不同性别血尿酸水平与冠心病及冠状动脉狭窄程度的关系

Abstract
Figure/Table
References (20)
Related Citation (15)

Download: PDF (608 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To study the relationship between serum uric acid levels of different genders and the degree of coronary heart disease and coronary artery stenosis. Methods A total of 500 patients with coronary heart disease who underwent percutaneous coronary intervention (PCI) in the Department of Cardiology, Langfang people′s Hospital Affiliated to Hebei Medical University from February 2012 to February 2016 were selected as the study subjects. They were divided into the male group (280 cases) and female group (220 cases) by sex, and the standard of blood uric acid in male was ＞420 μmol/L and female was ＞357 μmol/L. The male group was divided into hyperuricemia group (115 cases) and non-hyperuricemia group (165 cases), women with hyperuricemia group (73 cases) and non-hyperuricemia group (147 cases), the degree of coronary artery stenosis in each group was compared. The presence of adverse cardiac events, basic data and related serum indicators in the male and female groups were compared, and the relationship between the basic data and the occurrence of adverse cardiac events after PCI was further analyzed by logisitic regression analysis. Results There was no significant difference in the score of coronary artery stenosis between the male hyperuricemia group and the non-hyperuricemia group (P ＞ 0.05). The score of coronary artery stenosis in the female hyperuricemia group was higher than that in the non-hyperuricemia group (P ＜ 0.05). Adverse cardiac events in the male and female groups were associated with age, smoking, hypertension and family genetic history (all P ＜ 0.05). The logistic regression analysis showed that the age (male: OR = 6.234, 95%CI: 1.375-8.385; female: OR = 7.139, 95%CI: 1.325-11.288), smoking (male: OR =10.753, 95%CI: 4.592-19.586; female: OR = 8.953, 95%CI: 2.395-14.275), hypertension (male: OR = 8.174, 95%CI: 3.295-20.907; female: OR = 5.302, 95%CI: 1.857-8.076), family genetic history (male: OR = 7.053, 95%CI: 1.055-10.844; female: OR = 5.032, 95%CI: 1.287-9.058) were independent risk factors for adverse cardiac events after PCI in patients with coronary heart disease of different sex. The serum uric acid (OR =6.038, 95%CI: 1.405-9.17) was independent risk factors for adverse cardiac events after PCI in coronary heart disease female (P ＜ 0.05). Conclusion The serum uric acid level of female patients with coronary heart disease is closely related to the degree of coronary artery stenosis and adverse cardiac events after PCI.

Key words： Coronary heart disease Different genders Blood uric acid Degree of coronary stenosis Adverse cardiac event

Fund:河北省廊坊市科学技术研究与发展计划项目（2016013014）。

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	LI Yachao1 YANG Yanli1 AN Lei1 LIU Xinming2 LU Dianlin1 GUAN Zeyong1 XUE Zengming1▲

Cite this article:

LI Yachao1 YANG Yanli1 AN Lei1 LIU Xinming2 LU Dianlin1 GUAN Zeyong1 XUE Zengming1▲. The relationship between the serum uric acid level of different genders and the degree of coronary heart disease and coronary artery stenosis[J]. 中国医药导报, 2020, 17(11): 128-131.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I11/128

[1] Fadaei R，Parvaz E，Emamgholipour S，et al. The mRNA Expression and Circulating Levels of Visfatin and Their Correlation with Coronary Artery Disease Severity and 25-Hydroxyvitamin D [J]. Horm Metab Res，2016 48（4）：269-274.
[2] 牟凤群，陈通.老年缺血性脑卒中患者颈动脉硬化及颅内动脉狭窄与血清尿酸水平的相关性研究[J].中华老年医学杂，2015，34（11）：1213-1217.
[3] Cicero AFG，Fogacci F，Giovannini M，et al，Serum uric acid predicts incident metabolic syndrome in the elderly in an analysis of the Brisighella Heart Study [J]. Sci Rep，2018，8（1）：11529.
[4] 宋艳东，陶英，王苏，等.冠心病患者同型半胱氨酸、血尿酸水平与冠脉病变的相关性[J].中华急诊医学杂志，2017， 26（4）：430-433.
[5] 陈亮，陈韬，白元，等.老年冠心病患者血尿酸水平与冠状动脉病变程度的相关性[J].中华老年多器官疾病杂志，2013，12（3）：205-208.
[6] Zhang LQ，Van HL，Xiong M，et al. Metabolic and molecular insights into an essential role of nicotinamide phosphoribosyltransferase [J]. Cell Death Dis，2017，8（3）：e2705.
[7] 孙丹，付志方，焦红梅，等.血尿酸肌酐比对老年慢性阻塞性肺疾病患者气流受限程度的预测价值[J].中华临床医师杂志：电子版，2017，11（18）：2229-2233.
[8] 刘圣文，乔树宾，徐波，等.不同年龄冠心病患者经桡动脉介入治疗的安全性和有效性对比分析[J].中华医学杂志，2010，90（40）：2852-2855.
[9] 包柄楠，孙秀芹，赵怡，等.不同性别老年冠心病冠状动脉旁路移植术患者代谢性危险因素特征[J].中华老年心脑血管病杂志，2013，15（6）：569-571.
[10] 唐艳芳，刘智勇，刘景艳，等.血尿酸水平与冠心病的关联研究[J].中华全科医学，2012，10（6）：868-870.
[11] 袁越，陈红方，刘峰，等.冠心病病人住院期间不良心脏事件影响因素研究[J].护理研究，2013，27（5）：428-430.
[12] Narendra S，Das UK，Tripathy SK，et al. Superoxide Dismutase，Uric Acid，Total Antioxidant Status，and Lipid Peroxidation Assay in Chronic and Aggressive Periodontitis Patients [J]. J Contemp Dent Pract，2018，19（7）：874-880.
[13] 唐国栋，郑耐心，张慧平，等.老年冠心病患者PCI术后不良心脏事件危险因素分析[J].山东医药，2017，57（4）：61-63.
[14] 黄群，范立超.血清尿酸水平与不同性别早发冠心病的相关性研究[J].中国现代医生，2017，55（8）：35-37.
[15] Liu J，Zhao Z，Mu Y，et al. Gender Differences in the Association between Serum Uric Acid and Prediabetes： A Six-Year Longitudinal Cohort Study [J]. Int J Environ Res Public Health. 2018，15（7）. pii：E1560.
[16] Petrikova J，Janicko M，Fedacko J，et al. Serum Uric Acid in Roma and Non-Roma-Its Correlation with Metabolic Syndrome and Other Variables [J]. Int J Environ Res Public Health，2018，15（7）. pii：E1412.
[17] 吴琳，陈素欣，吕新湖，等.不同性别老年高尿酸血症与冠状动脉病变程度的相关性研究[J].河北医药，2016， 38（10）：1491-1493.
[18] Markovi■ BM，■au?觢evi■ A，Brizi■ I，et al. A relation of serum homocysteine，uric acid and C-reactive protein level in patients with acute myocardial infarction [J]. Med Glas（Zenica），2018，15（2）：101-108.
[19] 杨波，高玉梅，商鲁翔，等.老年冠心病患者血尿酸与冠状动脉狭窄程度的相关性[J].中华老年心脑血管病杂志，2016，18（8）：812-814.
[20] Benli E，Cirakoglu A，Ayy?覦ld?覦z SN，et al. Comparison of serum uric acid levels between prostate cancer patients and a control group [J]. Cent European J Urol，2018，71（2）：242-247.