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| Expression and significance of P-tau-181, IL-1β and AD7c-NTP in patients with Alzheimer′s disease |
| LI Min1 YE Lijun2 YU Changfa3 FU Pan1 XUE Yufeng1▲ |
1.Department of Neurology, the First People′s Hospital of Taizhou, Zhejiang Province, Taizhou 318020, China;
2.Department of Blood Transfusion, the First People′s Hospital of Taizhou, Zhejiang Province, Taizhou 318020, China;
3.Department of Laboratory, the First People′s Hospital of Taizhou, Zhejiang Province, Taizhou 318020, China |
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Abstract Objective To explore the expression and clinical significance of serum phosphorylated tau protein (P-tau-181), interleukin-1β (IL-1β) and urinary Alzheimer′s disease (AD) associated neurofilament protein (AD7c-NTP) in patients with AD. Methods A total of 76 patients with AD were selected as the AD group who were hospitalized in the Department of Neurology, Taizhou First People′s Hospital from January 2017 to June 2019. According to the clinical dementia scale score, they were divided into 26 cases in mild group, 29 cases in moderate group and 21 cases in severe group. A total of 35 healthy people who underwent physical examination at the same time were selected as the control group. Serum P-tau-181, IL-1β and AD7c-NTP in urine were detected by enzyme-linked immunosorbent assay. The expression levels of P-tau-181, IL-1β and AD7c-NTP were compared in each group, and the diagnostic efficacy of P-tau-181, IL-1β and AD7c-NTP in AD were analyzed. Results The expressions of P-tau-181, IL-1β, and AD7c-NTP in AD group were higher than those in control group (all P < 0.05). The expression levels of P-tau-181, IL-1β, and AD7c-NTP in the severe group were higher than those in the moderate and mild groups. The expression levels of P-tau-181, IL-1β, and AD7c-NTP in the moderate group were higher than those in the mild group (all P < 0.05). The area under curve (AUC) of P-tau181 in the diagnosis of AD was 0.898, the AUC of IL-1β was 0.851, and the AUC of AD7c-NTP was 0.847. Conclusion The expression of P-tau-181, IL-1β and AD7c-NTP in AD patients is elevated, which can be used as a detection index for clinical diagnosis of AD, and it can also classify the severity of lesions, which has important clinical significance.
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