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| Comparative analysis of the effect of hypothyroidism and subhypothyroidism on pregnancy outcome and fetus in pregnant women |
| JI Ying1 ZHU Bei2 MA Zongli1▲ |
1.Department of Gynecology and Obstetrics, Rugao Hospital Affiliated to Nantong University, Jiangsu Province, Rugao 226500, China;
2.Department of Endocrinology, Rugao Hospital Affiliated to Nantong University, Jiangsu Province, Rugao 226500, China |
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Abstract Objective To analyze and compare the effect of hypothyroidism (“hypothyroidism” for short) and sub-clinical hypothyroidism (“subhypothyroidism” for short) on pregnancy outcome and fetus in pregnant women. Methods From July 2016 to June 2019, 80 cases of pregnant women who received prenatal examination and gave birth in Rugao People’s Hospital Affiliated to Nantong University were selected as the research objects. Ten weeks of pregnancy patients were performed thyroid function, and they were divided into subhypothyroidism group (30 cases) and hypothyroidism group (50 cases). The pregnancy outcomes and fetal adverse outcomes were compared between the two groups. Results There were no statistically significant differences in the incidence of hypertensive disease during pregnancy, postpartum hemorrhage, premature rupture of membranes, preterm delivery and anemia between two groups (P > 0.05); the incidence of gestational diabetes in subthyroidism group were significantly higher than those in hypothyroidism group (P < 0.05). No placenta previa or placental abruption occurred in both groups. There were no low birth weight infants between two groups. There were no statistically significant differences in the incidence of malformation and fetal distress, 5 min Apgar score (P > 0.05). Conclusion Both hypothyroidism and subhypothyroidism in pregnant women have adverse effects on pregnancy outcome and fetus, and have adverse factors on the physical and fetal development of pregnant women. Subhypothyroidism is relatively higher in some pregnancies and fetal adverse outcomes, so it is very important to screen thyroid function in early clinical stage and implement relevant intervention measures.
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