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Predictive value of DRAGON score on clinical outcome of bridging therapy in patients with serial occlusion of tandem internal carotid artery and middle cerebral artery |
WU Feifei TANG Wuzhuang WANG Liangliang▲ |
Department of Neurology, Yixing Hospital Affiliated to Jiangsu University, Jiangsu Province, Yixing 214200, China |
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Abstract Objective To study the predictive value of DRAGON score on clinical outcome of bridging therapy in patients with serial occlusion of internal carotid artery and middle cerebral artery (TIM). Methods A total of 96 occlusion of TIM patients underwent bridging therapy in Yixing Hospital Affiliated to Jiangsu University from January 2018 to December 2021 were selected and divided into good prognosis group (0-2 points, 57 cases) and poor prognosis group (3-6 points, 39 cases) according to the modified Rankin scale score at three months after treatment. The differences of the general data and DRAGON score between the two groups were compared. The influencing factors of the prognosis of occlusion of TIM patients were analyzed by logistic regression. The predictive value of DRAGON score was evaluated by receiver operator characteristic (ROC) curve. Results The proportion of American Society for Interventional and Therapeutic Neuroradiology (ASITN) grade 0-2, proportion of modified thrombolysis in cerebral infarction (mTICI) grade 0-2a, and DRAGON score in the poor prognosis group were higher than those in the good prognosis group (P<0.05). The results of multivariate analysis showed that ASITN grade (OR=4.697, 95%CI: 2.044-10.796), mTICI grade (OR=3.904, 95%CI: 1.699-8.972), DRAGON score (OR=4.166, 95%CI: 1.813-9.575) were prognostic factors of patients with occlusion of TIM after bridging therapy (P<0.05). The area under the ROC curve of DRAGON score was 0.865 (P<0.05). Conclusion DRAGON score is an important factor affecting the prognosis of bridging therapy in patients with occlusion of TIM, and has a certain predictive value for the prognosis.
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