术前短期大剂量非那雄胺对经尿道前列腺电切术围术期出血的影响

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Abstract Objective To evaluate the effect of preoperative short-term high-dose application of Finasteride on perioperative bleeding of transurethral resection of prostate. Methods From June 2015 to December 2016, 120 patients with benign prostatic hyperplasia (BPH) treated at Renming Hospital of Wuhan University were selected. According to the preoperative clinical data, the total of 120 patients were randomly divided into three groups and the amount of every group was 40. The 10 mg group and 20 mg group respectively took 10 mg and 20 mg of Finasteride daily for two weeks and the control group did not take any durg before the operation. All the operations were finished by the same surgeon and the results of operation time, intraoperative blood loss, amount of bleeding index, the strength of bleeding, postoperative bladder lavage fluid volume and time, postoperative international prostate symptom score (IPSS), flow rate of the maximum urinary and the weight of removed prostatic tissue should be collected in statistical analysis and comparison. Results All operations were successfully and the three groups of patients had no difference among the aspects of postoperative IPSS, flow rate of the maximum urinary and the weight of removed prostatic tissue (P > 0.05). Compared with the control group, both the 10 mg and 20 mg groups had statistically significant differences in the aspects of operation time, intraoperative blood loss, amount of bleeding index, the strength of bleeding, postoperative bladder lavage fluid volume and time (P < 0.05). Compared with 10 mg group, the 20 mg group in the aspects of operation time, intraoperative blood loss, bleeding index, the strength of bleeding and postoperative bladder lavage time decreased significantly with statistical differences (P < 0.05), and there was no significant difference between the two groups in the aspect of postoperative bladder lavage fluid volume (P > 0.05). Conclusion The preoperative short-term usage of large doses Finasteride (20 mg/d) can effectively reduce perioperative bleeding, the time of operation and postoperative bladder lavage fluid volume.

Key words： Finasteride Benign prostatic hyperplasia Transurethral resection of prostate Bleeding volume

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	XU Kailiang CHENG Fan RAO Ting RUAN Yuan YU Weiming YUAN Run ZHANG Xiaobin

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XU Kailiang CHENG Fan RAO Ting RUAN Yuan YU Weiming YUAN Run ZHANG Xiaobin. Effect of preoperative short-term usage of large doses Finasteride on perioperative bleeding in patients with transurethral resection of prostate[J]. 中国医药导报, 2017, 14(36): 72-75.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I36/72

[1] 黄静宇，王行环，杨中华，等.经尿道双极等离子前列腺电切术在大体积前列腺增生（＞80 g）患者中的应用[J].临床外科杂志，2013，21（11）：832-834.
[2] Pastore AL，Mariani S，Barrese F，et al. Transurethral resection of prostate and the role of pharmacological treatment with dutasteride in decreasing surgical blood loss [J]. J Endourol，2013，27（1）：68-70.
[3] Mcconell JD，Barry MJ，Bruskewit Z，et al. Benign prostatic hyperplasis：diagnosis and treatment in Clinical Practice Guideline [M]. Rockville MD：Agency for Health Care Policy and Research，1994.
[4] 谭媛，石翊飒.经尿道前列腺电切术中出血量测定方法的研究进展[J].国际麻醉学与复苏杂志，2015，36（3）：243-246.
[5] Shrivastava A，Gupta VB. Various treatment options for benign prostatic hyperplasia：a current update [J]. J Midlife Health，2012，3（1）：9-10.
[6] 王可兵，周祥福，高新.经尿道前列腺电切术的几种方法[J].中华腔镜泌尿外科杂志，2008，6（2）：54-56.
[7] Mebust WK，Holtgrewe HL，Cockett ATK，et al. Transurethral prostatectomy：immediate and postoperative complications.Cooperative study of 13 participating institutions evaluating 3885 patients [J]. J Urol，1989，141（2）：243-247.
[8] Sharif MR，Shaabani A，Mahmoudi H，et al. Association of the serum vascular endothelial growth factor levels with benign prostate hyperplasia and prostate malignancies [J]. Nephrourol Mon，2014，6（3）：e14778.
[9] Amory JK，Wang C，Swerdolff RS，et al. The effect of 5alpha-reductase inhibition with dutasteride and finasteride on semen parameters and serum hormones in healthy men [J]. J Clin Endocrinol Metab，2007，92（5）：1659-1665.
[10] Hagerty JA，Ginsberg PC，Harmon JD，et al. Pretreatment with finasteride decreases perioperative bleeding associated with transurethral resection of the prostate [J]. Urology，2000，55（5）：684-689.
[11] Kavanagh LE，Jack GS，Lawrentschuk N，et al. Prevention and management of TURP-related hemorrhage [J]. Nat Rev Urol，2011，8（9）：504-514.
[12] Jia G，Heverhagen JT，Polzer H，et al. Dynamic contrast enhanced magnetic resonance imaging as a biological marker to noninvasively assess the effect of finasteride on prostatic suburethral microcirculation [J]. J Urol，2006， 176（5）：2299-2304.
[13] Lund L，Moller Ernst-Jensen K，Torring N，et al. Impact of Finasteride treatment on perioperative bleeding before transurethral resection of the prostate：a prospective randomized study [J]. Scand J Urol Nephrol，2005，39（2）：160-162.
[14] Busetto GM，Giovannone R，Antonini G，et al. Short-term pretreatment with a dual 5α-reductase inhibitor before bipolar transurethral resection of the prostate （B-TURP）：evaluation of prostate vascularity and decreased surgical blood loss in large prostates [J]. BJU InT，2015，116（1）：117-123.
[15] 杨立杰，于文晓，杨顺利，等.膀胱内前列腺突出度Ⅲ级前列腺增生患者TURP治疗和药物治疗疗效比较研究[J].中国性科学，2016，25（6）：12-15.
[16] Aboumarzouk OM，Aslam MZ，Wedderburn A，et al. Should Finasteride Be Routinely Given Preoperatively For Turp? [J]. ISRN Urol，2013：458 353.
[17] 桑琦，孙丽娜，成显黔，等.长期应用非那雄胺治疗良性前列腺增生临床疗效分析[J].中国医学创新，2015，12（17）：141-144.
[18] 陶国斌，徐芹，朱红林，等.艾灸联合石蜡油灌肠治疗良性前列腺增生症合并急性尿潴留的临床疗效[J].中国性科学，2017，26（7）：86-88.
[19] Aminsharifi A，Salehi A，Noorafshan A，et al. Effect of Preoperative Finasteride on the Volume or Length Density of Prostate Vessels，intraoperative，Postoperative Blood Loss during and after Monopolar Transurethral Resection of Prostate：A Dose Escalation Randomized Clinical Trial Using Stereolog Methods [J]. Urol J，2016，13（1）：2562-2568.
[20] Donohue JF，Sharma H，Abraham S，et al. Transurethal prostate resection and bleeding：A randomized，placebo controlled trial of the role of Finasteride for decreasing operative blood loss [J]. J Urol，2002，168（5）：2024-2026.
[21] Sandfeldt L，Bailey DM，Hahn RG. Blood loss during transurethral resection of the prostate after 3 months of treatment with Finasteride [J]. Urology，2001，58（6）：972-976.
[22] 谭书韬，吴斌.TURP术前非那雄胺应用时间对围术期出血的影响[J].实用药物与临床杂志，2017，20（3）：283-286.
[23] 温海东，吕军，肖远松，等.比较围手术期应用度他雄胺和非那雄胺对经尿道前列腺电切术出血量的影响[J].现代泌尿外科杂志，2015，20（12）：867-870.
[24] 何二宝，李解方.非那雄胺剂量对减少经尿道前列腺电切术中出血的影响[J].现代泌尿外科杂志，2012，17（3）：287-289.