|
|
Research progress on natural antioxidants in the treatment of oxidative stress injury of testis in diabetes mellitus |
WAN Qianfan1 YANG Dan2#br# |
1.School of Clinical Medicine, Guizhou Medical University, Guizhou Province, Guiyang 550004, China;
2.Surgical Teaching and Research Section, Guizhou Medical University, Guizhou Province, Guiyang 550004, China |
|
|
Abstract Diabetes mellitus is becoming a severe global public health concern, with an annual increase in incidence and a younger trend. Long-term hyperglycemia in diabetic mellitus individuals can quickly lead to organ and system malfunction. Male diabetes mellitus exhibit a clear spermatogenesis problem, and their sexual and reproductive abilities are considerably reduced. Several natural antioxidants have been found in studies to protect oxidative stress injury of testis in diabetes mellitus. This article reviews the research progress of natural antioxidants in the treatment of diabetic men’s testicular oxidative stress injury caused by diabetes mellitus in order to provide a theoretical basis for natural antioxidants in the treatment of diabetic men’s testicular injury, as well as a reference and support for the development of new drugs.
|
|
|
|
|
[1] 杨文英.中国糖尿病的流行特点及变化趋势[J].中国科学:生命科学,2018,48(8):812-819.
[2] Liu D,Li Y,Qian Y,et al. Synergistic antioxidant performance of lignin and quercetin mixtures [J]. ACS Sustain Chem Eng,2017,5(9):8424-8428.
[3] Dias IH,Griffiths HR. Oxidative stress in diabetes-circulating advanced glycation end products,lipid oxidation and vascular disease [J]. Ann Clin Biochem,2014,51(2):125- 127.
[4] Tramarin A,Naldi M,Degani G,et al. Unveiling the molecular mechanisms underpinning biorecognition of early-glycated human serum albumin and receptor for advanced glycation end products [J]. Anal Bioanal Chem,2020,412(18):4245-4259.
[5] San-Martin A,Foncea R,Leighton F,et al. Nox1-based NADPH oxidase-derived superoxide is required for VSMC activation by advanced glycation end-products [J]. Free Radic Biol Med,2007,42(11):1671-1679.
[6] Mangoli E,Talebi AR,Anvari M,et al. Effects of experimentally-induced diabetes on sperm parameters and chromatin quality in mice [J]. Iran J Reprod Med,2013,11(1):53-60.
[7] Skurikhin EG,Pakhomova AV,Pershina OV,et al. Role of sertoli and Leydig cells in the regulation of spermatogonial stem cell and development of reproductive disorders in male C57Bl/6 mice with type 1 diabetes mellitus [J]. Bull Exp Biol Med,2017,164(2):127-131.
[8] Zhao YT,Qi YW,Hu CY,et al. Advanced glycation end products inhibit testosterone secretion by rat Leydig cells by inducing oxidative stress and endoplasmic reticulum stress [J]. Int J Mol Med,2016,38(2):659-665.
[9] Omolaoye TS,du Plessis SS. Male infertility:a proximate look at the advanced glycation end products [J]. Reprod Toxicol,2020,93:169-177.
[10] Nowotny K,Jung T,H?觟hn A,et al. Advanced glycation end products and oxidative stress in type 2 diabetes mellitus [J]. Biomolecules,2015,5(1):194-222.
[11] Corrêa LBNS,da Costa CAS,Ribas JAS,et al. Antioxidant action of alpha lipoic acid on the testis and epididymis of diabetic rats:morphological,sperm and immunohistochemical evaluation [J]. Int Braz J Urol,2019,45(4):815-824.
[12] Haghighian HK,Haidari F,Mohammadi-Asl J,et al. Randomized,triple-blind,placebo-controlled clinical trial examining the effects of alpha-lipoic acid supplement on the spermatogram and seminal oxidative stress in infertile men [J]. Fertil Steril,2015,104(2):318-324.
[13] Theodosis-Nobelos P,Papagiouvannis G,Tziona P,et al. Lipoic acid. Kinetics and pluripotent biological properties and derivatives [J]. Mol Biol Rep,2021,48(9):6539-6550.
[14] Talebi AR,Mangoli E,Nahangi H,et al. Vitamin C attenuates detrimental effects of diabetes mellitus on sperm parameters,chromatin quality and rate of apoptosis in mice [J]. Eur J Obstet Gynecol Reprod Biol,2014,181:32-36.
[15] Shrilatha B,Muralidhara. Early oxidative stress in testis and epididymal sperm in streptozotocin-induced diabetic mice:its progression and genotoxic consequences [J]. Reprod Toxicol,2007,23(4):578-587.
[16] Ayoubi A,Vaizadeh R,Omidi A,et al. Protective effects of vitamin C (ascorbic acid) in lead acetate exposed diabetic male rats:evaluation of blood biochemical parameters and testicular histopathology [J]. ■stanbul ■niversitesi Veteriner Fakültesi Dergisi,2015,41(1):84-91.
[17] 周清.维生素C改善TNF-α诱导的胰岛素抵抗的作用及其机制研究[D].杭州:浙江大学,2018.
[18] 丁丽娜,王志斌,王瑶,等.维生素C防治2型糖尿病研究进展[J].食品工业科技,2021,42(15):372-376.
[19] Sadoughi D,Edalatmanesh MA,Rahbarian R. Protective effect of curcumin on quality parameters of sperm and testicular tissue alterations in alloxan-induced diabetic rats as animal model [J]. Indonesian Biomed J,2019,11(3):240- 246.
[20] Khimmaktong W,Komolkriengkrai M,Boonyoung P,et al. Effects of curcumin on testis microvascular complication in streptozotocin-induced diabetes rats [J]. Funct Foods Health Dis,2019,9(1):34-51.
[21] Belhan S,Y?覦ld?覦r?覦m S,Huyut Z,et al. Effects of curcumin on sperm quality,lipid profile,antioxidant activity and histopathological changes in streptozotocin-induced diabetes in rats [J]. Andrologia,2020,52(6):e13584.
[22] Kocaadam B,■anlier N. Curcumin,an active component of turmeric (Curcuma longa),and its effects on health [J]. Crit Rev Food Sci Nutr,2017,57(13):2889-2895.
[23] 徐菲菲,缪成锋,池琛,等.姜黄素及其类似物J7对2型糖尿病大鼠睾丸氧化应激损伤的干预作用[J].中国应用生理学杂志,2019,35(2):145-149.
[24] 白鹭,李鸿,覃琴,等.黄酮类化合物对血管内皮细胞损伤的保护作用及机制研究进展[J].中国实验方剂学杂志,2020,26(12):203-211.
[25] 龙玲莉,郑淑慧,李宇彬.灯盏花素干预糖尿病模型大鼠睾丸组织增殖细胞核抗原和c-fos的表达[J].中国组织工程研究,2015,19(18):2917-2922.
[26] 赵雯,胡玥,龙玲莉,等.灯盏花素保护2型糖尿病大鼠睾丸损伤的机制研究[J].中山大学学报(医学科学版),2020,41(2):260-267.
[27] Roshankhah S,Jalili C,Salahshoor MR. Effects of crocin on sperm parameters and seminiferous tubules in diabetic rats [J]. Adv Biomed Res,2019,8(1):4.
[28] Hasanpour M,Ashrafi M,Erjaee H,et al. The effect of saffron aqueous extract on oxidative stress parameters and important biochemical enzymes in the testis of streptozotocin-induced diabetic rats [J]. Physiol Pharmacol,2018, 22(1):28-37.
[29] 王立哲,王振贤,马晓伟.藏红花素对糖尿病所致睾丸组织损伤保护作用的研究[J].天津中医药,2019,36(5):491-494.
[30] 谢圆媛,杨丹芬,王莉.藏红花素通过PGC-1α/SIRT3信号通路抑制慢性阻塞性肺疾病模型大鼠的气道炎症[J].临床肺科杂志,2020,25(11):1648-1654.
[31] 刘柏林.藏红花素对人胰腺癌HPAC细胞凋亡的影响[J].中国现代医药杂志,2016,18(7):6-9.
[32] 万强,罗辉.山楂叶总黄酮对糖尿病大鼠睾丸损伤的保护作用[J].现代中西医结合杂志,2013,22(35):3889- 3890.
[33] 王翀,马小茹,宋明明,等.山楂总黄酮对糖尿病大鼠睾丸保护作用及其对PCNA表达的影响[J].牡丹江医学院学报,2014,35(4):1-4.
[34] 覃春美,李刚,程宗华,等.山楂叶总黄酮调控肾组织p38MAPK信号通路干预糖尿病肾病大鼠氧化应激损伤的实验研究[J].检验医学与临床,2019,16(21):3131- 3134.
[35] 孙涛,邓婷,秦涛,等.山楂叶黄酮通过Nrf-2/ARE信号通路对H2O2诱导PC12细胞氧化应激损伤的保护作用研究[J].中药药理与临床,2021,37(4):47-55.
[36] 李玲,江美芳,王丹丹,等.银杏叶双黄酮化学成分及药理学研究进展[J].上海中医药大学学报,2022,36(2):101-108.
[37] 徐秋玲,孙卫,郑学芝,等.银杏叶提取物对糖尿病大鼠睾丸和附睾组织自由基和抗氧化水平的影响[J].中国全科医学,2009,12(2):114-116.
[38] 吴晓烨,王文艳,王蓉蓉,等.银杏叶提取物对2型糖尿病大鼠睾丸间质细胞雄激素合成的影响[J].中华男科学杂志,2008,14(4):371-376.
[39] García-Martínez BI,Ruiz-Ramos M,Pedraza-Chaverri J,et al. Hypoglycemic effect of resveratrol:a systematic review and meta-analysis [J]. Antioxidants,2021,10(1):69.
[40] Xu S,Gao Y,Zhang Q,et al. SIRT1/3 activation by resveratrol attenuates acute kidney injury in a septic rat model [J]. Oxid Med Cell Longev,2016,2016:7296092.
[41] 杜兆金,邹淑花.白藜芦醇对2型糖尿病大鼠睾丸PCNA、SOD表达及生精功能影响[J].辽宁中医药大学学报,2017,19(12):52-55.
[42] Bahmanzadeh M,Goodarzi MT,Rezaei Farimani A,et al. Resveratrol supplementation improves DNA integrity and sperm parameters in streptozotocin-nicotinamide-induced type 2 diabetic rats [J]. Andrologia,2019,51(8):e13313.
[43] 刘英姿,刘浩然,周源,等.山茱萸总皂苷对糖尿病大鼠睾丸病变的改善作用[J].中国现代医学杂志,2012,22(22):10-13.
[44] 许惠琴,郝海平,皮文霞,等.山茱萸环烯醚萜总苷对糖尿病大鼠肾皮质糖化终产物及其受体mRNA表达的影响[J].中药药理与临床,2003,19(4):9-12.
[45] 武向丽.黄芪甲苷对实验性糖尿病大鼠睾丸组织的保护作用[J].西部中医药,2017,30(11):32-36. |
|
|
|