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| Diagnostic value of grip strength for the nutritional risk of patients with nasopharyngeal carcinoma with concurrent radiotherapy and chemotherapy |
| WEI Jiejing1* LU Ting2* YING Yanping3 LING Ying3 HUANG Biaojin1 |
1.Department of Oncology, the First Affiliated Hospital of Guangxi Medical University, Guangxi Zhuang Autonomous Region, Nanning 530021, China;
2.Day Chemotherapy Center, the First Affiliated Hospital of Guangxi Medical University, Guangxi Zhuang Autonomous Region, Nanning 530021, China; 3.Department of Nursing, the First Affiliated Hospital of Guangxi Medical University, Guangxi Zhuang Autonomous Region, Nanning 530021, China |
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Abstract Objective To explore the diagnostic value of grip strength in nutritional risk assessment in patients with nasopharyngeal carcinoma undergoing concurrent radiotherapy and chemoradiotherapy. Method A total of 158 patients with nasopharyngeal carcinoma who were hospitalized in the Department of Oncology, the First Affiliated Hospital of Guangxi Medical University from September 2019 to December 2020 were selected. General data, disease-related data, blood indicators, grip strength, and nutritional risk scores were collected. Patients were grouped by nutritional risk screening 2022 (NRS2002), patients with NRS2002 scores ≥3 points were classified into the nutritional risk group (65 cases), and those with NRS2002 < 3 points were classified into the non-nutritional risk group (93 cases). Nutritional risk factors in patients with simultaneous chemoradiotherapy for nasopharyngeal carcinoma were analyzed by logistic regression. The grip strength of patients with nasopharyngeal carcinoma was divided into five groups. From small to large, they were divided into the lowest level group 1 (≤22.60 kg), the low level group 2 (＞22.60 to 28.70 kg), the medium level group 3 (＞28.70 to 33.70 kg), the high level group 4 (＞33.70 to 38.90 kg) and the highest level group 5 (＞38.90 kg). Trend test was used to analyze the relationship between grip strength and nutritional risk, and receiver operating characteristic (ROC) curve was used to determine the critical value of nutritional risk in patients with simultaneous chemoradiotherapy of nasopharyngeal carcinoma. Results There were statistically significant differences in gender, arm circumference, calf circumference, height, body weight, body mass index, hemoglobin, albumin, prealbumin, creatinine, and grip strength between the two groups (P＜0.05). The results of multivariate analysis showed that creatinine and grip strength were the factors affecting nutritional risk in nasopharyngeal carcinoma patients (P＜0.05). From the high level of grip strength to the low level of grip strength group, the nutritional risk of patients showed an upward trend with the decrease of grip strength. The area under ROC curve of grip strength predicting nutritional risk in patients with concurrent radiotherapy and chemotherapy of nasopharyngeal cancer was ＞0.5. The presence of nutritional risk could be judged when the grip strength of male was <32.0 kg and that of female was <20.2 kg. Conclusion Grip strength can be used as a screening index for nutritional risk in patients with nasopharyngeal carcinoma undergoing concurrent chemoradiotherapy.
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