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2017 Vol. 14, No. 36
Published: 2017-12-25
 
 
4 Study on the relation of SHIP2 with proliferation, apoptosis and cell cycle in Hep-2 cells after radiation
LIANG Huiling HE Xiaoqin GAN Yuanyuan ZHOU Yujie XIONG Lin TANG Tian XU Ximing
Objective To explore the relation between the expression of SHIP2 and proliferation, apoptosis and cell cycle in Hep-2 cells after radiotherapy. Methods Lupine carcinoma Hep-2 cells were divided into the experiment group (treated with 2, 4, 8 Gy X- ray) and the control group (treated with 0 Gy). CCK-8 was repeatedly used to detect the proliferation of the cells 12, 24, 36 h and 48 h after the treatment. The most appropriate and exact time to detect cells in the subsequent experiment was set up following the result of proliferation. Then apoptosis was evaluated by AnnexinV- FITC/PI double staining flow cytometry and cell cycle was evaluated by PI single staining flow cytometry. RT-qPCR and Western-blot were used to detect the expression of SHIP2 mRNA and its protein. Results Compared with the control group, Hep-2 cells' proliferation in the experiment group was inhibited (all P ＜ 0.05) . As the dose of ray increased, the viability descended, and the most remarkable result arose 48 h after the treatment. There was a remarkable increase in apoptosis of the experiment group (all P ＜ 0.01). After treated with 4 Gy and 8 Gy X-ray G2/M phase arrest was remarkable too (all P ＜ 0.01). The expression of SHIP2 mRNA and SHIP2 protein in the experiment group was lower than those of the control group (all P ＜ 0.01). Conclusion In Hep-2 cells, low expression of SHIP2 after the treatment with X-ray, may be one important pathway of X-ray inhibiting cell proliferation and increasing cell apoptosis and G2/M phase arrest.
2017 Vol. 14 (36): 4-8,20 [Abstract] ( 238 ) HTML (1 KB)  PDF (935 KB)  ( 153 )
9 Study on the blood flow effect of Invigorating Spleen, Benefiting Qi, Controlling Blood Formula and its decomposed recipes on Simvastatin-induced zebrafish cardiac hemorrhage model
ZHANG Yayue TIAN Shaodan QI Shuo WANG Chong CHEN Xinyi DONG Qing
Objective To observe the effect of Invigorating Spleen, Benefiting Qi, Controlling Blood Formula on the blood flow of Simvastatin-induced zebrafish cardiac hemorrhage model and to explore the relationship among the hemodynamic changes of zebrafish by different treatment. Methods The fertilized egg of 660 72-hour Albino zebrafish in melanin allele mutation was randomly divided into the normal control group, the model control group and group A (Invigorating Spleen Granule Formulations), B (Invigorating Spleen, Benefiting Qi Granule Formulations), C (Invigorating Spleen, Benefiting Qi, Replenishing Blood Granule Formulations), D (Invigorating Spleen, Benefiting Qi, Replenishing Blood, Controlling Blood Granule Formulations) with different concentrations (100, 250, 500, 750, 1000 μg/mL) of experimental drugs. Each group of 30. First, the zebrafish of group A, B, C, D were treated with different concentrations of drugs for 4 hours, and then with 50 μmol/L Simvastatin for 30 minutes. Next, through collecting blood flow imaging of the 20 zebrafish in each group by heartbeat blood flow analysis system, the blood flow was analyzed and the improvement rate was calculated. Results ①Compared with the model control group, different concentrations of drug groups in group A, B had no effects on the improvement of blood flow in Simvastatin-induced zebrafish hemorrhage model; however, 500, 750,1000 μg/mL of drugs in group C, D could significantly increase the improvement rate of blood flow in zebrafish hemorrhage model (P ＜ 0.05). ②In ameliorating the model's velocity of blood flow and its improvement rate, 1000 μg/mL of Invigorating Spleen, Benefiting Qi, Replenishing Blood, Controlling Blood Formula was superior to that of Invigorating Spleen, Benefiting Qi, Replenishing Blood Formula. Conclusion The comprehensive application of invigorating spleen, benefiting qi, replenishing blood, controlling blood can ameliorate the blood flow of Simvastatin-induced zebrafish cardiac hemorrhage model, which reflects the theory of “qi is the commander of blood and blood is the mother of qi”.
2017 Vol. 14 (36): 9-12,24 [Abstract] ( 610 ) HTML (1 KB)  PDF (743 KB)  ( 87 )
13 Study on protective effects and mechanism of liquiritin on photoaging hacat cells induced by UVB
ZHANG Lihong1 FU Yun2 LIAO Jian3 ZHANG Qiong2 WANG Yeqiu1 ZHANG Yanhong1 LI Jianmin2
Objective To investigate the protective effects and the mechanism of liquiritin on photoaging human keratinocytes (HaCaT) cells induced by ultraviolet B (UVB). Methods The different concentrations of liquiritin were used on HaCaT cells, the best effective and safe concentration of liquiritin was determined by methyl thiazolyl tetrazolium(MTT). The photoaging model was set up by the irradiation of UVB at irradiation dose of 30 mJ/cm2. It was used to treat liquiritin + UVB group cells 24 h with 10-7, 10-6, 10-5 mol/L, the effects of liquiritin on the proliferation rate of photoaging model HaCaT cells were detect by MTT. The activity of glutathione (GSH), catalase (CAT) and the content of malondialdehyde (MDA) were detected by the corresponding kits. The detection of interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) protein expression were detected by Western blot. Results The liquiritin with the concentrations of 10-7, 10-6, 10-5 mol/L had no obvious effect on the proliferation and inhibition of HaCaT cells (P > 0.05), which were the best safe and effective concentrations. Compared with the blank group, the cell proliferation rate of the UVB group was significantly decreased, the activity of GSH and CAT was significantly decreased, and the content of MDA was significantly increased, the expression of IL-1β, IL-6 and TNF-α protein were increased (P < 0.01). Compared with the UVB group, the cell proliferation rates of the (10-7, 10-6, 10-5) mol/L liquiritin+UVB group were significantly increased, the activity of GSH and CAT was significantly increased, the content of MDA was significantly decreased, the expression of IL-1β, IL-6 and TNF-α protein were significantly decreased (P < 0.05 or P < 0.01). Conclusion Liquiritin can protect HaCaT cells photoaging, which mechanism is related to the improvement of antioxidant enzyme activity and inhibition of inflammatory cytokines.
2017 Vol. 14 (36): 13-16,51 [Abstract] ( 309 ) HTML (1 KB)  PDF (1065 KB)  ( 367 )
17 Establishment of mice model of inflammation-associated colorectal cancer and expression of vasohibin-1 in colorectal cancer
WANG Lei SHI Junli LI Bingqing
Objective To investigate the establishment of mice model of inflammation-associated colorectal cancer and expression of vasohibin-1 (VASH-1) in colorectal cancer. Methods Thirty male mice (C57BL/6) were randomly divided into two groups according to the body weight. Group A was given right intraperitoneal administration of azoxymethane (AOM) 10 mg/kg first, and free drink of 1.5%-2.5% dextran sulfate sodium (DSS) at the first, fourth, seventh week later for 7 d, which drunk distilled water on the other time. Group B was given right intraperitoneal administration of normal saline 0.1 mL/10 g, then the mice were given distilled water on the other time. The mice of both groups were killed at the end of tenth week to observe the conditions of tumor formation. The immunohistochemical staining was performed to evaluate the expression of VASH-1 in the of tissue colorectal cancer. Results After modeling, the tumor formation rate of  group A was 53.33%, with the pathologic findings of adenocarcinoma, which of group B was 0.00%, the difference was statistically significant (P ＜ 0.05). VASH-1 had high expression in the colorectal cancer and low expression in normal colorectal tissues, with significant difference (P ＜ 0.05). Conclusion The tumor formation rate of mice model of inflammation-associated colorectal cancer induced by this method is high. The expression of VASH-1 in colorectal cancer is higher than that in normal colorectal tissues.
2017 Vol. 14 (36): 17-20 [Abstract] ( 291 ) HTML (1 KB)  PDF (814 KB)  ( 140 )
21 Influence of Gan Pi Shu on intestinal barrier function in liver cirrhosis rats
PAN Xiangxue ZHU Junfeng LI Yong
Objective To explore the protective effect of Gan Pi Shu on intestinal mucosal barrier in rats with liver cirrhosis. Methods A total of 36 male SD rats were divided randomly into 4 groups based on SAS proc plan sentence according to the order of weight to be large, with 9 rats in each group. The rats in the blank group were injected intraperitoneally with saline daily. The rats in the model group were injected intraperitoneally with carbon tetrachloride to establish the model of liver cirrhosis. The rates in the Gan Pi Shu group and the Duphalac group were given Gan Pi Shu and Duphalac respectively based on the model group. The plasma levels of endotoxin (ET), diamine oxidase (DAO), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) were measured. The pathological changes of liver and ileum tissue were observed by HE staining. Results The plasma levels of ET, DAO, TNF-α and IL-1β in Gan Pi Shu group were lower than those of model group, with statistically significant difference (P ＜ 0.05). DAO and IL-1β in Gan Pi Shu group were lower than those of Duphalac group, with statistically significant difference (P ＜ 0.05). The pathological changes of liver and ileum tissue in Gan Pi Shu and Duphalac group was better than that of model group. Conclusion Gan Pi Shu has the protective effect on the intestinal mucosal barrier in rats with liver cirrhosis, which can truncate the development process between intestinal mucosal barrier dysfunction and cirrhosis.
2017 Vol. 14 (36): 21-24 [Abstract] ( 243 ) HTML (1 KB)  PDF (634 KB)  ( 125 )
25 Effect of miR21 on cisplatin chemosensitivity of cervical cancer Hela cells and cisplatin-resistant Hela/DDP cells
YUE Xiaoxue1 MIAO Jinwei2 LU Pan1
Objective To detect the influence of miR21 gene expression on the sensitivity of cervical cancer Hela cells and cisplatin-resistant Hela/DDP cells to cisplatin. Methods Mature miR21 mimic, inhibitor and negative control (NC) miRNA were transfected into Hela and Hela/DDP cells by riboFECTTM CP. Hela cells were divided into mimic group, NC group and Blank group and Hela/DDP were divided into inhibitor group, NC group and Blank group. Real-time PCR was used to measure the expression of miR21 in each group. MTT was used to detect the half inhibitory concentration (IC50) of cisplatin. Results ①Real-time PCR results showed that the expression of miR21 was an average of (5.452±0.074) fold higher in Hela/DDP than in Hela (P < 0.01). The expression of miR21 in mimic group was obviously higher than those in NC and Blank groups (P < 0.01). The expression of miR21 in inhibitor group was significantly lower than those in NC and Blank groups (P < 0.01). There was no statistical difference between NC group and Blank group in Hela and Hela/DDP cells (P ＞ 0.05). ②MTT results showed that the sensitivity of Hela to cisplat in decreased after mimic transfection while the Hela/DDP increased after transfected with inhibitor (P < 0.05). There was no significant difference between NC group and Blank group (P ＞ 0.05). Conclusion ①The expression of miR21 is upregulated in Hela/DDP cells, while it wis down regulated in Hela cells. ②Over expression of miR21 in Hela can reduce its sensitivity to cisplatin obviously. Inhibition of miR21 in Hela/DDP can significantly increase its sensitivity tocisplatin.
2017 Vol. 14 (36): 25-28 [Abstract] ( 305 ) HTML (1 KB)  PDF (785 KB)  ( 82 )
29 Expression and clinical significance of Bax and nm23 protein in papillary thyroid microcarcinoma tissues
GU Guiyuan1 WANG Weige2 HUANG Shan3
Objective To study the expression and clinical significance of B lymphocyte tumor associated -2 related X protein (Bax), tumor metastasis suppressor gene 23 (nm23) protein in papillary thyroid microcarcinoma (PTMC) tissues. Methods One hundred and three paraffin specimens of PTMC patients who was given surgery treatment in Haian Affiliated Hospital to Nantong University from May 2016 to May 2017 were selected as observation group, the resection of the tumor was ≥ 5 cm far from paraffin embedded specimens of 103 cases of tumor adjacent tissues selected was as control group, another 100 patients with thyroid adenoma (TA) who was given surgery at the same time were chosen and enrolled as TA group, the expression of Bax and nm23 protein in each group was detected and compared, the relationship between the expression of Bax and nm23 protein and pathological parameters in the observation group was analyzed, and the correlation between Bax and nm23 protein was analyzed. Results The positive expression rates of Bax protein in the observation group and the TA group were significantly higher than the control group, and the differences were statistically significant (P < 0.05). The positive expression rate of nm23 protein in the observation group was significantly higher than the TA group and the control group, and the differences were statistically significant (P < 0.05). The positive expression rates of Bax and nm23 protein in the observation group with lymph node metastasis were significantly lower than without lymph node metastasis, and the differences were statistically significant (P < 0.05). According to the correlation analysis of Spearman, it was found that the expression of Bax was positively correlated with the expression of nm23 protein (r = 0.617, P < 0.05). Conclusion The expression of Bax and nm23 protein in PTMC tissues increased significantly, it is closely related to lymph node metastasis and both two indexes can be used as a monitoring target to evaluate the condition and prognosis of PTMC patients.
2017 Vol. 14 (36): 29-32 [Abstract] ( 271 ) HTML (1 KB)  PDF (711 KB)  ( 115 )
33 Mutation analysis of GJB2 gene in the deafness patients and the high risk population
JIANG Zhixin LIN Ning SHI Hui WANG Lijuan CHEN Wei FENG Jie HUANG Lili WU Yulin XU Haoqin
Objective To analyze the mutation frequency and spectrum of GJB2 gene hotspot mutations in the deafness patients and the high risk population. Methods There were 59 cases of deafness patients and 49 cases of high risk population in Jiangsu who were collected from November 2014 to March 2017. Four common mutations of GJB2 gene were detected by fluorescencence PCR technique. The mutation data were analyzed and summarized, and all results were further validated by Sanger sequencing. Results Allelic variants were observed in 84 of the 108 subjects with a positive rate of 77.78% (84/108). The incidences of c.235del C, c.299-300delAT, c.176del16bp and c.512insAACG were 62.96% (68/108), 17.59% (19/108), 12.96% (14/108) and 0.93% (1/108) respectively. The carrying rates of homozygous genes in GJB2 c.235del C and biallelic mutations in GJB2 in the deafness patients were 30.51% (18/59) and 28.81% (17/59). No homozygous genes and biallelic mutations were found in the high risk population. All results further validated by Sanger sequencing showed consistent with those by fluorescence PCR technique. Conclusion In this study, c.235delC mutation is the hotspot of GJB2 gene mutation. GJB2 c.235del C homozygous genes are the most common molecular risk factors followed by GJB2 biallelic mutations.
2017 Vol. 14 (36): 33-36 [Abstract] ( 361 ) HTML (1 KB)  PDF (774 KB)  ( 125 )
37 Research progress of factors affecting Staphylococcus biofilm formation
CHEN Ya YE Lianhua▲ HUANG Yunchao
Bacterial infection has become a clinical situation that can't completely avoid, including pathogens and conditioned pathogens. Bacterial biofilm becomes an effective way to protect bacteria, increases the bacteria against the body immune defense and the resistance to antibiotics. Staphylococcus biofilm formation affected by multiple factors and multi-gene regulation, including the external environmental factors, such as organism immune response and external organic matter, the internal genes regulation are mainly sarA, agr, aap, ica. This paper summarizes the formation of Staphylococcal biofilm, the external environmental factors and internal gene regulation factors that affecting biofilm formation, which can be used as a reference for the study and treatment of Staphylococcal biofilm targeted drugs.
2017 Vol. 14 (36): 37-42 [Abstract] ( 261 ) HTML (1 KB)  PDF (617 KB)  ( 99 )
43 Application of bridge combined fixation system in humeral fracture
ZONG Yonggang1 MA Yong2
Humeral fracture is a common clinical disease of orthopedics. There are diverse treatments of humeral fracture, but each one still has its own limitations. In view of these shortcomings, bridge combined fixation system, as a new internal fixation device, is gradually applied to the treatment of humeral fracture and has achieved satisfactory results. This study reviews relevant literature reports, summarizes the bridge-based internal fixation system research including origin and development, basic research, clinical application and other aspects of bridge-based internal fixation system. The result shows that the bridge-type combined internal fixation system has a good performance in many experiments such as materials science, biomechanics, biological effects and other experiments and can effectively treat some clinical diseases of orthopedics such as humeral comminuted fractures, surgical neck fractures of humerus, distal humerus fractures, simple humeral shaft fractures and so on, which demonstrates its superiority and provides the evidence for further popularizing the clinical application of the bridge combined internal fixation system.
2017 Vol. 14 (36): 43-46,56 [Abstract] ( 258 ) HTML (1 KB)  PDF (596 KB)  ( 87 )
47 Research progress of ultrasound, magnetic resonance, and radionuclide imaging for the evaluation of cardiac function in different periods after myocardial reperfusion
MA Yunxia MU Yuming
The acute myocardial infarction is a myocardial damage caused by the sudden interruption of part blood circulation of myocardium. The opening of early target vessels is the key to treat acute myocardial infarction, the thrombolysis and coronary interventional therapy(PCI) have been widely used, and the myocardium detection after reperfusion, the reperfusion of damaged vessels, recovery of reversible injuries, microcirculatory disturbance, structure and motor function of heart and so on all need to be evaluated. Different imaging techniques have different assess priorities for the cardiac function after PCI, and different time periods have different values after PCI. This paper reviews the echocardiography, cardiac magnetic resonance (CMR) and radionuclide imaging in the assessment of heart at different periods after myocardial reperfusion.
2017 Vol. 14 (36): 47-51 [Abstract] ( 285 ) HTML (1 KB)  PDF (553 KB)  ( 201 )
52 Research advances of retrospective ECG-gated CT angiography in aortic dissection with the involvement of aortic branch
SUN Qiulian JIA Yulin XIAO Xigang▲
Retrospective ECG-gated CT angiography (CTA) is a new technology for aorta. It can not only acquire the same information as the routine non-ECG-gated CTA, but also acquire the information of intimal flap motion characterization and the involvement of aortic branch according to multiphase dynamic reconstruction. Therefore, in the case of acute aortic dissection with the involvement of aortic branch, blood-supply of aortic branch can be assessed by retrospective ECG-gated CTA effectively.
2017 Vol. 14 (36): 52-56 [Abstract] ( 248 ) HTML (1 KB)  PDF (554 KB)  ( 185 )
57 Effects of Icariin on the expression of β-catenin, ALP and RUNX2 in osteoblasts
ZHOU Xianjin ZHANG Yanfang
Osteopenia is caused by the loss of bone mass when bone formation guided by osteoblasts is less than the bone absorption induced by osteoclasts. According to the traditional Chinese medicine, herba epimedii can treat osteoporosis. Besides, studies have shown that Icariin, the characteristic component of herba epimedii can promote bone formation, improve the alkaline phosphatase (ALP) activity, and also  up-regulate the expression of key factor beta-catenin, ALP and runt-related transcription factor 2 of osteoblast. However, Icariin has different effects on the proliferation and differentiation of osteoblasts. Therefore, Icariin has an attractive prospect in clinical treatment of osteoporosis, but its mechanism needs further study.
2017 Vol. 14 (36): 57-59,88 [Abstract] ( 295 ) HTML (1 KB)  PDF (832 KB)  ( 181 )
60 An study of the correlation between college students′ lifestyle and their physical health
XU Huaping QIU Hui
Objective To observe the correlation between college students′ lifestyle and physical health, in order to provide a basis for promoting the healthy lifestyle of college students and improve the physical fitness of college students. Methods One hundred and eighty students from grade 2013 of Shanghai University of TCM were selected by stratified sampling method. Their physical fitness and lifestyle during 2015-2016 academic year were investigated and the correlation was analyzed. Results Thirty-six students were overweight and obese, accounted for 20%. The average performance of middle-distance running for male and female students was in passing grade. There was no statistically significant difference between male and female students′ life style total score (P > 0.05). The score of boys′ exercise behavior was significantly higher than that of the girls′ exercise behavior (P < 0.01), while the score of girls′ interpersonal support behavior was significantly higher than that of the boys′ interpersonal support behavior (P < 0.01). College students′ exercise behavior was positively correlated with the height, body weight, vital capacity, and standing long jump (P < 0.01); the scores of students′ lifestyle were positively correlated with body weight and BMI (P < 0.05). Conclusion The average health of college students is in passing grade. The healthy lifestyle of college students has an influence on the physical fitness level, among which the exercise behavior has a great influence on the physical fitness level. It is suggested that communities, families and schools should be linked together to foster a healthy lifestyle and create a harmonious environment for college students.
2017 Vol. 14 (36): 60-63 [Abstract] ( 243 ) HTML (1 KB)  PDF (432 KB)  ( 166 )
64 Research on the related factors of loneliness of professional women
CHEN Gang1 JIANG Lihua1 HUANG Chengbing1 ZHENG Zhi1 WANG Yisen2 SI Tianmei3
Objective To investigate the status of loneliness of professional women and discuss its risk factors, in order to formulate further effective of intervening measures for provide the reliable evidence. Methods From January to April  in 2015, 427 professional women were selected from 10 institutes directly under Huai′an Women′s Federation, and they were adopted with UCLA loneliness scale and life event scale (LES), simplified coping style questionnaire (SCSQ), social support rating scale (SSRS), quality of life enjoyment and satisfaction questionnaire (Q-LES-Q-SF). Results Among respondents, there were 50 casess with unapparent loneliness, accounted for 11.7%, others had varying degree of loneliness. According to the results of the UCLA loneliness scale, the respondents were divided into low loneliness group (≤32 scores) and high loneliness group (≥33 scores). The differences between the two groups were statistically significant in terms of marriage, coping style, social support and quality of life satisfaction (P < 0.05). Logistics regression analysis results manifested that no spouse (OR=2.406, 95%CI: 1.123-5.516) and negative coping (OR=1.279, 95%CI: 1.202-1.361) were risk factors of loneliness, while objective support (OR=0.837, 95%CI: 0.739-0.949), subjective support (OR=0.822, 95%CI: 0.761-0.888) and life quality satisfaction degree (OR=0.908, 95%CI: 0.876-0.940) were protective factors of loneliness. Conclusion There is a higher incidence of loneliness among professional women， professional women with no spouses, poor social support, and poor coping styles have a higher risk of having a moderate or higher degree of loneliness.
2017 Vol. 14 (36): 64-67 [Abstract] ( 250 ) HTML (1 KB)  PDF (447 KB)  ( 218 )
68 Analysis of the correlation between blood glucose control in diabetic patients and sickness status of partner
LI Zhiyong1▲ WAN Xu2▲ HUANG Wei1 LING Xiaoyuan1 WU Bin2 MA Jing3
Objective To investigate the correlation between blood glucose control of elderly patients with type 2 diabetes mellitus and their partner sickness status in Shanghai Pujiang Community and to provide reference for the scientific management of diabetes. Methods A cross-sectional epidemiological investigation was conducted on elderly patients in the community from January to March 2017, 215 patients with type 2 diabetes were randomly selected, and the patients were divided into the solitary group, the partner positive group and the partner negative group according to their living conditions and whether their partners had diabetes or not. The data of personal background information, medical history and medication, self-management behavior, physical examination and blood biochemical indicators was collected. The target rate of glycosylated hemoglobin (HbA1c) was set as ＜7.0%. The single factor variance analysis, t-test and chi-square test were used for statistical analysis. Results There were no significant differences in blood pressure, blood lipids and body mass index among the three groups (P ＞ 0.05), while the patients in the partner positive group had better control of HbA1c (P < 0.05). Compared with the solitary group, the patients in the partner positive group had more related knowledge of diabetes (P < 0.05), more exercise (P < 0.05), and better sleep quality (P < 0.05). Conclusion Blood glucose control in diabetic patients is affected by their partners′ disease, which may be related to the level of self-management behavior. To strengthen the management of chronic diseases in the community, it is necessary to pay attention to the self-management education of solitary patients and diabetic knowledge education of the patients and their partners.
2017 Vol. 14 (36): 68-71 [Abstract] ( 311 ) HTML (1 KB)  PDF (367 KB)  ( 138 )
72 Effect of preoperative short-term usage of large doses Finasteride on perioperative bleeding in patients with transurethral resection of prostate
XU Kailiang CHENG Fan RAO Ting RUAN Yuan YU Weiming YUAN Run ZHANG Xiaobin
Objective To evaluate the effect of preoperative short-term high-dose application of Finasteride on perioperative bleeding of transurethral resection of prostate. Methods From June 2015 to December 2016, 120 patients with benign prostatic hyperplasia (BPH) treated at Renming Hospital of Wuhan University were selected. According to the preoperative clinical data, the total of 120 patients were randomly divided into three groups and the amount of every group was 40. The 10 mg group and 20 mg group respectively took 10 mg and 20 mg of Finasteride daily for two weeks and the control group did not take any durg before the operation. All the operations were finished by the same surgeon and the results of operation time, intraoperative blood loss, amount of bleeding index, the strength of bleeding, postoperative bladder lavage fluid volume and time, postoperative international prostate symptom score (IPSS), flow rate of the maximum urinary and the weight of removed prostatic tissue should be collected in statistical analysis and comparison. Results All operations were successfully and the three groups of patients had no difference among the aspects of postoperative IPSS, flow rate of the maximum urinary and the weight of removed prostatic tissue (P > 0.05). Compared with the control group, both the 10 mg and 20 mg groups had statistically significant differences in the aspects of operation time, intraoperative blood loss, amount of bleeding index, the strength of bleeding, postoperative bladder lavage fluid volume and time (P < 0.05). Compared with 10 mg group, the 20 mg group in the aspects of operation time, intraoperative blood loss, bleeding index, the strength of bleeding and postoperative bladder lavage time decreased significantly with statistical differences (P < 0.05), and there was no significant difference between the two groups in the aspect of postoperative bladder lavage fluid volume (P > 0.05). Conclusion The preoperative short-term usage of large doses Finasteride (20 mg/d) can effectively reduce perioperative bleeding, the time of operation and postoperative bladder lavage fluid volume.
2017 Vol. 14 (36): 72-75 [Abstract] ( 288 ) HTML (1 KB)  PDF (408 KB)  ( 129 )
76 Influence of Docetaxel combined with Zoledronic Acid on curative effect and prognosis of patients with hormone refractory prostate cancer
WU Yongzhi CHEN Shiwei
Objective To explore the influence of Docetaxel combined with Zoledronic Acid on curative effect and prognosis of patients with hormone refractory prostate cancer (HRPC). Methods From November 2015 to November 2016, 92 cases of patients with HRPC treated in No. 174 Hospital of PLA were selected and divided into the control group and the observation group according to random number table, with 46 cases in each group. The control group was treated with intravenous drip of Docetaxel and the observation group was given intravenous drip of Zoledronic Acid 100mL which diluted by 5% glucose injection or 0.9% sodium chloride injection on the bases of control group. The total effective rate and the incidence of adverse reactions in the two groups were compared between the two groups. The European organization for research and treatment questionnaire of cancer quality of life questionnaire core 30 (EROTC-QLQ-C30) was used to assess the life quality of patients in the two groups. Results The total effective rate in the observation group was significantly higher than that of the control group, the incidence of adverse reactions was significantly lower than that of the control group, with statistically significant differences (P ＜ 0.05). The scores of each work energy, symptom, single item and total score of EROTC-QLQ-C30 in the observation group were all significantly higher than those of the control group, with statistically significant differences (P ＜ 0.05). Conclusion Docetaxel combined with Zoledronic Acid in the treatment of HRPC have low side effect and better clinical effect. It can significantly improve life quality of patients. It is a safe and effective treatment method.
2017 Vol. 14 (36): 76-79 [Abstract] ( 294 ) HTML (1 KB)  PDF (402 KB)  ( 152 )
80 Risk factors and strategies of acute consciousness disorder of elderly patients with hip fracture
GONG Jian LUO Cheng FENG Zhijie KONG Qinhai ZHANG Hongbin LIANG Junsheng
Objective To explore the risk factors of postoperative acute consciousness disorder of elderly patients with hip fracture and control measures. Methods Clinical data of 229 cases of elderly patients with hip fracture treated in the Second Hospital of Tangshan City from February 2014 to February 2017 were analyzed retrospectively. The incidence, clinical features and risk factors of postoperative acute conscious disturbance were analyzed, and then prevention and cure measures were discussed. Results Of 229 elderly patients with hip fracture, there were 62 cases of postoperative acute consciousness disorders, with the rate of 27.07%. Single factor analysis result showed that there were significant difference in age, postoperative infection, diabetes, adverse psychological factors, duration of anesthesia, mode of anesthesia, time of operation, intraoperative blood loss, postoperative pain score of postoperative acute consciousness disorders of elderly patients with hip fracture (P < 0.05). Multivariate Logistic analysis result showed that, age over 70 years, postoperative infection, diabetes, adverse psychological factors, anesthesia, intraoperative blood loss, postoperative pain scores were independent factors influencing the occurrence of acute consciousness disorders (OR=3.656, 1.857, 2.556, 2.031, 1.965, 2.062, 2.607, all P < 0.05). Conclusion The risk factors of acute consciousness disorders are age more than 70 years, postoperative infection, diabetes, adverse psychological factors, general intravenous anesthesia, intraoperative blood loss more and postoperative pain scores high. It should pay attention in clinical, and give intensive nursing, and strengthen perioperative care of elderly patients with hip fracture.
2017 Vol. 14 (36): 80-83 [Abstract] ( 300 ) HTML (1 KB)  PDF (446 KB)  ( 116 )
84 Analysis of the application of Rivaroxaban after anti-fibrinolysis with Tranexamic acid in total hip arthroplasty
FAN Yanan1 WEN Yangyang1 LI Wenlong2 ZHU Yingjie2 LIU Youwen2
Objective To evaluate the safety and efficacy of Rivaroxaban anticoagulation in the prevention of venous thromboembolism (VTE) after Tranexamic anti-fibrinolysis in total hip arthroplasty (THA) patients. Methods From March 2015 to September 2016, sixty patients with osteonecrosis of femoral head accepted THA in Henan Luoyang Orthopedic Traumatological Hospital were divided into two groups by random number table, with 30 cases in each group. The patients in group A were treated with low molecular weight heparin calcium to prevent VTE, while the patients in group B were treated with Rivaroxaban. In both groups, preoperative intravenous injection and postoperative intracavitary injection of Tranexamic acid were performed. The blood loss volume, the occurrence rates of VTE, blood transfusion and anticoagulation-related bleeding events, and blood coagulation between the two groups were recorded and compared. Results There was no significant difference in blood loss volume and transfusion rate between the two groups (P ＞ 0.05). During the follow-up, it had no symptomatic pulmonary embolism and deep venous thrombosis in the both groups, and there was no significant difference in the rate of VTE between the two groups (P ＞ 0.05). As for anticoagulant bleeding events, major bleeding events were not found in the two groups, and there was no significant difference in non-major bleeding events (P ＞ 0.05). Postoperative coagulation test showed that the prothrombin time and activated partial thromboplastin time in both groups were longer in the safety range than in the preoperative period, and there was no statistically significant difference between groups at the same time (P > 0.05). Conclusion The use of low molecular weight heparin calcium or rivaroxaban in the prevention of venous thromboembolism in patients with THA are both safe and effective. However low molecular weight heparin calcium requires subcutaneous injection and dose adjustment. In contrast，patients in Rivaroxaban are more receptive and compliant, which can be ensured that the postoperative drug prevention VTE time and improve surgical safety.
2017 Vol. 14 (36): 84-88 [Abstract] ( 242 ) HTML (1 KB)  PDF (486 KB)  ( 161 )
89 Analysis on correlative factor of bronchial asthma in children's early life
WANG Shuxia CHEN Weibin
Objective To provide reference for clinical prevention and treatment of child bronchial asthma by discussing its related factors in early stage of life. Methods 157 cases of children with asthma and 224 cases of children with non-respiratory illnesses were selected into groups for control study. They were all 0 to 14 years old and diagnosed by pediatric clinic of Yueyang Hospital of Integrated Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine during August 2015 to August 2016. Children in the same group had related illness, same age, sex, nationality, place of residence of psychosomatic related diseases or reaction case-control studies were conducted between 157 cases of children with asthma and 224 cases of normal children, in which χ２ test and Logistic regression model analysis methods were adopted to analyze the risking elements in the early life stage of bronchial asthma children. Results The result of univariate analysis indicated that： 11 elements might be related with asthma, which includes morning sickness, hypertension of pregnancy, emotional stability, smoking or passive smoking during pregnancy, caesarean section, premature birth, breast feeding, eat egg, soy, fish and shellfish, peanuts, nuts during breast feeding, use of antibiotics within one year of age, keeping pets, recurrent respiratory tract infection. Logistic regression analysis results showed that: risking factors were smoking or passive smoking during pregnancy, caesarean section, premature birth, eat egg, soy, fish and shellfish, peanuts, nuts during breast feeding, use of antibiotics within one year of age and recurrent respiratory tract infection. Protective factors were breast feeding, Emotional stability and keeping pets. Conclusion Pregnant women and children a should be kept away from all kinds of risking factors and strengthen the protection factors.
2017 Vol. 14 (36): 89-92 [Abstract] ( 265 ) HTML (1 KB)  PDF (466 KB)  ( 124 )
93 Effects of the number and fragmentation rate of in vitro fertilized embryos on blastocyst formation
LI Na1 WEI Jing2
Objective To investigate the effects of the number of in vitro fertilized embryos and the ratio of fragments on blastocyst formation. Methods From January to October 2016, 200 patients who underwent in vitro fertilization in Liuzhou Worker′s Hospital were given embryos 3 days after completion of fertilization, grouping of embryos according to the number of blastocysts, they were divided into 2-3c group (2-3 cells), 4c group (4 cells), 5c group (5 cells), 6c group (6 cells), 7c group (7 cells), 8c group (8 cells), 9c group (9 cells), 10c group (10 cells), 11c group (11 cells), 12c group (12 cells), more than 13c group (more than 13 cells). Grading operations on fragments. The effect of cell number and fragmentation level (the fragmentation rate of grade 1 is less than 5%; the fragmentation rate of grade 2 is >5%-20%; the fragmentation rate of stage 3 is >20%-30%; and the fragmentation rate of grade 4 is higher than 30%.) on the quality of blastocysts during embryo transfer was analyzed. Results The effective blastocyst formation rate and the high quality blastocyst formation rate in 8c group were the highest, in the 1-2 grade fragment level of the blastula and the 3-4 fragment level of the blastula(χ2=200.760, 119.162, 243.532, 136.395, all P < 0.01). Conclusion In in vitro fertilization embryo transfer, the level of grade 1-2 and grade 3-4 is all 8c group, and the quality of blastocyst is the best. This result has a reference value for guiding the selection of high-quality embryos.
2017 Vol. 14 (36): 93-96,128 [Abstract] ( 274 ) HTML (1 KB)  PDF (987 KB)  ( 77 )
97 Observation of the intervention effect of Xinfuning combined with life style on cervical HR-HPV persistent infection
CHEN Haiyan SHI Yun
Objective To investigate the combined effect of Xinfuning and life style intervention on cervical high-risk human papillomavirus (HR-HPV) persistent infection. Methods Screening of gynecological clinic in Dongzhimen Hospital of Beijing University of Chinese Medicine from February 2014 to January 2016, 200 patients who were eligible for inclusion and exclusion criteria for cervical HR-HPV persistent infection were selected. According to the sequence of random number tables, they were divided into four groups: union group (50 cases), treatment group (50 cases), intervention group (50 cases), control group (50 cases), the union group was treated with Xinfuning combined with life style intervention. The treatment group was treated with Xinfuning, the intervention group was given life style intervention, the control group would not adopt any interference, the intervention effect(negative conversion situation of HR-HPV) was compared among each groups. Results The total effective rate of the union group after 6 months was 86.0%, 66.0% in treatment group, 58.0% in intervention group, 32.0% in control group. The total effective rate of combined treatment group was higher than the treatment group, the intervention group and the control group. The difference was statistically significant (P < 0.05). According to the age group, the highest peak of the persistent infection of the cervix occurred in the group over 50 years old (32%), and the second was the group less than 20 years old (29%), but there was no statistical difference between age groups (P > 0.05). Conclusion Xinfuning united with life style intervention in the treatment of cervical HR-HPV persistent infection can increase negative conversion rate, and it is significant to improve the treatment of the patients.
2017 Vol. 14 (36): 97-100 [Abstract] ( 287 ) HTML (1 KB)  PDF (458 KB)  ( 135 )
101 Clinical effect of Pioglitazone combined with Alprostadil in treating diabetic nephropathy
ZHONG Dingliang1 MO Xiaoqing2
Objective To investigate the clinical effect of Pioglitazone combined with Alprostadil in treating diabetic nephropathy (DN). Methods From May 2015 to February 2017, 98 patients with DN in Zhujiang Hospital of Southern Medical University were divided into treatment group and control group by random number table, with 49 cases in each group. The treatment group was treated with Pioglitazone and Alprostadil, while the control group was treated with Pioglitazone, continuous treatment for 6 months. The levels of high sensitivity C-reactive protein (HS-CRP), glycosylated hemoglobin (HbA1c), serum creatinine (Scr), urea nitrogen (BUN), serum cystatin C (Cys-C), 24-hour urinary albumin (24 h UAE), serum adipose-specific serine protease inhibitor (Vaspin), insulin resistance index (HOMA-IR) were analyzed before and after treatment in both groups. Results Before treatment, there were no statistically significant differences in the levels of HS-CRP, HbA1c, Scr, BUN, Cys-C, Vaspin, HOMA-IR, 24 h UAE between the two groups (P > 0.05). Six month after treatment, all of these indicators were improved in the two groups, and those of the treatment group were better than those of the control group, with statistically significant difference (P < 0.05). There was no statistically significant difference in the adverse effects rate between the two groups(P > 0.05). Conclusion The clinical effect of Pioglitazone combined with Alprostadil in treating diabetic nephropathy is better, which is worthy of clinical application.
2017 Vol. 14 (36): 101-103 [Abstract] ( 274 ) HTML (1 KB)  PDF (416 KB)  ( 144 )
104 The clinical significance of enteral nutritional emulsion combined with Polyethylene Glycol Electrolyte Powder in rectal cancer patientsˊ bowel preparation
DU Yuan1 YANG Benxin1 NIE Shuangfa2 LI Lei2 FEI Jiandong2▲
Objective To investigate the clinical significance of enteral nutritional emulsion combined with Polyethylene Glycol Electrolyte Powder in rectal cancer patients′ bowel preparation. Methods From December 2015 to May 2017, 61 patients with rectal cancer treated with surgery in Department of General Surgery, the First Affiliated Hospital of Hebei North University were selected as research objects, and they were divided into observation group (31 cases) and control group (30 cases) by random number table. The observation group was given to oral Compound Polyethylene glycol Electrolyte Powder and enteral nutrition before operation, and the control group was given to intestinal preparation of traditional mechanical enema. The effects of bowel preparation and the expression of intestinal epithelial tight junction protein (occludin) and IgA in intestinal mucosa between two group were compared. Results There was no significant difference in intestinal cleanliness between the two groups (P > 0.05). The tolerance of bowel preparation of patients in observation group was better than control group (P < 0.05). Preoperative Bifidobacterium / E.coli (B/E) ratio was reversed in the two groups. The B/E ratio in the observation group was increased significantly after the surgery, while the postoperation B/E reversal ratio was decreased significantly in the control group (P < 0.05). Seven days after surgery, the bacterial DNA in blood in the observation group was significantly lower than those in control group (P < 0.05), the percentage of positive in occludin protein cells and IgA in the observation group was significantly lower than those in the control group (P < 0.05). The intravenous blood C reactive protein content and average heart rate in the observation group were significantly lower than those in control group, and the duration of fever and the time of white blood cell count to normal were significantly shorter than those in the control group (P < 0.05). While the incidence of postoperative complications of the two groups was not statistically significant (P > 0.05). Conclusion Oral Compound Polyethylene Glycol Electrolyte Powder and enteral nutrition before surgery, which can improve tolerance of the patients with rectal cancer, reduce injury degree of intestinal immunological barrier, decrease the occurrence of systemic inflammatory reaction and local complications during early period of postoperation, in order to promote postoperative recovery.
2017 Vol. 14 (36): 104-108 [Abstract] ( 253 ) HTML (1 KB)  PDF (529 KB)  ( 128 )
109 Efficacy of rehabilitation of integrated Chinese and western medicine in treating benign prostatic hyperplasia
SUN Jie CHEN Tingting LI Ying PENG Yanxia ZHANG Hui WU Liang
Objective To observe the clinical effect of moxibustion combined with functional electrical stimulation (FES) in the treatment of mild and moderate benign prostatic hyperplasia, and compare with single use of oral Finasteride. Methods Sixty patients with benign prostatic hyperplasia treated in Beijing Xiaotangshan Hospital from May 2014 to October 2015 were collected and divided into two groups according to random number table method, with 30 cases in each group. The experimental group was treated with moxibustion combined with FES, and the control group was treated with single oral Finasteride, the course was 6 weeks. The clinical efficacy of the two groups was compared. Results After treatment, the scores of international prostate symptom score (IPSS), quality of life (QOL) and residual urine volume in the two groups were all lower than those before treatment, the differences were statistically significant (P ＜ 0.05), but there were no statistically significant differences of prostate volume before and after treatment (P ＞ 0.05). After treatment, the scores of IPSS, QOL and residual urine volume in the experimental group were all lower than those of control group (P ＜ 0.05). Conclusion Moxibustion combined with FES has definite curative effects in improving the clinical symptoms of voiding dysfunction and residual urine volume of patients with mild and moderate benign prostatic hyperplasia, which is better than single use of oral Finasteride. However, there are no significant effects in improving the prostate volume in the two groups.
2017 Vol. 14 (36): 109-112 [Abstract] ( 251 ) HTML (1 KB)  PDF (362 KB)  ( 135 )
113 Study on medication rules of traditional Chinese medicine in the treatment of coronary heart disease based on data mining
ZHENG Kun WU Jiarui ZHANG Feifei
Objective To investigate the medication rules of famous senior Chinese physician in the treatment of coronary heart disease. Methods The prescriptions about famous senior Chinese physician in the treatment of coronary heart disease were collected, the database was built based on traditional Chinese medicine (TCM) inheritance assist system software platform. Apriori algorithm and complex system entropy cluster were used to analyze the utilizing frequency of all drugs in the prescription and couplet medicines and the association rules, prescription principles between different medicines. Results Totally 985 drugs were enrolled, the frequently adopted drugs were Salvia Miltiorrhiza, Rhizoma Chuanxiong, Poria Cocos, Radix Astragali, Fructus Trichosanthis, and so on; and the frequently adopted drug combinations were "Rhizoma Chuanxiong, Salvia Miltiorrhiza" "Salvia Miltiorrhiza, Radix Astragali" "Salvia Miltiorrhiza, Fructus Trichosanthis", and so on. The drug combinations with association rules ＞0.7 included "Corydalis Rhizoma-＞Salviae Miltiorrhiza" "Salviae Miltiorrhiza, Longstamen Onion Bulb-＞Fructus Trichosanthis" "Longstamen Onion Bulb-＞Fructus Trichosanthis" "Chinese Magnoliavine, Salvia Miltiorrhiza-＞Dwarf Lilyturf Tuber", etc. 36 groups of core group were excavated, and 18 new prescriptions were obtained. Conclusion Famous senior Chinese physician in the treatment of coronary heart disease often use the drugs of activating circulation to remove blood stasis, tonifying qi and relaxing vein, reducing phlegm and resolving masses, which reflects a refined and rational compatibility and the principles of TCM to treat symptoms and root causes. This study has reference value for clinic, and TCM inheritance assist system is valuable to explore the medication rules of famous senior Chinese physician.
2017 Vol. 14 (36): 113-116 [Abstract] ( 262 ) HTML (1 KB)  PDF (826 KB)  ( 333 )
117 Study on the prescription rule of Helicobacter pylori infection based on traditional Chinese medicine inheritance support system
LIN Yishan1 JIANG Feng2
Objective To study the prescription rule of traditional Chinese medicine (TCM) in the treatment of Helicobacter pylori (Hp) infection. Methods The literatures of TCM in the treatment of Hp infection from CNKI and CQVIP were searched from January 2007 to January 2017, the recipe database was screened and set up, the TCM inheritance support system was used to carry out data mining, and the core drugs and its meridian tropism, prescription rules, core combination were analyzed. Results A total of 108 prescriptions about Hp infection were selected, including 159 herbs, and 30 drugs were used for more than 10 times. By analyzing the meridian tropism, TCM for Hp infection were mainly spleen and stomach meridian, followed by lung and liver meridian. Conclusion The Chinese medicine for the treatment of Hp is mainly clearing heat and removing toxicity, strengthening spleen and benefiting qi. The most frequent herbs for clearing heat and removing toxicity are Rhizoma Coptidis, Herba Taraxaci, etc, the most frequent herbs for strengthening spleen and benefiting qi are Radix Glycyrrhizae, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, Poria, Radix Astragali seu Hedysari, etc.
2017 Vol. 14 (36): 117-120 [Abstract] ( 408 ) HTML (1 KB)  PDF (812 KB)  ( 206 )
121 Exploration and analysis of sphygmology system of ten layers pulse of "Bianque"
XIONG Mingfeng LAN Qin WU Chunhong WANG Tengyu
According to record in the literatures, “ten layers pluse” is evolved from the pulse method of “Bianque” soybean weighting positioning pulse level. This method is named based on the levels of the pulse, which are lung, large intestine, heart, small intestine, spleen, stomach, liver, gallbladder, kidney and urinary bladder from the outside to the inside. There are differences of the levels of the pulse between this pulse method and traditional pulse method, which also shows that each pulse site has different relationship with zang-fu viscera and the fingering of the body, and puts forward the theory of "pulse level" innovatively. Ten layers pulse is not only a pulse diagnosis method, but also a series of disease analysis and treatment evaluation system, which can be used to identify the cause of disease, predict major symptoms, establish therapeutic methods, deduce prognosis and assess the efficacy.
2017 Vol. 14 (36): 121-124 [Abstract] ( 252 ) HTML (1 KB)  PDF (738 KB)  ( 298 )
125 Clinical effect of Shuqing Pills in treating residual jaundice of liver diseases
KANG Yanyan WANG Yunqi LI Zhaohui GENG Lanshu LI Chengyu SU Guoquan SHEN Lixian
Objective To observe the clinical effect of Shuqing Pills in treating residual jaundice of liver disease. Methods From March 2015 to March 2017, 100 patients diagnosed residual jaundice of liver disease in Hebei TCM Liver Disease Hospital were selected, they were randomly divided into two groups, with 50 cases in the treatment group (including 41 cases of hepatitis, 9 cases of liver cirrhosis) and 50 cases in the control group (including 38 cases of hepatitis, 12 cases of liver cirrhosis). The treatment group was treated with Shuqing Pills, the control group was treated with Yinzhihuang Granules. 30 days is one course of treatment, 1-2 courses of treatment according to the disease. The total bilirubin levels were observed before and after treatment, the total effective rate of the two groups were compared, Meanwhile, adverse reactions during the treatment were monitored. Results After treatment, the total bilirubin levels of the two groups were decreased (P < 0.05); sixty days after treatment, the total bilirubin level of the treatment group was lower than that of the control group (P < 0.05). The total effective rate of the treatment group was better than that of the control group (P < 0.05). The total effective comparison in the subgroups: the rates of the cirrhosis subgroup and the hepatitis subgroup in the treatment group were better than those in the control group respectively (P < 0.05); besides, the rates of the hepatitis subgroup were better than those of the cirrhosis subgroup in the same group (P < 0.05). In the treatment group, two patients experienced mild gastrointestinal distress, and the gastrointestinal symptoms were relieved after discontinuation, and no other serious adverse reactions were observed. Conclusion Shuqing Pills can significantly reduce the level of bilirubin in patients with residual jaundice of liver disease, and less adverse reactions, which is worthy of clinical application.
2017 Vol. 14 (36): 125-128 [Abstract] ( 320 ) HTML (1 KB)  PDF (788 KB)  ( 132 )
129 Clinical progress and clinical empirical summary of patients with ulcerative colitis combined with anxiety and/or depression
WANG Liyuan1 ZHU Weining2 SHI Ling3
Ulcerative colitis is a common clinical disease, with intricate pathogenesis. whether from the angle of inducement or complication to study, it shows that the disease is closely related to emotion. The disease involves multiple viscera, such as spleen, stomach, heart, gut, kidney, etc. Its syndrome types in traditional Chinese medicine are complex, and the common clinical manifestations are syndrome of liver depression and spleen deficiency, damp-heat of large intestine, deficiency of spleen and stomach, spleen-stomach weakness, Yang deficiency of spleen and kidney, etc, in which syndrome of liver depression and spleen deficiency is especially common. Its treatment often combines both Chinese and western medicine. Although western medical treatment plays a role in this disease, it is easy to lead to severe complications and drug dependence. It is difficult to withdrawal and bring huge mental pressure to patients. However, traditional Chinese medicine in the treatment of this diseases has significant advantage. It is based on the holistic view and syndrome differentiation of traditional Chinese medicine, and applies “the Holism of Physical and Spirit” throughout the principle, method, prescription and medicine. It combines with the general recuperation of Chinese traditional medicine, acupuncture and massage, and music therapy. It aims to treat both symptoms and root causes, and give priority to the root causes, in order to cure radically, regulate visceral functions, balance Yin and Yang, and ultimately achieve the goal of cure.
2017 Vol. 14 (36): 129-132 [Abstract] ( 247 ) HTML (1 KB)  PDF (791 KB)  ( 110 )
133 About the thought of “one divided into three” and its clinical significance in Huangdi Neijing
YE Taisheng1 YAO Qiong2▲
“One divided into three” is a philosophical epistemology, it is one of the most basic thinking methods, and also the rational thinking of Chinese philosophy. Based on this, it sorts out the ideological content of “one divided into three” in the book of Huangdi Neijing, which is formed in the period of TCM theory formation. It is not only the development of traditional Chinese medicine theory, but also the internal requirement of innovative understanding of the rules of modern disease diagnosis and treatment. The connotation of “one divided into three” is analyzed from “three as the value” and “three as the rule”. It is found that “one divided into three” inspired the theory of “because, machine, syndrome, cure”, and has universal theoretical value. At the same time, to explore the significance of “one divided into three” in the treatment of traditional Chinese medicine, and put forward “Qi, blood, water” three points dialectical method, to treat diabetic nephropathy as an example to illustrate its logical persuasion, is a new way of clinical diagnosis and treatment of traditional Chinese medicine.
2017 Vol. 14 (36): 133-136 [Abstract] ( 265 ) HTML (1 KB)  PDF (751 KB)  ( 244 )
137 Effect of "Cuyu Xunxi Formula" on postoperative wound healing of mixed hemorrhoids and simple low anal fistula
QIU Fei1 ZHENG De2 QU Yin2 YANG Wei2 WANG Qingming2 LU Hong2 LU Yafeng2
Objective To investigate the effect of "Cuyu Xunxi Formula" on postoperative wound healing of mixed hemorrhoids and simple low anal fistula. Methods One hundred and twenty cases of postoperative patients with mixed hemorrhoids and 144 cases of postoperative patients with simple low anal fistula treated in Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from December 2013 to December 2015 were collected. By using high and low concentration, long and short time of fumigation, the changes of wound pain, edema, exudation and hemorrhage were observed after operation for 3, 7, 14 days, and the comprehensive effects of the four factors for postoperative symptom scores were analyzed by multi-factor analysis of variance. Results The effects of drugs on postoperative pain between the two diseases had no significant differences. The improvement degree of edema and exudation of anal fistula was most obvious on the 14th day after surgery. There was significant difference in terms of hemorrhage between the two diseases on the 7th and 14th day after surgery. Meanwhile, the dilution ratio had different effects on the improvement of edema between the two diseases on the 7th day after surgery, while the time of fumigation had different effects on the improvement of exudation of the two diseases. Conclusion "Cuyu Xunxi Formula" has great effects on postoperative symptoms of simple low anal fistula during the course of 14-day treatment, while dilution ratio and fumigation time have greater influences on the postoperative symptoms during the course of 7-day treatment.
2017 Vol. 14 (36): 137-140,144 [Abstract] ( 256 ) HTML (1 KB)  PDF (811 KB)  ( 112 )
141 Discussion about the academic source of Sisheng Xinyuan and the Lingnan Yangke school
LIU Ming HE Yibin CAI Bingqin
The formation of philosophy, technique and skills of the TCM academic schools are much more associated with the classics of TCM and the representative inheritor. Lingnan Yangke school is a branch of TCM Yangke in Lingnan, and the modern famous doctor Huang Yaoshen and Contemporary famous doctor Cai Binqin are two major representative inheritors. Doctor Huang's tutor Lu Pengzhu is praised highly on the academic thoughts in Sisheng Xinyuan written by Huang Yuanyu. Huang Yuanyu-Lu Pengzhu-Huang Yaoshen-Cai Bingqin is one of the inheritance venation in the Lingnan Yangke school. Huang advocate some views of concept of TCM “correspondence between man and heaven” “spleen and stomach middle qi” “the viscera dialectics is to adjust the inside and outside”, the simple and effective character of prescription still widely impact on academic influence of genre, it is of unique significance to excavate and organize the experience of TCM.
2017 Vol. 14 (36): 141-144 [Abstract] ( 280 ) HTML (1 KB)  PDF (750 KB)  ( 343 )
145 Observation on the curative effect of Tangtong Lotion combined with electromagnetic therapy for early diabetic foot
WANG Zhufeng1 WANG Baojun2 LI Yuxiu1 WU Rui1 LI Aijun1 ZHANG Ying1 XU Xiaoying3
Objective To investigate the curative effect of Tangtong Lotion combined with electromagnetic therapy for early diabetic foot. Methods Ninety-three patients with early diabetic foot treated in Department of Endocrinology, South Branch, Guang′anmen Hospital, China Academy of Chinese Medical Sciences from October 2014 to October 2016 were selected and randomly divided into treatment group (48 cases) and control group (45 cases). Both groups strictly controlled blood glucose, blood pressure and blood fat. The treatment group was added with Tangtong Lotion in foot bath with the function of electromagnetic therapy, lavipeditum for 20 min each day. The control group was given warm water in foot bath with the function of electromagnetic therapy, lavipeditum for 20 min each day. The continuous lavipeditum in both groups lasted for 6 months. The changes of glycosylated hemoglobin (HbA1c), fasting blood glucose (FPG), C-reactive protein (CRP), blood fat [triacylglycerol (TG), cholesterol (CHO)] and total blood viscosity were observed. Results After treatment for 3, 6 months, the effective rates in the treatment group were all higher than those of control group, the differences were statistically significant (P ＜ 0.05). After treatment for 3, 6 months, the levels of HbA1c, FPG, CRP, TG, CHO, total blood viscosity in the two groups were all lower than those before treatment (P ＜ 0.05), which of treatment group were significantly lower than those of control group, the differences were statistically significant (P ＜ 0.05). Conclusion Tangtong Lotion combined with electromagnetic therapy has positive therapeutic effect on early diabetic foot, which is safe and effective.
2017 Vol. 14 (36): 145-148 [Abstract] ( 218 ) HTML (1 KB)  PDF (740 KB)  ( 198 )
149 Social support, self-esteem status and correlation in hospitalized patients with schizophrenia
YANG Tao TANG Luping WANG Shuai LIU Haisheng ZHOU Zhenhe TIAN Lin▲
Objective To explore the social support, self-esteem status and the correlation in hospitalized patients with schizophrenia. Methods From December 2012 to June 2015, 85 cases of hospitalized patients in Department of Psychiatric, Wuxi Mental Health Center who met with the diagnostic criteria of schizophrenia according to ICD-10 were enrolled as observation group and 86 healthy volunteers were enrolled as the control group. The social support scale and self-esteem scale were used to measure the social support and the self-esteem of the two groups. The positive and negative symptom scale was used to assess the mental status of schizophrenic patients. Pearson correlation analysis was used to analyze the related factors of the social support and the self-esteem. Results The score of social support in the observation group (53.65±17.24) was significantly lower than that of control group (62.15±12.10), with highly statistically significant difference (t = 3.737，P ＜ 0.01). The score of self-esteem in the observation group (29.31±4.06) was significantly lower than that of control group (31.56±4.24), with highly statistically significant difference (t = 3.547，P ＜ 0.01). In the observation group, the social support was neglectively correlated with the negative symptom scale (r = -0.228，P ＜ 0.05), but with no correlation with age, weight, age of onset, duration of disease, positive symptom scale, general pathological scale, highest nitrogen equal dose (r = -0.156-0.090，all P ＞ 0.05). In the observation group, self-esteem was positively correlated with the positive symptom scale, general pathological scale (r = 0.266，P ＜ 0.05; r = 0.285, P ＜ 0.01), but with no correlation with age, weight, age of onset, duration of disease, negative symptom scale, highest nitrogen equal dose (r = -0.162-0.112，all P ＞ 0.05）. Conclusion Compared with the normal population, the social support and self-esteem of hospitalized patients with schizophrenia are low. Social support for schizophrenia patients is correlated with the negative symptom scale, and its self-esteem is correlated with positive symptom scale and general pathological scale.
2017 Vol. 14 (36): 149-152 [Abstract] ( 232 ) HTML (1 KB)  PDF (733 KB)  ( 207 )
153 Innovate community medication service mode，establish safe medication service mechanism
ZHANG Lei1 ZHANG Hong2
With the deepening and promotion of the medical and health system reform, community drug use plays an important role in promoting human health and building healthy China. How to effectively reduce the risk of community drug use behavior, promote safety and rational use of drugs, need further in-depth exploration and analysis. In this paper, by referring a large number of reference materials, combined with the actual work, the current status of drug use in urban community residents were retrospectively analyzed. It is beneficial to explore and optimize the community drug use service model and establish a safe medication service mechanism, which will further reduce the risk of community residents′drug use and enhance the level of medical treatment at the grassroots level.
2017 Vol. 14 (36): 153-156 [Abstract] ( 243 ) HTML (1 KB)  PDF (687 KB)  ( 152 )
157 Study on the correlation between occurrence of enuresis and constipation in children
YUAN Bin HU Chanchan
The mechanism of enuresis in children remains unclear. Clinical observation found that enuresis always combined with constipation. The symptoms of enuresis can significantly reduced after gave laxative treatment, which showed that constipation is closely related to enuresis. However, as a common cause of enuresis, constipation was rarely studied. The congenital spina bifida, pelvic floor muscle coordination disorder, psychological factors are the common pathogenic factors of enuresis and constipation, and rectal distension is an important factor which constipation lead to enuresis. Chronic constipation can affect the function of lung, spleen, liver and kidney, and lead to the spleen-energy, lung-energy and kidney-energy deficiency, liver constraint transforming into fire, etc. The above pathological changes can affect the gasification function of bladder and cause enuresis.
2017 Vol. 14 (36): 157-159 [Abstract] ( 272 ) HTML (1 KB)  PDF (682 KB)  ( 137 )
160 Comparative study on stance construction via vocabulary resources in abstracts of medical journals
XUE Yingli ZHU Xiaojuan HAN Rong
Based on the stance triangle, 270 abstracts from 18 Asian, European and American oncology journals respectively were randomly sampled. Statistically, LIWC2007 and Antconc3.2.4 were used to detect different pragmatic functions of stance adverbs, evaluative adjectives, stance verbs and we-words used in the abstracts. The findings indicate that stance construction via vocabulary resources in abstracts of medical papers published in international prestigious oncology journals varies strikingly. European writers and American writers highlight stance positioning and expression by using a variety of stance words, especially the initial stance adverbs. Additionally, stance words used in abstracts from European and American journals outnumber those from Asian journals. The findings also indicate that there is a positive correlation between the variety and frequency of stance words and thesis quality embodied by impact factor of journals. Additionally, the co-using of stance adverbs, stance verbs and we-words embody such multi-functions of stance words as evaluation, positioning and aligning, ultimately, to highlight the stance expression. This study can provide references and insight into stance words acquisition and develop medical academics'good command of stance vocabulary for academic discourse stance projection and construction.
2017 Vol. 14 (36): 160-164 [Abstract] ( 236 ) HTML (1 KB)  PDF (743 KB)  ( 164 )
165 Comparative study on body shape and function of Han, Uygur and Kazak nationalities medical college students in Xinjiang Uygur Autonomous Region from 2006 to 2016
LIU Minjuan1 KANG Ling2 Patiman1 SHEN Ye1 JIANG Tao1
Objective To understand the physical health status of the medical students of Han, Uygur and Kazak nationalities in Xinjiang Uygur Autonomous Region, to obtain their body shapes, function change law and characteristic, in order to discuss on the methods and strategies of improving students′ physical health. Methods The physical examination data of medical college students in Xinjiang Uygur Autonomous Region from 2006 to 2016 were collected and arranged by anthropometry, the dynamic changes and differences among the Han, Uygur and Kazakh students were compared and analyzed by mathematical statistics. Results From 2006 to 2016, within the same ethnic group, male height was increasing year by year (P < 0.05), the change in height of female students was not obvious (P > 0.05). The growth rates of male and female body mass index (BMI) increased rapidly, and the vital capacity was significantly decreased overall (P < 0.01). Among ethnic groups, the weight of the Han and Kazak male students was significantly higher than that of the Uyghur male students, the vital capacity of Han female students was better than that of the Uyghur female students (P < 0.01). Conclusion In the past decade, the Han, Uygur and Kazakh nationalities medical college students in Xinjiang Uygur Autonomous Region have a fast growth in body weight and BMI, and the total lung capacity has declined overall, and there is a difference in the degree of variation among ethnic groups
2017 Vol. 14 (36): 165-168 [Abstract] ( 304 ) HTML (1 KB)  PDF (878 KB)  ( 113 )
169 Exploration into strengthening the education of medical ethics of medical students with multiple way sin the New Situation
YANG Dan1 YIN Hejia1 ZHANG Xian1 YUAN Na1 LI Yanlin2 HAN Rui1
With the more social appeals for medical ethics, the status of medical ethics education is rising day by day. This paper reviews the history of the development of medical ethics education from home and abroad, analyzes the problems existing in current medical ethics education of medical students based on the state of our country, combining with the new situation to discuss the education of medical ethics of medical students, it should be thought deeply the measures from aspects of paying more attention to education, innovating education mode, creating educational environment, improving platform construction and building Chinese characteristic education to strengthen medical ethics education of medical students in multiple ways. The main goal is to improve the level of medical ethics education for medical students, and to cultivate high-quality medical talents with both ability and morality.
2017 Vol. 14 (36): 169-172 [Abstract] ( 773 ) HTML (1 KB)  PDF  (0 KB)  ( 59 )
173 Causes analysis of acute kidney injury in patients with sepsis in EICU
LIU Mei
Objective To investigate the influencing factors of acute kidney injury (AKI) in patients with sepsis in the emergency intensive care unit (EICU). Methods From January 2012 to March 2014, a total of 102 patients with sepsis admitted to EICU in the Affiliated Hospital of Qinghai University were selected as the research subjects and divided into sepsis groups (without AKI 66 cases) and sepsis with AKI group (36 cases) according to the presence of AKI. The clinical data of the patients were compared between the two groups. The independent risk factors of AKI in patients with sepsis in EICU were analyzed by univariate and multivariate analysis. Results The incidence of AKI was 35.29% (36/102). Univariate analysis showed that there were significant differences in the history of hypertension, mean arterial pressure (MAP), APACHEⅡ, 24 h urine, Scr, the score of 24 h net fluid input, oxygenation index, urea nitrogen (BUN), arterial lactate score and serum myoglobin (MYO) between the two groups (P ＜ 0.05). Multivariate Logistic regression analysis showed that high MAP score(OR = 2.136, P = 0.007, 95%CI: 1.115-3.898), high APACHE score (OR = 2.058, P = 0.004, 95%CI:1.011-3.458), high Scr score(OR = 2.210, P = 0.005, 95%CI: 1.019-3.998), high arterial blood lactate score (OR=2.368, P=0.003, 95%CI:1.128-3.987) and high MYO level(OR = 2.587, P = 0.002, 95%CI:1.127-4.027) were independent risk factors of AKI in patients with sepsis on admission to EICU (P ＜ 0.05). Conclusion The higher scores of MAP, APACHEⅡ, Scr, arterial lactate and MYO level are, the higher the risk of AKI in patients with sepsis is. Therefore, it is suggested that the reasonable prevention and treatment measures should be taken for patients in EICU.
2017 Vol. 14 (36): 173-176 [Abstract] ( 263 ) HTML (1 KB)  PDF (736 KB)  ( 115 )
177 Establishment of pediatric clinical research complex talents training system in large hospitals
ZHANG Jie1 NI Xin2
The clinical skills is the most basic quality requirements for the doctors, but for large hospital professionals, only to master the clinical skills is not enough, which is just as important as the cultivation and training of scientific research ability and clinical skills training. At the same time, with the concept of translational medicine deepen into China's medical pediatric health system and development planning, pediatric department in large hospitals urgently need to train a number of clinical research complex talents to promote the core competitiveness of the hospital. This paper first discusses the current problems in pediatric clinical research of compex talents cultivation, analyzes the system of the training status of pediatric clinical research talents in Beijing Children's Hospital, finally puts forward the countermeasures for sustainable development: strengthen the consciousness of scientific research, establish talent evaluation standards, actively promote the achivevements transformation and implementation of double tutor system.
2017 Vol. 14 (36): 177-180 [Abstract] ( 245 ) HTML (1 KB)  PDF (693 KB)  ( 177 )
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