原位组织工程技术修复骨与软骨损伤的应用进展

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Abstract With the accelerating pace of life and the aggravation of the aging society, the incidence of bone and cartilage injury diseases is increasing. Traditional methods of treating bone and cartilage injuries have the disadvantages of long treatment time, poor curative effect and high cost. In order to better treat the disease, scholars put forward the concept of in situ tissue engineering technology. Through good scaffold materials and the regulation of its own microenvironment, under the guidance of cytokines, autologous seed cells (stem cells/progenitor cells) are recruited from the injured site to repair the damaged bone and cartilage, eliminating the need for traditional tissue engineering techniques. The required exogenous seed cells avoid the shortcomings of prolonged propagation of exogenous seed cells in vitro and possible immune rejection caused by implantation in the body, greatly shortening the treatment time and reducing the treatment failure rate. It has achieved remarkable results in the treatment of bone and cartilage injuries. By consulting the literature, this article summarizes and introduces the principles and clinical effects of in situ tissue engineering in the treatment of bone and cartilage injuries for reference.

Key words： In situ tissue engineering technology Bone Cartilage Seed cells Cytokines Scaffold materials

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	ZHANG Juntao1* YUE Chen2* TANG Yanfeng2 JIA Yudong2 LIU Youwen2

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ZHANG Juntao1* YUE Chen2* TANG Yanfeng2 JIA Yudong2 LIU Youwen2. Application progress of in situ tissue engineering technology to repair bone and cartilage injury[J]. 中国医药导报, 2021, 18(3): 39-42.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2021/V18/I3/39

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