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| Effect of Western medicine assisted by modified Gancao Fuzi Decoction in the treatment of patients with hemiplegia after stroke on inflammatory factors and Klotho protein |
| JIANG Rongrong GU Jiamei |
| Department of Pharmacy, Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, Jiangsu Province, Suzhou 215101, China |
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Abstract Objective To observe the effect of Western medicine assisted by modified Gancao Fuzi Decoction in the treatment of patients with hemiplegia after stroke on inflammatory factors and Klotho protein, and to provide reference for clinical treatment. Methods One hundred and eighteen patients with hemiplegia after stroke admitted to Suzhou Hospital of Integrated Traditional Chinese and Western Medicine from August 2017 to August 2019 were selected. According to the treatment method, they were divided into two groups, with 59 cases in each group. The conventional group was given routine Western medicine treatment, such as active improvement circulation, regulation of brain cell metabolism, nutrition of nerve, and so on. The traditional Chinese medicine group was treated with modified Gancao Fuzi Decoction on the basis of conventional group. Both groups were treated continuously for four weeks. The changes of fibroblast growth factor 23 (FGF23), Klotho protein, highly sensitive C reactive protein (hs-CRP), interleukin-1β (IL-1β), endothelium-derived hyperpolarizing factor (EDHF), endothelin (ET), and modified Barthel index (BI) score, Fugl-Meyer assessment (FMA) score, modified Ashworth scale (MAS) were recorded before and after treatment, the total effective rate of clinical treatment in two groups was statistically analyzed. Results After treatment, the total effective rate of the traditional Chinese medicine group was higher than that of the conventional group, and the difference was statistically significant (P ＜ 0.05). The FGF23, Klotho protein, hs-CRP, IL-1β, ET and MAS score of the two groups were lower than those before treatment (P ＜ 0.05). The EDHF level and BI score and FMA score were higher than those before treatment (P ＜ 0.05), the FGF23, Klotho protein, hs-CRP, IL-1β, ET and MAS score of the traditional Chinese medicine group were lower than those of the conventional group (P ＜ 0.05), and the EDHF level and BI score and FMA score were higher than those of the conventional group (P ＜ 0.05). Conclusion Western medicine assisted by modified Gancao Fuzi Decoction in the treatment of hemiplegia after stroke can regulate the expression of FGF23 and Klotho protein, inhibit the inflammatory state, and improve the curative effect.
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