基于数据挖掘探讨周彩云教授从“湿毒”立论辨治急性痛风性关节炎的用药规律

doi:10.20047/j.issn1673-7210.2023.02.29

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Abstract Objective To analyze the medication rule of Professor Zhou Caiyun in the treatment of acute gouty arthritis based on data mining software Traditional Chinese Medicine Inheritance Assistance Platform (V2.5) and Cytoscape 3.7.2. Methods Data of patients with acute gouty arthritis treated by Professor Zhou Caiyun in the outpatient department of Xiyuan Hospital, China Academy of Chinese Medical Sciences from September, 2019 to December, 2021 were collected. Using association rules and complex system entropy clustering method, data mining and network visualization analysis were carried out to summarize the frequency, channel tropism, nature, flavour, and couplet medicines combination of traditional Chinese medicine, explore the core prescription, and explore the medication rule. Results A total of 77 traditional Chinese medicines were included in 130 prescriptions, among which the most frequently used medicines were Puerariae Lobatae Radix, Portulacae Herba, Lysimachiae Herba, Dioscoreae Spongiosae Rhizoma, Siegesbeckiae Herba, Plantaginis Herba, Lygodii Spora, Plantaginis Semen, Lonicerae Japonicae Flos, Phellodendri Chinensis Cortex, and Benincasae Exocarpium. The four nature of drugs were mainly cold, the five flavours were mainly sweet, and the channel tropism was mainly liver and kidney channels. The drug combinations with high frequency were Puerariae Lobatae Radix and Portulacae Herba; Puerariae Lobatae Radix, Portulacae Herba, and Lysimachiae Herba, etc. Four new prescriptions were dug, which were Fritillariae Thunbergii Bulbus, Benincasae Exocarpium, Sepiae Endoconcha, Carthami Flos, and Chrysanthemi Flos; Artemisiae Scopariae Herba, Stir-Atractylodis Macrocephalae Rhizoma, Abri Herba, and Curcumae Radix; Lysimachiae Herba, Achyranthis Bidentatae Radix, Astragali Radix, Dendrobii Caulis, and Polygalae Radix; Stephaniae Tetrandrae Radix, Polyporus, Clematidis Radix Et Rhizoma, corn beard, and Rehmanniae Radix. Conclusion Professor Zhou Caiyun’s treatment of acute gout arthritis is based on the theory of “dampness toxin”. The main treatment methods are clearing heat and promoting diuresis, detoxifying for removing obstruction in collaterals, and tonifying liver and kidney as well as nourishing spleen and stomach.

Key words： Gout Dampness toxin Data mining Medication rule Zhou Caiyun

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	CHEN Yifan ZHOU Caiyun WANG Xin

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CHEN Yifan ZHOU Caiyun WANG Xin. Medication rule of Professor Zhou Caiyun in the treatment of acute gouty arthritis from the viewpoint of “dampness toxin” based on data mining[J]. 中国医药导报, 2023, 20(2): 126-129,134.

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https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2023.02.29 OR https://www.yiyaodaobao.com.cn/EN/Y2023/V20/I2/126

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