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| Effects of Hengqing Ⅱ Prescribtion and Donepezil Hydrochloride on patients with Alzheimer’s disease and its mechanism |
| MENG Shengxi |
| Department of Traditional Chinese Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China |
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Abstract Objective To explore the effects of Hengqing Ⅱ Prescribtion combined with Donepezil Hydrochloride on patients with Alzheimer’s disease (AD) and its mechanism. Methods A total of 107 AD patients admitted to Shanghai Jiao Tong University Affiliated Sixth People’s Hospital from January 2018 to January 2019 were randomly divided into control group（53 cases） and treatment group（54 cases） according to the random number table method. Both groups were given routine therapy. The control group was given Donepezil Hydrochloride Tablets on the basis of conventional treatment, and the treatment group was given Hengqing Ⅱ Prescribtion and Donepezil Hydrochloride Tablets on the basis of conventional treatment. The treatment course of both groups was three months. The cognitive scores of AD asesment scale-cognitive section (ADAS-Cog), activities of daily living (ADL), the montreal cognitive assessment scale (MoCA), neuropsychiatric inventory (NPI) and mini-mentalstateexamination (MMSE) were recorded before and after treatment. The levels of serum Aβ precursor protein (APP), Aβ1-42, homocysteine (Hcy), interleukin-1 (IL-1), IL-6 and IL-10 were measured. Adverse reactions were recorded. Results The scores of ADAs-cog and NPI of both groups after treatment were lower than before treatment, the scores of ADL, MoCA and MMSE were higher than those before treatment, the levels of serum APP, Aβ1-42, Cys C, Hcy, IL-1, IL-6 and IL-10 were all lower than those before treatment, the differences were statistically significant (P ＜ 0.05 or P ＜ 0.01). After treatment, the scores of ADAs-cog and NPI of the treatment group were lower than those in the control group, the scores of ADL, MoCA and MMSE were higher than those in the control group, and the levels of APP, Aβ1-42, Cys C, Hcy, IL-1, IL-6 and IL-10 were lower than those in the control group the differences were statistically significant (all P ＜ 0.05). There was no significant difference in the total adverse reaction rate between the two groups (P ＞ 0.05). Conclusion Hengqing Ⅱ Prescribtion combined with Donepezil Hydrochloride can significantly improve cognitive function of AD patients, which was exerted by decreasing the levels of serum APP, Aβ1-42, Cys C, Hcy, IL- 1, IL- 6 and IL-10 of AD patients.
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