肝脾舒对肝硬化大鼠肠屏障功能的保护作用

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Abstract Objective To explore the protective effect of Gan Pi Shu on intestinal mucosal barrier in rats with liver cirrhosis. Methods A total of 36 male SD rats were divided randomly into 4 groups based on SAS proc plan sentence according to the order of weight to be large, with 9 rats in each group. The rats in the blank group were injected intraperitoneally with saline daily. The rats in the model group were injected intraperitoneally with carbon tetrachloride to establish the model of liver cirrhosis. The rates in the Gan Pi Shu group and the Duphalac group were given Gan Pi Shu and Duphalac respectively based on the model group. The plasma levels of endotoxin (ET), diamine oxidase (DAO), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) were measured. The pathological changes of liver and ileum tissue were observed by HE staining. Results The plasma levels of ET, DAO, TNF-α and IL-1β in Gan Pi Shu group were lower than those of model group, with statistically significant difference (P ＜ 0.05). DAO and IL-1β in Gan Pi Shu group were lower than those of Duphalac group, with statistically significant difference (P ＜ 0.05). The pathological changes of liver and ileum tissue in Gan Pi Shu and Duphalac group was better than that of model group. Conclusion Gan Pi Shu has the protective effect on the intestinal mucosal barrier in rats with liver cirrhosis, which can truncate the development process between intestinal mucosal barrier dysfunction and cirrhosis.

Key words： Diamine oxidase Intestinal mucosa Cirrhosis Gan Pi Shu

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	PAN Xiangxue ZHU Junfeng LI Yong

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PAN Xiangxue ZHU Junfeng LI Yong. Influence of Gan Pi Shu on intestinal barrier function in liver cirrhosis rats[J]. 中国医药导报, 2017, 14(36): 21-24.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I36/21

[1] Ramos AR，Matte U，Goldani HA，et al. Intestinal permeability assessed by 51Cr-EDTA in rats with CCl4-induced cirrhosis [J]. Arq Gastroenterol，2010，47（2）：188-192.
[2] Scarpellini E，Valenza V，Gabrielli M，et al. Intestinal permeability in cirrhotic patients with and without spontaneous bacterial peritonitis：is the ring closed? [J]. Am J Gastroenterol，2010，105（2）：323-327.
[3] Lee S，Son SC，Han MJ， et al. Increased intestinal macromolecular permeability and urine nitrite excretion associated with liver cirrhosis with ascites [J]. World J Gastroentero，2008，14（24）：3884-3890.
[4] NoIan JP. The role of intestinal endotoxin in liver injury：a long and evolving history [J]. HepatoIogy，20l0，52（5）：l829-l835.
[5] Shen DZ. A target role for mast cell in the prevention and therapy of hepatic fibrosis [J]. Med Hypotheses，2008，70（4）：760-764.
[6] Kalambokis G，Tsianos EV.Endotoxaemia in the pathogenesis of cytopenias in livercirrhosis. Could oral antibiotics raise blood counts? [J]. Med Hypotheses，2011，76（1）：105.
[7] NoIan JP. The role of intestinal endotoxin in liver injury：a long and evolving history [J]. HepatoIogy，20l0，52（5）：l829-l835.
[8] Cavasin MA，Semus H，Pitts K，et al. Acute effects of endothelin receptor antagonists on hepatic hemodynamics of cirrhotic and noncirrhotic rats [J].Can J Physiol Pharm，2010，88（6）：636-643.
[9] 赵康，赵詹东，刘黎明，等. 软肝消臌汤治疗肝硬化模型大鼠的效果及机制[J].中国老年学杂志，2017，37（15）：3676-3678.
[10] 冯因克，刘亚敏，陈启龙.慢性乙型肝炎后肝硬化中西医治疗研究进展[J].中国医药导报，2016，13（29）：28-31.
[11] 王灵台.王灵台肝病论治经验集[M].上海：上海科学技术出版社，2009.
[12] 潘相学，郑昱.肝脾舒合剂治疗肝热脾虚型便秘型肠易激综合征临床观察[J].上海中医药大学学报，20l2，26（3）：41-43.
[13] 马坤芳，王德旺，任勇.β-环糊精选择性提取虎杖化学成分及体外抗内毒素活性研究[J].上海中医药杂志，2008， 42（8）：81-82.
[14] 张磊，沙焕臣，马清涌，等.白藜芦醇对大鼠重症急性胰腺炎肠道屏障的保护作用[J].2009，30（1）：10-14.
[15] Xie B，Xu Z，Hu L，et al. Pterostilbene inhibits human multiple myeloma cells via ERK1/2 and JNK pathway in vitro and in vivo [J]. Int J Mol Sci，2016，17（11）：1972.
[16] Kucas IK，Kolodziej H. Trans-resveratrol induces apoptosis through ROS-triggered mitochondria-dependent pathways in A549 human lung adenocarcinoma epithelial cells [J].Planta Med，2015，81（12）：1038-1044.
[17] Kong Y，Chen G，Xu Z，et al. Pterostilbene induces apoptosis and cell cycle arrest in diffuse large B-cell lymphoma cell [J]. Sci Rep，2016，6（10）：37417.
[18] Dong J，Guo H，Chen Y. Pterostibene induces apoptosis through caspase activation in ovarian cancer cells [J]. Eur J Gynaecol Oncol，2016，37（3）：342-347.
[19] 金剑，赵庆.大黄素对裸鼠人结肠癌细胞移植瘤的移植作用及机制[J].山东医药，2017，57（20）：37-39.
[20] 窦志华，陈敏，罗琳，等.茵陈蒿汤方剂配伍对黄疸模型小鼠血清生化指标的影响[J].中国医药导报，2016，13（13）：93-95.