中国北京人群高尿酸血症与非酒精性脂肪肝的相关性研究

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Abstract Objective To investigate the association between hyperuricemia and nonalcoholic fatty liver (NAFLD) in Beijing of China. Methods A total of 6750 participants who enrolled in the physical examination from July 2017 to May 2018 at the Health Checkup Center of Luhe Hospital in Tongzhou District, Beijing. The data included the basic information of the population and the corresponding biochemical indicators and abdominal color ultrasound. The differences in the basic data, biochemical indicators, metabolic syndrome, and the incidence of fatty liver between hyperuricemia and non-hyperuricemia were compared. According to the literature, the quartiles of serum uric acid level were analyzed and whether hyperuricemia was an independent risk factor for NAFLD after controlling for multiple confounders using binary logistic regression. Results In men, the body weight, body mass index (BMI), total cholesterol (TC), low density lipoprotein cholesterol (HDL-C) and creatinin (Scr) of patients with hyperuricemia were higher than those without hyperuricemia (P < 0.05), while the high density lipoprotein cholesterol (HDL-C) level was lower (P ＜ 0.05). In women with hyperuricemia, weight, BMI, alanine aminotransferase, asparagine aminotransferase, TG, TC, LDL-C, and Scr were higher than those without hyperuricemia (P ＜ 0.05), while HDL-C levels were lower (P < 0.05). The incidence of NAFLD and metabolic syndrome in both men and women with hyperuricemia was higher than that of non-hyperuricemia (P ＜ 0.05). After correction for various confounding factors, for every 50 mol/L increase in serum uric acid, the risk of occurrence of NAFLD increased by 11.2% (P ＜ 0.05). After stratifying uric acid levels according to quartile, logistic regression was used to find that the risk of nonalcoholic fatty liver increased with the increase of serum uric acid level after multiple confounding factors were corrected (blood uric acid ≤270 μmol/L as a reference, the blood uric acid in 271-320 μmol/L crowd their risk of the occurrence of NAFLD was 1.258 times (95%CI:1.012-1.563), blood uric acid in 321-379 μmol/L, the risk was 1.523 times (95%CI:1.226-1.892), the risk of occurrence was 1.696 times (95%CI: 1.338-2.148) in serum uric acid ≥380 μmol/L. Serum uric acid was positively correlated with NAFLD, which was an independent risk factor for the occurrence of NAFLD. Conclusion The uric acid is an independent risk factor for NAFLD disease and that it is gender-differentiated. Women are more relevant than men.

Key words： Nonalcoholic fatty liver Hyperuricemia Gender differences Correlation studies Occurrence risk

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	ZHANG Yuanyuan YANG Longyan WANG Yan SUN Rongxin FU Ying ZHAO Dong

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ZHANG Yuanyuan YANG Longyan WANG Yan SUN Rongxin FU Ying ZHAO Dong. Correlation analysis of hyperuricemia and nonalcoholic fatty liver in Beijing of China[J]. 中国医药导报, 2020, 17(11): 111-115.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I11/111

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