|
|
|
| The effect of Escitalopram combined with electroacupuncture in the treatment of geriatric depression and its effect on brain neurotransmitter and near infrared brain function quantification |
| TIAN Le ZHANG Huiru WANG Yi WANG Jianjun NI Jingjing JING Lan▲ |
| Department of Neurology, Inner Mongolia Mental Health Center, Inner Mongolia Autonomous Region, Huhhot 010020, China |
|
|
|
Abstract Objective To explore the effect of Escitalopram combined with electroacupuncture in the treatment of geriatric depression (GD) and its effect on brain neurotransmitters and near infrared brain function quantification. Methods Total 108 GD patients diagnosed and treated in Neurology Department and Psychiatry Department of Inner Mongolia Mental Health Center from October 2017 to October 2018 were selected. According to different treatment schemes, they were divided into two groups, with 54 cases in each group. Control group was treated with Escitalopram and observation group was treated with electroacupuncture on this basis for 4 weeks. Clinical effect, HAMD score, EEG ultra-slow fluctuation analysis and NIR brain function quantification were compared between two groups. Results The total effective rate of observation group was higher than that of control group (P < 0.05). After treatment, HAMD scores of two groups were lower than before treatment, observation group was lower than control group, the differences were highly statistically significant (P < 0.01). After treatment, the levels of dopamine, noradrenaline, 5-hydroxytryptamine (5-HT) and acetylcholine receptor (AchR) in observation group were higher than those before treatment and those in control group, the levels of glutamate and γ-aminobutyric acid in observation group were lower than those before treatment and those in control group, the levels of 5-HT and AchR in control group were higher than those before treatment, the differences were statistically significant (P < 0.05 or P < 0.01). After treatment, oxyhemoglobin (Oxy-Hb) in both groups was lower than that before treatment, observation group was lower than control group, the differences were highly statistically significant (P < 0.01). Conclusion The combination of Escitalopram and electroacupuncture have significant effect in the treatment of GD patients, which can help to improve their neurotransmitter level and regulate the concentration of Oxy-Hb in the prefrontal cortex and alleviate depressive symptoms, thus improving the therapeutic effect of depression.
|
|
|
|
|
|
[1] 蒋荣泉，吴美娟，何国军.加味柴胡汤联合帕罗西汀对抑郁症患者血清炎症因子、生活质量及疗效的影响[J].中华中医药学刊，2016，34（5）：1250-1252.
[2] 曾令烽，梁伟雄，曹烨，等.不同程度认知障碍与老年患者抑郁症相关性研究[J].中华中医药杂志，2016，31（5）：1906-1913.
[3] 杨玉兴，权元文，杨艳斐，等.120例老年抑郁症患者临床表现及中医证候特征研究[J].中华中医药杂志，2017， 32（8）：3833-3836.
[4] 别怀玺，任丽平，李笑，等.重复经颅磁刺激联合疗法对老年抑郁症患者的早期干预效果[J].中华老年心脑血管病杂志，2018，20（8）：867-869.
[5] 胡会婷，王敏忠.艾司西酞普兰治疗脑卒中后抑郁及对患者神经功能认知功能的影响[J].河北医学，2018，24（2）：325-328.
[6] 中华医学会精神病学分会.中国精神障碍分类与诊断标准第三版（精神障碍分类）[J].中华精神科杂志，2001， 34（3）：184-188.
[7] 王佩蓉，杨春玉.中西医结合治疗抑郁症的疗效及对患者血清单胺类神经递质的影响[J].中华中医药学刊，2017， 35（5）：1336-1339.
[8] 李海聪，李求兵，杨毅玲，等.抗抑郁治疗对老年高血压合并抑郁障碍患者血压的影响[J].中华老年心脑血管病杂志，2016，18（2）：143-148.
[9] Too LK，Yau B，Baxter AG，et al. Double deficiency of toll-like receptors 2 and 4 alters long-term neurological sequelae in mice cured of pneumococcal meningitis [J]. Sci Rep，2019，9（1）：16189.
[10] Halász P. Newer studies on the strong link between sleep and epilepsy：epilepsy as an epileptic transformation of sleep plastic functions [J]. Ideggyogy Sz，2019，72（9/10）：304-314.
[11] Ortega RL，Dakterzada F，Arias A，et al. Usefulness of CSF biomarkers in predicting the progression of amnesic and nonamnesic mild cognitive impairment to Alzheimer′s disease [J]. Curr Aging Sci，2019，12（1）：35-42.
[12] Hirose-Ikeda M，Chu B，Zhao P，et al. Trophic factors are essential for the survival of grafted oligodendrocyte progenitors and for neuroprotection after perinatal excitotoxicity [J]. Neural Regen Res，2019. [epub ahead of print]
[13] Garcez FB，Apolinario D，Campora F，et al. Delirium and post-discharge dementia：results from a cohort of older adults without baseline cognitive impairment [J]. Age Ageing，2019，48（6）：845-851.
[14] Iliadou P，Kladi A，Frantzidis CA，et al. The pattern of mu rhythm modulation during emotional destination memory： comparison between mild cognitive impairment patients and healthy controls [J]. J Alzheimers Dis，2019， 71（4）：1201-1215.
[15] 齐玉，王高华，王惠玲.近红外光谱成像技术在抑郁症中的研究进展[J].临床精神医学杂志，2017，27（1）：65-67.
[16] Verònica Gálvez，Ho KA，Alonzo A，et al. Neuromodulation therapies for geriatric depression [J]. Cur Psych Rep，2015，17（7）：59.
[17] 卢伟明.艾司西酞普兰与舍曲林治疗脑卒中后抑郁患者的疗效及对炎症因子、NSE、NPY的影响[J].中华全科医学，2017，15（8）：1340-1341，1401.
[18] 闫玲玲.艾司西酞普兰合并支持性心理治疗对首发老年抑郁症患者的作用分析[J].中国现代药物应用，2018， 12（24）：188-189.
[19] 范雪云.艾司西酞普兰合并电针对老年抑郁症的临床疗效及生活质量分析[J].中国现代医生，2018，56（2）：77-79.
[20] 伍远菲，吴升伟，廖雪珍，等.密集颅部电针刺激治疗和针刺治疗对抑郁症患者再入院风险的影响[J].中医药临床杂志，2018，30（3）：497-501.
[21] 冼益民，梁艳安，朱丽华，等.电针治疗肝气郁结气虚血瘀型缺血性中风后抑郁疗效观察[J].新中医，2018，50（9）：185-187.
[22] 常晶莹，韩思龙.电针配合耳压治疗抑郁症的临床疗效观察[J].内蒙古中医药，2017，36（8）：124-125.
[23] 李春，黄波，唐海宁，等.癫痫伴发焦虑抑郁患者脑神经递质活动的脑电超慢涨落图表现分析[J].中国医学物理学杂志，2018，35（3）：369-372. |
|
|
|
