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2020 Vol. 17, No. 11
Published: 2020-04-15
 
 
4 Effect of Aifeitimeng Tang on vascular smooth cell migration and proliferation-related proteins in rabbits with atherosclerosis
Haiernishaguli·Yiming1,2 Mireguli·Kmili3 DOU Qin2 LI Zhijian2 Silafu·Aibai1,2
Objective To investigate the effect of Aifeitimeng Tang on vascular smooth cell migration and proliferation. Methods Forty-eight rabbits were randomly divided into normal group, model group, positive control group and Aifeitimeng Tang high, medium and low dose groups, with 8 rabbits in each group. Normal group was given normal feed. Other 5 groups were fed high-fat diet, once a day for 60 consecutive days. Model group was gavaged with normal saline, Simvastatin Tablets in positive control group were gavaged with 0.002 g/kg and Aifeitimeng Tang was gavaged with low, medium and high dose groups with 3.3, 6.5, 13.0 g/kg, once a day, for 60 consecutive days. Immunohistochemistry was used to determine the effect of Aifeitimeng Tang on proliferating cell nuclear antigen (PCNA) and platelet derived growth factor (PDGF) in rabbits with AS, PCNA protein expression was detected by Western blot. Results In normal group, a small number of PCNA positive cells were observed, and a small amount of uneven brown-yellow granules were observed in the nucleus. The percentage of PCNA positive cells in model group was higher than that in normal group (P < 0.01). The percentage of PCNA positive cells in Aifeitimeng Tang high, medium and low dose groups were lower than those in model group (P < 0.05 or P < 0.01). A small number of PDGF positive cells were observed in normal group, and a small amount of uneven brown-yellow granules were observed in the nucleus. The percentage of PDGF positive cells in model group was higher than that in normal group (P < 0.05), and the percentage of PDGF positive cells in Aifeitimeng Tang low and high dose groups were lower than those in model group (P < 0.05). Conclusion Aifeitimeng Tang has a significant inhibitory effect on the formation of experimental rabbits model of AS, and its mechanism is related to the decrease of PCNA and PDGF content in the vascular wall and the decrease of PCNA protein expression in the vascular wall of rabbits.
2020 Vol. 17 (11): 4-7 [Abstract] ( 144 ) HTML (1 KB)  PDF (658 KB)  ( 156 )
8 Effect of Bushen Huatan Decoction on bone remodeling balance in ovariectomized osteoporosis rats
ZHOU Ya′na1* ZHOU Guangwen2* ZHANG Lin3 ZHANG Yan4 TAN Zhangkui4 LI Zhangqing4 HUANG Shiyi4 XIONG Mengxin4 XIANG Nan4
Objective To study the effect of Bushen Huatan Decoction on bone remodeling balance in ovariectomized osteoporosis rats. Methods Thirty-six month old female SD rats were divided into three groups: sham operation group, model group and traditional Chinese medicine group according to the random number table method, with 10 rats in each group. In sham operation group and traditional Chinese medicine group, the model was made by ovariectomy. In sham operation group, only the same amount of fat was removed. 5 weeks after operation, rats in traditional Chinese medicine group were given Bushen Huatan Decoction, and rats in sham operation group and model group were given the same amount of normal saline. 12 weeks after rats were killed, the content and localization of bone morphogenetic protein 2 (BMP2), runt related transcription factor 2 (RUNX2), osteoprotegerin (OPG), nuclear factor kappa B receptor activating factor ligand (RANKL) in serum and bone tissue were detected by enzyme-linked immunosorbent assay, Western blot and immunohistochemistry respectively. Bone mineral density of rats was measured by micro CT, and the differences of each index between each group were analyzed. Results Bone mineral density and serum BMP2, RUNX2, OPG and OPG/RANKL contents of model group and traditional Chinese medicine group were lower than those of sham operation group, and RANKL content was higher than that of sham operation group, with statistically significant differences (P < 0.05). Bone mineral density and serum BMP2, RUNX2, OPG, OPG/RANKL content of the rats in traditional Chinese medicine group were higher than those in model group, and RANKL content was lower than that in model group, with statistically significant difference (P < 0.05). BMP2, RUNX2, OPG and OPG/RANKL gray values of bone tissue in model group and traditional Chinese medicine group were lower than those in sham operation group, and the RANKL gray values were higher than those in sham operation group (P < 0.05). BMP2, RUNX2, OPG and OPG/RANKL gray values of bone tissue in traditional Chinese medicine group were higher than those in model group, and RANKL gray values were lower than those in model group, the differences were statistically significant (P < 0.05). The results of immunohistochemistry showed that the positive expression of BMP2, RUNX2 and OPG was mainly located in the cytoplasm of bone marrow stromal cells and osteoblasts around the trabecula; the positive expression of RANKL was located in osteoclasts at the border of bone, which were brownish yellow granules. Conclusion Bushen Huatan Decoction can regulate bone remodeling balance through BMP2/Smad/RUNX2 signal pathway and OPG/RANKL/RANK signal pathway to treat postmenopausal osteoporosis.
2020 Vol. 17 (11): 8-11,24 [Abstract] ( 150 ) HTML (1 KB)  PDF (1007 KB)  ( 156 )
12 Effect of siRNA interference Annexin A7 on cervical cancer cell lines Ki67 and P16
ZHOU Xing1 CHEN Xue1 CUI Lei2 SUN Jirui1 ZHANG Bingxin1 LI Yixuan1 ZHANG Jinku1▲
Objective To study the effect of Annexin A7 expression inhibition on Ki67 and P16 of Hela cells. Methods After cell culture, the cells were divided into the siRNA interference group, the negative control group and the blank control group for small interfering RNA (siRNA) interference to inhibit the expression of Annexin A7 in Hela cells of cervical cancer cell line. After the interference efficiency was identified by Western blot, the effect of the inhibition of Annexin A7 on the expression of Ki67 and P16 in Hela cells was detected by laser confocal immunofluorescence assay. Results Annexin A7 expression in the siRNA intervention group was significantly lower than that in the negative control group and the blank control group, with statistically significant difference (P ＜ 0.05). Compared with the negative control group and the blank control group, Ki67 positive products were significantly reduced in the siRNA interference group, and the difference was statistically significant (P ＜ 0.05). There was no statistically significant difference in P16 positive products among the siRNA interference group, the negative control group and the blank control group (P ＞ 0.05). Conclusion Annexin A7 may get involved in upregulated cell proliferation of squamous cell carcinoma of the cervix.
2020 Vol. 17 (11): 12-14 [Abstract] ( 147 ) HTML (1 KB)  PDF (616 KB)  ( 205 )
15 Value of combined detection of fecal genes SDC2 and BMP3 methylation in screening for colorectal cancer
PAN Hui1 HUANG Yanying2 WANG Guoxin3 WU Hui1 SONG Huidong4 HUANG Yingfeng1
Objective To investigate the diagnostic performance of stool gene syndecan-2(SDC2) and bone morphogenetic protein 3(BMP3) methylation in colorectal cancer. Methods Fecal samples were collected from 64 patients admitted to Guangzhou Twelfth People′s Hospital Affiliated to Guangzhou Medical University and the Cancer Hospital Affiliated to Sun Yat-sen University from May to September 2019, of which 29 cases were in the colorectal cancer group, 9 cases were in the adenoma group, and 26 cases were in the control group (patients without colon cancer, adenoma). Fecal DNA was extracted, and methylation-specific PCR was used to detect the methylation of fecal genes SDC2 and BMP3 of patients in three groups. The sensitivity and specificity of colorectal cancer and adenoma were compared. Results The combined detection of stool gene SDC2 and BMP3 were more sensitive than BMP3 in the diagnosis of colorectal cancer, and the differences were statistically significant (P ＜ 0.05). The comparison of AUC values of SDC2, BMP3, and combined detection in colorectal cancer were highly statistically significant (P ＜ 0.01). The AUC value of the combined test was higher than that of the BMP3 test, and the difference was statistically significant (Z = 2.361, P ＜ 0.05). The detection rate of BMP3 and combined detection on different distribution sites were statistically significant (P ＜ 0.05). Conclusion The diagnostic performance of stool gene SDC2 and BMP3 detection in colorectal cancer is better than that of BMP3 detection, but there is no significant improvement compared with SDC2 detection.
2020 Vol. 17 (11): 15-19 [Abstract] ( 299 ) HTML (1 KB)  PDF (679 KB)  ( 103 )
20 Research of small-molecule histone deacetylase inhibitors on anti-inflammatory activity
ZHAO Shiyu LIU Yutian KUANG Haixue LYU Shaowa
At present, the treatment of inflammatory response and immune response diseases has attracted the attention of the global pharmaceutical community, while the search for new anti-inflammatory drugs and anti-inflammatory activity mechanism has become a research hotspot. Histone deacetylase inhibitor (HDACI) has the characteristics of inhibiting the growth of inflammatory cells, leading to cell differentiation and death, and inhibiting the formation of inflammation. The latest research found that HDACI can be used to treat inflammatory diseases. The types of HDACI are complex with many studies, but they lack a summary review of progress in inflammation. Therefore, this paper summarizes the research progress of HDACI and the main anti-inflammatory mechanism of HDACI, such as hydroxams, short-chain fatty acids, cyclic peptides, and formamide, in order to provide ideas for finding new anti-inflammatory drugs and mechanisms.
2020 Vol. 17 (11): 20-24 [Abstract] ( 172 ) HTML (1 KB)  PDF (860 KB)  ( 51 )
25 Research progress in the treatment of knee synovitis by fumigating and washing with traditional Chinese medicine
TIAN Biao1,2 CHEN Bo1,2 CHANG Yuewen1 DU Guoqing1,2
Fumigation and washing therapy of traditional Chinese medicine (TCM) is a common method for osteologists to treat knee synovitis. As an important part of TCM therapy, fumigation and washing therapy of TCM has a long history, various methods of use, and flexible drug compatibility. In this paper, through the computer system to retrieve the Chinese databases such as CNKI, Wanfang, VIP and SinoMed, especially the clinical literature about the treatment of knee synovitis literature by fumigating and washing with TCM in the past five years, analyzing and summarizing find that: pure TCM fumigation or TCM fumigation combined with TCM internal medicine, acupuncture, physical therapy, articular cavity injection therapy has a certain clinical effect, but the fumigation temperature, fumigation treatment such as fumigation temperature and fumigation treatment course and fumigation method has not yet formed unified agreement or guide to guide clinical. TCM fumigation treatment of knee synovitis is worthy of further research and verification, in order to explore the mechanism of action and scope of application, better serve the clinical.
2020 Vol. 17 (11): 25-27,31 [Abstract] ( 199 ) HTML (1 KB)  PDF (586 KB)  ( 309 )
28 Advances in the design of pH-sensitive nanostructures for tumor therapy
ZHENG Peiyu1 YANG Bo1▲ CHEN Zhong2 XUE Hao1 ZHANG Yanjun1 PENG Haisheng2▲
In recent years, tumor has been the focus of nanomedicine research, and the extracellular acidic environment of tumor provides a new idea for targeted therapy of tumor. The pH-sensitive structure changes conformation with the change of pH. The combination of pH-sensitive structure and nanostructure is used to construct the pH-sensitive nanostructure to promote the uptake of tumor cells. This paper reviews the recent research on pH-sensitive nanostructures used for tumor targeted drug delivery, describes the types of pH-sensitive nanostructures, and describes the combination of pH-sensitive structures and nanostructures. Further understanding of pH-sensitive nanostructures will help design more effective drug delivery systems to address the challenges of tumor therapy.
2020 Vol. 17 (11): 28-31 [Abstract] ( 139 ) HTML (1 KB)  PDF (802 KB)  ( 367 )
32 Application progress of tonifying liver and kidney in ophthalmology of traditional Chinese medicine
ZHANG Bin LI Qingsong GAN Jingyun GUI Yanxiang WANG Yahui XU Yuan
According to traditional Chinese medicine, most of the patients in the later stage of eye diseases suffer from prolonged diseases and injure yin, and those with old and frail suffer from exhaustion, deficiency of liver and kidney, and asthenia of essence and blood. For the later stage of diseases and chronic recurrent diseases, the treatment based on traditional Chinese medicine syndrome differentiation is often more advantageous than western medicine. As the basic theories of eye diseases of traditional Chinese medicine, the “five-wheel theory” and “liver-orifice theory” expounds the close relationship between the eye and the liver and kidney, and provides a theoretical basis for the treatment of eye diseases from the liver and kidney. Internal treatment is widely used in internal and external eye diseases of traditional Chinese medicine. As one of the internal treatment methods of traditional Chinese medicine, tonifying liver and kidney is mainly used for the treatment of eye diseases caused by liver and kidney insufficiency, such as hepatic fatigue, ptosis of eyelid, senile cataract, vitreous opacity, blue blindness, after visual garment detachment surgery, blurred vision, blue wind glaucoma, retinopathypigmentosa and so on. By searching related literature, this paper briefly describes the application progress of liver and kidney supplementing in ophthalmology of traditional Chinese medicine in recent years.
2020 Vol. 17 (11): 32-35,52 [Abstract] ( 126 ) HTML (1 KB)  PDF (907 KB)  ( 106 )
36 Research on service satisfaction of the elderly under different integration of medical care service models in Yantai
DENG Guifang1,2 WANG Fang2 LI Xi2
Objective To understand the four integration of medical care service models in Yantai, and investigate and analyze the service satisfaction of the elderly, and provide suggestions for better development of integration of medical care service. Methods Four representative institutions under the 4 modes of Yantai in 2018 were selected by typical sample for field investigation. The basic situation and service satisfaction of 210 elderly people were investigated through questionnaires. Data analysis was performed by SPSS 25.0 statistical software and thematic framework method. Results A total of 240 questionnaires were distributed in this survey, and 220 were recovered. The effective recovery rate was 87.5%. The four models of Yantai were integrated into the national integration of medical care service system. There were statistically significant differences among the elderly in the four institutions with different marital status, disability, and overall health status (P ＜ 0.05). There were statistically significant differences in satisfaction of medical care, cultural entertainment, and spiritual comfort services in the four institutions (P ＜ 0.05). Conclusion Yantai′s four integration of medical care service models are fully developed. It is still necessary to strengthen the deep integration of medical care and old-age care, take the needs of the elderly as the guide, and improve the health and old-age care services in terms of publicity and education, service projects, and service personnel.
2020 Vol. 17 (11): 36-39 [Abstract] ( 196 ) HTML (1 KB)  PDF (408 KB)  ( 192 )
40 ESI-based bibliometric analysis on discipline competitiveness of 48 medical universities in mainland China
TAN Yihong1 FEI Pengfe1 ZHANG Chao1,2
Objective To quantitative analysis of discipline competitiveness of 48 medical universities in mainland China. Methods With the help of essential science indicators (ESI), the indexes of ESI papers, ESI rankings, highly cited papers, and hot papers in 48 medical universities were compared by quantitatively analysis. Results Capital Medical University ranked first in the ESI ranking of medical universities in the country with 233 297 citations, and ranked 596th worldwide. Nanjing Medical University had the most ESI subjects among the 48 universities. Capital Medical University ranked first in terms of volume of publications, published 23 930 papers, and ranked 334th in the world. The Second Military Medical University was ranked first in 48 medical universities with 14.05 articles cited. Capital Medical University has 13 hot papers, ranked first. Followed by Nanjing Medical University, there are 6 hot papers. Clinical medicine is a discipline included in 48 medical universities in the ESI ranking nationwide. In addition, 23 universities have 1% of the top 1 disciplines in pharmacology and toxicology ESI. Conclusion There is a certain distance between domestic medical universities and first-class foreign universities in terms of the number of high-impact papers and the index of citations, and it is urgent to further strengthen and improve.
2020 Vol. 17 (11): 40-43 [Abstract] ( 153 ) HTML (1 KB)  PDF (411 KB)  ( 235 )
44 Analysis of the occurrence and influencing factors of postoperative iatrogenic atrial septal defect in patients with atrial fibrillation
WU Siwen1 ZHANG Rongfeng2 YIN Xiaomeng2 DONG Yingxue2 XIAO Xianjie2 GAO Lianjun2
Objective To investigate the occurrence and influencing factors of postoperative iatrogenic atrial septal defect (ASD) in patients with atrial fibrillation, and to provide evidence for the prevention and treatment of iatrogenic ASD. Methods From December 2014 to December 2017, 118 cases with atrial fibrillation who underwent atrial septal puncture in the First Affiliated Hospital of Dalian Medical University were selected. According to the results of transthoracic echocardiography(TTE) or transesophageal echocardiography(TEE), they were divided into iatrogenic ASD group (n = 18) and normal healing group (n = 83). The clinical data of two groups were compared and the influencing factors of iatrogenic ASD were analyzed. The patients with iatrogenic ASD were followed up for 3 months and the prognosis was observed. Results In iatrogenic ASD group, all patients underwent radiofrequency ablation. Ten cases who underwent left atrial appendage occlusion and 7 cases who underwent frozen balloon ablation were excluded in normal healing group. Patients with iatrogenic ASD were followed up for 3 months, 1 case had lacunar cerebral infarction and 2 cases had migraine. The incidence of persistent atrial fibrillation and international normalized ratio  in iatrogenic ASD group was higher than that in normal healing group (P < 0.05), and the left atrial diameter was larger than that in normal healing group (P < 0.05). Logistic regression analyze showed that left atrial diameter＞38 mm was an independent risk factor for iatrogenic ASD (OR = 1.119, 95%CI:1.006-1.245, P = 0.038). Conclusion Iatrogenic ASD is frequent after radiofrequency ablation of atrial fibrillation. The increase of left atrial diameter is an independent risk factor for iatrogenic ASD. Iatrogenic ASD can still lead to clinical events, which should be paid more attention.
2020 Vol. 17 (11): 44-47 [Abstract] ( 198 ) HTML (1 KB)  PDF (512 KB)  ( 155 )
48 The application effect of Perindopril in patients with coronary heart disease after percutaneous coronary interventions and its influence on neurohormone and endothelial function
ZHOU Xiaoming1 DENG Guiming2 TAN Qi1▲
Objective To observe the application effect of Perindopril in patients with coronary heart disease after percutaneous coronary interventions, and analyze its influence on neurohormone and endothelial function. Method From December 2013 to December 2017, 120 cases with coronary heart disease who underwent percutaneous coronary interventions in the First Hospital of Hu′nan University of Chinese Medicine were selected. They were divided into the control group (60 cases) and the observation group (60 cases), according to different treatment regimens. The control group was received routine basic treatment and percutaneous coronary intervention according to their condition, and the observation group was received Perindopril Tablets orally on the basis of treatment in the control group. The course of treatment was 3 months. The neurohormone, endothelial function and cardiac function indexes before and after treatment of the two groups were compared and the incidence of ischemic events 1 year after operation was recorded in both groups. Results Before treatment, there was no statistically significant difference in angiotensin Ⅱ (Ang Ⅱ), aldosterone (ALD) and atrial natriuretic peptide (ANP) level of the two groups (P > 0.05). After treatment, Ang Ⅱ, ALD and ANP levels of the two groups were lower than those before treatment, and the observation group was lower than the control group, and the differences were statistically significant (all P < 0.05). Before treatment, there was no significant difference in the endothelial progenitor cells (EPCs), nitric oxide (NO) and endothelin-1 (ET-1) level between the two groups (P > 0.05). After treatment, the EPCs and NO levels in the two groups were higher than those before treatment, and the levels of ET-1 were lower than before treatment, and the EPCs and NO levels in the observation group were higher than those in the control group, the levels of ET-1 were lower than those in the control group, with statistically significant differences (all P < 0.05). Before treatment, there was no statistically significant difference in left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV) and left ventricular ejection fraction (LVEF) level between the two groups (P > 0.05). After treatment, LVEDV and LVESV levels in the two groups were lower than those before treatment, and LVEF levels were higher than those before treatment. LVEDV and LVESV levels in the observation groups were lower than those in the control group, and LVEF levels were higher than those in the control group, with statistically significant differences (all P < 0.05). The incidence of ischemic events 1 year after operation in the observation group was significantly lower than that in the control group, with statistically significant differences (P < 0.05). Conclusion Perindopril can effectively improve the level of neurohormone and endothelial injury after percutaneous coronary intervention in patients with coronary heart disease, improve the pumping function of the heart, and reduce the occurrence of postoperative clinical ischemic events.
2020 Vol. 17 (11): 48-52 [Abstract] ( 147 ) HTML (1 KB)  PDF (522 KB)  ( 187 )
53 Relationship between serum soluble PD-1 level and carotid atherosclerotic plaque in type 2 diabetes mellitus patients
LIN Yuanyuan ZOU Xinyu HUANG Xuemei WEI Haitao
Objective To investigate the relationship between serum soluble PD-1 (sPD-1) level and carotid atherosclerotic plaque in type 2 diabetes mellitus （T2DM） patients. Methods From October 2016 to March 2019，100 cases with T2DM patients who admitted to the First People′s Hospital of Nanning of Guangxi Zhuang Autonomous Region were selected. According to the presence or absence of carotid atherosclerotic plaque, they were divided into plaque group (54 cases) and non-plaque group (46 cases). General information, biochemical index and the serum sPD-1 level and carotid Crouse integral of two groups were compared. Logistic regression analysis was used for multivariate analysis. Results The systolic blood pressure level and the proportion of smoking and drinking in plaque group were higher than those in non-plaque group (P < 0.05). The C-reactive protein, triacylglycerol levels in plaque group were higher than those in non-plaque group (P < 0.05). Serum sPD-1 levels and carotid Crouse integral in plaque group were higher than those in non-plaque group (P < 0.05), and serum sPD-1 level was positively correlated with carotid Crouse integral (r = 0.384, P = 0.023). Logistic regression analysis showed that smoking, drinking, C-reactive protein and sPD-1 level were independent risk factors for carotid atherosclerotic plaque formation in T2DM patients (P < 0.05). ROC curve analysis showed that the critical value of sPD-1 was 1.41 ng/mL, the area under the curve was 0.824, the sensitivity was 81.24%, the specificity was 78.79% (95%CI:0.669-0.979，P = 0.027). Conclusion Serum sPD-1 level may all increase the risk of carotid atherosclerotic plaque formation in T2DM patients. Monitoring serum sPD-1 level can be used to diagnose carotid atherosclerotic plaque.
2020 Vol. 17 (11): 53-56 [Abstract] ( 189 ) HTML (1 KB)  PDF (571 KB)  ( 106 )
57 Correlation between GDF-15 expression and left ventricular remodeling after myocardial infarction
ZHANG Xiaojun ZHANG Xin LI Li QIN Ruili YU Yongling
Objective To investigate the correlation between GDF-15 and left ventricular remodeling after myocardial infarction. Methods From January 2018 to May 2019, 50 cases with acute myocardial infarction who admitted to the First Affiliated Hospital of Baotou Medical College (“our hospital” for short) were selected as the study group. 50 elderly healthy people who came to physical examination center of our hospital for physical examination during the same period were selected as the control group. Clinical data of two groups were collected, and the level of N-terminal pro-brain B-type natriuretic peptides (NT-proBNP), growth differentiation factors-15 (GDF-15) and left ventricular remodeling correlation index value were compared. According to NYHA classification and heart failure stage, the study group was divided into 4 subgroups respectively, NT-proBNP, GDF-15, left ventricular mass index (LVMI), left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD) levels of two groups were compared. Pearson correlation analysis was used for correlation analysis, and ROC curve analysis was used for diagnostic efficacy evaluation. Results NT-proBNP, GDF-15, LVEDD and LVMI levels of the study group were significantly higher than those of the control group, while LVEF values were significantly lower than those of the control group (P < 0.01). The higher the NYHA classification, the higher the levels of NT-proBNP, GDF-15, LVEDD and LVMI, and the lower the levels of LVEF (all P < 0.05). The higher the heart failure stage, the higher the levels of NT-proBNP, GDF-15 and LVMI (all P < 0.05). Serum GDF-15 level was negatively correlated with LVEF (r = -0.421, P < 0.001) and positively correlated with NT-proBNP, LVEDD and LVMI (r = 0.424, 0.478, 0.396; P < 0.001). The area under NT-proBNP curve was 0.789, and the optimal cut-off point was 199.45 pg/mL. The area under the curve of GDF-15 was 0.796, and the optimal cut-off point was 144.36 pg/mL. Conclusion Serum GDF-15 is closely related to left ventricular remodeling and increases with the increase of heart failure staging and cardiac function classification, and its diagnostic value for left ventricular remodeling is basically equal to that of NT-proBNP.
2020 Vol. 17 (11): 57-60 [Abstract] ( 114 ) HTML (1 KB)  PDF (559 KB)  ( 87 )
61 Analysis on the treatment of acute promyelocytic leukemia with arsenic-containing agent regimen
LIU Feng1 JIA Haipeng2 DUAN Yanchao2
Objective To retrospectively analyze the difference in clinical efficacy and cost between Arsenic-containing agent and non-arsenic-containing agent in patients with acute promyelocytic leukemia. Methods From December 2012 to December 2016, a total of 27 cases of adult acute promyelocytic leukemia patients primary treated in Affiliated Hospital of Guilin Medical University were selected. According to the different induction program, they were divided into observation group (12 cases) and control group (15 cases). The observation group was treated with arsenic-containing agent and the control group was treated with non-arsenic-containing agent. The differences of efficacy and adrerse reactions, blood dosage and medical expenses between the two groups were compared. Results There was no statistically significant difference between the two groups in the rates of complete remission, the time required to obtain CR, the 2-year overall survival rate, the dosage of red blood cells, platelets and plasma, the duration of treatment, and the cost of treatment (all P > 0.05). Conclusion The efficacy and cost of induction therapy in patients with acute promyelocytic leukemia with arsenic-containing agent is similar to that with non-arsenic-containing agent, but it′s necessary to study the large size sample further.
2020 Vol. 17 (11): 61-64,75 [Abstract] ( 122 ) HTML (1 KB)  PDF (680 KB)  ( 136 )
65 Analysis of correlation between blood pressure variability and prognosis of patients with acute cerebral infarction
SONG Daohui XI Chunhua▲ MU Yanfang ZHANG Liufu ZHANG Tingting
Objective To analyze the relationship between blood pressure variability (BPV) and 3-month prognosis of acute cerebral infarction. Methods From November 2018 to April 2019, 42 patients with acute cerebral infarction in Department of Neurology of Hefei Binhu Hospital (“our hospital” for short) were selected as acute cerebral infarction group, and the end point was 3-month after the onset of the disease. Meanwhile, 32 persons taken healthy physical examination in Outpatient Department of our hospital were selected as control group. Parameters of blood pressure variability between two groups were compared, including 24-hour systolic blood pressure coefficient of variation (24hSBPcv), 24-hour diastolic blood pressure coefficient of variation (24hDBPcv), daytime systolic blood pressure coefficient of variation (dSBPcv), daytime diastolic blood pressure coefficient of variation (dDBPcv), nocturnal systolic blood pressure coefficient of variation (nSBPcv), nocturnal diastolic blood pressure coefficient of variation (nDBPcv), 24-hour systolic blood pressure standard deviation (24hSSD), 24-hour diastolic blood pressure standard deviation (24hDSD), daytime systolic pressure standard deviation (dSSD), daytime diastolic pressure standard deviation (dDSD), nighttime systolic pressure standard deviation (nSSD) and nighttime diastolic pressure standard deviation (nDSD). Linear regression was used to analyze the correlation between 3-month prognosis of acute cerebral infarction and different blood pressure variability parameters. Results There was no significant difference in gender, age, history of hypertension, diabetes, smoking, drinking and atrial fibrillation between two groups (P > 0.05). The levels of triacylglycerol, total cholesterol, high density lipoprotein cholesterol and low density lipoprotein cholesterol between two groups were compared, with no significant difference (P > 0.05). The nSBPcv, 24hSSD, 24hDSD, dSSD and nSSD of acute cerebral infarction group were higher than those of control group, the differences were statistically significant (P < 0.05). 24-hour ambulatory blood pressure circadian rhythm of two groups was significantly different (P < 0.05). 24hSBPcv, dSBPcv, 24hSSD and dSSD were correlated with prognosis after 3-month of cerebral infarction (P < 0.05). Conclusion BPV is an important factor in the prognosis of cerebral infarction. 24hSSD, dSSD, 24hdSBPcv and dSBPcv in patients with acute cerebral infarction are related to the prognosis of 3-month.
2020 Vol. 17 (11): 65-68 [Abstract] ( 140 ) HTML (1 KB)  PDF (465 KB)  ( 58 )
69 The effect of Escitalopram combined with electroacupuncture in the treatment of geriatric depression and its effect on brain neurotransmitter and near infrared brain function quantification
TIAN Le ZHANG Huiru WANG Yi WANG Jianjun NI Jingjing JING Lan▲
Objective To explore the effect of Escitalopram combined with electroacupuncture in the treatment of geriatric depression (GD) and its effect on brain neurotransmitters and near infrared brain function quantification. Methods Total 108 GD patients diagnosed and treated in Neurology Department and Psychiatry Department of Inner Mongolia Mental Health Center from October 2017 to October 2018 were selected. According to different treatment schemes, they were divided into two groups, with 54 cases in each group. Control group was treated with Escitalopram and observation group was treated with electroacupuncture on this basis for 4 weeks. Clinical effect, HAMD score, EEG ultra-slow fluctuation analysis and NIR brain function quantification were compared between two groups. Results The total effective rate of observation group was higher than that of control group (P < 0.05). After treatment, HAMD scores of two groups were lower than before treatment, observation group was lower than control group, the differences were highly statistically significant (P < 0.01). After treatment, the levels of dopamine, noradrenaline, 5-hydroxytryptamine (5-HT) and acetylcholine receptor (AchR) in observation group were higher than those before treatment and those in control group, the levels of glutamate and γ-aminobutyric acid in observation group were lower than those before treatment and those in control group, the levels of 5-HT and AchR in control group were higher than those before treatment, the differences were statistically significant (P < 0.05 or P < 0.01). After treatment, oxyhemoglobin (Oxy-Hb) in both groups was lower than that before treatment, observation group was lower than control group, the differences were highly statistically significant (P < 0.01). Conclusion The combination of Escitalopram and electroacupuncture have significant effect in the treatment of GD patients, which can help to improve their neurotransmitter level and regulate the concentration of Oxy-Hb in the prefrontal cortex and alleviate depressive symptoms, thus improving the therapeutic effect of depression.
2020 Vol. 17 (11): 69-72 [Abstract] ( 136 ) HTML (1 KB)  PDF (832 KB)  ( 94 )
73 Effect of Naoxintong Capsules on neurological function in cardiogenic stroke patients
YUAN Xin1 PANG Nuo2 ZHAO Man1 KANG Lishan1 MA Liqiao1
Objective To investigate the effect of Naoxintong Capsules on neurological function in cardiogenic stroke patients. Methods From January 2017 to December 2018, a total of 118 patients with cardiogenic stroke who were treated in Hebei Friendship Hospital were divided into the control group (58 cases) and the treatment group (60 cases) by random number table method. The control group was received routine treatment, while the treatment group was received Naoxintong Capsules on the basis of routine treatment. The National Institutes of Health Stroke Scale (NIHSS) score, clinical efficacy and blood lipid level were observed after 3 months of treatment. Results After 3 months of treatment, the total effective rate in the treatment group was significantly higher than that in the control group, and the difference was statistically significant (P ＜ 0.05); the NIHSS score of patients of the two groups were significantly lower than before treatment, while the treatment group was significantly lower than the control group, and the differences were statistically significant (P ＜ 0.05); the triacylglycerol and total cholesterol in the two groups were lower than before the treatment, while the treatment group were significantly lower than the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Naoxintong Capsules has good curative effect on cardiogenic stroke and can improve the degree of neurological deficits of patients, which is worthy of clinical promotion.
2020 Vol. 17 (11): 73-75 [Abstract] ( 177 ) HTML (1 KB)  PDF (453 KB)  ( 188 )
76 Expression and significance of TH1/TH2 drift and T-bet/GABA-3 in peripheral blood of patients with cervical lesions
SAI Xingyue LI xiaohong DU Rong
Objective To study the correction between transcription factors GATA-3,T-bet and TH cytokine in patients with cervical lesions and their expression level and significance in peripheral blood. Methods A total of 76 patients who were admitted to the First Affiliated Hospital of Xinjiang Medical University from January 2017 to January 2019 were selected. According to the cervical thinprep cytologic test, they were divided into control group (33 cases), low-grade squamous intraepithelial lesion (L-SIL) group (10 cases) and high-grade squamous intraepithelial lesion (H-SIL) group (33 cases). The expression levels of GATA-3 and T-bet in serum were detected by Rt-PCR, and the TH cytokine levels in serum of three groups were detected by flow cytometry. Pearson correlation analysis was used for correlation analysis. Results The expressions of interleukin (IL)-4 and IL-10 in H-SIL group and L-SIL group were higher than those in control group, and the expression of GATA-3 was higher than that in control group, while the expression of T-bet in L-SIL group was lower than that in control group, and the differences were statistically significant (all P < 0.05). IFN-γ was positively correlated with T-bet (r = 0.65, P < 0.05), and negatively correlated with GATA-3 (r = -0.51, P < 0.05). IL-4 was positively correlated with GATA -3 (r = 0.56, P < 0.05), and negatively correlated with T-bet (r = -0.72, P < 0.05). IL-10 was negatively correlated with T-bet (r = -0.65, P < 0.05). Conclusion Peripheral blood of patients with L-SIL shows dominance of TH1 cells and up-regulated T-bet gene expression, while that of patients of H-SIL shows dominance of TH2 cells and down-regulated T-bet gene expression. It can be seen that the occurrence of L-SIL and H-SIL is related to TH cytokines, GATA and T-bet.
2020 Vol. 17 (11): 76-79 [Abstract] ( 141 ) HTML (1 KB)  PDF (565 KB)  ( 75 )
80 Effect of Shengyangyishen Decoction combined with Loratadine in the treatment of children with asthma and allergic rhinitis
HU Yan1 JIANG Huizhen2 LUO Jie3
Objective To explore the clinical effect of Shengyangyishen Decoction combined with Loratadine in the treatment of children with asthma and allergic rhinitis. Methods From Octomber 2016 to Octomber 2019, 86 cases with asthma and allergic rhinitis children in Panzhihua Maternal and Child Health Hospital of Sichuan Province were selected. According to the random number table method, they were devided into control group and treatment group, with 43 cases in each group. Control group was treated with Loratadine, while treatment group was treated with Shengyangyishen Decoction combined with Loratadine. The two groups were treated for 4 weeks. The clinical efficacy of two groups were compared. The traditional Chinese medicine (TCM) syndrome scores, forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), peak expiratory flow (PEF) and serum level of interleukin-6 (IL-6), IL-8, IL-10 of two groups before and after treatment were compared. The adverse reactions of two groups during the treatment were recorded and compared. Results The clinical efficacy of treatment group was higher than that of control group (P < 0.05). After treatment, FEV1, FVC, PEF levels in two groups were significantly higher than those before treatment, and treatment group were higher than control group (all P < 0.05). After treatment, the TCM syndrome scores in two groups were significantly lower than those before treatment, and treatment group were lower than control group (all P < 0.05). The serum levels of IL-6 and IL-8 in two groups were lower than those before treatment, and the serum levels of IL-10 were higher than those before treatment, and the serum levels of IL-6 and IL-8 in treatment group were lower than those in control group, and the serum levels of IL-10 were higher than those in control group (all P < 0.05). There were no serious adverse reaction of two groups during treatment. Conclusion Shengyangyishen Decoction combined with Loratadine have a significant clinical effect in the treatment of children with asthma and allergic rhinitis, which can significantly reduce clinical symptoms, improve lung function, inhibit inflammatory response, and has a good safety.
2020 Vol. 17 (11): 80-83,97 [Abstract] ( 138 ) HTML (1 KB)  PDF (789 KB)  ( 189 )
84 Clinical effect of hyperthermia combined with chemoradiotherapy in the treatment of locally advanced non-small cell lung cancer
ZHAO Kai WANG Zhiwu YANG Junquan
Objective To observe the clinical effect of hyperthermia combined with radiotherapy and chemotherapy in the treatment of locally advanced non-small cell lung cancer (NSCLC) and its effect on survival. Methods A total of 110 patients with locally advanced NSCLC admitted to the Chemoradiot Department of Tangshan People′s Hospital from January 2015 to January 2017 were selected. They were divided into the observation group and the control group by random number table method, with 55 cases in each group. The observation group received synchronous radiotherapy and chemotherapy combined with hyperthermia, and the control group received synchronous radiotherapy and chemotherapy. The short-term efficacy, incidence of toxic and side effects and long-term survival of the two groups were compared. Results The effective rate of the observation group was significantly higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). There was no statistically significant difference in the incidence of radiation esophagitis, radiation pneumonia, myelosuppression and radiation dermatitis between the two groups (P ＞ 0.05). The 2-year cumulative survival rate of the observation group was higher than that of the control group, and the difference was statistically significant (P ＞ 0.05). Conclusion The short-term efficacy of hyperthermia combined with radiotherapy and chemotherapy in the treatment of locally advanced NSCLC is accurate, and the survival rate is improved compared with that of radiotherapy and chemotherapy alone.
2020 Vol. 17 (11): 84-87 [Abstract] ( 159 ) HTML (1 KB)  PDF (537 KB)  ( 110 )
88 Expression of serum nerve growth factor and cellular immunity in breast cancer and its correlation with clinicopathological feature
WANG Wenhui1 WEN Yuanyuan2 CHEN Hao1
Objective To investigate the expression of serum nerve growth factor (NGF) and cellular immunity in breast cancer patients and its correlation with clinicopathological feature. Methods A total of 49 breast cancer patients diagnosed in Hangzhou Maternity Hospital and Zhejiang Zhoushan Hospital from March 2015 to February 2018 were selected as the observation group. A total of 45 patients with benign breast disease who were hospitalized at the same time were selected as the control group. A total of 47 female patients with physical examination at the same time were selected as the normal group. The expression levels of NGF in each group were determined by enzyme-linked immunosorbent assay. The levels of CD3+, CD4+, CD8+ and CD4+/CD8+ in each group were determined by flow cytometry. The clinicopathological data of the patients were recorded and counted. The levels of NGF and cellular immunity in each group and the levels of NGF and cellular immunity in different clinicopathological data of breast cancer in the observation group were analyzed. The correlation between NGF, cellular immunity level and clinicopathological data of breast cancer patients was analyzed by Pearson analysis. Results The levels of NGF and cellular immunity in the three groups were statistically significant (P ＜ 0.05). The level of NGF in the observation group was higher than that in the control group and the normal group, and the level of NGF in the control group was higher than that in the normal group, with statistically significant differences (P ＜ 0.05). The levels of CD3+, CD4+ and CD4+/CD8+ in the observation group were lower than those in the control group and the normal group, and the level of CD8+ was higher than that in the control group and the normal group, with statistically significant differences (P ＜ 0.05). There was no significant difference in the levels of CD3+, CD4+, CD8+ and CD4+/CD8+ between the control group and the normal group (P ＞ 0.05). The levels of NGF, CD3+, CD4+, CD8+ and CD4+/CD8+ in breast cancer tissues were not statistically significant differences in terms of age and histopathological type (P ＞ 0.05). The levels of NGF, CD3+, CD4+, CD8+ and CD4+/CD8+ in breast cancer tissues were compared in terms of tumor maximum diameter, pathological grading, differentiation degree and lymph node metastasis, with statistically significant differences (P ＜ 0.05). The Pearson correlation analysis results showed that the NGF and CD8+ levels were positively correlated with the maximum tumor diameter, pathological grading, differentiation degree and lymph node metastasis (P ＜ 0.05). The levels of CD3+, CD4+ and CD4+/CD8+ were negatively correlated with the maximum tumor diameter, pathological grading, differentiation degree and lymph node metastasis (P ＜ 0.05). Conclusion The high expression of NGF in breast cancer patients leads to the decline of cellular immunity level in the body, and the expression level of both is correlated with the pathology feature. Strengthening the determination of NGF and cellular immunity level can assess the severity of the disease in patients and guide clinical treatment.
2020 Vol. 17 (11): 88-92 [Abstract] ( 146 ) HTML (1 KB)  PDF (523 KB)  ( 127 )
93 Relationship between NLR, TgAb and cervical lymph node metastasis in papillary thyroid carcinoma
XU Ke YANG Fang XIE Yinghai WANG Peibin
Objective To explore the relationship between neutrophil to lymphocyte ratio (NLR), thyroglobulin antibody (TgAb) and cervical lymph node metastasis of papillary thyroid carcinoma. Methods A clinical study was conducted on 135 patients with papillary thyroid carcinoma diagnosed and treated in Huainan First People′s Hospital from January 2017 to September 2019. The patients were divided into the non-metastatic group (72 cases) and the metastatic group (63 cases) according to whether they had cervical lymph node metastasis. Clinical data and medical history of patients in the two groups were recorded. NLR value was measured by automatic blood cell analyzer, biochemical indicators of the patients were measured by automatic biochemical analyzer, and serum TgAb level was measured by enzyme-linked immunosorbent assay. Logistic regression model was used to analyze the influencing factors of cervical lymph node metastasis, and receiver operating characteristic (ROC) curve was used to predict the value of NLR and serum TgAb for cervical lymph node metastasis. Results Tumor diameter, uric acid, urea nitrogen, creatinine, total bilirubin, NLR and serum TgAb were significantly higher in the metastatic group than in the non-metastatic group (P ＜ 0.05). There was no statistically significant difference between the two groups in gender, age, history of hypertension, history of coronary heart disease, history of diabetes, combined goiter, number of tumors, cholesterol, triglyceride, high density lipoprotein and low density lipoprotein (P ＞ 0.05). Logistic regression model showed that elevated NLR and serum TgAb levels were independent risk factors for cervical lymph node metastasis in patients with papillary thyroid carcinoma (P ＜ 0.05). The clinical value of NLR combined with serum TgAb [AUC = 0.874, 95%CI (0.816 - 0.932), sensitivity = 89.76%, specificity = 90.58%] in predicting cervical lymph node metastasis was significantly better than that of NLR [AUC = 0.753, 95%CI (0.673 - 0.833), sensitivity = 76.53%, specificity = 79.12%] and serum TgAb [AUC = 0.796, 95%CI (0.724 - 0.869), sensitivity = 80.47%, specificity = 83.91%] alone. Conclusion Abnormally elevated levels of NLR and serum TgAb levels are closely related to the occurrence of cervical lymph node metastasis in patients with papillary thyroid carcinoma. Early combined detection is helpful to predict the risk of cervical lymph node metastasis in patients with papillary thyroid carcinoma, so as to provide reference for clinical development of targeted intervention programs.
2020 Vol. 17 (11): 93-97 [Abstract] ( 147 ) HTML (1 KB)  PDF (593 KB)  ( 80 )
98 Effect of early diuretic combined with enhanced recovery after surgery on postoperative recovery of colon and rectal cancer patients
MA Nan1 MA Shanxin2 LI Yan1 LIN Weishan2 TAO Guanglin2
Objective To investigate the effect of early diuretic injection therapy combined with enhanced recovery after surgery (ERAS) on colon and rectal cancer after elective surgery. Methods A total of 214 patients who received elective surgery for colon and rectal cancer from January 2017 to December 2018 in Dongying District People′s Hospital of Dongying City in Shandong Province, were randomly divided into the intervention group and the control group according to the random number table method, with 107 patients in each group. The intervention group was treated with intravenous furosemide 10 mg on day 1 and day 2 after surgery and combined with ERAS, and the control group was treated with ERAS intervention alone. The hospital stay, readmission rate within 30 days, defecation time, weight change and incidence of complications were compared between the two groups after surgery. Results There was no statistically significant difference in length of hospital stay, readmission rate within 30 days, and weight change between the two groups after surgery (P ＞ 0.05). Defecation time in the intervention group after surgery was significantly longer than that in the control group, and the difference was statistically significant (P ＜ 0.05). There was no statistically significant difference in the incidence of acute renal injury, hypokalemia, CT drainage needed for abscess, wound infection, reentry surgery, and intestinal obstruction between the two groups after surgery (P ＞ 0.05). Conclusion Early use of furoxime diuretics combined with ERAS is not conducive to postoperative recovery of colon and rectal cancer patients.
2020 Vol. 17 (11): 98-101 [Abstract] ( 110 ) HTML (1 KB)  PDF (543 KB)  ( 166 )
102 Meta-analysis of risk factors for ventilator-associated pneumonia in adult patients with ICU
FANG Jinlin HUANG Yanzhou YE Hongfang
Objective To systematically evaluate the risk factors of ventilator-associated pneumonia (VAP) in adult patients in the intensive care unit (ICU). Methods Chinese Knowledge Network, Wanfang, VIP, PubMed, Cochrane Library and Web of Science were searched to collect publicly published studies on the risk factors of VAP in adult patients with ICU at home and abroad, from January 2009 to December 2018. Literature review was conducted independently by two evaluators following the criteria for inclusion. If there were differences, a third-party evaluation was conducted to discuss and select the literature that met the inclusion criteria. Revman 5.3 software was used for meta-analysis and the combined odds ratio (OR) of each risk factor was calculated. Results A total of 12 articles were included in the study, all of which were case-control studies. Age≥60 years, mechanical ventilation time≥7 days, coma, acute physiological and acute physiology and chronic health evaluation Ⅱ (APACHEⅡ) ≥ 15 points, use of antibiotics, antacids, and tracheotomy are risk factors for VAP in adult patients with ICU (OR ＞ 1, P ＜ 0.05). Conclusion Adult patients in ICU who are older, have longer mechanical ventilation, are in a coma, have higher APACHE Ⅱ scores, use antibiotics, use antacids, and have tracheostomy are more likely to cause VAP. Whether parenteral nutrition is a risk factor for VAP in adult patients with ICU may be related to the way parenteral nutrition is administered.
2020 Vol. 17 (11): 102-106,110 [Abstract] ( 195 ) HTML (1 KB)  PDF (1474 KB)  ( 225 )
107 Clinical effect of peripatellar acupuncture combined with warm acupuncture in the treatment of knee osteoarthritis
TANG Hongzhi1 WEI Xiaodong2 LIAO Shichuan1
Objective To observe the clinical effect of peripatellar acupuncture combined with warm acupuncture in the treatment of knee osteoarthritis, and to find the optimal clinical combined intervention scheme for the treatment of knee osteoarthritis. Methods From March 2018 to July 2019, a total of 60 patients with knee osteoarthritis in the Sichuan Orthopedic Hospital were enrolled. They were divided into the treatment group and the control group by computer random method, with 30 cases in each group. The treatment group received peripatellar acupuncture combined with warm acupuncture once every other day for a total of 2 weeks, while the control group received oral Celecoxib Capsules 200 mg once a day for 2 weeks. The visual analogue scale (VAS) and the western ontario and Mcmaster (WOMAC) were used as observation indicators for evaluation. After treatment, the clinical efficacy of the two groups was assessed. Results After treatment, the VAS score of the two groups were significantly lower than those before the treatment, while those in the treatment group was lower than those in the control group, and the differences were statistically significant (P ＜ 0.05). After treatment, the pain, stiffness, daily life difficulty score, and total score of the two groups were significantly lower than those before treatment, while those in the treatment group were lower than those in the control group, and the differences were statistically significant (P ＜ 0.05). The total effective rate in the treatment group was significantly higher than that in the control group, and the difference was statistically significant (P ＜ 0.05). The incidence of adverse reactions in the treatment group was significantly lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Peripatellar acupuncture combined with warm acupuncture and oral Celecoxib Capsules can significantly improve the pain and function of knee osteoarthritis patients, however, peripatellar acupuncture combined with warm acupuncture is more effective.
2020 Vol. 17 (11): 107-110 [Abstract] ( 153 ) HTML (1 KB)  PDF (609 KB)  ( 118 )
111 Correlation analysis of hyperuricemia and nonalcoholic fatty liver in Beijing of China
ZHANG Yuanyuan YANG Longyan WANG Yan SUN Rongxin FU Ying ZHAO Dong
Objective To investigate the association between hyperuricemia and nonalcoholic fatty liver (NAFLD) in Beijing of China. Methods A total of 6750 participants who enrolled in the physical examination from July 2017 to May 2018 at the Health Checkup Center of Luhe Hospital in Tongzhou District, Beijing. The data included the basic information of the population and the corresponding biochemical indicators and abdominal color ultrasound. The differences in the basic data, biochemical indicators, metabolic syndrome, and the incidence of fatty liver between hyperuricemia and non-hyperuricemia were compared. According to the literature, the quartiles of serum uric acid level were analyzed and whether hyperuricemia was an independent risk factor for NAFLD after controlling for multiple confounders using binary logistic regression. Results In men, the body weight, body mass index (BMI), total cholesterol (TC), low density lipoprotein cholesterol (HDL-C) and creatinin (Scr) of patients with hyperuricemia were higher than those without hyperuricemia (P < 0.05), while the high density lipoprotein cholesterol (HDL-C) level was lower (P ＜ 0.05). In women with hyperuricemia, weight, BMI, alanine aminotransferase, asparagine aminotransferase, TG, TC, LDL-C, and Scr were higher than those without hyperuricemia (P ＜ 0.05), while HDL-C levels were lower (P < 0.05). The incidence of NAFLD and metabolic syndrome in both men and women with hyperuricemia was higher than that of non-hyperuricemia (P ＜ 0.05). After correction for various confounding factors, for every 50 mol/L increase in serum uric acid, the risk of occurrence of NAFLD increased by 11.2% (P ＜ 0.05). After stratifying uric acid levels according to quartile, logistic regression was used to find that the risk of nonalcoholic fatty liver increased with the increase of serum uric acid level after multiple confounding factors were corrected (blood uric acid ≤270 μmol/L as a reference, the blood uric acid in 271-320 μmol/L crowd their risk of the occurrence of NAFLD was 1.258 times (95%CI:1.012-1.563), blood uric acid in 321-379 μmol/L, the risk was 1.523 times (95%CI:1.226-1.892), the risk of occurrence was 1.696 times (95%CI: 1.338-2.148) in serum uric acid ≥380 μmol/L. Serum uric acid was positively correlated with NAFLD, which was an independent risk factor for the occurrence of NAFLD. Conclusion The uric acid is an independent risk factor for NAFLD disease and that it is gender-differentiated. Women are more relevant than men.
2020 Vol. 17 (11): 111-115 [Abstract] ( 225 ) HTML (1 KB)  PDF (624 KB)  ( 142 )
116 Expression and significance of P-tau-181, IL-1β and AD7c-NTP in patients with Alzheimer′s disease
LI Min1 YE Lijun2 YU Changfa3 FU Pan1 XUE Yufeng1▲
Objective To explore the expression and clinical significance of serum phosphorylated tau protein (P-tau-181), interleukin-1β (IL-1β) and urinary Alzheimer′s disease (AD) associated neurofilament protein (AD7c-NTP) in patients with AD. Methods A total of 76 patients with AD were selected as the AD group who were hospitalized in the Department of Neurology, Taizhou First People′s Hospital from January 2017 to June 2019. According to the clinical dementia scale score, they were divided into 26 cases in mild group, 29 cases in moderate group and 21 cases in severe group. A total of 35 healthy people who underwent physical examination at the same time were selected as the control group. Serum P-tau-181, IL-1β and AD7c-NTP in urine were detected by enzyme-linked immunosorbent assay. The expression levels of P-tau-181, IL-1β and AD7c-NTP were compared in each group, and the diagnostic efficacy of P-tau-181, IL-1β and AD7c-NTP in AD were analyzed. Results The expressions of P-tau-181, IL-1β, and AD7c-NTP in AD group were higher than those in control group (all P < 0.05). The expression levels of P-tau-181, IL-1β, and AD7c-NTP in the severe group were higher than those in the moderate and mild groups. The expression levels of P-tau-181, IL-1β, and AD7c-NTP in the moderate group were higher than those in the mild group (all P < 0.05). The area under curve (AUC) of P-tau181 in the diagnosis of AD was 0.898, the AUC of IL-1β was 0.851, and the AUC of AD7c-NTP was 0.847. Conclusion The expression of P-tau-181, IL-1β and AD7c-NTP in AD patients is elevated, which can be used as a detection index for clinical diagnosis of AD, and it can also classify the severity of lesions, which has important clinical significance.
2020 Vol. 17 (11): 116-119 [Abstract] ( 274 ) HTML (1 KB)  PDF (643 KB)  ( 186 )
120 The relationship between the expression of miR-155 in peripheral blood and the differentiation of CD8+T cells in patients with pulmonary tuberculosis
WEI Liancun
Objective To investigate the relationship between the expression of microRNA-155 (miR-155) in peripheral blood mononuclear cells (PBMC) and the differentiation of CD8+T cells in patients with pulmonary tuberculosis. Methods A total of 88 patients with pulmonary tuberculosis infection who admitted to the Fourth People′s Hospital of Qinghai Province from January 2017 to June 2019. Among them, 42 cases were active pulmonary tuberculosis (active group), 46 cases were latent tuberculosis infection (latent group), and 50 cases were healthy during the same period as control group. The expressions of miR-155, T lymphocyte subsets in PBMC and interferon-γ (IFN-γ), interleukin-4 (IL-4) and IFN-γ/IL-4 in three groups were observed, the levels of IFN-γ, IL-4 and IFN-γ/IL-4 in CD8+T cells of patients with different miR-155 expression were analyzed. Results The expressions of miR-155, CD3+CD8+, IFN-γ and IL-4 in PBMC of the active group and latent group were higher than those of the control group, and the activity group was higher than the latent group (P < 0.05), the IFN-γ/IL-4 ratio in the active group was higher than that in the control group (P < 0.05). The percentage of PBMC CD3+CD4+ cells and CD4+/CD8+ ratio in active group and latent group were lower than those in control group, and the active group were lower than those in latent group (P < 0.05). The ratios of IFN-γ, IL-4 and IFN-γ/IL-4 in the high expression group of miR-155 was higher than that of the low expression group of miR-155 (P < 0.05). The expression of PBMC miR-155 was positively correlated with IFN-γ, IL-4 and IFN-γ/IL-4 ratio (r = 0.695, P = 0.000; r = 0.477, P = 0.000; r = 0.446, P = 0.000). Conclusion PBMC miR-155 is highly expressed in patients with pulmonary tuberculosis, which induces activation of CD8+T cells and differentiation into cytotoxic T ceu 1 phenotype.
2020 Vol. 17 (11): 120-123 [Abstract] ( 120 ) HTML (1 KB)  PDF (751 KB)  ( 94 )
124 Investigation and risk factors analysis of intracranial infection in patients undergoing craniotomy
ZHANG Xiaolei JI Yuanyuan WANG Jun XU Yueqiao
Objective To analyze the intracranial infection and related risk factors in patients undergoing craniotomy. Methods A total of 1088 patients with craniotomy who admitted to Xuanwu Hospital of Capital Medical University from January to December 2018 were selected. The general and clinical data of all patients were collected. Logistic regression analysis was used for further analysis. The intracranial infection in 1088 patients with craniotomy was observed and the ndependent risk factors for intracranial infection in patients undergoing craniotomy were analyzed. Results Among the 1088 patients, 43 developed intracranial infection. The patients with intracranial infection, 4 (9.3%) died, and the remaining 39 patients recovered and were discharged from the hospital after receiving appropriate treatment. The independent risk factors for intracranial infection in craniotomy patients were the duration of operation and the time of drainage tube placement. Duration of operation [OR = 6.698, 95%CI: 3.511-12.780, P = 0.027], the time drainage tube placement [OR = 2.603, 95%CI: 1.284-5.278, P = 0.018.] Conclusion The risk ratio of intracranial infection in patients with craniotomy is low, but the mortality rate is high. The independent risk factors that affect the occurrence of intracranial infection in patients with craniotomy are the duration of the operation and the time of drainage tube placement.
2020 Vol. 17 (11): 124-127 [Abstract] ( 134 ) HTML (1 KB)  PDF (635 KB)  ( 70 )
128 The relationship between the serum uric acid level of different genders and the degree of coronary heart disease and coronary artery stenosis
LI Yachao1 YANG Yanli1 AN Lei1 LIU Xinming2 LU Dianlin1 GUAN Zeyong1 XUE Zengming1▲
Objective To study the relationship between serum uric acid levels of different genders and the degree of coronary heart disease and coronary artery stenosis. Methods A total of 500 patients with coronary heart disease who underwent percutaneous coronary intervention (PCI) in the Department of Cardiology, Langfang people′s Hospital Affiliated to Hebei Medical University from February 2012 to February 2016 were selected as the study subjects. They were divided into the male group (280 cases) and female group (220 cases) by sex, and the standard of blood uric acid in male was ＞420 μmol/L and female was ＞357 μmol/L. The male group was divided into hyperuricemia group (115 cases) and non-hyperuricemia group (165 cases), women with hyperuricemia group (73 cases) and non-hyperuricemia group (147 cases), the degree of coronary artery stenosis in each group was compared. The presence of adverse cardiac events, basic data and related serum indicators in the male and female groups were compared, and the relationship between the basic data and the occurrence of adverse cardiac events after PCI was further analyzed by logisitic regression analysis. Results There was no significant difference in the score of coronary artery stenosis between the male hyperuricemia group and the non-hyperuricemia group (P ＞ 0.05). The score of coronary artery stenosis in the female hyperuricemia group was higher than that in the non-hyperuricemia group (P ＜ 0.05). Adverse cardiac events in the male and female groups were associated with age, smoking, hypertension and family genetic history (all P ＜ 0.05). The logistic regression analysis showed that the age (male: OR = 6.234, 95%CI: 1.375-8.385; female: OR = 7.139, 95%CI: 1.325-11.288), smoking (male: OR =10.753, 95%CI: 4.592-19.586; female: OR = 8.953, 95%CI: 2.395-14.275), hypertension (male: OR = 8.174, 95%CI: 3.295-20.907; female: OR = 5.302, 95%CI: 1.857-8.076), family genetic history (male: OR = 7.053, 95%CI: 1.055-10.844; female: OR = 5.032, 95%CI: 1.287-9.058) were independent risk factors for adverse cardiac events after PCI in patients with coronary heart disease of different sex. The serum uric acid (OR =6.038, 95%CI: 1.405-9.17) was independent risk factors for adverse cardiac events after PCI in coronary heart disease female (P ＜ 0.05). Conclusion The serum uric acid level of female patients with coronary heart disease is closely related to the degree of coronary artery stenosis and adverse cardiac events after PCI.
2020 Vol. 17 (11): 128-131 [Abstract] ( 185 ) HTML (1 KB)  PDF (608 KB)  ( 182 )
132 Study on the medication rule of cough variant asthma from the perspective of wind theory
JING Weichao1 LIU Lujia1 WANG Youpeng2 LI Zhijun3
Objective To analyze the prescription medication rule of cough variant asthma (CVA) from the perspective of wind theory. Methods By using computer retrieval, combinated of “cough variant asthma” or “wind cough” and “treatment from wind”, “wind”, “dispelling wind” and “expelling wind”. The literatures about treating CVA from wind theory were retrieved from CNKI, VIP database, and Wanfang data knowledge service platform from January 1979 to July 2019. Then, the data was put into the software of Chinese medicine inheritance assistant platform to analyze the rule of prescription medication. Results The study eventually included 127 articles and 127 prescriptions, including 120 herbal medicine. The herbal medicine′s use and frequency was analyzed, more than 20 times were Periostracum Cicadae, Radix Glycyrrhizae, Semen Armeniacae Amarum, Herba Ephedrae, etc, then the use pattern of prescription was got. Eight core drug combinations and four new candidates were found. Conclusion The prescriptions for CVA treated by wind theory are mostly used for dispersing wind and dissipating heat, dispelling wind and resolving exterior symptoms, clearing away heat and resolving wind, dispersing lung and relieving cough. Emphasis is laid on the compatibility and application of wind medicine with cough-relieving drugs, lung-promoting drugs, blood-activating and collateral-dredging drugs, etc, so as to provide reference for the clinical medication of the patients treated by wind.
2020 Vol. 17 (11): 132-135,139 [Abstract] ( 144 ) HTML (1 KB)  PDF (796 KB)  ( 196 )
136 Discussion on the construction idea of knowledge base of ancient books for Lingnan warm disease
TANG Weiping1 XU Jian1 LI Bing2 WU Lei1
Lingnan warm disease is an important academic school in the field of traditional Chinese medicine. Since the Jin Dynasty, ancient books have recorded a large number of academic thoughts and medical records of Lingnan warm disease doctors. Scattered information could be centralized and correlated through introducing ontology into the digital resources of ancient books. This manuscript summarizes the current research situation of the knowledge base of ancient books and discusses how to build the knowledge base of Lingnan warm disease of ancient books based on ontology. It includes information extraction and transformation, automatic semantic annotation, construction of ontology and ontology knowledge base, and information mining. Thus explore the implicit knowledge in ancient books and realize the knowledge extraction, knowledge reasoning and knowledge discovery of ancient books.
2020 Vol. 17 (11): 136-139 [Abstract] ( 150 ) HTML (1 KB)  PDF (694 KB)  ( 219 )
140 A meta-analysis on the effect and safety of addition and reduction of Chaishao Liujunzi Decoction in the treatment of chronic gastritis
GAO Gaiya1 XUE Jingdong2 BAI Yanyan1 LI Sha2
Objective To analyze the efficacy and safety of addition and reduction of Chaishao Liujunzi Decoction in treating chronic gastritis by meta analysis. Methods Database of CNKI, VIP and Wanfang by computer was searched, the randomized controlled trial of the treatment of chronic gastritis with the method of subject word + free word was searched. Retrieved time was limited to September 2019. Meta analysis with Revman 5.3 software was used. Systematic evaluation of Chaishao Liujunzi Decoction in the treatment of chronic gastritis on total clinical efficiency, adverse reactions, recurrence rate, traditional Chinese medicine syndrome score, quality of life, pathological effect of gastric mucosa, anti Helicobacter pylori infection were carried out. Results Total of 15 studies, all in Chinese literature, included 1386 patients. Meta analysis results suggested that the addition and reduction of Chaishao Liujunzi Decoction could significantly improve total clinical efficiency of chronic gastritis [OR = 3.96, 95%CI (2.84-5.53), P < 0.000 01], reduce adverse reaction [OR = 0.28, 95%CI (0.10-0.77), P = 0.01], reduce recurrence rate [OR = 0.36, 95%CI (0.16-0.80), P = 0.01], alleviate traditional Chinese medicine syndrome score (P ＜ 0.05), improve quality of life (P ＜ 0.05), improve gastric mucosa atrophy [OR = 2.69, 95%CI (1.38-5.26), P = 0.004], improve intestinal metaplasia of gastric mucosa [OR = 3.19, 95%CI (1.32-7.70), P = 0.01], but improve dysplasia of gastric mucosa [OR = 2.12, 95%CI (0.97-4.67), P = 0.06] and the efficacy of anti Helicobacter pylori infection were not exact. Conclusion Addition and reduction of Chaishao Liujunzi Decoction can significantly improve clinical efficacy of chronic gastritis, but due to the limitation of the quality of the included studies, the above conclusions need to be verified by more high-quality randomized controlled trial.
2020 Vol. 17 (11): 140-144,156 [Abstract] ( 160 ) HTML (1 KB)  PDF (1328 KB)  ( 193 )
145 Clinical efficacy of abdominal acupuncture on nasal symptoms and quality of life in patients with moderate to severe allergic rhinitis
ZHAO Qianyu1 LIU Yunxia2 CHEN Zhigang1，3
Objective To evaluate the effect of abdominal acupuncture on moderate and severe allergic rhinitis. Methods From January to July 2017, 66 patients with allergic rhinitis were selected from Department of Acupuncture and Otolaryngology of Dongzhimen Hospital of Beijing University of Chinese Medicine. They were divided into two groups according to the random number table method, with 33 cases in each group. 2 cases in treatment group and 3 cases in control group were dropped out, finally, there were 31 cases in treatment group and 30 cases in control group. Treatment group was treated with abdominal acupuncture and control group with budesonide nasal spray for 4 weeks. The nasal symptoms, accompanying symptoms and quality of life scores of two groups were compared. Results After 2 weeks and 4 weeks of treatment, the total nasal symptom score (TNSS) and total non-nasal symptom score (TNNSS) in both groups were significantly lower than those before treatment, which in the treatment group after 4 weeks of treatment were lower than those after 2 weeks of treatment (P ＜ 0.01). And the TNSS score in the treatment group was higher than that in the control group after 2 weeks of treatment (P ＜ 0.01). After 2 weeks and 4 weeks of treatment, all scores of rhinoconjunctivitis quality of life questionnaire in both groups were significantly lower than those before treatment (P ＜ 0.01), among which, the score of sleep in the treatment group after 4 weeks of treatment was lower than that in the control group (P ＜ 0.05). Conclusion Abdominal acupuncture can significantly relieve the nasal symptoms and improve patient′s quality of life, especially in improving the quality of sleep.
2020 Vol. 17 (11): 145-148 [Abstract] ( 137 ) HTML (1 KB)  PDF (638 KB)  ( 202 )
149 Effect of Modified Duhuo Jisheng Decoction combined with Celecoxib in the treatment of knee osteoarthritis
XIAO Qiang1 GUO Zilong1 XU Ningning2
Objective To investigate the effect of Modified Duhuo Jisheng Decoction combined with Celecoxib in the treatment of knee osteoarthritis (KOA). Methods One hundred and nine patients with KOA admitted to the First Hospital of Zhangjiakou City from October 2016 to August 2019 were selected, they were divided into control group (n = 54) and study group (n = 55) according to random number table method. Control group was treated with Celecoxib Capsules and study group was treated with Modified Duhuo Jisheng Decoction. After 30 days of treatment, clinical efficacy, pain status, knee joint function and related cytokines of two groups were compared. The occurrence of adverse reactions during treatment of two groups was recorded. Results Total clinical effective rate of study group was higher than that of control group (P < 0.05). After 30 days of treatment, VAS score of two groups was lower than that before treatment, while the knee joint function score was higher than that before treatment (P < 0.05). After 30 days of treatment, VAS score of study group was lower than that of control group and the knee joint function score was higher than that of control group (P < 0.05). After 30 days of treatment, the levels of IL-1β, IL-6, MMP-3 and SOD in two groups were lower than those before treatment (P < 0.05). After 30 days of treatment, the levels of IL-1β, IL-6, MMP-3 and SOD in study group were lower than those in control group (P < 0.05). There was no significant difference in the incidence of adverse reactions between two groups (P > 0.05). Conclusion The effect of Modified Duhuo Jisheng Decoction in the treatment of KOA is definite, which can effectively improve clinical symptoms and knee joint function of patients. The main mechanism may be caused by improving related cytokines.
2020 Vol. 17 (11): 149-152 [Abstract] ( 162 ) HTML (1 KB)  PDF (639 KB)  ( 245 )
153 Effect of Huamoyan Granules on serum inflammatory cytokines of gouty arthritis with accumulated dampness-heat
ZHANG Yitong LIANG Hui XIE Jihui WEI Pengzhou LI Qian WANG Guanjun
Objective To discuss the effect of Huamoyan Granules on serum inflammatory cytokines of gouty arthritis with accumulated dampness-heat. Methods From March 2017 to June 2018, 60 patients with acute gouty arthritis admitted to Shijiazhuang Hospital of Traditional Chinese Medicine were divided into treatment group and control group according to the random number table method, with 30 cases in each group. Ttreatment group was treated with Huamoyan Granules + Ibuprofen Sustained-Release Capsules, while control group was treated with Ibuprofen Sustained-Release Capsules. After 7 days of treatment, clinical effect and the levels of CRP, ESR, IL-1β, IL-6 and IL-8 before and after treatment were compared between two groups. Results Clinical effect of treatment group was better than that of control group, the difference was statistically significant (P < 0.05). CRP levels and ESR of two groups after treatment were lower than those before treatment, and treatment group was lower than control group (P < 0.05). Levels of IL-1β, IL-6 and IL-8 in two groups after treatment were lower than those before treatment, and those in treatment group were lower than those in control group (P < 0.05). Conclusion Huamoyan Granules + Ibuprofen Sustained-Release Capsules in the treatment of acute gouty arthritis with accumulated dampness-heat has good clinical effect. Mechanism may be related to the decrease of serum IL-1β, IL-6, IL-8 and other inflammatory factors.
2020 Vol. 17 (11): 153-156 [Abstract] ( 246 ) HTML (1 KB)  PDF (678 KB)  ( 143 )
157 Current status of legislation administration of traditional Chinese acupuncture in various states in the United States
CUI Yu1 LENG Wenjie2 LI Fuwu1 WU Feng1
This article collects the acupuncture management related documents of 47 states and 1 Special Zone in the United States that have legislation on acupuncture, and summarizes the conditions and requirements of acupuncture license applicants and the practice management of acupuncture practitioners in each state. It was found that the development of Chinese medicine and acupuncture is unbalance in each state in the United States, but the (National Certification Commission for Acupuncture and Oriental Medicine) certification was the mainstream trend of professional qualifications admission. The threshold of practicing medicine for Chinese medicine practitioners in the United States is increasing, but the status of acupuncturists has not been improved accordingly; the Chinese acupuncture legislation in various states helps the orderly development of Chinese medicine acupuncture in the United States, and can better serve the local people. However, the separate legislation of acupuncture from traditional Chinese medicine has also promoted the trend of acupuncture as an independent medicine, affecting the overall development of traditional Chinese medicine. Due to the special permission of western doctors for acupuncture, Chinese acupuncture has become more localized. It will face greater challenges for Chinese acupuncturists and Chinese medical services to enter the US market.
2020 Vol. 17 (11): 157-160 [Abstract] ( 161 ) HTML (1 KB)  PDF (393 KB)  ( 371 )
161 Clinical effect of Saw Palmetto Fruit Extract Capsules in the treatment of acute prostatitis
SUN Xinbo CHEN Congbo YAO Qisheng
Objective To observe the clinical effect of Saw Palmetto Fruit Extract Capsules on acute prostatitis. Methods From May 2017 to July 2018, a total of 62 patients with acute prostatitis admitted to the Department of Urology, Taihe Hospital, Shiyan City, Hubei Province were selected as the study subjects. According to the random number table method, they were divided into control group and observation group, with 31 cases in each group. The control group was treated with Tansoroxin Hydrochloride Sustained-Release Capsules + Shuangshitonglin Capsules + Antibiotics, and the observation group was treated with Saw Palmetto Fruit Extract Capsules + Shuangshitonglin Capsules + Antibiotics. After 4 weeks, prostate specific antigen (PSA), lecithin body (LD), procalcitonin (PCT), C-reactive protein (CRP), blood white blood cell count (WBC), urine white blood cell count (UWBC), prostatic fluid white blood cell count (PFWBC), prostate volume and transitional band volume were examined. The total effective rates and the incidence of adverse reactions were compared between the two groups. The recurrence rate was followed up 6 months later. Results After treatment, PSA, PCT and CRP in two groups were lower than before treatment, and LD was higher than before treatment, moreover, PSA, PCT and CRP in the observation group were lower than those in the control group, LD was higher than that in the control group (P ＜ 0.05). Prostate volume and transitional band volume in both groups were lower than before treatment, and the observation group was lower than the control group (P ＜ 0.05). WBC, UWBC and PFWBC in two groups were lower than before treatment, and those in the observation group was lower than those in the control group (P ＜ 0.05). The total effective rate of the observation group was higher than that of the control group (P ＜ 0.05). The total incidence of adverse reactions and recurrence rate in the observation group were lower than those in the control group (P ＜ 0.05). Conclusion Saw Palmetto Fruit Extract Capsules as an adjuvant treatment of acute prostatitis can enhance the clinical efficacy of traditional treatment methods.
2020 Vol. 17 (11): 161-164 [Abstract] ( 176 ) HTML (1 KB)  PDF (362 KB)  ( 132 )
165 Investigation on the demand for on-the-job training of medical nurses in tertiary hospitals and its influencing factors
WANG Xianyu1 LIU Yun2 HAN Xue1 ZENG Xing3
Objective To investigate the status of post training needs of nursing assistants in tertiary hospitals of Jiangsu Province and analyze the influencing factors. Methods From April to May 2019, 330 nursing assistants from 11 tertiary hospitals in Jiangsu province were selected by cluster sampling. Their training demand scores were investigated through self-made questionnaire and the influencing factors of their training intentions were analyzed according to the general demographic data. Results Different educational level, whether to obtain the national recognized professional qualifications and different types of health care workers, and the differences were statistically significant in on-the-job training demand (P ＜ 0.05). Multi-factor analysis showed that education level, national recognized professional qualification and working mode were the main influencing factors of their training needs (P ＜ 0.05). Conclusion The subjective intention of post training needs of nursing assistants is low. It is suggested that managers develop diversified training methods and scientific assessment system to ensure the quality of medical care services.
2020 Vol. 17 (11): 165-168 [Abstract] ( 227 ) HTML (1 KB)  PDF (501 KB)  ( 241 )
169 Application of systematic teaching model in clinical teaching of nurses in the department of rehabilitation
LIU Ling1 TAN Min2 YE Zhenli1 LIU Zuoyan1
Objective To explore the application effect of the systematic teaching mode in the clinical teaching of nurses in rehabilitation department. Methods A retrospective investigation was conducted to select 30 nurses in the Department of Rehabilitation Medicine, West China Hospital, Sichuan University (hereinafter referred to as “our hospital”) from September to December 2018 (control group) and 30 nurses in our hospital from march to June 2019 (observation group) as study subjects. The routine teaching mode was adopted in the control group and the observation group was systematically taught on the basis of the control group. The examination results, satisfaction and post competency of the two groups were compared at the end of the course. Results Examination results, satisfaction and post competency of nurses in the observation group were all higher than those in the control group, with statistically significant differences (P ＜ 0.05). Conclusion The systematic teaching mode can improve the examination results, satisfaction and post competence of clinical nursing, and it's worthy of further promotion.
2020 Vol. 17 (11): 169-172 [Abstract] ( 146 ) HTML (1 KB)  PDF (499 KB)  ( 149 )
173 Analysis on the effect of nursing intervention for primipara breast-feeding based on the theory of behavioral staged transformation
CHEN Tingting WAN Li▲
Objective To explore the effect of nursing intervention based on the behavioral transition theory on breastfeeding of the first parturient. Methods From January 2017 to January 2019 in the Nanjing First Hospital, a total of 120 primiparas were selected as the research object. According the random number table method, they were divided into control group and observation group, each group with 60 primiparas. The control group was given routine breastfeeding nursing instruction, while the observation group was given 4 stages of nursing intervention of breastfeeding according to the theory of phased change of behavior. The puerperas in both groups were subjected to continuous intervention for 6 months. The knowledge of breastfeeding before and after intervention were compared between the two groups, and the efficacy of breastfeeding and the rate of exclusive breastfeeding were compared at 1 week postpartum, 6 weeks postpartum and 6 months postpartum. Results The scores of feeding knowledge after intervention in both groups were higher than those before intervention, and the scores in the observation group were higher than those in the control group after intervention (P ＜ 0.05). The differences in intergroup comparison, time point comparison and interaction were all statistically significant (all P ＜ 0.05). Further pairwise comparison and intra-group comparison, the self-efficacy score of maternal breastfeeding in the observation group at 1 week postpartum, 6 weeks postpartum and 6 months postpartum showed a significant increasing trend, and the differences were statistically significant (P ＜ 0.05). In the control group, there was no significant change at each time point, and the difference was not statistically significant (P ＞ 0.05); the self-efficacy scores of the observation group at 1 week postpartum, 6 weeks postpartum and 6 months postpartum were significantly higher than those of the control group, with statistically significant differences (P ＜ 0.05). The rate of exclusive breastfeeding in the observation group were higher than those in the control group at 1 week postpartum, 6 weeks postpartum and 6 months postpartum (P ＜ 0.05). Conclusion The theory of phased change of behavior can better adapt to the psychological and physiological nursing needs of puerpera in each stage, gradually meet the knowledge needs of puerpera in breastfeeding, effectively improve the efficacy of breastfeeding, extend the time of exclusive breastfeeding, and be beneficial to the health and growth of puerpera and newborn.
2020 Vol. 17 (11): 173-176 [Abstract] ( 119 ) HTML (1 KB)  PDF (506 KB)  ( 104 )
177 Application effect of the concept of enhanced recovery after surgery in the perioperative period of patients with lumbar degenerative disease
FAN Liying ZHANG Gelin WU Wei XUE Jianli CHENG Bin
Objective To explore the application effect of the concept of enhanced recovery after surgery in patients with lumbar degenerative disease during perioperative period. Methods A total of 72 patients diagnosed as degenerative diseases of the lumbar spine in the Third Department of Orthopedics, the Second Affiliated Hospital of Xi′an Jiaotong University from November 2016 to October 2018 who underwent initial surgery were selected as the study objects. According to the random number table method, they were divided into control group and observation group, with 36 cases in each group. The control group used the routine rehabilitation program, the observation group used the enhanced recovery program. Visual analogue scale (VAS) and Japanese orthopaedic Association (JOA) score were observed and recorded before surgery, 1 and 2 weeks after surgery. Results VAS scores 1 and 2 weeks after surgery were lower than those before surgery, and JOA scores were higher than those before surgery, moreover, VAS score 2 weeks after surgery was lower than 1 week after surgery, and JOA score 2 weeks after surgery was higher than 1 week after surgery, with all statistically significant differences (all P ＜ 0.05). VAS and JOA scores were compared between the two groups 1 and 2 weeks after surgery, there were statistically significant differences (all P ＜ 0.05). There was no significant difference in total incidence of postoperative complications between the two groups (P ＞ 0.05). Conclusion The concept of enhanced recorery after surgery is applied to the perioperative period of the first lumbar degenerative disease, which can effectively relieve the pain in the waist and legs of patients, accelerate the early recovery of patients, reduce the occurrence of adverse reactions during the perioperative period, and improve the clinical efficacy.
2020 Vol. 17 (11): 177-180 [Abstract] ( 115 ) HTML (1 KB)  PDF (678 KB)  ( 157 )
181 Sensitivity analysis of observational studies: “E-value” interpretation
JIANG Qiyu SUN Lijun BI Jingfeng▲
Through the interpretation of the new sensitivity analysis method E-value, a simple and practical sensitivity analysis method for observational research is introduced to readers. In this method, Relative Risk (RR) was used as the main research index to construct a statistical model of RR sensitivity analysis, so as to predict the minimum correlation strength of unknown confounders with exposure factors and outcomes that can explain away the research results (RR values). The method also extended RR to sensitivity analysis of Odds ratio, Hazard ratio and mean of outcome changes through statistical transformation. This method provides a simple and reliable method for sensitivity analysis of observational research, and it is suggested to provide corresponding results of sensitivity analysis in future observational research reports and papers, but it should be noted that this sensitivity analysis cannot replace rigorous scientific research design.
2020 Vol. 17 (11): 181-185,192 [Abstract] ( 416 ) HTML (1 KB)  PDF (796 KB)  ( 290 )
186 Analysis of constraint factors in the patent transformation of medical devices in Hubei Province
JIANG Yawei GAO Xiang XU Yanping ZHANG Wei FANG Bin ZUO Wanjun JIANG Xun
Objective To analysis the constraint factors in the process of patent transformation of medical devices. Methods From March to July 2019, questionnaires were issued to patent holders, technical backbone of patent transformation enterprises (including incubation enterprises) and investment fund practitioners in 5 academic groups and 4 enterprises. The factors affecting the transformation platform and technology involved in the patent transformation of medical devices, the unit transformation environment, the difficulty of obtaining the patent product registration certificate, the capital situation, and the sales channels were investigated, and the data were sorted out to get the question outline. According to the judgment sampling method, 31 people from the above three categories were selected for interview, and the sequence of patent transformation process and force field analysis were used for analysis. Results A total of 170 questionnaires were issued and 158 valid answers were received. The problem focuses on high annual patent fee, difficulty in obtaining patent product registration certificate, lack of funds; lack of conversion conditions, poor sales, etc. Fifteen persons think the patent maintenance cost is higher, 15 persons lack of conversion platform and technology, 8 persons failing to crack down on counterfeit products, 5 persons whose products are not covered by the insurance, 5 persons with signature change of high quality patent, 4 persons with long time and high cost to obtain product production qualification, 4 people early participation in the fund withdrew. Conclusion For the successful transformation of medical device patents, it is necessary to improve the quality of patents and introduce various policies conducive to the transformation based on the experience of developed countries.
2020 Vol. 17 (11): 186-188,196 [Abstract] ( 160 ) HTML (1 KB)  PDF (947 KB)  ( 75 )
189 Development of mental health services for officers and soldiers in domestic non-war military operations
ZHAO Chunhai SHI Xiufang LI Wenjuan ZHENG Yongjun
Psychological service in the domestic non-war military action has gone through the stages of expert tour, psychological doctor accompany guarantee, psychological service team support guarantee and so on. As a kind of task-based mode, the tour of experts includes mental state assessment, mental health education, mental health consultation and psychological intervention. The outstanding characteristic that psychological doctor accompanies safeguard is “whole journey” service; psychological and medical security synchronization, psychological outpatient, physical examination; tour and other forms of medical service officers and soldiers; the political and industrial departments shall take the lead in organizing mental health guarantee; the psychological work and ideological work shall promote each other. Psychological service team is the embodiment of the development of psychological service guarantee to professional team and support mode in recent years. Its classification guarantee, the division of responsibility, the element layout has a better scientific nature. Standard and full professional security is the need for military afficers and soldiers mental health security.
2020 Vol. 17 (11): 189-192 [Abstract] ( 120 ) HTML (1 KB)  PDF (678 KB)  ( 216 )
193 Teaching experience on granulomatous lobular mastitis
ZHANG Dongxiao FU Na DONG Hao HUANG Qiao ZHAO Wenjie SUN Yujian
Granulomatous lobular mastitis is one of the common diseases in department of galactophore. Its clinical manifestations are diversity and surgical skills are demanding. It is one of the difficulties in breast surgery clinical teaching. This research uses the classification method, comparative method, case teaching method, multimedia teaching, operation exercise and other means to solve the problem of clinical teaching. This research introduces some attempts and experience of Beijing Hospital of Traditional Chinese Medicine, Capital Medical University in teaching this disease in order to improve the teaching level.
2020 Vol. 17 (11): 193-196 [Abstract] ( 181 ) HTML (1 KB)  PDF (676 KB)  ( 71 )
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