基于文献挖掘中医药治疗儿科哮喘的用药规律研究

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Abstract Objective To find out the medication rules of traditional Chinese medicine in treating infantile asthma and analyze the network by data mining. Methods The literatures of China National Knowledge Infrastructure (CNKI) from January 2009 to December 2019 were organized, with the theme of “pediatric asthma” and “Chinese medicine”, and the statistics were made on Chinese medicine treatment rules, traditional Chinese medicine compound dosage forms, combined use of Western medicine. The frequency statistics, drug pair statistics and the extraction and sorting of the main compatibility relationship of traditional Chinese medicine for treating pediatric asthma were carried out by Bibexcel analysis software. A visual network was built by NetDraw in Ucinet 6.0 software. Results From the statistical results, the traditional Chinese medicine compound dosage forms for treating pediatric asthma were mainly decoctions, patches, plasters and pastes. Western medicine was mostly combined with glucocorticoids and traditional Chinese medicine. The main treatment of traditional Chinese medicine for pediatric asthma was “ventilating lung qi and suppressing dyspnea”, “suppressing dyspnea and relieving cough”, and the drugs with the flavours of “bitter, sweet, pungent” and the nature of “cold, warm, clam”, and mostly belong to “lung, spleen, kidney” were mainly used. The most frequently used drug was ephedra (63 times), the most frequently used drug pair was ephedra and bitter apricot seed (43 times). In network relationship compatibility, ephedra, milkvetch root, earthworm, white mulberry root-bark and bitter apricot seed were all located at the center point. Conclusion At present, the treatment of pediatric asthma tends to choose a topical dosage form with high compliance. The main treatments are “ventilating lung qi”, “suppressing dyspnea” and “relieving cough”, and mainly use the drugs of superficies-relieving, dissipating phlegm, relieving cough and suppressing dyspnea. The data mining of medication rules of traditional Chinese medicine for pediatric asthma has guiding significance for clinical medicine, and has certain value for the inheritance and development of traditional Chinese medicine.

Key words： Pediatric asthma Traditional Chinese medicine Medication rules Data mining

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	REN Yuzhe1 YU Zhou1 CHEN Hong2 YANG Zeyi3 PENG Xuejin1 YANG Xiangzheng1

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REN Yuzhe1 YU Zhou1 CHEN Hong2 YANG Zeyi3 PENG Xuejin1 YANG Xiangzheng1. Study on medication rules of traditional Chinese medicine in treating infantile asthma based on literatures mining[J]. 中国医药导报, 2021, 18(3): 168-172.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2021/V18/I3/168

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