基于网络药理学探讨名老中医从瘀论治胃癌的作用机制

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Abstract Objective To explore the medication rules of famous old TCM doctors in treating gastric cancer from stasis, and to discuss the molecular mechanism of the core drugs based on network pharmacology. Methods Literatures related to the treatment of gastric cancer of famous old TCM doctors from January 1, 2000 to October 1, 2019 were screened in CNKI, Wanfang Data, VIP databases by computer, and the prescriptions of famous old TCM doctors were collected by manual search of books. Ancient and modern medical records cloud platform (V1.5.6) was used to analyze common medicine combinations and key prescriptions. Traditional Chinese medicine system pharmacology database and analysis platform (TCMSP), GeneCards and on-line Mendelian inheritance in man (OMIM) databases were used to screen the effective targets of drug target and disease target interaction, and the effective targets were imported in String database to get protein-protein interaction (PPI) network. The effective targets were analyzed by R software for gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) related pathway enrichment and analysis. Results Totally 68 prescriptions were included and eight core drugs were obtained, 131 active components and 62 effective targets of core drugs were screened. The GO pathway enrichment analysis of the targets was mainly focused on steroid hormone response, reaction to toxic substances, nuclear receptor activity, etc. KEGG pathway enrichment analysis showed that the main action pathways were PI3K-Akt signaling pathway, apoptosis, MAPK signaling pathway and hypoxia-inducible factor 1 (HIF-1) signaling pathway, etc. Conclusion The results of this study suggest that the core drugs of promoting blood circulation for removing blood stasis mainly play a role in gastric cancer by influencing cell cycle, promoting apoptosis, reversing chemotherapy resistance and affecting angiogenesis, and they provide a theoretical basis for the later experimental study.

Key words： Network pharmacology Data mining Blood stasis Gastric cancer Famous old TCM doctors

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	LI Binbin1* JIANG Min2* WANG Chaoran1 JIANG Lujian1 ZHOU Qin2 ZUO Minghuan2 JIANG Miao3

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LI Binbin1* JIANG Min2* WANG Chaoran1 JIANG Lujian1 ZHOU Qin2 ZUO Minghuan2 JIANG Miao3. Discussion on mechanism of famous old TCM doctors in treating gastric cancer from stasis based on network pharmacology[J]. 中国医药导报, 2021, 18(3): 145-150.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2021/V18/I3/145

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