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| Analysis on the medication rules of arthralgia in Centennial Hundred Chinese Medicine Clinicians Series based on data mining |
| CHEN Tiantian1 YUAN Jie2 CHEN Jie2 HAN Zucheng2 LIU Dongling2 WANG Min3 YU Penglong1 WEI Shujun4 WANG Jin2 |
1.School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Sichuan Province, Chengdu 610075, China;
2.Department of Encephalopathy Rehabilitation, Encephalopathy Hospital, Shaanxi Provincial Hospital of Traditional Chinese Medicine, Shaanxi Province, Xi’an 710003, China;
3.Orthopedic Department of Integrated Traditional Chinese and Western Medicine, Xi’an Honghui Hospital, Shaanxi Province, Xi’an 710054, China;
4.School of Basic Medicine Sciences, Chengdu University of Traditional Chinese Medicine, Sichuan Province, Chengdu 610075, China |
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Abstract Objective To analyze the medication rules of arthralgia in Centennial Hundred Chinese Medicine Clinicians Series by data mining technology. Methods The prescriptions for the treatment of arthralgia in Centennial Hundred Chinese Medicine Clinicians Series were collected and established a database. The prescriptions were analyzed by using the integration rules and complex system entropy hierarchical clustering and other data analysis methods of “traditional Chinese medicine inheritance support system (V2.5)”. Results The analysis of the 393 screened prescriptions showed that the common drugs used by hundreds of TCM doctors in modern times to treat arthralgia are Radix Angelicae Sinensis, Ramulus Cinnamomi, Radix Achyranthis Bidentatae, Radix Paeoniae Alba, Radix Glycyrrhizae, Radix Clematidis, Radix Astragali seu Hedysari, Radix Gentianae Macrophyllae, Herba Taxilli, Radix Stephaniae Tetrandrae. The flavours of drugs in prescriptions mostly are bitter, sweet and pungent, the nature is warm, and the drugs of prescriptions mostly belong to the liver, spleen and kidney meridians. High-frequency drug combinations (medicine pairs) include Radix Astragali seu Hedysari-Radix Angelicae Sinensis, Radix Angelicae Sinensis-Ramulus Cinnamomi, Radix Angelicae Sinensis-Radix Paeoniae Alba, Radix Paeoniae Alba-Ramulus Cinnamomi, Radix Glycyrrhizae-Ramulus Cinnamomi, Radix Astragali seu Hedysari-Ramulus Cinnamomi, Radix Achyranthis Bidentatae-Radix Angelicae Sinensis, Rhizoma Ligustici Chuanxiong-Radix Angelicae Sinensis, Radix Clematidis-Herba Taxilli, Caulis Spatholobi-Radix Angelicae Sinensis, etc. New prescriptions include Radix Rehmanniae Preparata-Rostellularia procumbens (L.) Ness, Cortex Magnoliae Officinalis-Herba Lophatheri, Fructus Arctii-Radix Paeoniae Alba, Radix Rubiae-Semen Armeniacae Amarum, Caulis Akebiae-Cornu Cervi Pantotrichum, etc. Conclusion Based on traditional Chinese medicine inheritance support system and using data mining technology, it is found that most of hundreds modern Chinese medicine practitioners treat arthralgia follow the therapeutic principle of “treating cold syndrome with heat methods”, “treating deficiency syndrome with tonifying methods”, “treating excess syndrome with purgative methods”, it reflects the academic idea of treating arthralgia from insufficiency of vital qi and the mixture causes of wind, cold and dampness, and it conforms to the principle of TCM treating both manifestation and root cause of disease.
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