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| Effect of ultrasonic atomization of traditional Chinese medicine on seasonal allergic conjunctivitis and its influence on tear film stability |
| ZHANG Guanghong1,2 MO Guoyan3 HUANG Rong1,2 XUE Linping4 LI Dujun1,2 LUO Jihong1,2 |
1.Department of Ophthalmology, Hubei Provincial Hospital of Traditional Chinese Medicine, Hubei Province, Wuhan 430061, China;
2.Department of Ophthalmology, Hubei Province Academy of Traditional Chinese Medicine, Hubei Province, Wuhan 430074, China;
3.Key Laboratory of Chinese Medicine Resource and Compound Prescription, Ministry of Education, Hubei University of Chinese Medicine, Hubei Province, Wuhan 430065, China;
4.Ophthalmology Teaching and Research Office, Hubei University of Chinese Medicine, Hubei Province, Wuhan 430065, China |
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Abstract Objective To observe the effect of ultrasonic atomization of traditional Chinese medicine(TCM) on seasonal allergic conjunctivitis(SAC) and its influence on tear film stability. Methods A prospective, randomized, controlled study was conducted from October 2018 to September 2019 in Department of Ophthalmology, Hubei Provincial Hospital of TCM. A total of 60 patients (116 eyes) diagnosed with SAC were selected in the study and divided into two groups according to the random number table method, 30 patients (59 eyes) in control group and 30 patients (57 eyes) in observation group. Both groups were treated with 0.1% olopatadine hydrochloride eye drops, while control group was treated with ultrasonic atomization of normal saline and observation group was treated with ultrasonic atomization of TCM. After continuous treatment for seven days, the clinical efficacy of the two groups was compared and the subjective symptom score, sign score, total score and tear film stability indexes before and after treatment were analyzed: noninvasive keratograph tear breakup time (NIk-BUT) and corneal fluorescein staining (FL) score. Results After treatment, total effective rate of observation group was significantly higher than that of control group(P ＜ 0.05). After treatment, subjective symptom scores, signs scores and total scores of both groups were lower than those before treatment, and the observation group were lower than those in the control group (P ＜ 0.05). After treatment, Nik-BUT in both groups was significantly longer than that before treatment, FL scores in both groups was significantly lower than that before treatment, moreover, Nik-BUT of the observation group was longer than the control group, and FL score was lower than the control group, the differences were statistically significant (P ＜ 0.05). Conclusion Ultrasound atomization of TCM can obviously improve the clinical effect of SAC, alleviate the symptoms and signs of patients, stabilize the tear film. It can prevent the occurrence of dry eyes and has good clinical application value.
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