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| Analysis of related factors of bone metabolism situation of premature infants at birth |
| WANG Haibo1 WANG Yumei2 PAN Zhaojun3 CHEN Ying2▲ LIN Xiaofei1 LIU Juan3 |
| 1.Department of Pediatrics, Huai’an Maternal and Child Health Hospital, Medical College of Yangzhou University, Jiangsu Province, Huai’an 223002, China; 2.Department of Child Health, Huai’an Maternal and Child Health Hospital, Medical College of Yangzhou University, Jiangsu Province, Huai’an 223002, China; 3.Department of Neonatology, Huai’an Maternal and Child Health Hospital, Medical College of Yangzhou University, Jiangsu Province, Huai’an 223002, China |
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Abstract Objective To analyze the relationship between serum bone metabolism indexes and factors such as gestational age and body weight and body length of premature infants at birth. Methods A total of 287 premature infants who were hospitalized in Neonatal Intensive Care Unit of Huai’an Maternal and Child Health Hospital, Medical College of Yangzhou University from March 2017 to February 2018 were enrolled. According to gestational age，they were divided into <32 weeks group (68 cases), 32-33+6 weeks group (77 cases) and ≥34 weeks group (142 cases); according to the weight, they were divided into <1500 g group (38 cases), 1500-2499 g group (202 cases) and ≥2500 g group (47 cases); according to the relationship between birth weight and gestational age, they were divided into small-gestational age group (SGA group, 50 cases), appropriate gestational age group (AGA group, 231 cases) and larger-gestational age group (LGA group, 6 cases). Serum calcium, phosphorus, alkaline phosphatase, 25-hydroxyvitamin D and insulin-like growth factor-Ⅰ (IGF-Ⅰ) were detected and compared in each group at birth and the relationship between bone metabolism indexes and body length at birth in premature infants were analyzed. Results Serum calcium levels of premature infants at birth in ≥34 weeks group were higher than those in <32 weeks group and 32-33+6 weeks group, and serum calcium levels in 32-33+6 weeks group were higher than those in <32 weeks group (all P < 0.05). Serum calcium, IGF-Ⅰ levels in 2500 g group and 1500-2499 g group were higher than those in <1500 g group (all P < 0.05). Serum calcium and IGF-Ⅰ levels were positively correlated with body length at birth (r = 0.419, 0.221, P < 0.05). Serum phosphorus levels in AGA group were higher than those in SGA group (P < 0.05). Conclusion The levels of serum calcium, phosphorus and IGF-Ⅰ of premature infants at birth are related to their gestational age, body weight, body length and other indexes，and these indexes can be used as important monitoring indexes of bone metabolism in premature infants during hospitalization.
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