热疗联合放化疗治疗局部晚期非小细胞肺癌的临床效果

Abstract
Figure/Table
References (22)
Related Citation (15)

Download: PDF (537 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To observe the clinical effect of hyperthermia combined with radiotherapy and chemotherapy in the treatment of locally advanced non-small cell lung cancer (NSCLC) and its effect on survival. Methods A total of 110 patients with locally advanced NSCLC admitted to the Chemoradiot Department of Tangshan People′s Hospital from January 2015 to January 2017 were selected. They were divided into the observation group and the control group by random number table method, with 55 cases in each group. The observation group received synchronous radiotherapy and chemotherapy combined with hyperthermia, and the control group received synchronous radiotherapy and chemotherapy. The short-term efficacy, incidence of toxic and side effects and long-term survival of the two groups were compared. Results The effective rate of the observation group was significantly higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). There was no statistically significant difference in the incidence of radiation esophagitis, radiation pneumonia, myelosuppression and radiation dermatitis between the two groups (P ＞ 0.05). The 2-year cumulative survival rate of the observation group was higher than that of the control group, and the difference was statistically significant (P ＞ 0.05). Conclusion The short-term efficacy of hyperthermia combined with radiotherapy and chemotherapy in the treatment of locally advanced NSCLC is accurate, and the survival rate is improved compared with that of radiotherapy and chemotherapy alone.

Key words： Non-small cell lung cancer Radiotherapy Chemotherapy Hyperthermia

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHAO Kai WANG Zhiwu YANG Junquan

Cite this article:

ZHAO Kai WANG Zhiwu YANG Junquan. Clinical effect of hyperthermia combined with chemoradiotherapy in the treatment of locally advanced non-small cell lung cancer[J]. 中国医药导报, 2020, 17(11): 84-87.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I11/84

[1] Herbst RS，Morgensztern D，Boshoff C. The biology and management of non-small cell lung cancer [J]. Nature，2018，553（7689）：446-454.
[2] 郑荣寿，孙可欣，张思维，等.2015年中国恶性肿瘤流行情况分析[J].中华肿瘤杂志，2019，41（1）：19-28.
[3] Engelhardt KE，Feinglass JM，DeCamp MM，et al. Treatment trends in early-stage lung cancer in the united states，2004 to 2013：A time-trend analysis of the national cancer data base [J]. J Thorac Cardiovasc Surg，2018，156（3）：1233-1246.
[4] 吴双，杨泽，张远净，等.局部晚期非小细胞肺癌诱导化疗后同期放化疗与同期放化疗疗效及安全性meta分析[J].中华肿瘤防治杂志，2017，24（1）：55-61.
[5] 顾培，吴丹丹，黄灿红.放疗联合热疗对老年局部晚期非小细胞肺癌的效果及安全性观察[J].南通大学学报：医学版，2019，39（3）：215-217.
[6] Werner-Wasik M，Paulus R，Curran WJJ，et al. Acute esophagitis and late lung toxicity in concurrent chemoradiotherapy trials in patients with locally advanced non-small-cell lung cancer：Analysis of the radiation therapy oncology group （rtog）database [J]. Clin Lung Cancer，2011， 12（4）：245-251.
[7] Chen AP，Setser A，Anadkat MJ，et al. Grading dermatologic adverse events of cancer treatments：The common terminology criteria for adverse events version 4.0 [J]. J Am Acad Dermatol，2012，67（5）：1025-1039.
[8] Beaumont H，Bertrand AS，Klifa C，et al. Radiology workflow for recist assessment in clinical trials：Can we reconcile time-efficiency and quality? [J]. Eur J Radiol，2019， 118：257-263.
[9] Vasanthan A，Mitsumori M，Park JH，et al. Regional hyperthermia combined with radiotherapy for locally advanced non-small cell lung cancers：A multi-institutional prospective randomized trial of the international atomic energy agency [J]. Int J Radiat Oncol Biol Phys，2005，61（1）：145-153.
[10] 温本，谢美强，颜劲，等.热疗联合同步放化疗在局部晚期非小细胞肺癌中应用[J].广东医科大学学报，2017， 35（6）：640-643.
[11] Neshasteh-Riz A，Eyvazzadeh N，Rostami A，et al. Cytogenetic damage from hyperthermia，6 mV X-rays，and topotecan in glioblastoma spheroids，simultaneously，and separately [J]. J Cancer Res Ther，2018，14（6）：1273-1278.
[12] Zhang T，Pan Q，Xiao S，et al. Docetaxel combined with intraperitoneal hyperthermic perfusion chemotherapy and hyperthermia in the treatment of advanced ovarian cancer [J]. Oncol Lett，2016，11（5）：3287-3292.
[13] Issels RD，Lindner LH，Verweij J，et al. Effect of neoadjuvant chemotherapy plus regional hyperthermia on long-term outcomes among patients with localized high-risk soft tissue sarcoma：The eortc 62961-esho 95 randomized clinical trial [J]. JAMA Oncol，2018，4（4）：483-492.
[14] Schlemmer M，Wendtner CM，Lindner L，et al. Thermochemotherapy in patients with extremity high-risk soft tissue sarcomas（hr-sts）[J]. Int J Hyperthermia，2010，26（2）：127-135.
[15] Kalapurakal JA，Mittal BB，Sathiaseelan V. Re-irradiation and external hyperthermia in locally advanced，radiation recurrent， hormone refractory prostate cancer：A preliminary report [J]. Br J Radiol，2001，74（884）：745-751.
[16] Oei AL，Vriend LE，Crezee J，et al. Effects of hyperthermia on DNA repair pathways：One treatment to inhibit them all [J]. Radiat Oncol，2015，10（1）：165.
[17] Yang WH，Xie J，Lai ZY，et al. Radiofrequency deep hyperthermia combined with chemotherapy in the treatment of advanced non-small cell lung cancer [J]. Chin Med J（Engl），2019，132（8）：922-927.
[18] Ando K，Suzuki Y，Kaminuma T，et al. Tumor-specific cd8-positive t cell-mediated antitumor immunity is implicated in the antitumor effect of local hyperthermia [J]. Int J Hyperthermia，2018，35（1）：226-231.
[19] 赵家棣，苏海龙，曲希侠，等.热疗联合放疗或化疗治疗晚期非小细胞肺癌63例临床分析[J].中华物理医学与康复杂志，2004，26（5）：64.
[20] 温本，谢美强，郑文滔，等.热疗联合放化疗治疗局部晚期非小细胞肺癌的临床分析[J].中国癌症防治杂志，2014， 6（2）：175-177.
[21] 金倩文.局部晚期非小细胞肺癌治疗现状及趋势[J].疑难病杂志，2019，18（8）：860-864.
[22] Kok HP，Korshuize-van Straten L，Bakker A，et al. Online adaptive hyperthermia treatment planning during locoregional heating to suppress treatment-limiting hot spots [J]. Int J Radiat Oncol Biol Phys，2017，99（4）：1039-1047.