血压变异性与急性脑梗死患者预后的相关性分析

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Abstract Objective To analyze the relationship between blood pressure variability (BPV) and 3-month prognosis of acute cerebral infarction. Methods From November 2018 to April 2019, 42 patients with acute cerebral infarction in Department of Neurology of Hefei Binhu Hospital (“our hospital” for short) were selected as acute cerebral infarction group, and the end point was 3-month after the onset of the disease. Meanwhile, 32 persons taken healthy physical examination in Outpatient Department of our hospital were selected as control group. Parameters of blood pressure variability between two groups were compared, including 24-hour systolic blood pressure coefficient of variation (24hSBPcv), 24-hour diastolic blood pressure coefficient of variation (24hDBPcv), daytime systolic blood pressure coefficient of variation (dSBPcv), daytime diastolic blood pressure coefficient of variation (dDBPcv), nocturnal systolic blood pressure coefficient of variation (nSBPcv), nocturnal diastolic blood pressure coefficient of variation (nDBPcv), 24-hour systolic blood pressure standard deviation (24hSSD), 24-hour diastolic blood pressure standard deviation (24hDSD), daytime systolic pressure standard deviation (dSSD), daytime diastolic pressure standard deviation (dDSD), nighttime systolic pressure standard deviation (nSSD) and nighttime diastolic pressure standard deviation (nDSD). Linear regression was used to analyze the correlation between 3-month prognosis of acute cerebral infarction and different blood pressure variability parameters. Results There was no significant difference in gender, age, history of hypertension, diabetes, smoking, drinking and atrial fibrillation between two groups (P > 0.05). The levels of triacylglycerol, total cholesterol, high density lipoprotein cholesterol and low density lipoprotein cholesterol between two groups were compared, with no significant difference (P > 0.05). The nSBPcv, 24hSSD, 24hDSD, dSSD and nSSD of acute cerebral infarction group were higher than those of control group, the differences were statistically significant (P < 0.05). 24-hour ambulatory blood pressure circadian rhythm of two groups was significantly different (P < 0.05). 24hSBPcv, dSBPcv, 24hSSD and dSSD were correlated with prognosis after 3-month of cerebral infarction (P < 0.05). Conclusion BPV is an important factor in the prognosis of cerebral infarction. 24hSSD, dSSD, 24hdSBPcv and dSBPcv in patients with acute cerebral infarction are related to the prognosis of 3-month.

Key words： Blood pressure variability Blood pressure monitoring Cerebral infarction Circadian rhythm

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	SONG Daohui XI Chunhua▲ MU Yanfang ZHANG Liufu ZHANG Tingting

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SONG Daohui XI Chunhua▲ MU Yanfang ZHANG Liufu ZHANG Tingting. Analysis of correlation between blood pressure variability and prognosis of patients with acute cerebral infarction[J]. 中国医药导报, 2020, 17(11): 65-68.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I11/65

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