自拟补肾化痰方联合二甲双胍对多囊卵巢综合征胰岛素抵抗及氧化应激的影响

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Abstract Objective To explore the effect of self-made Bushen Huatan Decoction combined with Metformin on insulin resistance and oxidative stress in polycystic ovary syndrome (PCOS). Methods From June 2018 to June 2019, 70 patients with PCOS insulin resistance in Jiangyan Hospital of Traditional Chinese Medicine of Taizhou City in Jiangsu Province were selected and divided into control group and observation group according to random number table method, with 35 cases in each group. Control group was treated with Metformin, and observation group was treated with self-made Bushen Huatan Decoction on the basis of control group. The course of treatment was three months. Clinical efficacy, traditional Chinese medicine syndrome score, body mass index, hormone level before and after treatment and adverse reaction of two groups were observed. Results Total effective rate of observation group was higher than that of control group (P < 0.05). After treatment, traditional Chinese medicine syndrome scores of two groups were lower than those before treatment, and observation group was lower than that control group, the differences were statistically significant (P < 0.05). After treatment, body mass index, luteinizing hormone (LH)/follicle stimulating hormone (FSH), fasting blood glucose (FBG) and insulin resistance index (HOMA-IR) of two groups were lower than those before treatment, and glutathione peroxidase (GSH-Px) of two groups was higher than that before treatment, body mass index, LH/FSH, FBG and HOMA-IR of observation group were lower than those of control group, and GSH-Px of observation group was higher than that of control group, the differences were statistically significant (P < 0.05). There was no significant difference in incidence of adverse reactions between two groups (P > 0.05). Conclusion Self-made Bushen Huatan Decoction combined with Metformin has significant effect on PCOS insulin resistance, it has high safety and can improve oxidative stress and estrogen levels.

Key words： Self-made Bushen Huatan Decoction Metformin Polycystic ovary syndrome Insulin resistance

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	LIU Zhiqin1 DING Dongmei2 XU Shumei1

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LIU Zhiqin1 DING Dongmei2 XU Shumei1. Effect of self-made Bushen Huatan Decoction combined with Metformin on insulin resistance and oxidative stress in polycystic ovary syndrome[J]. 中国医药导报, 2021, 18(3): 160-163.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2021/V18/I3/160

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