自噬相关蛋白Beclin1在食管鳞癌中表达特点及临床意义的meta分析

doi:10.20047/j.issn1673-7210.2023.02.22

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Abstract Objective To systematically evaluate the expression characteristics and clinical significance of autophagy related protein Beclin1 in esophageal squamous cell carcinoma (ESCC). Methods The literatures of expression characteristics of Beclin1 in ESCC and its relationship with clinicopathological features were searched by computer from the inception to December 2021 in PubMed, Web of Science, CNKI, Wanfang Data, and VIP. Meta-analysis was performed by RevMan 5.4. Results A total of 13 literatures were included, including 1 080 ESCC patients. The results of meta-analysis showed that Beclin1 expression in ESCC group was lower than that in control group (OR=0.09, 95%CI: 0.05-0.17, P＜0.000 01). Beclin1 expression in highly and moderately differentiated ESCC patients was higher than that in poorly differentiated ESCC patients (OR=2.01, 95%CI: 1.49-2.72, P＜0.000 01). Beclin1 expression in ESCC patients with TNM stage Ⅰ-Ⅱ was higher than that in patients with stage Ⅲ-Ⅳ (OR=2.78, 95%CI: 1.76-4.41, P＜0.000 1). Beclin1 expression in ESCC patients with infiltration depth from T1-T2 was higher than that in T3-T4 patients (OR=2.16, 95%CI: 1.58-2.97, P＜0.000 01). Beclin1 expression in ESCC patients without lymph node metastasis was higher than that in patients with lymph node metastasis (OR=0.26, 95%CI: 0.14-0.49, P＜0.000 1). Conclusion Beclin1 expression is closely related to the clinicopathological features of ESCC, and Beclin1 may be an important target involved in the occurrence and development of ESCC.

Key words： Autophagy Beclin1 Esophageal squamous cell cancer Meta-analysis

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	FAN Xiangrong1 ZHAO Hang1 WU Hongyang1 XU Shaoqing1 FAN Huanfang2

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FAN Xiangrong1 ZHAO Hang1 WU Hongyang1 XU Shaoqing1 FAN Huanfang2. Meta-analysis of the expression characteristics and clinical significance of autophagy related protein Beclin1 in esophageal squamous cell carcinoma[J]. 中国医药导报, 2023, 20(2): 97-100.

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https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2023.02.22 OR https://www.yiyaodaobao.com.cn/EN/Y2023/V20/I2/97

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