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2023 Vol. 20, No. 2 Published: 2023-01-15

	4	Discussion of Professor Wu Liqun’s medication rules and mechanism in the treatment of tic disorders in children based on data mining and network pharmacology
		GAO Shiyu1 WU Liqun2 LI Panpan1 LU Chen1 ZHANG Ningning1 WANG Baosheng1
		DOI: 10.20047/j.issn1673-7210.2023.02.01
		Objective To explore Professor Wu Liqun’s medication rules and mechanism in the treatment of tic disorders (TD) in children based on data mining and network pharmacology. Methods Medical record data of children with TD treated by Professor Wu Liqun from Dongfang Hospital, Beijing University of Chinese Medicine from April 2018 to July 2021 were collected, and traditional Chinese medicine inheritance computing platform V3.0 was used to analyze medication patterns. The potential targets of core drugs and diseases were obtained by traditional Chinese medicine systems pharmacology database and analysis platform, Genecards, Malacards, and online Mendelian inheritance in man database. The active ingredient-target, protein-protein interaction network was constructed using Cytoscape and STRING platforms. Further, Metascape was used for GO and KEGG enrichment analysis of common targets. Results A total of 234 TD prescriptions were collected, involving 158 traditional Chinese medicines, which effects were mainly for supplementing deficiency, superficies-relieving, and suppressing hyperactive liver for calming endogenous wind. The drug natures were mainly for warming, cold, and calming, and the drug flavours were mainly for bitter, sweet, and pungent. The main channels are liver, lung, and spleen. Top five drugs in frequency of used were Radix Paeoniae Alba, Pericarpium Citri Reticulatae, Radix Puerariae, Ramulus Uncariae Cum Uncis, and Rhizoma Atractylodis Macrocephalae. A total of 53 active ingredients, 235 action targets, 1 092 disease targets, and 68 intersection targets were screened. GO analysis showed 1 029 biological processes, 74 cellular components, and 118 molecular functions. KEGG analysis showed 222 signaling pathways. Conclusion In the treatment of TD, Professor Wu Liqun mainly focuses on suppressing hyperactive liver for calming endogenous wind, and also replenishing spleen and stomach deficiency. The core drug can play its role through multi-component, multi-target and multi-pathway.
		2023 Vol. 20 (2): 4-10 [Abstract] ( 19 ) HTML (1 KB) PDF (2983 KB) ( 241 )

	11	Analysis of clinical acupoint characteristics by Professor Wang Leting in stroke treatment based on R language data mining technology
		GUAN Zijin1 FAN Xueming2 WANG Linpeng1 ZHAO Yin1 DU Kun1 WANG Peng1
		DOI: 10.20047/j.issn1673-7210.2023.02.02
		Objective To explore the clinical acupoint characteristics, acupoint selection rule, and prescription characteristics of Professor Wang Leting in treating apoplexy. Methods From November 2018 to February 2020, Professor Wang Leting’s medical record study was carried out. A total of 54 acupuncture and moxibustion prescriptions were collected and recorded in the medical records of Beijing Hospital of Traditional Chinese Medicine from January 1961 to November 1963. The frequency analysis, association rule analysis, and cluster analysis were carried out by the reusable data mining tools developed by our research office. Results Professor Wang Leting used 45 acupoints in the treatment of stroke, with a total frequency of 490 times. The most used acupoints were Hégǔ (48 times), Bǎihuì (44 times), Yánglíngquán (41 times), Qūchí (40 times), and Zúsānlǐ (34 times). The most frequently used meridians are Yangming large Intestine Channel of hand, Shaoyang Gallbladder channel of foot and governor channel. The number of specific acupoints was 32, accounting for 71.1% of the total number of meridian points, and the total frequency of use was 578 times. The number and frequency of acupoints used at the intersection point was the highest (177 times), followed by the five-shu point (152 times), the yuan-primary point (57 times), the eight influential point (52 times), and the Luo -Connecting point (50 times). The results of association rules showed that in the treatment of stroke, the highest degree of acupoint correlation was Sǎnyīnjiǎo→Zúsǎnlǐ, Baǐhuì→Fēngfǔ. The clustering results showed that there were three kinds of acupoint combinations. Conclusion Based on real medical records, this study analyzed the acupoint characteristics and prescription characteristics of Professor Wang Leting in the treatment of stroke through data mining technology, and found that the rule of acupoint selection was in line with the prescription of “twelve needles on hands and feet”, paid attention to the adjustment of the overall function of patients, and at the same time with the “opening the body and awakening the spirit”, to improve the symptoms of dizziness. Professor Wang Leting, as the founding figure of modern acupuncture prescriptions, can express and inherit his academic thoughts through acupuncture prescriptions.
		2023 Vol. 20 (2): 11-15,25 [Abstract] ( 22 ) HTML (1 KB) PDF (1401 KB) ( 90 )

	16	Study on the anti-inflammatory effect of 4’-O-β-D-glucosyl-5-O-methylvisamminol in Radix Saposhnikoviae on lipopolysaccharide -induced RAW 264.7 cell injury#br# MENG Li1 ZHENG Wei2 LIU Pengpeng2 JIA Tianzhu2

		DOI: 10.20047/j.issn1673-7210.2023.02.03
		Objective To study the protective effect and mechanism of 4’-O-β-D-glucosyl-5-O-methylvisamminol in Radix Saposhnikoviae on inflammation of mice RAW264.7 cells induced by lipopolysaccharide (LPS). Methods RAW264.7 mononuclear macrophages were induced cellular inflammatory model by LPS. The proliferation effect of 4’-O-β-D-glucosyl-5-O-methylvisamminol with different concentrations(160, 80, 40, 20, 10 μmol/L) on mice RAW264.7 cells was detected by MTT assay. The experiment was divided into blank group, LPS group, positive control group (Indomethacin, 10 μmol/L), low (20 μmol/L), medium (40 μmol/L) and high (80 μmol/L) dose groups of 4’-O-β-D-glucosyl- 5-O-methylvisamminol. Blank medium was added to blank group and LPS group, and corresponding drugs were added to other dosing groups. LPS (10 μg/ml) was added after 2 h, the secretion of nitric oxide (NO) in supernatant of mice RAW264.7 was detected by Griess reagent method, the contents of prostaglandin E2 (PGE2) and tumor necrosis factor α (TNF-α) in the supernatant of mice RAW264.7 cells were determined by enzyme linked immunosorbent assay. The mRNA expressions of nuclear factor κB (NF-κB p65), interleukin-1β (IL-1β), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) were detected by RT-PCR. Toll like receptor 4 (TLR4) and NF-κB p65 protein expressions were detected by Western blot. Results 4’-O-β-D- glucosyl-5-O- methylvisamminol (10-80 μmol/L) had no effect on RAW264.7 cell viability. Compared with LPS group, the contents of NO, PGE2 and TNF-α in mice RAW264.7 cells were decreased in low, medium and high doses of 5-O-methylvisamminol side groups (P＜0.01). The mRNA expressions of NF-kB p65, IL-1β, INOS and COX-2 and the protein expressions of TLR4 and NF-kB p65 were decreased (P＜0.01). Conclusion 4’-O-β-D-glucosyl-5-O- methylvisamminol in Radix Saposhnikoviae inhibit the inflammation of RAW264. 7 cells induced by LPS has anti- inflammatory effect.
		2023 Vol. 20 (2): 16-20 [Abstract] ( 20 ) HTML (1 KB) PDF (1637 KB) ( 49 )

	21	Analysis of medication rules of palpitation in Revisiting the Jinjian of Ancient and Modern Famous Doctors·Palpitation and Severe Palpitation Volume
		LIU Jianzhao1 GAO Hongmei2 DONG Yujiang2
		DOI: 10.20047/j.issn1673-7210.2023.02.04
		Objective To analyze the medication rules of physicians in the past dynasties in the treatment of palpitation in Revisiting the Jinjian of Ancient and Modern Famous Doctors·Palpitation and Severe Palpitation Volume. Methods Common prescriptions used by physicians of all ages for palpitation and severe palpitation, which were included in the book Revisiting the Jinjian of Ancient and Modern Famous Doctors·Palpitation and Severe Palpitation Volume were reviewed and screened. The frequency, four nature and five flavours, channel tropism of drugs, and other properties were counted. The SPSS Modeler 18.0 was used for association rule analysis of high-frequency drugs, and the statistical software IBM SPSS Statistics 20.0 was used for factor analysis of high-frequency drugs. Results A total of 61 physicians, 312 ancient remedies and 320 traditional Chinese medicines were involved in this study, with a total frequency of 2 995 times. According to statistics, there were 36 kinds of high frequency drugs. The flavour of drugs was mainly sweet; the drug property was mainly flat; the main channel was the heart channel. The core of the drug category was tonifying deficiency drugs. The analysis of high-frequency drug association rules showed 21 common combinations. Factor analysis yielded 11 groups of common factors. Conclusion The treatment of palpitation in Revisiting the Jinjian of Ancient and Modern Famous Doctors·Palpitation and Severe Palpitation Volume mainly focuses on nourishing yin and nourishing blood, often combined with invigorating xinyang, nourishing the heart and calming the spirit, heat-clearing, resolving fluid retention, and dispelling phlegm, and other drugs.
		2023 Vol. 20 (2): 21-25 [Abstract] ( 25 ) HTML (1 KB) PDF (1181 KB) ( 174 )

	26	Comparative analysis of clinicopathological characteristics and MRI manifestations of breast cancer with different Ki-67 expression
		WANG Yanlong1 ZHU Lina2▲ XIAO Lan3 LI Xing2
		DOI: 10.20047/j.issn1673-7210.2023.02.05
		Objective To explore clinicopathological characteristics and MRI manifestations of breast cancer with different Ki-67 expression and compare their difference. Methods A total of 205 patients with non-special invasive breast cancer diagnosed by pathology were collected in Tumour Hospital Affiliated to Xinjiang Medical University from January 2014 to December 2018. Ki-67≥20% was used as the high expression group (146 cases), Ki-67<20% was used as the low expression group (59 cases). The clinicopathological characteristics, MRI manifestations and parameters(the maximum diameter of tumor, apparent diffusion coefficient [ADC] value, and early enhancement rate) between two groups were compared. Results There were no significant differences in lymph node metastasis and tumor shape between two groups (P＞0.05); while there were significant differences in histological grade, estrogen receptor, progesterone receptor, human epidermal growth factor receptor-2, p53 expression, tumor margin, internal enhancement characteristics, time-signal intensity curve type, the maximum diameter of tumor, ADC value, and early enhancement rate between two groups. Conclusion There are certain difference in clinicopathological characteristics and MRI manifestations of breast cancer with different Ki-67 expression, which is helpful to guide the clinical development of treatment strategies.
		2023 Vol. 20 (2): 26-29 [Abstract] ( 21 ) HTML (1 KB) PDF (855 KB) ( 129 )

	30	Study on the correlation between TIMP1 gene expression and prognosis and immunoinfiltration in colorectal cancer
		WANG Xinjun1 HUANG Yixin2
		DOI: 10.20047/j.issn1673-7210.2023.02.06
		Objective To explore the correlation between TIMP1 gene expression and prognosis and immune invasion of colorectal cancer. Methods RNA expression data from the Cancer Genome Atlas (TCGA) database were used to analyze the correlation between the expression level of TIMP1 gene and clinicopathologic features of colorectal cancer patients, and to analyze the expression of TIMP1 in colorectal cancer tumors and normal tissues. Kaplan-Meier survival analysis and Cox regression were used to analyze the correlation between TIMP1 and prognosis. Gene set enrichment analysis (GSEA) and single sample gene set enrichment analysis (ssGSEA) were used to study the enrichment pathway and function of TIMP1, and association analysis of immune cell infiltration was performed. Results TIMP1 was highly expressed in colorectal cancer and was associated with poor prognosis in patients with colorectal cancer. ECM pathway, MAPK pathway and immune-related pathway might be key pathways for TIMP1 regulation. Meanwhile, the expression of TIMP1 in colorectal cancer was related to the level of immune invasion. Conclusion TIMP1 can be a potential therapeutic target and prognostic biomarker for colorectal cancer.
		2023 Vol. 20 (2): 30-34 [Abstract] ( 14 ) HTML (1 KB) PDF (1703 KB) ( 90 )

	35	Research progress on natural antioxidants in the treatment of oxidative stress injury of testis in diabetes mellitus
		WAN Qianfan1 YANG Dan2
		DOI: 10.20047/j.issn1673-7210.2023.02.07
		Diabetes mellitus is becoming a severe global public health concern, with an annual increase in incidence and a younger trend. Long-term hyperglycemia in diabetic mellitus individuals can quickly lead to organ and system malfunction. Male diabetes mellitus exhibit a clear spermatogenesis problem, and their sexual and reproductive abilities are considerably reduced. Several natural antioxidants have been found in studies to protect oxidative stress injury of testis in diabetes mellitus. This article reviews the research progress of natural antioxidants in the treatment of diabetic men’s testicular oxidative stress injury caused by diabetes mellitus in order to provide a theoretical basis for natural antioxidants in the treatment of diabetic men’s testicular injury, as well as a reference and support for the development of new drugs.
		2023 Vol. 20 (2): 35-38,51 [Abstract] ( 25 ) HTML (1 KB) PDF (633 KB) ( 136 )

	39	Research progress on clinical application and mechanism of Chinese medicine pair of Sparganii Rhizoma-Curcumae Rhizoma against tumor
		DU Fang1 YU Maixia2 HU Bofan1 XU Peng2
		DOI: 10.20047/j.issn1673-7210.2023.02.08
		Sparganii Rhizoma-Curcumae Rhizoma is a Chinese medicine pair commonly used in clinical medicine to promote qi and blood circulation and remove blood stasis, which is widely used in tumor treatment. Modern physicians often achieve the therapeutic goal of anti-cancer and tumor suppressive by Chinese medicine pair of Sparganii Rhizoma-Curcumae Rhizoma with softening hardness and dissipating mass, strengthening body resistance, and invigorating spleen. Modern pharmacological studies have proved that Chinese medicine pair of Sparganii Rhizoma-Curcumae Rhizoma can not only inhibit the proliferation and growth of tumor cells, interfere with the cell cycle, but also play an anti-tumor role by regulating the body’s immunity and anti-angiogenesis. However, at present, there are few studies on its combination with immunotherapy and targeted therapy, as well as on the generation of new substances and pharmacological effects in their compatibility. It is expected that the summary of this paper can provide ideas for further research of this Chinese medicine pair.
		2023 Vol. 20 (2): 39-42 [Abstract] ( 23 ) HTML (1 KB) PDF (618 KB) ( 244 )

	43	Analysis of influencing factors of cognitive ability and level of hospice care in nurses based on structural equation model
		HU Yujie1 PAN Yuqin1▲ DU Hua2
		DOI: 10.20047/j.issn1673-7210.2023.02.09
		Objective To analyze the factors affecting cognitive ability and attitude of nurses in hospice care by using structural equation model. Methods General information, hospice care knowledge and hospice care attitude scale scores of 952 in-service nurses from the High-tech Zone of the First Affiliated Hospital of Anhui Medical University from January 2020 to January 2021 were obtained through questionnaire survey, and the influencing factors were analyzed by structural equation model. Results In this survey, 695 valid questionnaires were collected, with effective recovery of 73%. The average score of cognitive ability and level of hospice care was (12.65±2.81) points, and the average accuracy was 60.7%. The total score of nurses’ attitude towards taking care of terminal patients was (105.49±9.24), and 80.40% of them had a positive attitude. Univariate analysis showed that clinical nurses with different ages, working years, professional titles, and departments had statistically significant differences in cognitive ability and level scores of hospice care (P＜0.05). There were statistically significant differences in the scores of hospice care attitude of clinical nurses in different ages, working years, professional titles, and departments (P＜0.05). Pearson correlation analysis showed that hospice care attitude score was positively correlated with cognitive ability and level of nurses (P＜0.05). All fitting values of the structural equation model were within the acceptable range. The maximum total effect of experience factor on cognition and attitude of nurses in hospice care was 15.70, of which the direct effect was 15.48, and the indirect effect was 0.22 by influencing work factor. It was followed by family factor (4.67) and work factor (0.86). Conclusion Nurses’ cognition and attitude of hospice care need to be improved, and experience factors and family factors have a great influence on them. Targeted training can be adopted to improve the knowledge level and attitude of hospice care in the later stage, so as to provide a basis for the formulation of effective hospice care measures.
		2023 Vol. 20 (2): 43-47 [Abstract] ( 18 ) HTML (1 KB) PDF (921 KB) ( 131 )

	48	Effect of hydrophilic coated catheters on compliance and acceptability in patients with clean intermittent catheterization
		LONG Yuyang ZHANG Jianmei ZHU Liang YANG Jie ZENG Li YANG Ying YANG Yue
		DOI: 10.20047/j.issn1673-7210.2023.02.10
		Objective To explore the influence of hydrophilic coated catheter on catheterization compliance and acceptance in patients with clean intermittent catheterization. Methods A total of 232 neurogenic patients admitted to West China Hospital of Sichuan University from March to November 2020 were selected as research objects, and randomly divided into the observation group (with hydrophilic coating catheter, 116 cases) and the control group (with ordinary catheter, 116 cases). According to the score results of neurogenic bladder symptom scale (BNSS), intermittent catheterization difficulty questionnaire (ICDQ), intermittent catheterization adherence scale (ICAS) and intermittent catheterization acceptance test (I-CAT), the differences of neurogenic bladder symptoms, intermittent urinary catheterization compliance, acceptance and execution difficulty were observed and compared between the two groups. Results There were no significant differences in urinary incontinence, urinary storage and voiding, outcome score. and total score between the two groups (P＞0.05). There was no significant difference in CIC compliance score between the two groups (P＞0.05). The scores of multiple worries, self-esteem, and total scores of the observation group were lower than those of the control group, and the differences were statistically significant (P＜0.05). There were no significant differences in frequency, degree, and total score between the two groups (P＞0.05). Conclusion Compared with conventional catheters, the use of hydrophilic coated catheters can improve patients’ acceptance of clean intermittent catheterization, and does not affect patients’ compliance.
		2023 Vol. 20 (2): 48-51 [Abstract] ( 30 ) HTML (1 KB) PDF (491 KB) ( 80 )

	52	Clinical effect of Jiawei Jijiao Lihuang Decoction on patients with end-stage heart failure
		ZHAO Dongsheng1 SUN Jing2
		DOI: 10.20047/j.issn1673-7210.2023.02.11
		Objective To investigate the clinical effect of Jiawei Jijiao Lihuang Decoction on patients with end-stage heart failure, and the effects on left ventricular ejection fraction (LVEF) , N-terminal B-type natriuretic peptide (NT -proBNP), and hospitalization period. Methods A total of 62 patients with end-stage heart failure admitted to the Department of Cardiology, Shuyang County Hospital Affiliated to Nanjing University of Chinese Medicine from December 2018 to April 2021 were selected and they were divided into the traditional Chinese medicine group (31 cases) and the control group (31 cases) by random number table method. The control group was treated with the standard drug therapy recommended by the guideline, while the Chinese medicine group was treated with Jiawei Jijiao Lihuang Decoction on the basis of the standard drug therapy. The treatment period was seven days. Plasma NT-proBNP, LVEF, traditional Chinese medicine syndrome score, hospitalization period, liver and kidney function, electrolytes and blood routine were observed before and after treatment in both groups. Results After 7 days of treatment, the clinical efficacy of the traditional Chinese medicine group was better than that of the control group, and the difference was statistically significant (P＜0.05). There was no significant difference in the scores of traditional Chinese medicine symptoms, NT-proBNP and LVEF between the two groups before treatment (P＞0.05); after treatment, traditional Chinese medicine syndrome scores in both groups were lower than before treatment, and traditional Chinese medicine group was lower than control group (P＜0.05). After treatment, NT-proBNP in both groups was lower than that before treatment, and the traditional Chinese medicine group was lower than that in control group (P＜0.05). After treatment, LVEF in both groups was higher than that before treatment, and the traditional Chinese medicine group was higher than that in control group (P＜0.05). The duration of hospitalization in traditional Chinese medicine group was shorter than that in control group (P＜0.05). There was no significant difference in liver and kidney function electrolyte, blood routine and other safety indexes between two groups (P＞0.05). Conclusion Jijiao Lihuang Decoction is effective in improving the clinical symptoms and signs of patients with end-stage heart failure, decreasing the level of NT-proBNP, increasing LVEF, and shortening the period of hospitalization. It has a definite curative effect and no obvious adverse reaction, it can use Jijiao Lihuang decoction for clinical reference.
		2023 Vol. 20 (2): 52-55 [Abstract] ( 25 ) HTML (1 KB) PDF (570 KB) ( 31 )

	56	Changes in serum CXCL16 and sST2 levels in patients with severe heart failure and the relationship with prognosis
		ZHAO Jinghong1 QIAO Yan2 ZHANG Rongyi1 DENG Jianping1 CHEN Yong1
		DOI: 10.20047/j.issn1673-7210.2023.02.12
		Objective To investigate the relationship between serum C-X-C motif chemokine ligand 16 (CXCL16) and soluble suppression of tumorigenicity 2 (sST2) levels and the prognosis of patients with severe heart failure (SHF). Methods A total of 168 patients with SHF admitted to Nanchong Central Hospital from January 2020 to February 2021 were selected and they were divided into 41 cases in the death group and 127 cases in the survival group according to their prognosis. General information of patients was collected and serum CXCL16 and sST2 levels were measured by enzyme-linked immunosorbent assay. Multi-factor logistic regression was used to analyze the factors influencing death in SHF patients, and subject work characteristic curves were used to analyze the predictive value of serum CXCL16 and sST2 levels on death in SHF patients. Results The age of death group was longer than that of survival group, and the course of disease was longer than that of survival group. The New York Heart Association grade Ⅳ ratio, blood uric acid, B-type natriuretic peptide, CXCL16, and sST2 levels were higher than those of survival group, and systolic blood pressure and left ventricular ejection fraction were lower than those of survival group, with statistical significances (P＜0.05). Multivariate logistic regression analysis showed that disease duration, New York Heart Association grade, B-type natriuretic peptide, CXCL16, and sST2 were independent risk factors for death in patients with SHF, while systolic blood pressure and left ventricular ejection fraction were independent protective factors (P＜0.05). The area under the curve of the combined prediction of serum CXCL16 and sST2 was greater than that of serum CXCL16 and sST2 alone (P＜0.05). Conclusion Elevated serum CXCL16 and sST2 levels are independent risk factors for death within one year in SHF patients. Combined testing of serum CXCL16 and sST2 levels can enhance the predictive value of death in SHF patients.
		2023 Vol. 20 (2): 56-59 [Abstract] ( 24 ) HTML (1 KB) PDF (638 KB) ( 96 )

	60	Diagnostic value of olfactory tests in patients with Alzheimer’s disease and mild cognitive impairment in China
		GUO Wenjing1 ZHAO Aonan2 YAN Yi2 QIU Yinghui2 DENG Yulei1
		DOI: 10.20047/j.issn1673-7210.2023.02.13
		Objective To explore the diagnostic value of olfactory detection in patients with Alzheimer’s disease (AD) and mild cognitive impairment (MCI). Methods In this cross-sectional study, 75 patients with MCI, 75 patients with AD and 50 healthy subjects(HC group) admitted to the Department of Neurology of Ruijin Hospital from June 2016 to October 2019 were collected. The 16-item odor identification test from sniffin sticks (SS-16) was used as the main olfactory evaluation tool. The score of the test was used as the index to evaluate the subjects’ olfactory function, and the cognitive function in various cognitive fields, such as memory, orientation and operational ability, was assessed by the scale. Results The scores of mini mental state examination (MMSE), Montreal cognitive scale (MoCA), and SS-16 in AD group were lower than those in HC and MCI group, while the scores of MMSE, MoCA, and SS-16 in MCI group were lower than those in HC group, and the differences were statistically significant (P＜0.05). The ADL score in AD group was higher than that in HC group and MCI group, and the differences were statistically significant (P＜0.05). The accuracy of orange, leather, cinnamon, mint, banana, lemon, licorice, garlic, coffee, fenise, and fish in AD group were lower than that in HC and MCI groups; the accuracy of pineapple was lower than that in HC group; the accuracy of cinnamon and garlic in MCI group was lower than that in HC group, and the differences were statistically significant (P＜0.05). Receiver operating characteristic curve showed that the cut-off value of odor recognition score between AD and HC was 10 scores, the sensitivity was 88% and the specificity was 74%. The cut-off value of AD and MCI was 8 scores, the sensitivity was 56%, and the specificity was 90%. Multiple linear regression analysis showed that age and MMSE score were related to SS-16 (P＜0.05). Conclusion SS-16 is an effective tool for olfactory assessment in Chinese patients with AD, and anosmia is related to cognitive decline in patients with MCI.
		2023 Vol. 20 (2): 60-64 [Abstract] ( 16 ) HTML (1 KB) PDF (810 KB) ( 165 )

	65	Analysis of influencing factors in patients with ischemic leukodystrophy
		YE Xin1 LIU Shihua2 ZHANG Chao2 ZHONG Ping2▲
		DOI: 10.20047/j.issn1673-7210.2023.02.14
		Objective To investigate the influencing factors of disease progression in patients with white matter ischemic lesions (WMIL). Methods Clinical data of 215 patients with WMIL admitted to Suzhou Hospital of Anhui Medical University from June 2017 to September 2021 were collected. The degree of leukodystrophy was assessed according to the Fazekas scale; the control group (100 cases) had normal brain MRI. The serum concentration of asymmetric dimethylarginine (ADMA) was determined by enzyme-related immunosorbent assay. The clinical data and ADMA concentration of the two groups were compared to analyze the influencing factors of ischemic white matter lesions and the relationship between serum ADMA and the degree of white matter lesions. Results The proportion of hypertension and type 2 diabetes in WMIL group was higher than that in control group, while the serum ADMA concentration in light, medium and heavy WMIL group were higher than that in control group, and the differences were statistically significant (P＜0.05). Spearman rank correlation analysis showed that serum ADMA concentration in WMIL group was positively correlated with Fazekas score (r=0.850, P＜0.01). Multivariate logistic analysis showed that hypertension, diabetes history, and elevated serum ADMA were independent risk factors for WMIL progression (OR＞1, P＜0.05). Conclusion High concentration of ADMA is an independent factor affecting the progression of WMIL, and the higher the concentration, the more severe the degree of leukoencephalopathy.
		2023 Vol. 20 (2): 65-68 [Abstract] ( 27 ) HTML (1 KB) PDF (530 KB) ( 19 )

	69	Value of combined monitoring of bispectral index, transcranial Doppler, and intracranial pressure in prognosis assessment of severe craniocerebral injury
		DING Lili LIU Mengru SUN Haijun▲
		DOI: 10.20047/j.issn1673-7210.2023.02.15
		Objective To explore the value of combined monitoring of bispectral index (BIS), transcranial Doppler (TCD), and intracranial pressure (ICP) in prognosis assessment of severe craniocerebral injury. Methods A total of 80 patients with ICP with severe craniocerebral injury admitted to the First People’s Hospital of Suqian, Jiangsu Province from November 2018 to November 2021 were selected and divided into good prognosis group (59 cases) and poor prognosis group (21 cases) according to the Glasgow coma scale score 21 days after treatment. Basic data, BIS, ICP, and TCD data (mean blood flow velocity [Vm]) of all patients were collected, and sorted out. Logistic regression model was used to analyze the related factors of poor prognosis in patients with severe craniocerebral injury, and receiver operating characteristic curve (ROC) was used to evaluate the value of combined monitoring of BIS, TCD, and ICP in the prognosis assessment of severe craniocerebral injury. Results ICP in the poor prognosis group were higher than those in the good prognosis group, BIS, and Vm were lower than those in the good prognosis group (P＜0.05). The results of multivariate analysis showed that BIS, ICP, and Vm were influencing factors for poor prognosis of patients with severe craniocerebral injury (P＜0.05). The area under the curve of BIS, Vm, and ICP combined predicted the prognosis of severe craniocerebral injury was higher than that of each prediction alone (P＜0.05). Conclusion The combined monitoring of BIS, TCD, and ICP has a high value in the prognosis assessment of patients with severe craniocerebral injury, and worthy of clinicall attention.
		2023 Vol. 20 (2): 69-71,79 [Abstract] ( 21 ) HTML (1 KB) PDF (710 KB) ( 166 )

	72	Predictive value of DRAGON score on clinical outcome of bridging therapy in patients with serial occlusion of tandem internal carotid artery and middle cerebral artery
		WU Feifei TANG Wuzhuang WANG Liangliang▲
		DOI: 10.20047/j.issn1673-7210.2023.02.16
		Objective To study the predictive value of DRAGON score on clinical outcome of bridging therapy in patients with serial occlusion of internal carotid artery and middle cerebral artery (TIM). Methods A total of 96 occlusion of TIM patients underwent bridging therapy in Yixing Hospital Affiliated to Jiangsu University from January 2018 to December 2021 were selected and divided into good prognosis group (0-2 points, 57 cases) and poor prognosis group (3-6 points, 39 cases) according to the modified Rankin scale score at three months after treatment. The differences of the general data and DRAGON score between the two groups were compared. The influencing factors of the prognosis of occlusion of TIM patients were analyzed by logistic regression. The predictive value of DRAGON score was evaluated by receiver operator characteristic (ROC) curve. Results The proportion of American Society for Interventional and Therapeutic Neuroradiology (ASITN) grade 0-2, proportion of modified thrombolysis in cerebral infarction (mTICI) grade 0-2a, and DRAGON score in the poor prognosis group were higher than those in the good prognosis group (P＜0.05). The results of multivariate analysis showed that ASITN grade (OR=4.697, 95%CI: 2.044-10.796), mTICI grade (OR=3.904, 95%CI: 1.699-8.972), DRAGON score (OR=4.166, 95%CI: 1.813-9.575) were prognostic factors of patients with occlusion of TIM after bridging therapy (P＜0.05). The area under the ROC curve of DRAGON score was 0.865 (P＜0.05). Conclusion DRAGON score is an important factor affecting the prognosis of bridging therapy in patients with occlusion of TIM, and has a certain predictive value for the prognosis.
		2023 Vol. 20 (2): 72-75 [Abstract] ( 24 ) HTML (1 KB) PDF (633 KB) ( 22 )

	76	Effect of pelvic adhesiolysis combined with salpingostomy in the treatment of infertility caused by pelvic inflammation disease
		WU Linlin1 XU Hao2▲ LI Chihui3
		DOI: 10.20047/j.issn1673-7210.2023.02.17
		Objective To observe the clinical effect of laparoscopic pelvic adhesiolysis combined with salpingostomy in the treatment of infertility caused by pelvic inflammatory disease. Methods From August 2019 to November 2020, a total of 100 women of infertility caused by chronic pelvic inflammatory disease in childbearing age were selected. They were divided into observation group and control group according to the random number table, with 50 cases in each group. The control group was accepted with hysteroscopic hydrotubation therapy, and observation group was treated by laparoscopic pelvic adhesiolysis combined with salpingostomy on the basis of the control group. Serum follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2) between two groups before and after treatment were compared; 1-year follow-up, the natural conception rate and ectopic pregnancy rate were compared between two groups. Results After treatment, FSH decreased and E2 increased in both groups compared with before treatment; FSH in observation group was lower than that in control group, E2 was higher than that in control group (P＜0.05). There were no significant differences in LH between two groups before and after treatment (P＞0.05). The natural conception rate of observation group was higher than that of control group (P＜0.05); there was no significant difference in the incidence of ectopic pregnancy between two groups (P＞0.05). Conclusion In the treatment of infertile patients caused by pelvic inflammatory disease, more ideal clinical effect can be obtained by laparoscopic pelvic adhesiolysis combined with salpingostomy on the basis of hydrotubation.
		2023 Vol. 20 (2): 76-79 [Abstract] ( 25 ) HTML (1 KB) PDF (547 KB) ( 33 )

	80	Preventive effect of acupoint hot ironing with Aiyanbao combined with pelvic floor muscle training on postpartum urinary retention in primiparas with painless labor
		PAN Chengyao YANG Yuanyuan ZHENG Jingjing
		DOI: 10.20047/j.issn1673-7210.2023.02.18
		Objective To analyze the preventive effect of acupoint hot ironing with Aiyanbao combined with pelvic floor muscle training on postpartum urinary retention in primiparas with painless labor. Methods A total of 120 primiparas with painless labor in the Second Affiliated Hospital of Wenzhou Medical University from April 2021 to January 2022 were selected as the research subjects. They were divided into group A (40 cases), group B (40 cases), and group C (40 cases) by randon number table method. Group A was treated with acupoint hot ironing with Aiyanbao, group B was treated with pelvic floor muscle training, and group C was treated with acupoint hot ironing with Aiyanbao combined with pelvic floor muscle training. The clinical efficacy, the first spontaneous urination time after delivery, the first urine volume after delivery, the residual urine volume of bladder, the amount of postpartum hemorrhage, and waiting time for urination were compared in each group, and the incidence of postpartum urinary retention were recorded in each group. Results The total effective rate of group C was higher than that of group A and group B (P＜0.05). The first spontaneous urination time after delivery and waiting time for urination were shorter than those in group A and group B; the first urine volume after delivery was more than that in group A and group B, the residual urine volume of bladder and the amount of postpartum hemorrhage were less than those in group A and group B (P＜0.05). The incidence of postpartum urinary retention was lower than that in group A and group B (P＜0.05). Conclusion Acupoint hot ironing with Aiyanbao combined with pelvic floor muscle training can improve the first spontaneous urination time after delivery, the first urine volume after delivery, the residual urine volume of bladder, the amount of postpartum hemorrhage, shorten the waiting time for urination, reduce the incidence of postpartum urine retention, and improve the clinical intervention effect.
		2023 Vol. 20 (2): 80-83 [Abstract] ( 21 ) HTML (1 KB) PDF (526 KB) ( 86 )

	84	Effect of recombinant interferon α-2b inhalation combined with chest wall vibration in the treatment of children with bronchiolitis and its effect on immune function
		YU Xiao ZHOU Yan LI Dan ZHU Zhankui▲
		DOI: 10.20047/j.issn1673-7210.2023.02.19
		Objective To investigate the effect of recombinant interferon α-2b inhalation combined with chest wall vibration in the treatment of children with bronchiolitis and its effect on immune function. Methods A total of 120 children with bronchiolitis admitted to Fuyang Women’s and Children’s Hospital from March 2018 to May 2021 were selected as the research subjects. They were divided into combination group, observation group, and control group, with 40 cases in each group. The children in combination group received recombinant interferon α-2b inhalation combined with chest wall vibration therapy, observation group received recombinant interferon α-2b inhalation therapy, and control group received chest wall vibration therapy. The treatment lasted for seven days. The clinical efficacy of each group was compared; the expressions of interleukin-6 (IL-6), immunoglobulin G (IgG), IgA, IgE, and eosinophil (EOS) were compared before and after treatment; the recurrence rate of each group was compared after six months of follow-up. Results The clinical efficacy of combination group was better than that of observation group and control group (P＜0.05). After treatment, IL-6, IgE, and EOS were lower than those before treatment; IgG was higher than that before treatment (P＜0.05). After treatment, IL-6, IgE, and EOS in combination group were lower than those in observation group and control group; IgG was higher than that in observation group and control group (P＜0.05). The recurrence rate of combination group was lower than that of observation group and control group (P＜0.05). Conclusion Recombinant interferon α-2b inhalation combined with chest wall vibration therapy has good utility value for children with bronchiolitis, it can effectively reduce the clinical symptoms of children, and regulate the immune function, and has a better application value.
		2023 Vol. 20 (2): 84-87 [Abstract] ( 23 ) HTML (1 KB) PDF (522 KB) ( 26 )

	88	Diagnostic value of grip strength for the nutritional risk of patients with nasopharyngeal carcinoma with concurrent radiotherapy and chemotherapy
		WEI Jiejing1* LU Ting2* YING Yanping3 LING Ying3 HUANG Biaojin1
		DOI: 10.20047/j.issn1673-7210.2023.02.20
		Objective To explore the diagnostic value of grip strength in nutritional risk assessment in patients with nasopharyngeal carcinoma undergoing concurrent radiotherapy and chemoradiotherapy. Method A total of 158 patients with nasopharyngeal carcinoma who were hospitalized in the Department of Oncology, the First Affiliated Hospital of Guangxi Medical University from September 2019 to December 2020 were selected. General data, disease-related data, blood indicators, grip strength, and nutritional risk scores were collected. Patients were grouped by nutritional risk screening 2022 (NRS2002), patients with NRS2002 scores ≥3 points were classified into the nutritional risk group (65 cases), and those with NRS2002 < 3 points were classified into the non-nutritional risk group (93 cases). Nutritional risk factors in patients with simultaneous chemoradiotherapy for nasopharyngeal carcinoma were analyzed by logistic regression. The grip strength of patients with nasopharyngeal carcinoma was divided into five groups. From small to large, they were divided into the lowest level group 1 (≤22.60 kg), the low level group 2 (＞22.60 to 28.70 kg), the medium level group 3 (＞28.70 to 33.70 kg), the high level group 4 (＞33.70 to 38.90 kg) and the highest level group 5 (＞38.90 kg). Trend test was used to analyze the relationship between grip strength and nutritional risk, and receiver operating characteristic (ROC) curve was used to determine the critical value of nutritional risk in patients with simultaneous chemoradiotherapy of nasopharyngeal carcinoma. Results There were statistically significant differences in gender, arm circumference, calf circumference, height, body weight, body mass index, hemoglobin, albumin, prealbumin, creatinine, and grip strength between the two groups (P＜0.05). The results of multivariate analysis showed that creatinine and grip strength were the factors affecting nutritional risk in nasopharyngeal carcinoma patients (P＜0.05). From the high level of grip strength to the low level of grip strength group, the nutritional risk of patients showed an upward trend with the decrease of grip strength. The area under ROC curve of grip strength predicting nutritional risk in patients with concurrent radiotherapy and chemotherapy of nasopharyngeal cancer was ＞0.5. The presence of nutritional risk could be judged when the grip strength of male was <32.0 kg and that of female was <20.2 kg. Conclusion Grip strength can be used as a screening index for nutritional risk in patients with nasopharyngeal carcinoma undergoing concurrent chemoradiotherapy.
		2023 Vol. 20 (2): 88-92 [Abstract] ( 21 ) HTML (1 KB) PDF (715 KB) ( 49 )

	93	Expression of long noncoding RNA-AWPPH in the tissues of endometrial cancer patients and its relationship with pathological parameters and prognosis
		WANG Bing1 LIN Lin2 GU Te3
		DOI: 10.20047/j.issn1673-7210.2023.02.21
		Objective To investigate the expression of long noncoding RNA (lncRNA)-AWPPH in the tissues of endometrial cancer (EC) patients and its relationship with pathological parameters and prognosis. Methods A total of 93 EC patients admitted to Dalian Women and Children Medical Center (Group) from January 2017 to December 2018 were selected. LncRNA-AWPPH expression in EC tissues and paracancer tissues was detected by qRT-PCR, and the relationship between the expression and the pathological characteristics of EC was analyzed. According to the mean value of lncRNA-AWPPH expression, patients were divided into high lncRNA-AWPPH expression group (43 cases) and low lncRNA-AWPPH expression group (50 cases). Survival curves were used to analyze the three-year postoperative survival of the two groups. Results LncRNA-AWPPH expression in EC tissues was higher than that in paracancer tissues (P＜0.05). LncRNA-AWPPH expression in EC patients with different Federation Infernational of Gynecology and Obstetrics stages, depth of muscle infiltration, histological stages, lymphatic vascular space infiltration, and lymph node metastasis were statistically significant (P＜0.05). The three-year cumulative survival rate of high lncRNA-AWPPH expression group was lower than that of low lncRNA-AWPPH expression group, and the difference was statistically significant (P＜0.05). Conclusion LncRNA-AWPPH expression is up-regulated in EC tissues, and the survival of patients with high lncRNA-AWPPH expression is poor, which is worthy of further clinical study.
		2023 Vol. 20 (2): 93-96 [Abstract] ( 21 ) HTML (1 KB) PDF (573 KB) ( 33 )

	97	Meta-analysis of the expression characteristics and clinical significance of autophagy related protein Beclin1 in esophageal squamous cell carcinoma
		FAN Xiangrong1 ZHAO Hang1 WU Hongyang1 XU Shaoqing1 FAN Huanfang2
		DOI: 10.20047/j.issn1673-7210.2023.02.22
		Objective To systematically evaluate the expression characteristics and clinical significance of autophagy related protein Beclin1 in esophageal squamous cell carcinoma (ESCC). Methods The literatures of expression characteristics of Beclin1 in ESCC and its relationship with clinicopathological features were searched by computer from the inception to December 2021 in PubMed, Web of Science, CNKI, Wanfang Data, and VIP. Meta-analysis was performed by RevMan 5.4. Results A total of 13 literatures were included, including 1 080 ESCC patients. The results of meta-analysis showed that Beclin1 expression in ESCC group was lower than that in control group (OR=0.09, 95%CI: 0.05-0.17, P＜0.000 01). Beclin1 expression in highly and moderately differentiated ESCC patients was higher than that in poorly differentiated ESCC patients (OR=2.01, 95%CI: 1.49-2.72, P＜0.000 01). Beclin1 expression in ESCC patients with TNM stage Ⅰ-Ⅱ was higher than that in patients with stage Ⅲ-Ⅳ (OR=2.78, 95%CI: 1.76-4.41, P＜0.000 1). Beclin1 expression in ESCC patients with infiltration depth from T1-T2 was higher than that in T3-T4 patients (OR=2.16, 95%CI: 1.58-2.97, P＜0.000 01). Beclin1 expression in ESCC patients without lymph node metastasis was higher than that in patients with lymph node metastasis (OR=0.26, 95%CI: 0.14-0.49, P＜0.000 1). Conclusion Beclin1 expression is closely related to the clinicopathological features of ESCC, and Beclin1 may be an important target involved in the occurrence and development of ESCC.
		2023 Vol. 20 (2): 97-100 [Abstract] ( 20 ) HTML (1 KB) PDF (809 KB) ( 26 )

	101	Effect of retained the left colonic artery on gastrointestinal and anal function after laparoscopic D3 radical operation for rectal cancer
		CHEN Dezhong CHANG Jian WANG Zhangyu
		DOI: 10.20047/j.issn1673-7210.2023.02.23
		Objective To study the effect of retained the left colonic artery (LCA) on gastrointestinal and anal function after laparoscopic D3 radical operation for rectal cancer. Methods Eighty-five patients with rectal cancer admitted to Suzhou Jiulong Hospital Affiliated to Medical College of Shanghai Jiao Tong University from December 2016 to January 2020 were selected as the study objects, and they were divided into observation group (43 cases) and control group (42 cases) by lottery method. Both groups underwent laparoscopic D3 radical resection for rectal cancer. The observation group retained LCA, while the control group did not. Perioperative indexes and complication rate were compared between the two groups. Gastrointestinal function (motilin, gastrin, gastrointestinal quality of life index scale [GIQLI] score) and anal function (anal canal resting pressure, anal canal maximum systolic pressure, constipation scoring system [Wexner] score) were compared between the two groups before and after surgery. Kaplan-Meier method was used to plot the survival curve of patients, and the survival after two years of follow-up was compared. Results The first anal exhaust time and hospital stay in the observation group were shorter than those in the control group, and the free proportion of spleen flexion was lower than that in the control group (P＜0.05). The total complication rate of observation group was lower than that of control group (P＜0.05). After operation, the levels of motilin and gastrin in the two groups were lower than those before operation, and GIQLI score was increased, and the levels of motilin and gastrin in the observation group were higher than those in the control group, and GIQLI score was higher than that in the control group (P＜0.05). After surgery, the resting pressure and maximum systolic pressure of the anal canal in both groups decreased, while Wexner score increased, the resting pressure and maximum systolic pressure of the anal canal in the observation group were higher than those in the control group, while Wexner score was lower than those in the control group (P＜0.05). There was no significant difference in survival between the two groups (P＞0.05). Conclusion Retained of LCA in laparoscopic D3 radical resection of rectal cancer can shorten the time of first exhaust, reduce the incidence of postoperative complications, and accelerate the recovery of gastrointestinal and anal functions, with a good long-term prognosis.
		2023 Vol. 20 (2): 101-104 [Abstract] ( 23 ) HTML (1 KB) PDF (671 KB) ( 90 )

	105	Meta analysis of influencing factors of unplanned interruptionin in patients on continuous renal replacement therapy
		CHEN Yuqian LI Wenxiong▲ YANG Na
		DOI: 10.20047/j.issn1673-7210.2023.02.24
		Objective To systematically evaluate the influencing factors of unplanned interruption in patients on continuous renal replacement therapy (CRRT). Methods The published related literatures in CNKI, Wanfang, VIP, PubMed, EMbase, and other databases were searched by computer. The search time was from the date of creation to March, 2022. The influencing factors of unplanned disembarkation of CRRT were analyzed by meta analysis. Results A total of 16 research papers with 2 289 patients were included in this study. Prolongation of activated partial thromboplastin time (HR=0.939, 95%CI [0.899, 0.992], P＜0.001) was a protective factor for unplanned deactivation of CRRT. High platelet count (HR=1.002, 95%CI[1.000, 1.004], P＜0.001), low blood flow (HR=1.005, 95%CI [1.001, 1.032], P＜0.001), advanced age (OR=3.916, 95%CI[2.736, 5.604], P＜0.001), combined underlying disease (OR=3.386, 95%CI [2.460, 4.660], P＜0.001), ventilator use (OR=3.530, 95%CI[2.051, 6.074], P＜0.001), high hematocrit (HR=1.034, 95%CI[1.016, 1.051], P＜0.001) were risk factors for unplanned disembarkation of CRRT. Conclusion There are many factors influencing the unplanned interruption of CRRT, and nurses’ risk identifi-cation ability should be improved to enhance the ability of anticipatory care and improve the quality of CRRT.
		2023 Vol. 20 (2): 105-108,113 [Abstract] ( 23 ) HTML (1 KB) PDF (1091 KB) ( 79 )

	109	Analysis of characteristics and influencing factors of medical device related pressure injury in ICU patients
		DONG Zhenghui1 QI Jinfang2 LI Zhengang3 LI Yang2 WANG Zhiwei2 TAO Zhenzhen2
		DOI: 10.20047/j.issn1673-7210.2023.02.25
		Objective To understand the characteristics of medical device related pressure injury (MDRPI) in intensive care unit (ICU) patients, and to analyze its influencing factors. Methods A total of 280 ICU patients admitted to the First Affiliated Hospital of Xinjiang Medical University from June to December 2021 were selected. According to the occurrence of MDRPI, they were divided into occurrence group and non-occurrence group. The general data, clinical data, and device use of two groups were compared, and multivariate logistic regression was used to analyze the influencing factors. Results MDRPI occurred in 55 cases, with an incidence of 19.6%. There were significant differences in age, Braden scale score, acute physiology and chronic health evaluationⅡ(APACHEⅡ) score, ICU type, operation, prone position ventilation, disturbance of consciousness, use of vasoactive drugs, use of sedatives, enteral nutrition, hemoglobin, ICU stay time, and total number of medical device use between two groups(P＜0.05). Age, prone position ventilation, APACHEⅡ score, hemoglobin ＞120 g/L, total number of medical devices used, and use of non-invasive ventilation mask were the influencing factors for MDRPI in ICU patients (P＜0.05). Conclusion ICU patients may be prone to MDRPI due to age, prone position ventilation, critical condition, large number of medical devices used, and use of non-invasive ventilation masks. The nursing staff should conduct a comprehensive assessment of the patient and give preventive measures in anticipation to reduce the occurrence of MDRPI.
		2023 Vol. 20 (2): 109-113 [Abstract] ( 26 ) HTML (1 KB) PDF (637 KB) ( 121 )

	114	Clinical effect of traditional Chinese medicine acupoint application combined with warm moxibustion on patients with end-stage liver disease
		HAN Qian ZHAO Lina WANG Zhihua XIA Mengtian ZHENG Yanhua ZHANG Kun▲
		DOI: 10.20047/j.issn1673-7210.2023.02.26
		Objective To investigate the clinical effect of traditional Chinese medicine acupoint application combined with warm moxibustion on patients with end-stage liver disease. Methods A total of 150 patients with chronic end-stage liver disease admitted to Shijiazhuang Fifth Hospital (hereinafter referred to as “our hospital”) from November 2019 to January 2022 were selected, and they were divided into two groups by random number table method, with 75 cases in each group. The control group was given traditional Chinese medicine acupoint application therapy, and study group was given traditional Chinese medicine acupoint application combined with warm moxibustion, the treatment lasted for 20 days. The abdominal circumference, body weight, 24 h urine volume, liver function indexes (aspartate aminotransferase [AST], alanine aminotransferase [ALT], albumin [Alb], total bilirubin [TBil]), and model for end-stage liver disease (MELD) score were compared. Results After treatment, the abdominal circumference and body weight of two groups were lower than those before treatment, and 24 h urine volume was more than that before treatment (P＜0.05); the abdominal circumference and body weight of study group were lower than those of control group, and 24 h urine volume was more than that of control group (P＜0.05). The improvement effect of abdominal circumference of study group was better than that of control group (P＜0.05). After treatment, AST, ALT, and TBil of two groups were lower than those before treatment, and Alb was higher than that before treatment; and AST, ALT, and TBil of study group were lower than those of control group, and Alb was higher than that of control group (P＜0.05). At 10, 20, and 30 days after treatment, MELD scores in both groups were lower than those before treatment, and those in the MELD scores of study group were lower than that of control group(P＜0.05). Conclusion Traditional Chinese medicine acupoint application combined with warm moxibustion can improve the abdominal circumference and liver function of patients with end-stage liver disease, reduce the MELD score, and have a positive impact on the prognosis of patients.
		2023 Vol. 20 (2): 114-117 [Abstract] ( 22 ) HTML (1 KB) PDF (556 KB) ( 30 )

	118	Effect of Leizumab on diabetic retinopathy with neovascular glaucoma and the influence of serum levels of vascular endothelial growth factor and insulin-like growth factor-1
		SUN Feng YANG Xuelong WU Bing
		DOI: 10.20047/j.issn1673-7210.2023.02.27
		Objective To explore the effect of Leizumab on diabetic retinopathy (DR) with neovascular glaucoma (NVG) and the influence of serum levels of vascular endothelial growth factor (VEGF) and insulin-like growth factor-1 (IGF-1). Methods Eighty-three DR with NVG patients treated in Nanjing Gaochun People’s Hospital from November 2018 to November 2021 were selected and divided into simple operation group (47 cases, 48 eyes, underwent pars-plana vitrectomy) and pre-injection combined operation group (36 cases, 39 eyes, underwent pars-plana vitrectomy after preoperative injection of Leizumab) according to treatment methods. The perioperative conditions of the two groups were recorded and compared. The differences of intraocular pressure, visual acuity, and serum indexes were compared between the two groups before and after three months treatment. The incidence of postoperative complications in the two groups was analyzed. Results The operation time of the pre-injection combined operation group was shorter than that of the simple operation group, and the times of electrocoagulation hemostasis and neovascularization bleeding were lower than those of the simple operation group (P＜0.05). After three months treatment, the levels of intraocular pressure, VEGF, and IGF-1 in two groups were lower than those before treatment, the best corrected visual acuity was better than that before treatment, and the levels of intraocular pressure, VEGF, and IGF-1 in the pre-injection combined operation group were lower than that in the simple operation group, and the best corrected visual acuity was better than that in the simple operation group (P＜0.05). There was no significant difference in the total incidence of complications between the two groups (P＞0.05). Conclusion Pre-injection of Leizumab in the treatment of DR with NVG is effective and can shorten the operation time with high safety.
		2023 Vol. 20 (2): 118-121 [Abstract] ( 21 ) HTML (1 KB) PDF (523 KB) ( 50 )

	122	Changes of serum levels of hypothalamic-pituitary-adrenal axis hormones and its correlation with sleep quality and cognitive function in elderly patients with chronic insomnia
		JIANG Wei1 SONG Wandeng1 ZHANG Fubin2 HUANG Yan1 HE Youjun1 HU Xin1
		DOI: 10.20047/j.issn1673-7210.2023.02.28
		Objective To investigate the changes of serum levels of hypothalamic-pituitary-adrenal axis (HPA) hormones (corticotropin-releasing hormone [CRH], adrenocorticotropic hormone [ACTH], cortisol [COR]) and its correlation with sleep quality and cognitive function in elderly patients with chronic insomnia. Methods A total of 88 elderly patients with chronic insomnia in the 901th Hospital of the Joint Logistics Support Force of the Chinese People’s Liberation Army (hereinafter referred to as “our hospital”) from June 2019 to June 2021 were selected as the observation group, and 80 healthy subjects in our hospital during the same period were selected as the control group. Serological HPA hormones indicators (CRH, ACTH, COR), photoplethysmography monitoring indicators (total sleep time, sleep latency, sleep efficiency, arousal times), and sleep and cognition related scales (Pittsburgh sleep quality index [PSQI], insomnia severity index [ISI], mini-mental state examination [MMSE], and Montreal cognitive assessment [MoCA]) scores were compared between the two groups, the correlation between serological indexes and sleep and cognitive indexes in elderly patients with chronic insomnia was analyzed. Results The serum levels of CRH, COR, sleep latency, arousal times, PSQI, and ISI in the observation group were higher than those in the control group, the total sleep time, sleep efficiency, and scores of MMSE, MoCA in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05). Correlation analysis results showed that serum CRH and COR levels were positively correlated with sleep latency, wake times, PSQI, and ISI scores (r＞0, P＜0.05), and negatively correlated with total sleep time, sleep efficiency, and scores of MMSE, MoCA (r＜0, P＜0.05). Conclusion The increase of serum CRH and COR levels in elderly patients with chronic insomnia is closely related to the decline of sleep quality and cognitive impairment.
		2023 Vol. 20 (2): 122-125 [Abstract] ( 16 ) HTML (1 KB) PDF (530 KB) ( 136 )

	126	Medication rule of Professor Zhou Caiyun in the treatment of acute gouty arthritis from the viewpoint of “dampness toxin” based on data mining
		CHEN Yifan ZHOU Caiyun WANG Xin
		DOI: 10.20047/j.issn1673-7210.2023.02.29
		Objective To analyze the medication rule of Professor Zhou Caiyun in the treatment of acute gouty arthritis based on data mining software Traditional Chinese Medicine Inheritance Assistance Platform (V2.5) and Cytoscape 3.7.2. Methods Data of patients with acute gouty arthritis treated by Professor Zhou Caiyun in the outpatient department of Xiyuan Hospital, China Academy of Chinese Medical Sciences from September, 2019 to December, 2021 were collected. Using association rules and complex system entropy clustering method, data mining and network visualization analysis were carried out to summarize the frequency, channel tropism, nature, flavour, and couplet medicines combination of traditional Chinese medicine, explore the core prescription, and explore the medication rule. Results A total of 77 traditional Chinese medicines were included in 130 prescriptions, among which the most frequently used medicines were Puerariae Lobatae Radix, Portulacae Herba, Lysimachiae Herba, Dioscoreae Spongiosae Rhizoma, Siegesbeckiae Herba, Plantaginis Herba, Lygodii Spora, Plantaginis Semen, Lonicerae Japonicae Flos, Phellodendri Chinensis Cortex, and Benincasae Exocarpium. The four nature of drugs were mainly cold, the five flavours were mainly sweet, and the channel tropism was mainly liver and kidney channels. The drug combinations with high frequency were Puerariae Lobatae Radix and Portulacae Herba; Puerariae Lobatae Radix, Portulacae Herba, and Lysimachiae Herba, etc. Four new prescriptions were dug, which were Fritillariae Thunbergii Bulbus, Benincasae Exocarpium, Sepiae Endoconcha, Carthami Flos, and Chrysanthemi Flos; Artemisiae Scopariae Herba, Stir-Atractylodis Macrocephalae Rhizoma, Abri Herba, and Curcumae Radix; Lysimachiae Herba, Achyranthis Bidentatae Radix, Astragali Radix, Dendrobii Caulis, and Polygalae Radix; Stephaniae Tetrandrae Radix, Polyporus, Clematidis Radix Et Rhizoma, corn beard, and Rehmanniae Radix. Conclusion Professor Zhou Caiyun’s treatment of acute gout arthritis is based on the theory of “dampness toxin”. The main treatment methods are clearing heat and promoting diuresis, detoxifying for removing obstruction in collaterals, and tonifying liver and kidney as well as nourishing spleen and stomach.
		2023 Vol. 20 (2): 126-129,134 [Abstract] ( 22 ) HTML (1 KB) PDF (1475 KB) ( 61 )

	130	Analysis of Professor Zhu Shengliang’s prescription and medication rules for gastroesophageal reflux disease based on data mining
		ZHANG Nan1 CHENG Yanmei1 WANG Lei2 LI Yang1 ZHU Shengliang1
		DOI: 10.20047/j.issn1673-7210.2023.02.30
		To analyze the Professor Zhu Shengliang’s prescription and medication rules for gastroesophageal reflux disease based on data mining. Methods The effective first-diagnostic prescriptions of Professor Zhu Shengliang in the Gastroesophageal Reflux Disease Specialist Clinic, Yueyang Hospital of Integrated Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine from January 2011 to December 2021 was collected. The Traditional Chinese Medicine Inheritance Assistance Platform (V2.5) software was used to analyze the four nature of drugs and five flavours, the effect of channel tropism and the prescription and medication rules based on frequency analysis, association rules, improved mutual information method, and complex system entropy clustering algorithm, and to carry out visualization processing. Results A total of 354 effective prescriptions were included, involving 110 traditional Chinese medicines and 22 high-frequency drugs (≥90 times). The prescription drugs were mainly warm, cold, plain as a supplement; the five flavours were mainly bitter, pungent, and sweet. The channel tropism was mainly spleen, stomach, and liver channels. Traditional Chinese medicine syndrome differentiation included syndrome of heat stagnation in liver and stomach, syndrome of middle-deficiency and reversed flow of qi, syndrome of phlegm qi depression and blockade, etc. A total of 15 core Chinese medicines, 14 core combinations, 7 new prescriptions. Conclusion Professor Zhu Shengliang pays attention to regulating qi in the treatment of gastroesophageal reflux disease. He often uses the methods of invigorating the spleen and dispersing the stagnated liver-energy, relieving the gastric disorder and purgative, clearing heat and dissipating phlegm, nourishing yin and relieving pain, which can provide reference for the treatment of gastroesophageal reflux disease with traditional Chinese medicine.
		2023 Vol. 20 (2): 130-134 [Abstract] ( 17 ) HTML (1 KB) PDF (1249 KB) ( 29 )

	135	Professor Li Shuanglei’s experience on diabetic osteoporosis from kidney deficiency and blood stasis in collaterals
		DONG Liping1 TANG Aihua2 LI Shuanglei1 ZHOU Yexin1 LAI Chuchu1 ZHANG Xiaoting1
		DOI: 10.20047/j.issn1673-7210.2023.02.31
		As a systemic bone metabolic disease, diabetic osteoporosis is an important complication of diabetes, and has always been a difficult clinical problem. Professor Li Shuanglei is a famous traditional Chinese medicine doctor in Guangxi Zhuang Autonomous Region. Through many years of clinical practice and observation, Professor Li Shuanglei has rich experience in the prevention and treatment of diabetic osteoporosis. When consumptive thirst is dissipated for a long time, deficiency and excess are mixed, the kidney is deficient and the bone collateral is lost of nutrition, and the kidney dominating bone marrow function is reduced, and bone is withered and marrow is reduced, and then reduced to become “bone flaccid”; when consumptive thirst is dissipated for a long time, long disease into the collaterals, blood stasis blocks the kidney collaterals, blood stasis damages bone, which can further accelerate the bone damage, the formation of a vicious cycle. Professor Li Shuanglei first proposed that the core pathogenesis of diabetic osteoporosis is kidney deficiency and blood stasis in collaterals, and bone collateral damage, and the treatment should take tonifying kidney and removing blood stasis as the main principle. Professor Li Shuanglei makes addition and subtraction application according to Zhuanggu Formula, and achieves good practical results in the clinical diagnosis and treatment of diabetic osteoporosis. Based on the pathogenic characteristics of kidney deficiency and blood stasis in collaterals, Professor Li Shuanglei analyzes the relationship between kidney deficiency and blood stasis in collaterals and the incidence of diabetic osteoporosis, hoping to provide theoretical basis for clinical treatment of diabetic osteoporosis from different perspectives.
		2023 Vol. 20 (2): 135-138,143 [Abstract] ( 18 ) HTML (1 KB) PDF (764 KB) ( 59 )

	139	Medication rules of traditional Chinese medicine fumigation in the treatment of dry eye based on data mining
		GAO Miaoran1 YAN Xiaoling2 HUANG Sheng3 LUO Xianke1 LI Zhaoyan1 YANG Guohui1 YU Xinning1 ZHOU Jian2
		DOI: 10.20047/j.issn1673-7210.2023.02.32
		Objective To analyze medication rules of traditional Chinese medicine fumigation in the treatment of dry eye based on data mining. Methods A combination of computer and manual search was used to screen the literature on traditional Chinese medicine fumigation in the treatment of dry eyes from January 2004 to January 2022 in CNKI, VIP and Wanfang databases, and the prescriptions were entered into Excel tables and then imported into the Traditional Chinese Medicine Inheritance Support System (V2.5). Association rules, hierarchical clustering and other algorithms were adopted to conduct data mining from multiple dimensions such as drug frequency, four qi, five flavors of traditional Chinese medicine, meridian tropism, core drug combination and potential new formula combination. Results One hundred and twelve prescriptions contained 98 traditional Chinese medicines, most of which were cold, warm, and cold. Sweet, bitter, and pungent drugs were commonly used, and the channel tropism was mainly liver, lung, heart, stomach, and kidney channels. The top three Chinese medicines used were Chrysanthemi Flos, Menthae Haplocalycis Herba, Ophiopogonis Radix. Nineteen drug combinations were obtained. Phellodendri Chinensis Cortex and Menthae Haplocalycis Herba had the highest correlation. Nineteen groups of potential couplet medicines and six groups of core drug combinations were excavated, and three new drug combinations were obtained. Conclusion Traditional Chinese medicine fumigation in the treatment of dry eyes places equal emphasis on dispelling evil and supporting righteousness, mainly from the two perspectives of external wind heat and internal liver blood injury, on the basis of dispersing wind heat and nourishing liver yin, as well as promoting blood circulation, resolving stasis and drying dampness.
		2023 Vol. 20 (2): 139-143 [Abstract] ( 26 ) HTML (1 KB) PDF (1210 KB) ( 45 )

	144	Professor Xie Jingri’s experience in treating gastric precancerous lesion from ascending and descending of qi movement theory
		WANG Haiqiang1 XIONG Li2 MA Chenxi2 ZHANG Meng2 ZHANG Yang1 ZHENG Lihong3
		DOI: 10.20047/j.issn1673-7210.2023.02.33
		Gastric precancerous lesion is common digestive system diseases. Professor Xie Jingri believes that gastric precancerous lesion is located in the stomach, closely related to spleen, liver, and lung. Qi stagnation and imbalance of ascending and descending are the basis of the disease. The zang-fu viscera and qi movement are abnormal. The main inducements are deficiency, dampness, phlegm, blood stasis, toxin pathogenic factors, qi and blood loss, and imbalance of cold and heat. Therefore, Professor Xie proposes three principles of treatment of gastric precancerous lesion: first, regulate qi and blood to pass up and down; second, balance cold and heat to reconcile yin and yang; third, balance moisture and dryness to restore the rise and fall, according to the quantity of qi and blood, cold and heat to adjust usage and dosage of prescription, it can effectively relieve the clinical symptoms, delay or reverse the pathological changes of gastric atrophy, intestinal metaplasia and dysplasia.
		2023 Vol. 20 (2): 144-147 [Abstract] ( 18 ) HTML (1 KB) PDF (687 KB) ( 107 )

	148	Clinical effect of Qingre Xuanfei Ties in the treatment of recurrent infantile pneumonia
		WU Xinting1 BIAN Weini1▲ ZHENG Lingfang1 MENG Yuancui1 JIA Nan1 CHANG Pan2
		DOI: 10.20047/j.issn1673-7210.2023.02.34
		Objective To study clinical effect of Qingre Xuanfei Ties in the treatment of recurrent infantile pneumonia. Methods One hundred and six infants with recurrent pneumonia in Second Affiliated Hospital of Xian Medical College from January 2016 to June 2021 were selected and divided into conventional group and experimental group according to random number table method, with fifty three cases in each group. The conventional group was treated with conventional western medicine, while the experimental group was treated with Qingre Xuanfei Ties as an assistant of conventional western medicine. Both groups were treated continuously for one week. Clinical effect, Chinese medicine syndrome score, inflammatory factors [interleukin-4 (IL-4), tumor necrosis factor-α (TNF-α), C reactive protein (CRP)], immune function [immunoglobulin (Ig)A, IgM, IgG], adverse reaction and recurrence of two groups were compared. Results Clinical effect of experimental group was better than that of conventional group, with a statistically significant difference (P＜0.05). Before treatment, there was no significant difference in Chinese medicine syndrome scores between two groups (P＞0.05). After treatment, Chinese medicine syndrome scores of two groups were lower than those before treatment, and experimental group was lower than that conventional group, with statistically significant differences (P＜0.05). Before treatment, there were no significant differences in IL-4, TNF-α, and CRP levels between two groups (P＞0.05). After treatment, IL-4, TNF-α, and CRP levels of two groups were lower than those before treatment, and experimental group was lower than that conventional group, with statistically significant differences (P＜0.05). Before treatment, there were no significant differences in the levels of IgA, IgM, and IgG between two groups (P＞0.05). After treatment, the levels of IgA, IgM, and IgG in the two groups were lower than those before treatment, and experimental group was lower than that conventional group, with statistically significant differences (P＜0.05). There were no significant difference between two groups in the incidence of adverse reactions and the recurrence rate (P＞0.05). Conclusion Qingre Xuanfei Ties is effective in the treatment of recurrent infantile pneumonia. It can reduce the score of Chinese medicine syndrome, reduce inflammatory reaction, improve immune function, and has high safety.
		2023 Vol. 20 (2): 148-151,159 [Abstract] ( 20 ) HTML (1 KB) PDF (699 KB) ( 37 )

	152	Discussion on main treatment and concerted application rules of sānyīnjiāo point based on Zhenjiu Dacheng
		ZHOU Hongtu1 ZHOU Yanli2 ZHENG Mingchang1 LIU Jiangtao1 QIAO Lingmin1 LI Wenzhong1 YUAN Shixin1
		DOI: 10.20047/j.issn1673-7210.2023.02.35
		Objective To sort out the literature on the therapeutic effect of sānyīnjiāo point in Zhenjiu Dacheng, and to summarize main treatment and concerted application rules of sānyīnjiāo point. Methods Zhenjiu Dacheng was used as the retrieval source, the search terms included “sānyīnjiāo” and “yīnjiāo”, documents eligible for inclusion were collected according to the combination of electronic computer retrieval and manual retrieval. Main treatment and concerted application rules of sānyīnjiāo point were summarized through the establishment of database and frequency analysis. Results In Zhenjiu Dacheng, there were 138 articles about sānyīnjiāo, and 132 articles that meet the inclusion criteria. In Zhenjiu Dacheng, there were 132 times of diseases treated by sānyīnjiāo, and the main symptoms covered internal medicine, gynecology and surgery of traditional Chinese medicine. Among them, the frequency of application in internal medicine of traditional Chinese medicine was the highest, followed by gynecology of traditional Chinese medicine. There were 64 literatures in Zhenjiu Dacheng on the treatment of internal medicine of traditional Chinese medicine by sānyīnjiāo, mainly covering diseases of the spleen and stomach, kidney, and so on. There were 37 literatures in Zhenjiu Dacheng on the treatment of gynecology of traditional Chinese medicine, mainly covering menstrual diseases and pregnancy diseases. There were 114 acupuncture points used in concerted application with sānyīnjiāo in Zhenjiu Dacheng, and the total frequency of use was 470 times. The top ten matching points were zúsānlǐ, hégǔ, qìhǎi, shènshù, xíngjiān, zhōngjí, guānyuán, tàichōng, yīnlíngquán, and qūchí. And most of the matching points belonged to specific points such as front-mu point, back-shu point, and five-shu point. Conclusion Sānyīnjiāo points are widely used in traditional Chinese medicine diseases, especially good at treating diseases of internal medicine and gynecology of traditional Chinese medicine, and the matching points are commonly used for specific points such as front-mu point, back-shu point, and five-shu point.
		2023 Vol. 20 (2): 152-155 [Abstract] ( 18 ) HTML (1 KB) PDF (756 KB) ( 115 )

	156	Professor Li Peiwen’s experience in the treatment of chemotherapy induced oral mucositis of breast cancer based on “igniting fire and restoring yuan”
		NAN Yunxin1 ZHANG Lei1 CHEN Hongyang1 WAN Donggui2
		DOI: 10.20047/j.issn1673-7210.2023.02.36
		Commonly used chemotherapeutic drugs for breast cancer can often lead to oral mucositis, which seriously affects the quality of life of patients, such as paclitaxel, cyclophosphamide and doxorubicin liposomes and so on. Professor Li Peiwen believes that the fundamental pathogenesis of chemotherapy induced oral mucositis in breast cancer lies in deficiency of kidney yang and yang deficiency leads to water cooling. At the same time, the fire doesn’t warm the soil and the drugs attack, leading to deficiency of spleen yang. Therefore, the treatment should be based on igniting fire and restoring yuan and it is also important to replenish the soil. Qianyang Fengsui Dan or Jingui Shenqi Pills are commonly used to add or subtract. At the same time, Professor Li makes good use of wind medicine to disperse it and cooperates with the special medicine of collecting sores and promoting muscle. The clinical effect is satisfactory.
		2023 Vol. 20 (2): 156-159 [Abstract] ( 57 ) HTML (1 KB) PDF (652 KB) ( 184 )

	160	Effect of progressive evidence-based nursing exercise of affected extremity on rehabilitation of patients after breast cancer surgery
		WANG Yani1 GAO Jiao2▲ CHEN Yan1
		DOI: 10.20047/j.issn1673-7210.2023.02.37
		Objective To analyze the effect of progressive evidence-based nursing exercise of affected extremity on rehabilitation of patients after breast cancer Surgery. Methods A total of 98 patients admitted to the First Affiliated Hospital of the Air Force Military Medical University for breast cancer surgery from January 2019 to June 2020 were selected. They were divided into control group and observation group by random number table method, with 49 cases in each group. The control group adopted the routine nursing, and the observation group was combined with progressive evidence-based nursing on the basis of routine nursing. Posterior shoulder range of motion, upper limb function’ and infection were compared at 24 h and two weeks after surgery between the two groups. Results Two weeks after surgery, the shoulder joint activity and upper limb function scores of the two groups were higher than those at 24 h after surgery, and the observation group was higher than the control group, the differences were statistically significant (P＜0.05). The infection rate of the affected limb in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion Progressive evidence-based nursing exercise of affected extremity can improve the degree of shoulder joint activity and reduce the risk of infection.
		2023 Vol. 20 (2): 160-163,176 [Abstract] ( 18 ) HTML (1 KB) PDF (704 KB) ( 38 )

	164	Effect of PDCA cycle continuation care on foot care knowledge and self-management ability in diabetic foot patients
		XIE Zhenhui ZHU Yuchen▲
		DOI: 10.20047/j.issn1673-7210.2023.02.38
		Objective To analyze the effect of PDCA cycle continuation care on foot care knowledge and self-management ability in diabetic foot patients. Methods A total of 100 diabetic foot patients in the Department of Traditional Chinese Medicine of Liuzhou People’s Hospital of Guangxi Zhuang Autonomous Region from July 2019 to June 2021 were selected as the research objects. According to random number table method, the patients were divided into control group and observation group, with 50 cases in each group. The control group was given continuous care in the conventional way, and the observation group was given PDCA cycle continuation care. Both groups were intervened for six months. The mastery rate of foot care knowledge, mental state, and self-management ability of the two groups were compared. Results The mastery rate of foot care knowledge observation group was higher than that of control group (P＜0.05). After nursing, the anxiety and depression scores of the two groups were lower than those before, and the observation group were lower than those of the control group (P＜0.05). All dimensions and total scores of self-management ability in observation group were higher than those of the control group (P＜0.05). Conclusion PDCA cycle continuation care for diabetic foot patients can make patients proficient in foot care knowledge, relieve negative emotions, improve patients’ self-management ability, and can be promoted.
		2023 Vol. 20 (2): 164-167 [Abstract] ( 19 ) HTML (1 KB) PDF (553 KB) ( 53 )

	168	Effect of synchronous spouse empowerment education on pregnant women at high risk of gestational diabetes mellitus
		WU Saisai1 ZHANG Liqin2▲ ZHANG Haibo3 XU Wanqing4
		DOI: 10.20047/j.issn1673-7210.2023.02.39
		Objective To investigate the effect of synchronous spouse empowerment education on pregnant women at high risk of gestational diabetes mellitus. Methods Objective sampling method was used to select 100 pregnant women with high risk of gestational diabetes from January 2019 to December 2021 in the Ward Three of Obstetrics Department, Nantong Maternal and Child Health Hospital Affiliated to Nantong University, according to random number table method, they were divided into control group and experimental group, with 50 cases in each group. The control group was given routine obstetric health education, on the basis of the control group, the experimental group was given synchronous spouse empowerment education. The incidence of gestational diabetes mellitus, blood glucose level, pregnancy weight, maternal psychological status, and nursing satisfaction were compared between the two groups. Results The incidence of gestational diabetes mellitus in experimental group was lower than that in control group (P＜0.05); there was no significant difference in fasting blood glucose between the two groups (P＞0.05). The blood 1-hour postprandial glucose, and 2-hour postprandial glucose after sugar administration in experimental group were lower than those in control group (P＜0.05); there was no significant difference in pregnancy weight between the two groups (P＞0.05). The scores of anxiety and depression in both groups were lower than before intervention, and the score of anxiety and depression in experimental group were lower than those in control group (P＜0.05). Nursing satisfaction scores of experimental group was higher than that of control group (P＜0.05). Conclusion Synchronous spouse empowerment education for pregnant women at high risk of gestational diabetes can reduce the incidence of gestational diabetes, control the blood sugar level, reduce the negative emotions of anxiety and depression, and improve nursing satisfaction.
		2023 Vol. 20 (2): 168-171 [Abstract] ( 24 ) HTML (1 KB) PDF (530 KB) ( 99 )

	172	Effect of standardized outpatient nursing management on family function of children with asthma
		PENG Jiayun
		DOI: 10.20047/j.issn1673-7210.2023.02.40
		Objective To explore the effect of standardized outpatient nursing management on family function of children with asthma. Methods A total of 86 children with asthma who received intervention in the pediatric respiratory and asthma clinic of Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine from August 2020 to August 2021 were selected as the research objects. The group was divided into control group and observation group by the principle of random allocation of numbers, 43 cases in each group, respectively using routine nursing and standardized outpatient nursing management. Care preparedness scale (CPS), children’s asthma control test (C-ACT), family assessment de-vice (FAD) and child behavioral checklist (CBCL) were compared between the two groups. Results The scores of nursing concept, health knowledge, responsibility, and nursing skills of family caregivers in the observation group were higher than those in the control group, and the differences were statistically significant (P＜0.05). Activity restriction, wheezing symptoms, asthma control, and self-assessment scores in the observation group were higher than those in the control group, and the differences were statistically significant (P＜0.05). The emotional response, problem solving, emotional involvement, family role, communication and behavioral control scores, and total scores in the observation group were lower than those in the control group, and the differences were statistically significant (P＜0.05). After nursing, the psychological and behavioral scores of the two groups were lower than before intervention, while the observation group was lower than the control group, and the differences were statistically significant (P＜0.05). Conclusion For children with asthma, standardized outpatient nursing management can effectively improve the nursing ability and family function of the main family caregivers, effectively control the level of children with asthma, improve the adverse psychological behavior of children, worthy of promotion.
		2023 Vol. 20 (2): 172-176 [Abstract] ( 19 ) HTML (1 KB) PDF (681 KB) ( 49 )

	177	Effects of public account health education combined with cognitive behavioral nursing intervention on health behavior and self-efficacy of patients with coronary heart disease
		XUE Shumin WANG Juan YIN Jiao LIU Sha▲
		DOI: 10.20047/j.issn1673-7210.2023.02.41
		Objective To explore the effects of public account health education combined with cognitive behavioral nursing intervention on health behavior and self-efficacy of patients with coronary heart disease. Methods A total of 130 patients with coronary heart disease admitted to the Department of Cardiovascular Medicine, Tangdu Hospital, Air Force Military Medical University from January 2020 to December 2021 were selected as study object, they were divided into control group and observation group by random number table method, with 65 cases in each group. The control group was treated with routine nursing intervention, and the observation group was treated with public number health education combined with cognitive behavioral nursing intervention on this basis. Compliance rate of health behaviors, general self-efficacy scale (GSES) scores, self-management scores, and disease mastery were compared between the two groups. Results The compliance rates of correct medication, scientific diet, good habits, persistent exercise, and regular review of health behaviors in the observation group were higher than those in the control group (P＜0.05). After two weeks of intervention, GSES scores, and self-management scores in both groups were higher than before intervention, and the observation group was higher than the control group (P＜0.05); the rate of disease knowledge mastery in observation group was higher than that in control group (P＜0.05). Conclusion The application of public health education combined with cognitive behavioral nursing intervention in patients with coronary heart disease can improve patients’ health behavior, enhance patient’ sense of self-efficacy, and enhance patients’ disease cognition degree.
		2023 Vol. 20 (2): 177-180 [Abstract] ( 16 ) HTML (1 KB) PDF (598 KB) ( 60 )

	181	Effect of six-step breast massage nursing combined with low frequency pulse therapy instrument on maternal breast distension and uterine involution
		WEI Chongyang1 CHEN Huiping2 WAN Li1▲
		DOI: 10.20047/j.issn1673-7210.2023.02.42
		Objective To explore the effect of six-step breast massage nursing combined with low frequency pulse therapy instrument on maternal breast distension and uterine involution. Methods A total of 100 parturients who delivered successfully in Nanjing First Hospital, from June 2019 to June 2021 were selected. According to random number table method, the patients were divided into observation group and control group, with 50 cases in each group. The control group received routine nursing, and the observation group received six-step breast massage nursing combined with lowfrequency pulse therapy instrument intervention on the basis of the control group. Both groups were subjected to continuous intervention for three days. The improvement of the degree of breast tenderness, lactation, fundus height, and poor uterine involution were compared between the two groups. Results The improvement of breast tenderness in observation group was better than that in control group (P＜0.05); the first lactation time of the observation group was shorter than that of the control group, and the total lactation volume at 48 h postpartum was higher than that of the control group (P＜0.05); there was no statistical significance in the first measurement of fundus height between the two groups (P＞0.05); the last measurement of fundal height in observation group was lower than that in control group, and the uterine descending index was higher than that in control group (P＜0.05); the incidence of adverse uterine involution in observation group was lower than that in control group (P＜0.05). Conclusion Six-step breast massage nursing combined with low frequency pulse therapy instrument can improve the degree of maternal breast tenderness, promote postpartum lactation, and uterine involution, and the incidence of uterine involution is low.
		2023 Vol. 20 (2): 181-184 [Abstract] ( 23 ) HTML (1 KB) PDF (561 KB) ( 39 )

	185	Risk assessment and management of existing puncture bleeding complications in patients with intravenous thrombolysis and treatment experience in two cases
		ZHOU Ting1 LIU Li2 TANG Ge1 LIU Shudong1 SHI Haiyang1 ZHAO Libo1 ZHANG Lili3 YANG Deyu1
		DOI: 10.20047/j.issn1673-7210.2023.02.43
		For patients with acute cerebral infarction with easily compressible arterial puncture points, how to prevent complications of puncture point bleeding before intravenous thrombolysis is not elaborated in the current guidelines, and relevant reports are rare. This article reported the two patients with acute cerebral infarction with existing puncture sites were treated pass with intravenous thrombolysis. In case one, right radial artery puncture was performed one week before intravenous thrombolysis, and left radial artery puncture was performed two hours before thrombolysis, after intravenous thrombolysis, subcutaneous hematoma was found at both radial artery puncture sites, and false aneurysm was complicated at the right radial artery puncture site. After comprehensive treatment, such as fresh frozen plasma infusion, cryoprecipitate, elastic bandage, and compression of the radial artery, bleeding complications at the artery puncture site were controlled. In case two, right radial artery puncture was performed 26 hours before intravenous thrombolysis, and the radial artery puncture site was compressed by a compressor before intravenous thrombolysis, and no bleeding complications occurred at the puncture site. Although it is not contraindicated to perform intravenous thrombolysis within the last one week, patients should be assessed for the risk of complications from bleeding at the puncture site after receiving intravenous thrombolysis. For patients at higher risk, compression of the puncture site before thrombolysis may be considered to prevent complications of puncture site bleeding.
		2023 Vol. 20 (2): 185-188 [Abstract] ( 17 ) HTML (1 KB) PDF (869 KB) ( 117 )

	189	Application of flexible budget method in budget preparation of public hospitals
		WANG Qi MA Shiyuan MA Liya
		DOI: 10.20047/j.issn1673-7210.2023.02.44
		Effective budget preparation is a key factor in rational allocation of hospital resources. At present, there are problems such as insufficient coverage and insufficient matching with actual medical business in the budget preparation of public hospitals. This paper analyzes the applicability of the flexible budget method. Based on the concept of “business-finance integration”, the hospital budget goals are determined through overall planning, fixed and variable costs are divided, flexible quota standards are formulated and regularly updated, and paths such as information-based data centers are established to integrate flexible budgets. The budget law is reasonably applied to hospital budgeting. The study found that the scientific flexible budgeting method can intuitively reflect the supply and demand of various resources in hospital operation and the efficiency of use, especially the advantages of quantifying and reflecting the hospital budget, which can facilitate the hospital to use a more optimized plan to allocate resources, and ultimately achieve efficient hospitalization. Overall strategic plan.
		2023 Vol. 20 (2): 189-191,196 [Abstract] ( 22 ) HTML (1 KB) PDF (584 KB) ( 51 )

	192	Discussion on resilience governance mechanism of modern hospital disaster prevention and mitigation emergency system
		JIANG Shuai
		DOI: 10.20047/j.issn1673-7210.2023.02.45
		Resilience governance is an important part of the emergency management of modern hospitals responding to sudden disasters. Combined with the resilience response time and functional recovery of hospitals, the key problems faced by hospitals under the impact of sudden disasters were analyzed. Those problems were the imperfect hospital management system and emergency plan, the insufficient hospital emergency team and funds and materials, and the unreasonable layout of hospital building facilities and equipment. Furthermore, five dimensions of modern hospital resilience governance framework are proposed, which are the unified leadership and coordination management mechanism, building mechanism for disaster emergency response team, material reserve and capital investment mechanism, emergency facilities and equipment guarantee mechanism, intelligent information monitoring, and early warning mechanism. Under the role of resilience governance, hospitals are encouraged to quickly recover and maintain their functions, and ensure the normal development of medical services.
		2023 Vol. 20 (2): 192-196 [Abstract] ( 30 ) HTML (1 KB) PDF (964 KB) ( 139 )

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