the former has more obvious advantages of minimally invasive, which can reduce the risk of inflammation in patients, reduce the incidence of adverse reactions, and provide better safety.
2021 Vol. 18 (3): 84-87,92 [Abstract] ( 463 ) HTML (1 KB)  PDF (623 KB)  ( 520 )
88 Clinical study on the treatment of thoracolumbar burst fracture with spinal cord injury by modified limited decompression surgery with reserved posterior ligament complex
CHEN Feng GUAN Zhong▲
Objective To investigate the clinical application of modified limited decompression surgery with reserved posterior ligament complex to treat thoracolumbar burst fracture with spinal cord injury. Methods A total of 90 patients with thoracolumbar burst fractures with spinal cord injury who were admitted to Qinghai University Affiliated Hospital from June 2017 to June 2019 were selected as the research subjects and they were divided into observation group and control group according to the random number table method, with 45 patients in each group. The observation group was treated with posterior approach modified limited decompression internal fixation surgery on the basis of reserving the posterior ligament complex, while the control group was treated with conventional posterior approach decompression surgery. The operation situation and bone graft fusion situation of the two groups were collected and compared. The height of injured vertebrae and cobb angle before and seven days after operation of the two groups were observed and compared. At the same time, follow-up was conducted 12 months after operation to observe the average degree of loss of spinal correction angle and the incidence of complications in the two groups. Results The operation time of the observation group was longer than that of the control group, and the difference was statistically significant (P ＜ 0.05). However, both intraoperative blood loss and intraoperative blood transfusion in the observation group were lower than those in the control group, and the differences were statistically significant (all P ＜ 0.05). The bone graft fusion time in the observation group was shorter than that in the control group, with statistically significant difference (P ＜ 0.05). Within 12 months, the rate of bone graft fusion in the observation group was higher than that in the control group, with statistically significant difference (P ＜ 0.05). After treatment, the height of the anterior and posterior margins of the injured vertebra in both groups was higher than that before treatment, and the cobb angle was lower than that before treatment, with statistically significant differences (all P ＜ 0.05). The average degree of spinal correction angle loss 12 months after treatment in the observation group was lower than that in the control group, and the difference was statistically significant (P < 0.05). Within 12 months after treatment, the incidence of complications in the observation group was lower than that in the control group, with statistically significant difference (P ＜ 0.05). Conclusion The modified limited decompression surgery with reserved the posterior ligament complex has a more significant effect on patients with thoracolumbar burst fractures and spinal cord injury, it can maximize the improvement on the basis of retaining the joint capsule, ligament complex and some spinous processes of patients, and it can maintain the stability of the patient’s spine, reduce the incidence of other complications, which has a good clinical application value.
2021 Vol. 18 (3): 88-92 [Abstract] ( 230 ) HTML (1 KB)  PDF (651 KB)  ( 63 )
93 Comparison of the curative effect of proximal coated tapered stem and fully coated rectangular stem in total hip arthroplasty
GAO Feng LI Tongxian LI Huixia CAO Xuyang MENG Liying YANG Jianbo
Objective To compare the curative effect between the proximal coated tapered stem prosthesis and the fully coated rectangular stem prosthesis in total hip arthroplasty (THA). Methods From March 2018 to March 2019, a total of 64 patients with THA in Jizhong Energy Xingtai Mining Group General Hospital were selected, and a total of 32 patients with proximal coated tapered stem prosthesis and fully coated rectangular stem prosthesis were used. The operation time and intraoperative blood loss were compared, GE dual-energy X-ray absorptiometry was used to monitor the bone mineral density values around the prosthesis before and 1, 3, 6 and 12 months after the operation. And 6 months after surgery, Harris score and the incidence of adverse reactions of the prosthesis were combined the changes in bone mineral density, clinical efficacy and safety of the two prostheses were compared. Results There was no significant difference between the two groups in operation time and intraoperative blood loss (P ＞ 0.05). There was a statistically significant difference in bone mineral density between the two groups and times in Gruen 1 and 7 areas (P ＜ 0.05). The time point of the fully coated rectangular stem prosthesis group was higher than that of the proximal coated tapered stem prosthesis group, the difference was statistically significant (P ＜ 0.05). The Harris scores of the two groups at 6 months after surgery were significantly higher than those before surgery, while the fully coated rectangular stem prosthesis group was higher than that of the proximal coated tapered stem prosthesis group, and the difference was statistically significant (P ＜ 0.05). Re-examination of the DR images of the two groups at 12 months after the operation showed that the prosthesis was in good position, and there was no loosening, sinking, or re-fracture around the prosthesis. Conclusion Proximal coated tapered stem prosthesis and fully coated rectangular stem prosthesis used in THA to treat hip fractures have better results and safety, but the fully coated rectangular stem prosthesis is better than the proximal coated tapered stem prosthesis. It has advantages in terms of bone ingrowth around the prosthesis, relief of postoperative pain and faster recovery of joint function.
2021 Vol. 18 (3): 93-96 [Abstract] ( 242 ) HTML (1 KB)  PDF (730 KB)  ( 76 )
97 Observation on the clinical rehabilitation effect of fixed-point two-step therapy on giant lumbar disc herniation
WANG Xiaobin1 XIE Hongzhi2▲ LI Hongtao1 SHA Yihui1 YANG Qi1 LI Baoli3
Objective To explore the method and clinical rehabilitation effect of the fixed-point two-step method to treat huge lumbar disc herniation. Methods From January 2018 to February 2019, a total of 160 patients who were hospitalized in the Department of Orthopedics and Traumatology of the Daxing District Hospital of Integrated Traditional Chinese and Western Medicine in Beijing were selected and they were divided into treatment group and control group by random number table method, with 80 cases in both groups. The treatment group was treated with the responsibility fixed-point side wrench method combined with suspension traction, while the control group was treated with massage manipulation combined with suspension traction. The clinical efficacy, the visual analogue scale (VAS), the Japanese orthopaedic association assessment treatment score (JOA), rang of motion (ROM), and skin segmental somatosensory evoked potential (DSEP) recorded in the skin segment innervation area of the stimulated nerve root before and after treatment were compared. Results Compared with the control group, the total effective rate of the treatment group was increased, and the difference was statistically significant (P ＜ 0.05). The VAS of the two groups after treatment were lower than those before treatment, while the treatment group was lower than the control group, and the differences were statistically significant (P ＜ 0.05); the JOA scores of the two groups after treatment were higher than before treatment, and the treatment group was higher than the control group, and the differences were statistically significant (P ＜ 0.05). The joint range of motion of the two groups after treatment were significantly higher than those before treatment, while the treatment group was higher than the control group, and the differences were statistically significant (P ＜ 0.05). The latency value of the somatosensory evoked potential DSEP-P40 wave after treatment between the two groups were lower than those before treatment, while the treatment group was lower than the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion The application of fixed-point two-step method to treat giant lumbar disc herniation has a good clinical rehabilitation effect.
2021 Vol. 18 (3): 97-100,104 [Abstract] ( 250 ) HTML (1 KB)  PDF (673 KB)  ( 90 )
101 Correlation analysis between plasma homocysteine level and hip bone mineral density in elderly men
FAN Bin LI Xiaoyu ZHANG Ping
Objective To explore the relationship between plasma homocysteine level and hip bone mineral density in elderlymen. Methods A total of 246 male patients who were hospitalized in the Department of Geriatrics of Beijing Jishuitan Hospital from January 2015 to December 2017 were selected. According to their serum homocysteine levels, they were divided into high (H) Hcy group (≥15 μmol/L) and normal group with 160 cases (＜15 μmol/L), while the correlation between hip bone mineral density and Hcy levels in the two groups was studied. Results The PTH level of HHcy group was higher than that of normal group, and the difference was statistically significant (P ＜ 0.05). The bone mineral density of the femoral neck, greater trochanter and femur in the HHcy group were lower than those of the normal group, and the differences were statistically significant (P ＜ 0.05). Hcy level was negatively correlated with femoral neck, greater trochanter, and total bone mineral density of femur (r = -0.267, -0.165, -0.209, P ＜ 0.05). PTH level was negatively correlated with femoral neck, greater trochanter, and total bone mineral density of the femur (r = -0.160, -0.123, -0.133, P ＜ 0.05). Conclusion There is a negative correlation between hip bone mineral density and Hcy level in elderly male patients, and attention should be paid to the reduction of bone mineral density caused by high Hcy. Active treatment of hyperhomocysteinemia is of great significance to delay the reduction of hip bone mineral density.
2021 Vol. 18 (3): 101-104 [Abstract] ( 238 ) HTML (1 KB)  PDF (651 KB)  ( 127 )
105 Meta analysis of risk factors related to recurrence of henoch schonlein purpura in children
HE Songwei1 WANG Junhong2▲ ZHAO Qian1
Objective To systematically analyze the risk factors related to recurrence of henoch schonlein purpura (HSP) in children. Methods According to the method of evidence-based medicine, the relevant cohort study and case-control study on risk factors for HSP recurrence in children were searched in PubMed, Web of Science, Cochrane Library, CNKI, WanFang database and VIP database from January 2005 to January 2020. Based on inclusion and exclusion criterions, documents that meet the requirements were selected, the quality of the included literatures was evaluated, and the corresponding observation indicators (such as age, gender, race, onset season, course of disease, clinical manifestations, laboratory tests, therapeutic drugs, etc.) were extracted. The meta analysis was performed by RevMan 5.3 software. Results A total of 26 studies with 6933 HSP children were included. Meta analysis results showed that: the recurrent purpura (≥3 times) at first onset of the disease (OR = 2.43, 95%CI: 1.26-4.68, P = 0.008), joint swelling and pain at first onset of the disease (OR = 1.77, 95%CI: 1.07-2.93, P = 0.03), renal damage at first onset of the disease (OR = 2.46, 95%CI: 1.61-3.76, P < 0.0001), allergen positive (OR = 7.74, 95%CI: 3.84-15.60, P ＜ 0.000 01), respiratory tract infection after the first cure (OR = 2.35, 95%CI: 1.58-3.49, P ＜ 0.0001), no preventive medication after the first cure (OR = 5.35, 95%CI: 3.81-7.52, P ＜ 0.000 01), no diet control after the first cure (OR = 2.14, 95%CI: 1.56-2.94, P ＜ 0.000 01), and no sport restriction after the first cure (OR = 3.16, 95%CI: 2.08-4.78, P ＜ 0.000 01) were risk factors for HSP recurrence in children. The subgroup analysis showed that: the risk factors in Chinese population were glucocorticoid therapy (OR = 72.34, 95%CI：13.38-391.05, P < 0.000 01), older age (OR = 2.66, 95%CI:1.94-3.66, P < 0.000 01) and severe abdominal pain at first onset of the disease (OR = 2.19, 95%CI：1.42-3.36, P = 0.0004). The risk factors in non-Chinese population was glucocorticoid therapy (OR = 2.26, 95%CI：1.39-3.68, P = 0.001). Conclusion The risk factors for the recurrence of children’s HSP are the recurrent purpura, joint swelling and pain and renal damage at the first onset of disease, allergen positive, respiratory tract infection, no preventive drugs, no diet control and no sport restriction after the first cure. The recurrence rates of HSP children with older age, use of Glucocorticoid therapy, severe abdominal pain af first onset of the disease were different between Chinese and non-Chinese groups.
2021 Vol. 18 (3): 105-110 [Abstract] ( 401 ) HTML (1 KB)  PDF (1238 KB)  ( 51 )
112 Analysis of related factors of bone metabolism situation of premature infants at birth
WANG Haibo1 WANG Yumei2 PAN Zhaojun3 CHEN Ying2▲ LIN Xiaofei1 LIU Juan3
Objective To analyze the relationship between serum bone metabolism indexes and factors such as gestational age and body weight and body length of premature infants at birth. Methods A total of 287 premature infants who were hospitalized in Neonatal Intensive Care Unit of Huai’an Maternal and Child Health Hospital, Medical College of Yangzhou University from March 2017 to February 2018 were enrolled. According to gestational age，they were divided into <32 weeks group (68 cases), 32-33+6 weeks group (77 cases) and ≥34 weeks group (142 cases); according to the weight, they were divided into <1500 g group (38 cases), 1500-2499 g group (202 cases) and ≥2500 g group (47 cases); according to the relationship between birth weight and gestational age, they were divided into small-gestational age group (SGA group, 50 cases), appropriate gestational age  group (AGA group, 231 cases) and larger-gestational age group (LGA group, 6 cases). Serum calcium, phosphorus, alkaline phosphatase, 25-hydroxyvitamin D and insulin-like growth factor-Ⅰ (IGF-Ⅰ) were detected and compared in each group at birth and the relationship between bone metabolism indexes and body length at birth in premature infants were analyzed. Results Serum calcium levels of premature infants at birth in ≥34 weeks group were higher than those in <32 weeks group and 32-33+6 weeks group, and serum calcium levels in 32-33+6 weeks group were higher than those in <32 weeks group (all P < 0.05). Serum calcium, IGF-Ⅰ levels in 2500 g group and 1500-2499 g group were higher than those in <1500 g group (all P < 0.05). Serum calcium and IGF-Ⅰ levels were positively correlated with body length at birth (r = 0.419, 0.221, P < 0.05). Serum phosphorus levels in AGA group were higher than those in SGA group (P < 0.05). Conclusion The levels of serum calcium, phosphorus and IGF-Ⅰ of premature infants at birth are related to their gestational age, body weight, body length and other indexes，and these indexes can be used as important monitoring indexes of bone metabolism in premature infants during hospitalization.
2021 Vol. 18 (3): 112-115,119 [Abstract] ( 167 ) HTML (1 KB)  PDF (588 KB)  ( 141 )
116 Comparative analysis of the effect of hypothyroidism and subhypothyroidism on pregnancy outcome and fetus in pregnant women
JI Ying1 ZHU Bei2 MA Zongli1▲
Objective To analyze and compare the effect of hypothyroidism (“hypothyroidism” for short) and sub-clinical hypothyroidism (“subhypothyroidism” for short) on pregnancy outcome and fetus in pregnant women. Methods From July 2016 to June 2019, 80 cases of pregnant women who received prenatal examination and gave birth in Rugao People’s Hospital Affiliated to Nantong University were selected as the research objects. Ten weeks of pregnancy patients were performed thyroid function, and they were divided into subhypothyroidism group (30 cases) and  hypothyroidism group (50 cases). The pregnancy outcomes and fetal adverse outcomes were compared between the two groups. Results There were no statistically significant differences in the incidence of hypertensive disease during pregnancy, postpartum hemorrhage, premature rupture of membranes, preterm delivery and anemia between two groups (P > 0.05); the incidence of gestational diabetes in subthyroidism group were significantly higher than those in hypothyroidism group (P < 0.05). No placenta previa or placental abruption occurred in both groups. There were no low birth weight infants between two groups. There were no statistically significant differences in the incidence of malformation and fetal distress, 5 min Apgar score (P > 0.05). Conclusion Both hypothyroidism and subhypothyroidism in pregnant women have adverse effects on pregnancy outcome and fetus, and have adverse factors on the physical and fetal development of pregnant women. Subhypothyroidism is relatively higher in some pregnancies and fetal adverse outcomes, so it is very important to screen thyroid function in early clinical stage and implement relevant intervention measures.
2021 Vol. 18 (3): 116-119 [Abstract] ( 100 ) HTML (1 KB)  PDF (545 KB)  ( 126 )
120 Analysis of pregnancy complications and pregnancy outcomes in pregnant women of different production time and ages
HUANG Chuanyu
Objective To analyze the pregnancy complications and pregnancy outcomes in pregnant women of different production time and ages. Methods From January 2017 to December 2019, 10 300 pregnant women admitted to the People’s Hospital of Yi’nan County, Shandong Province were selected as research objects. According to the production time, they were divided into primipara group (3535 cases) and multipara group (6765 cases); according to the age, they were divided into <25 years old group (1296 cases), 25-30 years old group (2581 cases), >30-35 years old group (3976 cases), >35-40 years old group (1795 cases), and >40 years old group (652 cases). The incidence of pregnancy complications and pregnancy outcomes in pregnant women of different production time and ages, such as hypertensive disorder complicating pregnancy (HDCP), gestational diabetes mellitus (GDM), premature rupture of fetal membranes (PROM), fetal growth restriction (FGR), placenta previa, etc. were compared. Results The incidence of HDCP, GDM, PROM, FGR, placenta previa, and oligohydramnios in different age groups were statistically significant (all P < 0.05). Cesarean section rate and the incidence of perinatal death, premature delivery, neonatal asphyxia, macrosomia and postpartum hemorrhage in different age groups were statistically significant (all P < 0.05). The incidence of HDCP, GDM and PROM in multipara group were higher than those in pluripara group, while the incidence of FGR was lower than that in primipara group, and the differences were statistically significant (all P < 0.05). There were no significant difference in the incidence of placenta previa and oligohydramnios between two groups (P > 0.05). The incidence of preterm birth, cesarean section, neonatal asphyxia and macrosomia in multipara group were higher than those in primipara group, and the differences were statistically significant (all P < 0.05). There were no significant differences in the incidence of perinatal death and postpartum hemorrhage between two groups (P > 0.05). Conclusion Pregnancy complications and pregnancy outcomes are different in pregnant women of different production time stages and ages. In order to further reduce the incidence of pregnancy complications and improve the pregnancy outcome, it is necessary to strengthen pregnancy care and prenatal screening, and do a good job in pregnancy care and health education.
2021 Vol. 18 (3): 120-123,127 [Abstract] ( 404 ) HTML (1 KB)  PDF (571 KB)  ( 98 )
124 Effect of Polylactic Acid Gel combined with artificial cycle therapy after hysteroscopy transcervical resection of adhesion
XIA Zhiyong LAN Li RAN Wei
Objective To study the application effect of Polylactic Acid Gel combined with artificial cycle therapy after hysteroscopic transcervical resection of adhesion(TCRA). Methods A total of 210 patients with intrauterine adhesions (IUA) who underwent TCRA in Affiliated Hospital of North Sichuan Medical College from December 2018 to February 2020 were retrospectively analyzed, according to treatment methods, they were divided into experimental group (108 cases) and control group (102 cases). Control group was treated with artificial cycle therapy after TCRA, and experimental group was treated with Polylactic Acid Gel on the basis of control group. After three cycles of treatment, the uterine cavity morphology, menstrual improvement and incidence of readhesion, uterine cavity volume and endometrial thickness, and adverse reactions were compared between two groups. Results The total effective rates of uterine cavity morphology and menstruation improvement in experimental group were higher than those in control group, with statistically significant (P ＜ 0.05). The incidence of readhesion in experimental group was lower than that in control group, with statistically significant (P ＜ 0.05). Uterine cavity volume in experimental group was bigger than that in control group and endometrial thickness in experimental group was higher than that in control group, with statistically significant (P ＜ 0.05). There was no significant difference in the total incidence of adverse reactions between two groups (P ＞ 0.05). Conclusion The efficacy of Polylactic Acid Gel combined with artificial cycle therapy after hysteroscopic TCRA is significant, which is worthy of application and promotion.
2021 Vol. 18 (3): 124-127 [Abstract] ( 276 ) HTML (1 KB)  PDF (546 KB)  ( 59 )
128 Effect of ultrasonic atomization of traditional Chinese medicine on seasonal allergic conjunctivitis and its influence on tear film stability
ZHANG Guanghong1,2 MO Guoyan3 HUANG Rong1,2 XUE Linping4 LI Dujun1,2 LUO Jihong1,2
Objective To observe the effect of ultrasonic atomization of traditional Chinese medicine(TCM) on seasonal allergic conjunctivitis(SAC) and its influence on tear film stability. Methods A prospective, randomized, controlled study was conducted from October 2018 to September 2019 in Department of Ophthalmology, Hubei Provincial Hospital of TCM. A total of 60 patients (116 eyes) diagnosed with SAC were selected in the study and divided into two groups according to the random number table method, 30 patients (59 eyes) in control group and 30 patients (57 eyes) in observation group. Both groups were treated with 0.1% olopatadine hydrochloride eye drops, while control group was treated with ultrasonic atomization of normal saline and observation group was treated with ultrasonic atomization of TCM. After continuous treatment for seven days, the clinical efficacy of the two groups was compared and the subjective symptom score, sign score, total score and tear film stability indexes before and after treatment were analyzed: noninvasive keratograph tear breakup time (NIk-BUT) and corneal fluorescein staining (FL) score. Results After treatment, total effective rate of observation group was significantly higher than that of control group(P ＜ 0.05). After treatment, subjective symptom scores, signs scores and total scores of both groups were lower than those before treatment, and the observation group were lower than those in the control group (P ＜ 0.05). After treatment, Nik-BUT in both groups was significantly longer than that before treatment, FL scores in both groups was significantly lower than that before treatment, moreover, Nik-BUT of the observation group was longer than the control group, and FL score was lower than the control group, the differences were statistically significant (P ＜ 0.05). Conclusion Ultrasound atomization of TCM can obviously improve the clinical effect of SAC, alleviate the symptoms and signs of patients, stabilize the tear film. It can prevent the occurrence of dry eyes and has good clinical application value.
2021 Vol. 18 (3): 128-131 [Abstract] ( 131 ) HTML (1 KB)  PDF (1018 KB)  ( 34 )
132 Effects of speech rehabilitation training on phonological changes, psychological state and quality of life of children after cleft palate
YAO Yuan1 ZHAO Zhiyu1 WANG Chen2 ZHANG Chunguang1 LU Na1 CHEN Hui1
Objective To study the effect of speech rehabilitation training on phonetic changes, psychological status and quality of life of children after cleft palate. Methods A retrospective analysis of 60 cases of children undergoing regular speech rehabilitation training in the Affiliated Hospital of North China Science and Technology University after cleft palate surgery from January 2018 to December 2019 was designed. The patients’ vocal acoustic characteristic parameters, including, fundamental frequency F0, Jitter, shimmer, normalized noise energy (NNE), harmonic-noise ratio (HNR), and the standardized “mental health diagnostic test” (MHT) for children and the Chinese version of the pediatric quality of life inventory measurement models (PedsQL) 4.0 scale were evaluted. Results There was no significant difference in F0 before and after rehabilitation training (P ＞ 0.05). Jitter, shimmer and NNE after rehabilitation training were all lower than those before rehabilitation training, and HNR was higher than that before rehabilitation training, with statistically significant differences (all P ＜ 0.05). The scores of learning anxiety, human anxiety, terror tendency and total anxiety tendency after rehabilitation training were all lower than those before rehabilitation training, and the differences were statistically significant (all P ＜ 0.05). After rehabilitation training, the scores of physiological function, social function, emotional function and role function were significantly higher than those before rehabilitation training, with statistically significant differences (P ＜ 0.05). Conclusion Speech rehabilitation training is helpful to restore the clarity and coordination of the children’s speech after cleft palate, and improve the children’s psychological state and quality of life, which should be actively promoted and applied.
2021 Vol. 18 (3): 132-135 [Abstract] ( 264 ) HTML (1 KB)  PDF (551 KB)  ( 33 )
136 Correlation analysis of children’s oral health behaviors and caries
ZHAO Jing ZHANG Lizhen
Objective To observe the oral health behavior of children in Shunyi District of Beijing and to analyze the correlation between oral health behavior and the occurrence of dental caries. Methods The physical examination data of 469 children aged between 11 and 12 years old in the Hospital of Shunyi District Beijing from January 2017 to January 2018 were selected as the research objects. All the children received dental health examination, and oral health behaviors were investigated by using the oral health epidemiology questionnaire in Shunyi District, Beijing. The incidence of caries in children was observed, and all children were divided into occurrence group and non-occurrence group according to the incidence of dental caries, the effects of oral health behaviors on the occurrence of dental caries were analyzed. Results Of the 469 children, 85 children had dental caries, with an incidence rate of 18.12%; the proportion of effective brushing (occasionally or never), the age to start brushing (＞ five years old), the frequency of brushing teeth (once a day), the frequency of not using fluoride toothpaste, the frequency of sweets eating (≥two times a day), and the proportion of no regular oral health examination in the occurrence group were all higher than those in the occurrence group (P ＜ 0.05); brushing their teeth checked by logistic regression analysis results showed that the effective case (occasionally OR never), start brushing age (＞ five years old), number of brushing teeth every day (once a day), without the use of fluoride toothpaste, frequency of sweets to eat every day (≥two times) OR higher, not regular oral health inspection are the influence factors in the devebopment of dental caries in children (OR ＞ 1, P ＜ 0.05). Conclusion There are differences in oral health behaviors among children in Shunyi District of Beijing, bad oral health behaviors may be the main cause of dental caries, and there is a significant correlation between them. In order to reduce the incidence of dental caries, it is necessary to evaluate children’s oral health behaviors as early as possible and take appropriate interventions.
2021 Vol. 18 (3): 136-139 [Abstract] ( 166 ) HTML (1 KB)  PDF (549 KB)  ( 100 )
140 Effects of Hengqing Ⅱ Prescribtion and Donepezil Hydrochloride on patients with Alzheimer’s disease and its mechanism
MENG Shengxi
Objective To explore the effects of Hengqing Ⅱ Prescribtion combined with Donepezil Hydrochloride on patients with Alzheimer’s disease (AD) and its mechanism. Methods A total of 107 AD patients admitted to Shanghai Jiao Tong University Affiliated Sixth People’s Hospital from January 2018 to January 2019 were randomly divided into control group（53 cases） and treatment group（54 cases） according to the random number table method. Both groups were given routine therapy. The control group was given Donepezil Hydrochloride Tablets on the basis of conventional treatment, and the treatment group was given Hengqing Ⅱ Prescribtion and Donepezil Hydrochloride Tablets on the basis of conventional treatment. The treatment course of both groups was three months. The cognitive scores of AD asesment scale-cognitive section (ADAS-Cog), activities of daily living (ADL), the montreal cognitive assessment scale (MoCA), neuropsychiatric inventory (NPI) and mini-mentalstateexamination (MMSE) were recorded before and after treatment. The levels of serum Aβ precursor protein (APP), Aβ1-42, homocysteine (Hcy), interleukin-1 (IL-1), IL-6 and IL-10 were measured. Adverse reactions were recorded. Results The scores of ADAs-cog and NPI of both groups after treatment were lower than before treatment, the scores of ADL, MoCA and MMSE were higher than those before treatment, the levels of serum APP, Aβ1-42, Cys C, Hcy, IL-1, IL-6 and IL-10 were all lower than those before treatment, the differences were statistically significant (P ＜ 0.05 or P ＜ 0.01). After treatment, the scores of ADAs-cog and NPI of the treatment group were lower than those in the control group, the scores of ADL, MoCA and MMSE were higher than those in the control group, and the levels of APP, Aβ1-42, Cys C, Hcy, IL-1, IL-6 and IL-10 were lower than those in the control group the differences were statistically significant (all P ＜ 0.05). There was no significant difference in the total adverse reaction rate between the two groups (P ＞ 0.05). Conclusion Hengqing Ⅱ Prescribtion combined with Donepezil Hydrochloride can significantly improve cognitive function of AD patients, which was exerted by decreasing the levels of serum APP, Aβ1-42, Cys C, Hcy, IL- 1, IL- 6 and IL-10 of AD patients.
2021 Vol. 18 (3): 140-144 [Abstract] ( 261 ) HTML (1 KB)  PDF (414 KB)  ( 162 )
145 Discussion on mechanism of famous old TCM doctors in treating gastric cancer from stasis based on network pharmacology
LI Binbin1* JIANG Min2* WANG Chaoran1 JIANG Lujian1 ZHOU Qin2 ZUO Minghuan2 JIANG Miao3
Objective To explore the medication rules of famous old TCM doctors in treating gastric cancer from stasis, and to discuss the molecular mechanism of the core drugs based on network pharmacology. Methods Literatures related to the treatment of gastric cancer of famous old TCM doctors from January 1, 2000 to October 1, 2019 were screened in CNKI, Wanfang Data, VIP databases by computer, and the prescriptions of famous old TCM doctors were collected by manual search of books. Ancient and modern medical records cloud platform (V1.5.6) was used to analyze common medicine combinations and key prescriptions. Traditional Chinese medicine system pharmacology database and analysis platform (TCMSP), GeneCards and on-line Mendelian inheritance in man (OMIM) databases were used to screen the effective targets of drug target and disease target interaction, and the effective targets were imported in String database to get protein-protein interaction (PPI) network. The effective targets were analyzed by R software for gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) related pathway enrichment and analysis. Results Totally 68 prescriptions were included and eight core drugs were obtained, 131 active components and 62 effective targets of core drugs were screened. The GO pathway enrichment analysis of the targets was mainly focused on steroid hormone response, reaction to toxic substances, nuclear receptor activity, etc. KEGG pathway enrichment analysis showed that the main action pathways were PI3K-Akt signaling pathway, apoptosis, MAPK signaling pathway and hypoxia-inducible factor 1 (HIF-1) signaling pathway, etc. Conclusion The results of this study suggest that the core drugs of promoting blood circulation for removing blood stasis mainly play a role in gastric cancer by influencing cell cycle, promoting apoptosis, reversing chemotherapy resistance and affecting angiogenesis, and they provide a theoretical basis for the later experimental study.
2021 Vol. 18 (3): 145-150 [Abstract] ( 338 ) HTML (1 KB)  PDF (1388 KB)  ( 98 )
151 Analysis on the medication rules of arthralgia in Centennial Hundred Chinese Medicine Clinicians Series based on data mining
CHEN Tiantian1 YUAN Jie2 CHEN Jie2 HAN Zucheng2 LIU Dongling2 WANG Min3 YU Penglong1 WEI Shujun4 WANG Jin2
Objective To analyze the medication rules of arthralgia in Centennial Hundred Chinese Medicine Clinicians Series by data mining technology. Methods The prescriptions for the treatment of arthralgia in Centennial Hundred Chinese Medicine Clinicians Series were collected and established a database. The prescriptions were analyzed by using the integration rules and complex system entropy hierarchical clustering and other data analysis methods of “traditional Chinese medicine inheritance support system (V2.5)”. Results The analysis of the 393 screened prescriptions showed that the common drugs used by hundreds of TCM doctors in modern times to treat arthralgia are Radix Angelicae Sinensis, Ramulus Cinnamomi, Radix Achyranthis Bidentatae, Radix Paeoniae Alba, Radix Glycyrrhizae, Radix Clematidis, Radix Astragali seu Hedysari, Radix Gentianae Macrophyllae, Herba Taxilli, Radix Stephaniae Tetrandrae. The flavours of drugs in prescriptions mostly are bitter, sweet and pungent, the nature is warm, and the drugs of prescriptions mostly belong to the liver, spleen and kidney meridians. High-frequency drug combinations (medicine pairs) include Radix Astragali seu Hedysari-Radix Angelicae Sinensis, Radix Angelicae Sinensis-Ramulus Cinnamomi, Radix Angelicae Sinensis-Radix Paeoniae Alba, Radix Paeoniae Alba-Ramulus Cinnamomi, Radix Glycyrrhizae-Ramulus Cinnamomi, Radix Astragali seu Hedysari-Ramulus Cinnamomi, Radix Achyranthis Bidentatae-Radix Angelicae Sinensis, Rhizoma Ligustici Chuanxiong-Radix Angelicae Sinensis, Radix Clematidis-Herba Taxilli, Caulis Spatholobi-Radix Angelicae Sinensis, etc. New prescriptions include Radix Rehmanniae Preparata-Rostellularia procumbens (L.) Ness, Cortex Magnoliae Officinalis-Herba Lophatheri, Fructus Arctii-Radix Paeoniae Alba, Radix Rubiae-Semen Armeniacae Amarum, Caulis Akebiae-Cornu Cervi Pantotrichum, etc. Conclusion Based on traditional Chinese medicine inheritance support system and using data mining technology, it is found that most of hundreds modern Chinese medicine practitioners treat arthralgia follow the therapeutic principle of “treating cold syndrome with heat methods”, “treating deficiency syndrome with tonifying methods”, “treating excess syndrome with purgative methods”, it reflects the academic idea of treating arthralgia from insufficiency of vital qi and the mixture causes of wind, cold and dampness, and it conforms to the principle of TCM treating both manifestation and root cause of disease.
2021 Vol. 18 (3): 151-155,176 [Abstract] ( 115 ) HTML (1 KB)  PDF (881 KB)  ( 73 )
156 Effect of Western medicine assisted by modified Gancao Fuzi Decoction in the treatment of patients with hemiplegia after stroke on inflammatory factors and Klotho protein
JIANG Rongrong GU Jiamei
Objective To observe the effect of Western medicine assisted by modified Gancao Fuzi Decoction in the treatment of patients with hemiplegia after stroke on inflammatory factors and Klotho protein, and to provide reference for clinical treatment. Methods One hundred and eighteen patients with hemiplegia after stroke admitted to Suzhou Hospital of Integrated Traditional Chinese and Western Medicine from August 2017 to August 2019 were selected. According to the treatment method, they were divided into two groups, with 59 cases in each group. The conventional group was given routine Western medicine treatment, such as active improvement circulation, regulation of brain cell metabolism, nutrition of nerve, and so on. The traditional Chinese medicine group was treated with modified Gancao Fuzi Decoction on the basis of conventional group. Both groups were treated continuously for four weeks. The changes of fibroblast growth factor 23 (FGF23), Klotho protein, highly sensitive C reactive protein (hs-CRP), interleukin-1β (IL-1β), endothelium-derived hyperpolarizing factor (EDHF), endothelin (ET), and modified Barthel index (BI) score, Fugl-Meyer assessment (FMA) score, modified Ashworth scale (MAS) were recorded before and after treatment, the total effective rate of clinical treatment in two groups was statistically analyzed. Results After treatment, the total effective rate of the traditional Chinese medicine group was higher than that of the conventional group, and the difference was statistically significant (P ＜ 0.05). The FGF23, Klotho protein, hs-CRP, IL-1β, ET and MAS score of the two groups were lower than those before treatment (P ＜ 0.05). The EDHF level and BI score and FMA score were higher than those before treatment (P ＜ 0.05), the FGF23, Klotho protein, hs-CRP, IL-1β, ET and MAS score of the traditional Chinese medicine group were lower than those of the conventional group (P ＜ 0.05), and the EDHF level and BI score and FMA score were higher than those of the conventional group (P ＜ 0.05). Conclusion Western medicine assisted by modified Gancao Fuzi Decoction in the treatment of hemiplegia after stroke can regulate the expression of FGF23 and Klotho protein, inhibit the inflammatory state, and improve the curative effect.
2021 Vol. 18 (3): 156-159,180 [Abstract] ( 385 ) HTML (1 KB)  PDF (944 KB)  ( 97 )
160 Effect of self-made Bushen Huatan Decoction combined with Metformin on insulin resistance and oxidative stress in polycystic ovary syndrome
LIU Zhiqin1 DING Dongmei2 XU Shumei1
Objective To explore the effect of self-made Bushen Huatan Decoction combined with Metformin on insulin resistance and oxidative stress in polycystic ovary syndrome (PCOS). Methods From June 2018 to June 2019, 70 patients with PCOS insulin resistance in Jiangyan Hospital of Traditional Chinese Medicine of Taizhou City in Jiangsu Province were selected and divided into control group and observation group according to random number table method, with 35 cases in each group. Control group was treated with Metformin, and observation group was treated with self-made Bushen Huatan Decoction on the basis of control group. The course of treatment was three months. Clinical efficacy, traditional Chinese medicine syndrome score, body mass index, hormone level before and after treatment and adverse reaction of two groups were observed. Results Total effective rate of observation group was higher than that of control group (P < 0.05). After treatment, traditional Chinese medicine syndrome scores of two groups were lower than those before treatment, and observation group was lower than that control group, the differences were statistically significant (P < 0.05). After treatment, body mass index, luteinizing hormone (LH)/follicle stimulating hormone (FSH), fasting blood glucose (FBG) and insulin resistance index (HOMA-IR) of two groups were lower than those before treatment, and glutathione peroxidase (GSH-Px) of two groups was higher than that before treatment, body mass index, LH/FSH, FBG and HOMA-IR of observation group were lower than those of control group, and GSH-Px of observation group was higher than that of control group, the differences were statistically significant (P < 0.05). There was no significant difference in incidence of adverse reactions between two groups (P > 0.05). Conclusion Self-made Bushen Huatan Decoction combined with Metformin has significant effect on PCOS insulin resistance, it has high safety and can improve oxidative stress and estrogen levels.
2021 Vol. 18 (3): 160-163 [Abstract] ( 223 ) HTML (1 KB)  PDF (684 KB)  ( 54 )
164 Prescription rules analysis of Professor Zheng Huifang in treating metrorrhagia based on data mining
BI Yingxue1 HE Jing1 ZHENG Saisai2 ZHAO Ping2 SUI Xinyue1 LIU Hui3
Objective To explore the prescription and medication rules of Professor Zheng Huifang of national famous veteran Chinese medicine practitioners in the treatment of metrorrhagia through data mining. Methods The prescriptions of metrorrhagia diagnosed by Professor Zheng Huifang in the papers, books and medical records published in the past clinical teaching and scientific research were collected. And the standard data was entered into the traditional Chinese medicine inheritance support system, the corresponding database was established by using the platform, and the data was counted and analyzed. Results A total of 63 medical records of Professor Zheng Huifang were collected, including 271 prescriptions. According to the analysis, the high-frequency drugs were Radix Rehmannia Preparata, Radix Astragali seu Hedysari, liquorice root, Os Draconis, Rhizoma Atractylodis Macrocephala, ass hide glue, Fructus Schisandrae Chinensis, Herba Ecliptae, Fructus Corni and Radix Paeoniae Alba. According to the efficacy of traditional Chinese medicine, qi tonic, yin tonic, blood tonic and astringent drugs were more common. Through the analysis of the four qi and five flavors of traditional Chinese medicine, the drugs used were warm, mild, sweet, bitter and pungent. According to the analysis of the meridian tropism of drugs, the drugs of liver meridian were the most commonly used, followed by the drugs of kidney and spleen meridians. Through cluster analysis, three new combinations were obtained: Oyster shall, Os Draconis, Radix Angelicae Sinensis, Poria, Rhizoma Cimicifugae; Cornus officinalis, Rhizoma Dioscoreae, Radix Rehmanniae Preparata, sanqi; eucommia, ass hide glue, Rhizoma Atractylodis macrocephala, Schizonepeta tenuifolia, coix seed. Conclusion Through data mining, Professor Zheng Huifang in the treatment of metrorrhagia is mainly based on nourishing the spleen, kidney and liver, pay attention to the sweet and warm drugs in medication. The new prescription obtained through analysis needs to be further verified by clinicians. Through the analysis, it also provides the direction for the better application of traditional Chinese medicine in the clinical treatment of metrorrhagia.
2021 Vol. 18 (3): 164-167 [Abstract] ( 255 ) HTML (1 KB)  PDF (709 KB)  ( 75 )
168 Study on medication rules of traditional Chinese medicine in treating infantile asthma based on literatures mining
REN Yuzhe1 YU Zhou1 CHEN Hong2 YANG Zeyi3 PENG Xuejin1 YANG Xiangzheng1
Objective To find out the medication rules of traditional Chinese medicine in treating infantile asthma and analyze the network by data mining. Methods The literatures of China National Knowledge Infrastructure (CNKI) from January 2009 to December 2019 were organized, with the theme of “pediatric asthma” and “Chinese medicine”, and the statistics were made on Chinese medicine treatment rules, traditional Chinese medicine compound dosage forms, combined use of Western medicine. The frequency statistics, drug pair statistics and the extraction and sorting of the main compatibility relationship of traditional Chinese medicine for treating pediatric asthma were carried out by Bibexcel analysis software. A visual network was built by NetDraw in Ucinet 6.0 software. Results From the statistical results, the traditional Chinese medicine compound dosage forms for treating pediatric asthma were mainly decoctions, patches, plasters and pastes. Western medicine was mostly combined with glucocorticoids and traditional Chinese medicine. The main treatment of traditional Chinese medicine for pediatric asthma was “ventilating lung qi and suppressing dyspnea”, “suppressing dyspnea and relieving cough”, and the drugs with the flavours of “bitter, sweet, pungent” and the nature of “cold, warm, clam”, and mostly belong to “lung, spleen, kidney” were mainly used. The most frequently used drug was ephedra (63 times), the most frequently used drug pair was ephedra and bitter apricot seed (43 times). In network relationship compatibility, ephedra, milkvetch root, earthworm, white mulberry root-bark and bitter apricot seed were all located at the center point. Conclusion At present, the treatment of pediatric asthma tends to choose a topical dosage form with high compliance. The main treatments are “ventilating lung qi”, “suppressing dyspnea” and “relieving cough”, and mainly use the drugs of superficies-relieving, dissipating phlegm, relieving cough and suppressing dyspnea. The data mining of medication rules of traditional Chinese medicine for pediatric asthma has guiding significance for clinical medicine, and has certain value for the inheritance and development of traditional Chinese medicine.
2021 Vol. 18 (3): 168-172 [Abstract] ( 349 ) HTML (1 KB)  PDF (930 KB)  ( 49 )
173 Exploration study on traditional Chinese medicine syndrome of patients after transcatheter aortic valve replacement
YU Zikai1 WU Yongjian2▲ CHEN Keji1▲
Objective To explore the distribution of traditional Chinese medicine syndromes in patients after transcatheter aortic valve replacement (TAVR). Methods Seventy elderly patients with severe aortic stenosis who were successfully treated with TAVR in Fuwai Hospital, Chinese Academy of Medical Sciences from January 2018 to January 2019 were selected. The symptoms and physicochemical indexes of patients were gathered, and the main syndromes were concluded according to the clinical data by using cluster analysis. Results The top ten traditional Chinese medicine syndromes symptoms of patients after TAVR were tiredness and weakness (88.6%), shortness of breath after exercise (77.4%), palpitation after exercise (77.1%), dry mouth (70.0%), spiritlessness and lazy speech (60.0%), white and greasy fur (57.1%), stabbing pain in chest and hypochondrium (55.7%), palpitation and oppression in chest (54.3%), sweating after activity (52.9%), dark red tongue (52.9%). The results of cluster analysis showed that traditional Chinese medicine syndromes can be summarized as yang deficiency syndrome, syndrome of deficiency of both qi and yin, qi and blood deficiency, blood stasis and water stagnation syndrome. Conclusion Traditional Chinese medicine syndromes of patients after TAVR operation are mainly yang deficiency syndrome, qi and yin deficiency syndrome, qi and blood deficiency, blood stasis and water stagnation syndrome. It provides a theoretical basis for the treatment of traditional Chinese medicine
2021 Vol. 18 (3): 173-176 [Abstract] ( 126 ) HTML (1 KB)  PDF (787 KB)  ( 33 )
177 A case report of pigmented villous nodular synovitis in the left knee
FANG Yuanyuan1 YAO Jie1 DONG Bo2 LIU Fang1 LI Xiaowei1 YUAN Puwei2 LIU Deyu2
Pigmented villous nodular synovitis is a rare, destructive fibrous tissue cell proliferative synovial lesion. The pathogenesis is not yet clear. Most of them are joint pain and swelling in the early stage, and joint interlocking and limited activity can occur in the late stage. Due to lack of specific performance, easy to miss the diagnosis and misdiagnosis, and the recurrence rate after treatment is extremely high. The atticle will report here a case admitted to the Affiliated Hospital of Shaanxi University of Chinese Medicine on November 30, 2019. The patient was given synovial incision and exploratory cleaning of the left knee combined with postoperative radiotherapy, and no recurrence was observed for more than three months. The following conclusions are drawn: low incidence of villous nodular synovitis, lack of specific clinical manifestations, easy to miss diagnosis and misdiagnosis, MRI can be used for qualitative diagnosis, pathological examination is the gold standard for diagnosis, and disease synovectomy combined with radiotherapy is a relatively mature diagnosis and treatment plan, but it is easy to relapse after surgery, so postoperative radiotherapy and regular follow-up are extremely important for the prognosis of the disease.
2021 Vol. 18 (3): 177-180 [Abstract] ( 168 ) HTML (1 KB)  PDF (442 KB)  ( 119 )
181 Implementation and effect evaluation of standardized training in emergency department of new registered nurses
CHEN Huifeng1 TIAN Meimei2 JIANG Jinxia1 WANG Lingmin1 SHAO Haiyan1
Objective To discuss the implementation and effects of standardized training programs in emergency department of new registered nurses. Methods The convenience sampling method was adopted to select 136 new nurses from the emergency department of the Tenth People’s Hospital of Tongji University as the research objects. The 66 new nurses in the emergency department in August 2017 were set as the control group, and the 70 new nurses in the emergency department in August 2018 were set as the observation group. The control group adopted the traditional standardized training program for new nurses, and adopted the mode of teaching by professional instructors in the emergency department. The observation group adopted an innovative standardized training program for new nurses. After training, the new nurses’ clinical nursing ability, theory and skills and satisfaction were evaluated. Results The ability self-evaluation and peer evaluation of new nurses in the observation group were significantly higher than those of the control group, and the differences were highly statistically significant (P < 0.01). The theoretical and operational performance of new nurses in the observation group were higher than those of the control group, and the differences were highly statistically significant (P < 0.01). The satisfaction of new nurses in the observation group with teaching were higher than those in the control group, and the differences were statistically significant (P < 0.05 or P < 0.01). Conclusion The innovative standardized training program in the emergency department can effectively improve the clinical ability of new nurses and increase training satisfaction. Nursing managers should scientifically design and dynamically update training programs, and take multiple measures to carry out standardized training for new nurses, so that the comprehensive ability of new nurses can achieve a spiral progressive improvement.
2021 Vol. 18 (3): 181-184 [Abstract] ( 305 ) HTML (1 KB)  PDF (580 KB)  ( 70 )
185 Application effect of quality control circle in the reducing the number of real-time unreasonable prescriptions in outpatient department
LI Xin ZUO Jing GUO Meiqi ZHU Fangfang CHEN Lumei XU Deduo YU Nianxi WU Rong
Objective To analyze the application of quality control circle in the reducing the number of real-time unreasonable prescriptions in outpatient Department in Changzheng Hospital of the Second Military Medical University (hereinafter referred to as “our hospital”), to improve the quality of pharmaceutical care, and to promote patient safe and rational drug use. Methods From January to June 2019, the quality control circle was used to reduce the number of unreasonable prescriptions in the outpatient department of our hospital in real time, then we analyzed the causes leading to the high number of unreasonable prescriptions, formulated countermeasures and implemented. The tangible and intangible results before and after applying quality control circle program were compared and analyzed, then the improvement effect was evaluated. Results After applying quality control circle program, the average number of real-time unreasonable prescriptions per day decreased from 1392 to 618. The target achievement rate was 91.17% and the improvement rate was 55.60%. The quality control techniques, problem solving abilities, work responsibility and other intangible achievements of the circle members have been improved. Conclusion The number of real-time unreasonable prescriptions in outpatient department was reduced by using Quality Control Circle, and can further ensure the safe and rational drug use.
2021 Vol. 18 (3): 185-188 [Abstract] ( 113 ) HTML (1 KB)  PDF (686 KB)  ( 77 )
189 Research on citizen participation in medical science and technology decision in the “post conventional science era”
LU Xufeng
The traditional elite decision-making model of “government-scientists” is no longer suitable for the development of medical science and technology in the “post-conventional science era”. Medical science and technology decision-making requires the participation not only of government authorities and medical science and technology experts, but also of the general public as stakeholders. Citizen participation is beneficial to avoid decision risks, to promote the integration of instrumental rationality and value rationality in medical science and technology decision making, and to cultivate citizens’ ability to participate. In order to construct an effective mechanism for citizens to participate in the decision-making of medical science and technology, it is necessary to focus on changing ideas, perfecting laws, innovating ways and enhancing citizens’ medical science and technology literacy.
2021 Vol. 18 (3): 189-192 [Abstract] ( 203 ) HTML (1 KB)  PDF (549 KB)  ( 54 )
193 Clinical research of effect of post-abortion care services on patients after induced abortion
LIU Tingting ZHENG Mingkang
Objective To investigate the effect and clinical value of post-abortion care (PAC) services on patients after induced abortion. Methods From July 2018 to June 2019, 400 patients who underwent induced abortion in Zhuhai City Maternity and Child Health Hospital of Guangdong Province were selected for retrospective analysis. According to the intervention measures, they were divided into control group (178 cases) and experimental group (222 cases). Control group was given the introduction of basic matters needing attention before and after induced abortion, and no effective contraceptive method was adopted after induced abortion; experimental group received PAC services before and after induced abortion and adopted efficient contraceptive method after abortion. The experimental group was further divided into Ustar yue group (143 cases) and intrauterine device group (79 cases) according to the methods of contraception selected after surgery. Vaginal bleeding time after induced abortion, endometrial thickness one month after the treatment, recovery of menstruation, intrauterine adhesion, pelvic inflammation and contraception were compared between each group. Results Vaginal bleeding time in experimental group was shorter than that of control group; endometrial thickness one month after the treatment was higher than that of control group; incidence of intrauterine adhesion was lower than that of control group; menstrual recovery rate was higher than that of control group and repregnancy rate was lower than that of control group (all P < 0.01). Vaginal bleeding time in Ustar yue group was shorter than that of intrauterine device group; endometrial thickness one month after the treatment was higher than that of intrauterine device group; menstrual recovery rate was higher than that of intrauterine device group and repregnancy rate was lower than that of intrauterine device group (P < 0.05 or P ＜ 0.01). Conclusion PAC service effectively improves contraception effect and decreases incidence of induced abortion and incidence of “high-risk induced abortion”. For those who do not want to have babies and need long-time conception or with older age, intrauterine device insertion is cheap, convenient, safe and effective; for those having intention to have babies or those young women not having babies, taking orally Ustar yue has better contraception effect, and contributes to recovery of endometrium and menstruation, shortens vaginal bleeding time and decreases incidence of intrauterine adhesion. PAC service deserves promotion in clinical application.
2021 Vol. 18 (3): 193-196 [Abstract] ( 142 ) HTML (1 KB)  PDF (555 KB)  ( 66 )
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