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| Prescription rules analysis of Professor Zheng Huifang in treating metrorrhagia based on data mining |
| BI Yingxue1 HE Jing1 ZHENG Saisai2 ZHAO Ping2 SUI Xinyue1 LIU Hui3 |
1.College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Shandong Province, Ji’nan 250014, China;
2.the First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Shandong Province, Ji’nan 250014, China;
3.Department of Gynecology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Shandong Province, Ji’nan 250014, China |
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Abstract Objective To explore the prescription and medication rules of Professor Zheng Huifang of national famous veteran Chinese medicine practitioners in the treatment of metrorrhagia through data mining. Methods The prescriptions of metrorrhagia diagnosed by Professor Zheng Huifang in the papers, books and medical records published in the past clinical teaching and scientific research were collected. And the standard data was entered into the traditional Chinese medicine inheritance support system, the corresponding database was established by using the platform, and the data was counted and analyzed. Results A total of 63 medical records of Professor Zheng Huifang were collected, including 271 prescriptions. According to the analysis, the high-frequency drugs were Radix Rehmannia Preparata, Radix Astragali seu Hedysari, liquorice root, Os Draconis, Rhizoma Atractylodis Macrocephala, ass hide glue, Fructus Schisandrae Chinensis, Herba Ecliptae, Fructus Corni and Radix Paeoniae Alba. According to the efficacy of traditional Chinese medicine, qi tonic, yin tonic, blood tonic and astringent drugs were more common. Through the analysis of the four qi and five flavors of traditional Chinese medicine, the drugs used were warm, mild, sweet, bitter and pungent. According to the analysis of the meridian tropism of drugs, the drugs of liver meridian were the most commonly used, followed by the drugs of kidney and spleen meridians. Through cluster analysis, three new combinations were obtained: Oyster shall, Os Draconis, Radix Angelicae Sinensis, Poria, Rhizoma Cimicifugae; Cornus officinalis, Rhizoma Dioscoreae, Radix Rehmanniae Preparata, sanqi; eucommia, ass hide glue, Rhizoma Atractylodis macrocephala, Schizonepeta tenuifolia, coix seed. Conclusion Through data mining, Professor Zheng Huifang in the treatment of metrorrhagia is mainly based on nourishing the spleen, kidney and liver, pay attention to the sweet and warm drugs in medication. The new prescription obtained through analysis needs to be further verified by clinicians. Through the analysis, it also provides the direction for the better application of traditional Chinese medicine in the clinical treatment of metrorrhagia.
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[1] 刘凯，王艳国.中医传承辅助平台在中医药研究中应用现状[J].山东中医杂志，2015，34（5）：392-394.
[2] 郑惠芳，黄淑贞，孟庆洪，等.止血方治疗功血疗效观察（附：47例资料分析）[J].山东中医杂志，1983，2（5）：16-17.
[3] 郑惠芳，黄淑贞，孟庆洪，等.复旧固本治疗功血的体会——附205例疗效分析[J].山东中医学院学报，1985（3）：36-39.
[4] 张玉珍.中医妇产科学[M].北京：中国中医药出版社，2007：114.
[5] 高学敏.中药学[M].北京：中国中医药出版社，2017.
[6] 李健，卢朋，唐仕欢，等.基于中医传承辅助系统的治疗肺痈方剂组方规律分析[J].中国实验方剂学杂志，2012， 18（2）：254-257.
[7] 卢笑晖，单崎玮.基于中医传承辅助系统分析卢尚岭教授治疗头风病用药经验[J].中国实验方剂学杂志，2012， 18（9）：5-9.
[8] 杨洪军.中医传承辅助平台的开发及运用[M].福州：福建科学技术出版社，2013.
[9] 冯丽，阳纯平，李禺，等.抵当汤加减治疗瘀血内阻型崩漏出血期的临床应用[J].广州中医药大学学报，2019，36（1）：128-131.
[10] 张晓静，杜小利，邓玉娥，等.从脾胃论治崩漏[J].辽宁中医杂志，2019，46（8）：1631-1633.
[11] 王学梅，谢萍.逐瘀止血汤加减治疗崩漏60例疗效观察[J].辽宁中医杂志，2019，46（10）：2095-2098.
[12] 李皎.益气健脾固冲汤治疗脾虚型崩漏的效果分析[J].中国医药指南，2019，17（34）：195.
[13] 黄碧欣.举元煎加减配合艾灸对气虚型崩漏患者的临床疗效分析[J].中国社区医师，2020，36（4）：113-115.
[14] 施嫣嫣，张丽，丁安伟.墨旱莲化学成分及药理作用研究[J].吉林中医药，2011，31（1）：68-70.
[15] 任笑传，程凤银.墨旱莲的化学成分、药理作用及其临床应用[J].解放军预防医学杂志，2013，31（6）：559-561. |
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