|
|
Investigation and analysis of the ratio of urine microalbumin/urinary creatinine in adults in Suzhou community |
CHEN Bei SHEN Dong WEN Jiangtao ZHU Hongnan ZHANG Changsong |
Department of Laboratory, the Affiliated Suzhou Science and Technology Town Hospital of Nanjing Medical University, Jiangsu Province, Suzhou 215153, China |
|
|
Abstract Objective To investigate and analyze the distribution and abnormal rate of urinary microalbumin/urinary creatinine ratio (UACR) among adults in Suzhou community provide a theoretical basis for the prevention and treatment of chronic diseases. Methods The community adult residents filed in seven medical consortium communities in Suzhou High-tech Zone, Hengtang, Hu’guan, Yangshan, Zhenhu, Shishan, Tongan, and Dongzhu were selected from July 2017 to January 2020, while 14 350 cases were collected. All random urine microalbumin and urine creatinine values were detected, and the UACR value was calculated. The differences in the distribution of UACR in different age groups and genders, and the differences in the abnormal rates of UACR in different age groups and in different years were compared. Results Comparison of UACR values among different age groups showed statistically significant differences (P < 0.05). Further pairwise comparisons, the UACR values of the 70 to 80 years old group and the ≥80 years old group were compared with other age groups, and the differences were statistically significant (P < 0.05). The UACR level of women in the same age group were higher than that of men, and the differences were statistically significant (P < 0.05). Comparison of UACR values of different genders and age groups showed statistically significant differences (P < 0.05). Compared with the abnormal rate of UACR in different age groups, and the differences were statistically significant (P < 0.05). Compared with the abnormal rate of UACR from 2017 to 2020, and the differences were statistically significant (P < 0.05). Conclusion The distribution of UACR values is closely related to gender and age. The focus is on disease changes in people under 50 and over 70 in the region. At the same time, attention is paid to changes in data every year to strengthen the screening and prevention of early kidney damage.
|
|
|
|
|
[1] 郭慧欣,吴小荣,李海滨,等.糖尿病肾病早期诊断与治疗探究[J].陕西医学杂志,2014,43(11):1560-1561.
[2] Seccia TM,Caroccia B,Calò LA. Hypertensive nephropathy. Moving from classic to emerging pathogenetic mechanisms [J]. J Hypertens,2017,35(2):205-212.
[3] 陈碧玲,姚平,谭庆玲,等.糖尿病肾病等肾衰竭血液透析患者泌尿系感染临床分析[J].中华医院感染学杂志,2015,25(2):382-384.
[4] Cui J,Wan J,You D,et al. Interstitial complement C3 activation and macrophage infiltration in patients with hypertensive nephropathy [J]. Clin Nephrol,2017,88(12):328-337.
[5] Zhang L,Wang F,Wang L,et al. Prevalence of chronic kidney disease in China:a cross-sectional survey [J]. Lancet,2012,379(9818):815-822.
[6] 徐荣辉,彭丽容,许媛媛,等.上海市松江区洞泾镇老年慢性肾脏病筛查评估及并发症现状分析[J].公共卫生与预防医学,2019,30(6):90-94.
[7] 林雅慧,刘玉红,王宓,等.社区高危人群慢性肾脏病患病率及筛查策略研究[J].中国实用内科杂志,2018,38(12):1169-1172.
[8] Laliberté F,Bookhart BK,Vekeman F,et al. Direct all-cause health care costs associated with chronic kidney disease in patients with diabetes and hypertension:a managed care perspective [J]. J Manag Care Pharm,2009,15(4):312-322.
[9] Garg AX,Kiberd BA,Clark WF,et al. Albuminuria and renal insufficiency prevalence guides population screening:results from the NHANES Ⅲ [J]. Kidney Int,2002,61(6):2165-2175.
[10] Ramirez SP,McClellan W,Port FK,et al. Risk factors for proteinuria in a large,multiracial,southeast Asian population [J]. J Am Soc Nephrol,2002,13(7):1907-1917.
[11] 孙维娟,沈晔,黄燕萍,等.生活方式干预对早中期慢性肾脏病患者肾功能的影响[J].老年医学与保健,2017, 23(3):226-228,238.
[12] 赵汉君,葛智儒,杜安通,等.尿微量白蛋白/尿肌酐比值与慢性心力衰竭的关系分析[J].中国医药导刊,2016, 18(3):237-238,240.
[13] 余信强,张苏川.原发性高血压病人早期肾损伤影响因素的临床研究[J].蚌埠医学院学报,2019,44(2):167-170.
[14] 廖惠贞,朱晓洁,王春晖,等.糖尿病肾病早期诊断中相关检测指标的临床意义[J].中国卫生检验杂志,2017, 27(24):3561-3563.
[15] 刘小玲,张筠.点时间尿微量白蛋白/尿肌酐比值与24 h定量的临床评价[J].重庆医学,2005,34(10):1518-1520.
[16] 张学锋,朱立荣,刘建广,等.随机尿白蛋白/肌酐与24 h尿微量白蛋白相关性研究[J].天津医科大学学报,2012, 18(4):467-468.
[17] Mehrotra R,Budoff M,Hokanson JE,et al. Progression of coronary artery calcification in diabetics with and without chronic kidney disease [J]. Kidney Int,2005(68):1258-1266.
[18] 罗丽贞,张艳君,刘春林.胱抑素C与随机尿微量清蛋白/尿肌酐比值对原发性高血压病早期肾损害的诊断价值[J].国际检验医学杂志,2011,32(13):1515-1517.
[19] 郭丹丹,郭晓东,梁新秀,等.UACR在老年人群中的分布及其与心血管病危险因素的相关性研究[J].现代生物医学进展,2014,14(1):93-95,30.
[20] 周京敏,崔晓通,金雪娟,等.社区老年人群尿微量白蛋白/尿肌酐比值与心血管病危险因素的关系[J].中华心血管病杂志,2011,39(5):463-467.
[21] Wang YK,Yuan AH,Yu C. Correlation between microalbuminuria and cardiovascular events [J]. J Korean Med Sci,2013,6(10):973-978.
[22] Hao Z,Konta T,Takasaki S,et al. The Association between Microal-buminuria and Metabolic Syndrome in the General Population in Japan:The Takahata Study [J]. Intern Med,2007,46(7):341-346.
[23] 郑瑾,叶平,王凡,等.北京市2080名社区人群不同性别微量白蛋白尿患病率及相关因素研究[J].中华流行病学杂志,2010,31(11):1250-1254.
[24] 单婵娟,龙俊睿,顾春英,等.上海市闵行区慢性肾脏病高危人群患病情况及危险因素分析[J].第二军医大学学报,2018,39(1):44-49.
[25] Wu HY,Peng YS,Chiang CK,et al. Diagnostic performance of random urine samples using albumin concentration vs ratio of albumin to creatinine for microalbuminuria screening in patients with diabetes mellitus:a systematic review and meta-analysis [J]. JAMA Intern Med,2014,174(7):1108-1115. |
|
|
|