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| Correlation analysis between plasma homocysteine level and hip bone mineral density in elderly men |
| FAN Bin LI Xiaoyu ZHANG Ping |
| Department of Cadre Section, Beijing Jishuitan Hospital, Beijing 100035, China |
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Abstract Objective To explore the relationship between plasma homocysteine level and hip bone mineral density in elderlymen. Methods A total of 246 male patients who were hospitalized in the Department of Geriatrics of Beijing Jishuitan Hospital from January 2015 to December 2017 were selected. According to their serum homocysteine levels, they were divided into high (H) Hcy group (≥15 μmol/L) and normal group with 160 cases (＜15 μmol/L), while the correlation between hip bone mineral density and Hcy levels in the two groups was studied. Results The PTH level of HHcy group was higher than that of normal group, and the difference was statistically significant (P ＜ 0.05). The bone mineral density of the femoral neck, greater trochanter and femur in the HHcy group were lower than those of the normal group, and the differences were statistically significant (P ＜ 0.05). Hcy level was negatively correlated with femoral neck, greater trochanter, and total bone mineral density of femur (r = -0.267, -0.165, -0.209, P ＜ 0.05). PTH level was negatively correlated with femoral neck, greater trochanter, and total bone mineral density of the femur (r = -0.160, -0.123, -0.133, P ＜ 0.05). Conclusion There is a negative correlation between hip bone mineral density and Hcy level in elderly male patients, and attention should be paid to the reduction of bone mineral density caused by high Hcy. Active treatment of hyperhomocysteinemia is of great significance to delay the reduction of hip bone mineral density.
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[1] 中华医学会骨质疏松和骨矿盐疾病分会.原发性骨质疏松症诊疗指南（2017）[J].中华骨质疏松和骨矿盐疾病杂志，2017：413-443.
[2] 赵建文，王晓伟，孙天胜，等.老年髋部骨折术后1年死亡风险及危险因素分析[J].实用骨科杂志，2020，26（5）：19-23.
[3] 贾桠钧.老年男性2型糖尿病患者骨质疏松调查及与体质量指数、糖化血红蛋白、病程和肾功能关系研究[J].中国骨质疏松杂志，2020，26（1）：75-78.
[4] Cosman F，de Beur SJ，LeBoff MS，et al. Clinician’s Guide to Prevention and Treatment of Osteoporosis [J]. Osteoporosis Int，2014，25（10）：2359-2381.
[5] 李蓉蓉，沈芸.高同型半胱氨酸血症与骨质疏松的相关性[J].中国老年保健医学，2017，15（2）：72-76.
[6] Takao H，Leila S，Julien L，et al. Prevalence of Systemic Atherosclerosis Burdens and Overlapping Stroke Etiologies and Their Associations With Long-term Vascular Prognosis in Stroke With Intracranial Atherosclerotic Disease [J]. JAMA Neurology，2018，75（2）：203-211.
[7] 迟洁，宫艳艳，郑霄，等.HCY及MTHFR多态性与冠心病易感性的关系[J].河北医药，2020，42（8）：29-32.
[8] 李霞，周伟伟.妊娠期代谢综合征患者同型半胱氨酸等指标的变化及相关性研究[J].浙江医学，2020，42（2）：150-153.
[9] 黄奕铭，谭爱花，张海英，等.广西防城港市中年男性同型半胱氨酸与代谢综合征相关性分析[J].中国现代医药杂志，2019，21（7）：9-12.
[10] Ohishi T，Fujita T，Nishida T，et al. Factors Influencing Serum Homocysteine Levels in Postmenopausal Osteoporotic Females-Comparison to Urinary Collagen Crosslinks [J]. Endocr Res，2019，44（3）：117-125.
[11] álvarez-Sánchez N，álvarez-Ríos AI，Guerrero JM，et al. Homocysteine levels are associated with bone resorption in pre-frail and frail Spanish women：The Toledo Study for Healthy Aging [J]. Exp Gerontol，2018，15（108）：201-208.
[12] Mittal M，Verma R，Mishra A，et al. Relation of Bone Mineral Density with Homocysteine and Cathepsin K levels in Postmenopausal Women [J]. Indian J Endocrinol Metab，2018，22（2）：261-266.
[13] Saoji R，Das RS，Desai M，et al. Association of high-density lipoprotein，triglycerides，and homocysteine with bone mineral density in young Indian tribal women [J]. Arch Osteoporos，2018，13（1）：108.
[14] 杨鸿兵，李红，徐京烨，等.体检人群血清同型半胱氨酸与前臂桡骨远端骨密度相关性分析[J].中国慢性病预防与控制，2019，27（2）：54-56.
[15] 康伟勤，王瑞亮，董雪芬，等.2型糖尿病患者血浆同型半胱氨酸与骨代谢指标相关性研究[J].浙江医学，2018，40（9）：84-85，87.
[16] 李冬华，吴洁.绝经妇女MTHFR基因多态性与骨密度关系的meta分析[J].中国计划生育学杂志，2012，20（11）：731-735.
[17] Thomas PV，Anuradha K，Michael JV，et al. The role of homocysteine in bone remodeling [J]. Clin Chem Lab Med，2013，51（3）：579-580.
[18] 闫慧，高飞.同型半胱氨酸水平与骨密度及骨转化标志物的相关性分析[J].中国临床研究，2015，28（9）：1135-1138.
[19] 葛久欣，刘艳，王玉倩，等.叶酸片对老年H型高血压患者骨密度及动脉粥样硬化的价值[J].世界最新医学信息文摘：电子版，2013（24）：90-92.
[20] Jianwei R，Xiaokang G，Jinsong K，et al. Effect of B vitamin （folate，B6，and B12） supplementation on osteoporotic fracture and bone turnover markers：a meta-analysis [J]. Med Sci Monit，2015，21（10）：875-881.
[21] Yuefeng Z，Jie S，Qun C，et al. Plasma homocysteine level is a risk factor for osteoporotic fractures in elderly patients [J]. Clin Int，2016，11（10）：1117-1121.
[22] 徐国玲，颜晓东.中老年人不同季节血25羟维生素D水平变化及其与骨代谢关系的研究[J].中国临床新医学，2018，11（12）：32-35.
[23] 余洋，王路，杨丽君，等.补充维生素D和钙对中年女性糖耐量减低合并骨量减少患者糖代谢和骨代谢标志物的影响[J].中国基层医药，2018，25（20）：2681-2684.
[24] 周建妹，陈进，邓冰莹，等.高血压患者血清同型半胱氨酸水平与肌酐、尿酸、甲状旁腺激素的关系[J].心脑血管病防治，2018，18（5）：394-395.
[25] 龙林会，张德文，陈芳.慢性肾功能衰竭患者血清甲状旁腺激素与胱抑素C及同型半胱氨酸的相关性研究[J].现代医药卫生，2015（5）：673-675.
[26] Federica F，Jessica P，Vittoria CD，et al. The relative influence of serum ionized calcium and 25-hydroxyvitamin D in regulating PTH secretion in healthy subjects [J]. Bone，2019，8（125）：208-206. |
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