|
|
|
| Analysis of Professor Zhu Shengliang’s prescription and medication rules for gastroesophageal reflux disease based on data mining |
| ZHANG Nan1 CHENG Yanmei1 WANG Lei2 LI Yang1 ZHU Shengliang1 |
1.Department of Gastroenterology, Yueyang Hospital of Integrated Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China;
2.Department of Endocrinology, Shanghai Putuo District People’s Hospital, Shanghai 200060, China |
|
|
|
Abstract To analyze the Professor Zhu Shengliang’s prescription and medication rules for gastroesophageal reflux disease based on data mining. Methods The effective first-diagnostic prescriptions of Professor Zhu Shengliang in the Gastroesophageal Reflux Disease Specialist Clinic, Yueyang Hospital of Integrated Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine from January 2011 to December 2021 was collected. The Traditional Chinese Medicine Inheritance Assistance Platform (V2.5) software was used to analyze the four nature of drugs and five flavours, the effect of channel tropism and the prescription and medication rules based on frequency analysis, association rules, improved mutual information method, and complex system entropy clustering algorithm, and to carry out visualization processing. Results A total of 354 effective prescriptions were included, involving 110 traditional Chinese medicines and 22 high-frequency drugs (≥90 times). The prescription drugs were mainly warm, cold, plain as a supplement; the five flavours were mainly bitter, pungent, and sweet. The channel tropism was mainly spleen, stomach, and liver channels. Traditional Chinese medicine syndrome differentiation included syndrome of heat stagnation in liver and stomach, syndrome of middle-deficiency and reversed flow of qi, syndrome of phlegm qi depression and blockade, etc. A total of 15 core Chinese medicines, 14 core combinations, 7 new prescriptions. Conclusion Professor Zhu Shengliang pays attention to regulating qi in the treatment of gastroesophageal reflux disease. He often uses the methods of invigorating the spleen and dispersing the stagnated liver-energy, relieving the gastric disorder and purgative, clearing heat and dissipating phlegm, nourishing yin and relieving pain, which can provide reference for the treatment of gastroesophageal reflux disease with traditional Chinese medicine.
|
|
|
|
|
|
[1] El-Serag HB，Sweet S，Winchester CC，et al. Update on the epidemiology of gastro-oesophageal reflux disease：a systematic review [J]. Gut，2014，63（6）：871-880.
[2] Fock KM，Talley N，Goh KL，et al. Asia-Pacific consensus on the management of gastro-oesophageal reflux disease：an update focusing on refractory reflux disease and Barrett’s oesophagus [J]. Gut，2016，65（9）：1402-1415.
[3] 周金池，窦维佳，魏延，等.中国胃食管反流病患者焦虑抑郁患病率的Meta分析[J].中国全科医学，2021，24（5）：608-613.
[4] El-Serag H，Becher A，Jones R. Systematic review：persistent reflux symptoms on proton pump inhibitor therapy in primary care and community studies [J]. Aliment Pharmacol Ther，2010，32（6）：720-737.
[5] Reveles KR，Ryan CN，Chan L，et al. Proton pump inhibitor use associated with changes in gut microbiota composition [J]. Gut，2018，67（7）：1369-1370.
[6] Niu XP，Yu BP，Wang YD，et al. Risk factors for proton pump inhibitor refractoriness in Chinese patients with non-erosive reflux disease [J]. World J Gastroenterol，2013，19（20）：3124- 3129.
[7] 张泰，张北华，马祥雪，等.中西医结合治疗难治性胃食管反流病的优势[J].中国中西医结合杂志，2022，28（6）：1-8.
[8] 吕素，曹珊，李俊玲.中西医结合治疗胃食管反流复发率的Meta分析[J].中医学报，2022，37（5）：1120-1125.
[9] 中华医学会消化病学分会.2020年中国胃食管反流病专家共识[J].中华消化杂志，2020，40（10）：649-663.
[10] 张声生，朱生樑，王宏伟，等.胃食管反流病中医诊疗专家共识意见（2017）[J].中国中西医结合消化杂志，2017， 25（5）：321-326.
[11] 国家药典委员会.中华人民共和国药典[S].一部.北京：中国医药科技出版社，2020.
[12] 南京中医药大学.中药大辞典[M].2版.上海：上海科学技术出版社，2014.
[13] 国家中医药管理局《中华本草》编委会.中华本草[M].上海：上海科学技术出版社，1999.
[14] 钟赣生.中药学[S].北京：中国中医药出版社，2016.
[15] 张恒，张葆青.基于数据挖掘的中医药临床研究述评[J].中华中医药杂志，2020，35（11）：5378-5383.
[16] 马源，林雪宇，李剑，等.张仲景经方中生姜量效关系探讨[J].中国医药导报，2021，18（22）：137-140，144.
[17] 张金兰，李鲲，岳亚鹏，等.从《伤寒论》参草枣姜架构探析张仲景顾护脾胃思想[J].湖北中医杂志，2022，44（1）：40-42.
[18] 胡雪雨，王彦志，朱跃通，等.生姜止呕作用有效部位及其化学成分研究[J].中国新药杂志，2022，31（9）：893- 900.
[19] 刘怡妙，凌悦，徐旭，等.生姜的研究进展及其质量标志物的预测分析[J].中草药，2022，53（9）：2912-2928.
[20] Salah Khalil M. The postulated mechanism of the protective effect of ginger on the aspirin induced gastric ulcer：Histological and immunohistochemical studies [J]. Histol Hist- opathol，2015，30（7）：855-864.
[21] 朱丽，聂炜珏，孙志广.“辛开苦降方”的现代研究进展[J].中国中医基础医学杂志，2021，27（9）：1522-1524，1531.
[22] 徐景新，陈宏慈.中医药治疗肝胃不和型胃食管反流病的用药规律研究[J].中国医药导报，2021，18（26）：152- 156.
[23] 范青峰，杨小军.杨小军教授治疗功能性烧心经验[J].中国医药科学，2021，11（9）：51-54，86.
[24] 郑艺君，史中斐，吕咪，等.基于“三焦气化”论治胃食管反流病经验[J].北京中医药，2022，41（5）：524-527.
[25] 崔玉容，国嵩，刘倩，等.基于“滞、郁、瘀、虚”疾病观论治胃食管反流病[J].中国中西医结合消化杂志，2022， 30（3）：236-239.
[26] 苏坤涵，刘万里.从“凡十一脏取决于胆”论治胃食管反流病[J].中医学报，2022，37（7）：1390-1394.
[27] 杨楚琪，崔言坤，吴含章，等.从开阖枢论提壶揭盖法之调畅气机[J].中华中医药杂志，2022，37（5）：2436-2439. |
|
|
|
