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2022 Vol. 19, No. 26 Published: 2022-09-15

	5	Exploration and discussion on the clinical medication rules of traditional Chinese medicine in the treatment of tension-type headache based on data mining
		WANG Qing LIU Meisi SHI Bowen WANG Yuyao ZHAO Shibo WANG Liwei ZHAO Yonglie
		DOI: 10.20047/j.issn1673-7210.2022.26.01
		Objective To explore and discuss the clinical medication rules of traditional Chinese medicine in the treatment of tension-type headache. Methods The prescriptions of traditional Chinese medicine in the treatment of tension-type headache were retrieved and sorted from CNKI, Wanfang Data, VIP, China Biomedical Literature Service System, and PubMed. The retrieval time was from inception to January 2021. Excel 2013, SPSS Statistics 26.0, and SPSS Modeler 18.0 were used for analysis with the observation indexes of medication frequency, efficacy classification, nature and flavour, channel tropism, cluster analysis and association rules. Results A total of 157 prescriptions were included, containing 175 traditional Chinese medicines. There were 35 kinds of traditional Chinese medicine with medication frequency ≥15, most of which were Chuanxiong Rhizoma, Paeoniae Radix Alba, Glycyrrhizae Radix Et Rhizoma, Bupleuri Radix, Angelicae Sinensis Radix and Angelicae Dahuricae Radix. Their medicinal properties were mainly warm, cold, and calm, flavours were mainly pungent, sweet, and bitter, channel tropism were mainly liver, lung, and spleen channels. Most of the drugs were relieving superficies medicines. The system cluster analysis was divided into four groups of drug combinations, and 16 drug combinations with high support were found by association rule analysis. Conclusion The overall therapeutic principles of traditional Chinese medicine in the treatment of tension-type headache to dispel pathogenic wind and relieve pain, promote blood circulation for removing obstruction in collaterals, disperse stagnated liver qi and suppress hyperactive liver, invigorate spleen for resolving masses. Its medication regularity can provide reference for clinical treatment and new drug research and development.
		2022 Vol. 19 (26): 5-8,23 [Abstract] ( 23 ) HTML (1 KB) PDF (2022 KB) ( 94 )

	9	Role of ferroptosis gene and related long non-coding RNA in hepatocellular carcinoma occurrence and prognosis
		YAO Yuanqian1 LYU Jianlin2 LIU Linlin1 WANG Guangyao2
		DOI: 10.20047/j.issn1673-7210.2022.26.02
		Objective To investigate the mechanism of ferroptosis in hepatocellular carcinoma and the prognostic value of long non-coding RNA (lncRNA). Methods Hepatocellular carcinoma transcriptome data were downloaded from TCGA database, ferroptosis differential genes were screened and enriched analyzed; lncRNA associated with ferroptosis was obtained by correlation test; Cox regression analysis was used to construct a prognostic model. According to the risk scoring formula, the risk scores were calculated, and the patients with liver cancer were divided into high, low risk groups, and survival analysis and immune differential analysis were performed. Results Eighty-four ferroptosis differential genes were selected. Enrichment analysis showed correlation with mTOR metabolism, glycolysis, and γ interferon respond, and 17 ferroptosis lncRNAs were included to construct a prognostic model. The prognosis of low-risk group was better than that of high-risk group (P < 0.01); receiver operating characteristic curve showed that the model had good predictive ability. The analysis of immune microenvironment revealed that a variety of immune cells had different infiltration, and 17 immune checkpoints with different expression were identified. Conclusion Both ferroptosis genes and related lncRNAs play important regulatory roles in liver cancer, and the changes of immune microenvironment are also potential targets for liver cancer treatment.
		2022 Vol. 19 (26): 9-14 [Abstract] ( 24 ) HTML (1 KB) PDF (4167 KB) ( 238 )

	15	Construction and validation of a nomogram prediction model for the risk of constipation in patients with coronary heart disease after percutaneous coronary intervention
		WEN Fangfang1 DU Haiwei2 GUO Xiaolan1 XI Xiaoli1 HU Jianqiang1 CHENG Miaomiao1▲
		DOI: 10.20047/j.issn1673-7210.2022.26.03
		Objective To construct a nomogram prediction model for the risk of constipation in patients with coronary heart disease after percutaneous coronary intervention, and to conduct internal verification. Methods The clinical data of 398 patients with coronary heart disease who underwent percutaneous coronary intervention in the Department of Cardiology, the Second Affiliated Hospital of Air Force Military Medical University from January 2019 to December 2020 were collected retrospectively. The patients were divided into normal defecation group (262 cases) and constipation group (136 cases) according to whether constipation occurred. The differences of clinical data between the two groups were compared, and the influencing factors of constipation were screened by logistic regression model. R 3.4.3 software was used to construct a nomogram prediction model for the risk of constipation in patients with coronary heart disease after percutaneous coronary intervention, and the Bootstrap method and Hosmer-Lemeshow goodness-of-fit test were used to verify the model internally. Receiver operating characteristic (ROC) curve was used to analyze the diagnostic value of the model. Results In the constipation group, the proportions of age > 60 years, Killip grade Ⅲ-Ⅳ, opioid use after surgery, number of stents implanted > 3, anxiety/depression, diabetes mellitus, and smoking history were higher than those in the normal defecation group, and the proportion of regular exercise was lower than that in the normal defecation group, and the differences were statistically significant (P ＜ 0.05). Logistic regression analysis showed that age > 60 years old, Killip grade Ⅲ-Ⅳ, opioid use after surgery, anxiety/depression, and diabetes mellitus were independent risk factors for constipation after percutaneous coronary intervention (OR = 2.945, 4.859, 3.624, 3.082, 2.770, P ＜ 0.05), regular exercise was a protective factor (OR = 0.447, P ＜ 0.05). The internal validation results of the nomogram prediction model showed that the observed curve was basically consistent with the acceptable curve and the ideal curve (P ＞ 0.05). The area under ROC curve of the nomogram prediction model was 0.788 (95%CI: 0.742-0.833, P < 0.05). Conclusion The nomogram prediction model for the risk of constipation in patients with coronary heart disease after percutaneous coronary intervention has a good degree of calibration and discrimination, which is helpful for medical staff to individualize the risk of constipation in patients.
		2022 Vol. 19 (26): 15-18,33 [Abstract] ( 18 ) HTML (1 KB) PDF (1233 KB) ( 108 )

	19	Medication experience in the treatment of arthralgia syndrome based on data mining of Ren Zhai Zhi Zhi Fang Theory
		YANG Yue1 LI Lu2 YUAN Bo2 CUI Weilu3 GE Lin2 CAO Wei1
		DOI: 10.20047/j.issn1673-7210.2022.26.04
		Objective To study Yang Shiying’s medication experience in treating arthralgia syndrome in Ren Zhai Zhi Zhi Fang Theory. Methods The internal prescription for the treatment of arthralgia syndrome in Ren Zhai Zhi Zhi Fang Theory was sorted out and entered into the traditional Chinese medicine inheritance computing platform V3.0 for statistics and analysis of medication rules, and the nature and flavour, channel tropism, efficacy, frequency, association rules and clustering of drugs were discussed. Results A total of 47 decoction for internal administration were recorded, with a total of 100 traditional Chinese medicines, most of which were warm, calm nature, sweet, pungent, and bitter flavour drugs. The drugs mainly returned to the spleen, heart, liver, and lung channels, and the effects were mostly to replenish deficiency, relieve superficies, warming interior, promote blood circulation, and remove blood stasis and so on. Twenty-three traditional Chinese medicines with drug frequency ≥six, 28 high-frequency drug combinations, 24 association rules between drugs were obtained, and four kinds of prescriptions were obtained by clustering. Conclusion Yang Shiying believes that the etiology and pathogenesis of arthralgia syndrome were mainly external evil invasion and internal positive deficiency; kidney cold and blood stasis; spleen injury and phlegm stagnation. The treatment of arthralgia syndrome is not only dispelling wind and eliminating dampness, but also paying attention to “kidney”, “spleen”, “phlegm” and “blood”, using the methods of warming kidney and nourishing blood, strengthening spleen and eliminating phlegm, warming meridian, and activating blood, taking into account both internal and external evil, which can provide certain reference and basis for clinical treatment of arthralgia syndrome.
		2022 Vol. 19 (26): 19-23 [Abstract] ( 16 ) HTML (1 KB) PDF (1593 KB) ( 27 )

	24	Visual analysis of treatment of spinal cord injury with olfactory ensheathing cells by CiteSpace
		YANG Yubing LI Jiaxi GUO Dong ZHANG Chengyi TIAN Fuyu CHANG Su’e LI Jialiang HE Xijing
		DOI: 10.20047/j.issn1673-7210.2022.26.05
		Objective To investigate the research status, hotspots, and future trends of olfactory ensheathing cells transplantation in the treatment of spinal cord injury in the past 20 years. Methods Literatures published in 1999 to 2021 were retrieved in the core collection of Web of Science with the subject words “spinal injur *” and “OEC” or “OECs”, bibliometric analysis and visual analysis were carried out based on CiteSpace. Results A total of 370 articles were included, including 324 works. From 2002 to 2013, the number of published papers showed an increasing trend year by year, and then the annual number of published papers remained stable in the region. CELL TRANSPLANTATION, EXPERIMENTAL NEUROLOGY, and GLIA were the top three journals with the largest number of publications. St John JA, Griffith University, and China ranked first in terms of authors, institutions, and countries respectively. Keywords are Schwann cells, functional repair, in vitro, transplantation, glia, regeneration, axonal regeneration, etc. Conclusion CiteSpace software is used to visually analyze the relevant literature on olfactory ensheathing cells transplantation in the treatment of spinal cord injury, to show the current research status and hot spots in this field, and to provide certain data reference for scholars in related fields in the future.
		2022 Vol. 19 (26): 24-28,38 [Abstract] ( 21 ) HTML (1 KB) PDF (1877 KB) ( 144 )

	29	Visual analysis of knowledge map of traditional Chinese medicine in the treatment of chronic pelvic pain based on CiteSpace
		ZHAO Jiajing1 HUANG Wenling2 FU Hanxue1
		DOI: 10.20047/j.issn1673-7210.2022.26.06
		Objective To analyze the research of in the traditional Chinese medicine treatment of chronic pelvic pain in the past 20 years based on CiteSpace, and to explore and find the research hotspots and trends in the field. Methods The advanced retrieval was conducted in China National Knowledge Internet database, and the retrieval time was from January 2000 to July 2021. The retrieval expression was as follows TI= (“chronic pelvic pain”OR“CPP”) AND (SU= “Traditional Chinese medicine” OR “traditional Chinese medicine” OR “Traditional Chinese medicine” OR “integrated traditional Chinese AND western medicine” OR “Chinese medicine”), the search category was selected as journals, and further screening was performed. The RefWorks file was imported into CiteSpace software, and the author, organization cooperation network. and keywords were visually analyzed. Results A total of 193 literatures were included. A total of 303 authors were included in the author cooperation map, and 28 core authors with equal or more than two articles were included; a total of 208 institutions were included in the research institute cooperation map, among which 19 institutions published equal or more than two papers. Finally, a total of 236 keywords were included in the map, among which seven keywords appeared equal or more than 12 times. Conclusion The research focus of traditional Chinese medicine treatment of chronic pelvic pain mainly focuses on pelvic inflammatory disease and endometriosis, and the clinical treatment mainly Chinese medicine enema, Chinese medicine compound, etc.
		2022 Vol. 19 (26): 29-33 [Abstract] ( 29 ) HTML (1 KB) PDF (1580 KB) ( 66 )

	34	Research and application progress of infant body composition assessment methods
		TAO Yifei LI Yan WU Rong▲
		DOI: 10.20047/j.issn1673-7210.2022.26.07
		Infant body composition is an important index to evaluate infants’ nutritional status. By infering nutritional status through body composition, nutritional problems can be found in time and nutritional interventions can be formulated. However, the unique physiology and behavior of infants bring some challenges to the assessment of body composition, and the range of methods to measure infant body composition is relatively narrow. At present, a series of studies have been carried out on the assessment of infant body composition, and some progress has been made. This article reviews the research and application progress of commonly used infant body composition assessment methods. These methods mainly include anthropometry, air displacement plethysmography, dual-energy X-ray absorption, bioelectrical resistance, isotope dilution, and magnetic resonance imaging.
		2022 Vol. 19 (26): 34-38 [Abstract] ( 13 ) HTML (1 KB) PDF (539 KB) ( 103 )

	39	Research progress of PD-1/PD-L1 inhibitors in the treatment of metastatic colorectal cancer
		YIN Zhucheng LIANG Xinjun
		DOI: 10.20047/j.issn1673-7210.2022.26.08
		Colorectal cancer is one of the most common malignant tumors in the world. Most patients have metastases at diagnosis, the prognosis is poor. In recent years, immune checkpoint inhibitors have made a breakthrough progress in the treatment of a variety of malignant tumors, which is one of the current research hotspots. Monotherapy or combination therapy with programmed death-1 (PD-1)/programmed cell death ligand-1 (PD-L1) inhibitors may provide clinical benefit for patients with DNA mismatch repair defects/high microsatellite instability metastatic colorectal cancer (mCRC). The efficacy of monotherapy in patients with mismatch repair proficient/microsatellite stable mCRC is poor, and the feasibility of combination therapy with PD-1/PD-L1 inhibitors is being explored. This article reviews the application of PD-1/PD-L1 inhibitors in first-line, second-line, and posterior line treatment of mCRC patients, as well as the clinical research status and progress of PD-1/PD-L1 inhibitors monotherapy and combination therapy in different types of mCRC patients, so as to provide evidence for clinical application.
		2022 Vol. 19 (26): 39-42,57 [Abstract] ( 23 ) HTML (1 KB) PDF (540 KB) ( 93 )

	43	Status quo and correlation analysis of decision-making fatigue and occupational well-being among nurses in cardiovascular medicine
		XIE Wenjing SUN Guozhen▲ GAO Min WEN Gaoqin
		DOI: 10.20047/j.issn1673-7210.2022.26.09
		Objective To investigate the status quo of decision-making fatigue and occupational well-being of nurses in cardiovascular medicine, and to explore the relationship between them, so as to provide a theoretical basis for promoting nurses’ occupational well-being. Methods From October to November 2021, a convenience sampling method was used to investigate 704 cardiovascular nurses in Jiangsu Province by means of an online questionnaire. The survey tools included general information questionnaire, decision fatigue scale, and medical staff occupational well-being scale. Results A total of 655 valid questionnaires were recovered, with an effective recovery rate of 93.04%. Compared with different age, professional title, job position, monthly income, and participate in the night shift nurses had different decision-making fatigue degrees, and the differences were statistically significant (P ＜ 0.05). Compared with the difference of occupational well-being of nurses with jobs position, monthly income and participated in the night shift, and the differences were statistically significant (P ＜ 0.05). The total score of decision fatigue scale was negatively correlated with the total score of occupational well-being (r ＜ 0, P ＜ 0.01). The total score of the decision fatigue scale was negatively correlated with the scores of physical and mental health, value/ability manifestation, social support, economic income, and work environment in the occupational happiness scale (r ＜ 0, P ＜ 0.01). Conclusion The higher the decision-making fatigue of nurses, the lower the level of occupational well-being. Managers should pay close attention to the degree of decision-making fatigue of nurses, and reduce the decision-making fatigue of nurses with scientific and effective methods to improve their occupational well-being.
		2022 Vol. 19 (26): 43-46 [Abstract] ( 15 ) HTML (1 KB) PDF (585 KB) ( 124 )

	47	Qualitative study on the barriers to the implementation of thermal insulation measures in the perioperative period
		MA Wenjuan1,2 ZHANG Hongyan3 LI Li1,2▲
		DOI: 10.20047/j.issn1673-7210.2022.26.10
		Objective To explore the barriers to the implementation of thermal insulation measures in the perioperative period, to provide a reference for the targeted optimization team to implement body temperature management. Methods After the approval of the Ethics Committee of the First Affiliated Hospital of Xinjiang Medical University, a purpose-based sampling method was used from December 2020 to May 2021. A total of 43 nurses, anesthesiologists, anesthesiologists and surgeons were selected for semi-structured interviews. Based on the theoretical domain framework, an interview outline was developed and the interview content was recorded and transcribed. The interview recording was coded using direct content analysis, and the relevant theoretical domain framework (TDF) domains that affected the implementation of perioperative insulation measures were identified. Results After 43 interviews, the data reached saturation. This study identifies barriers related to 11 domains of the theoretical domain framework, namely knowledge, skills, memory attention and decision-making processes, social/professional roles and identities, environmental context and resources, beliefs about abilities, emotions, social influences, reinforcement, behavior regulation, and information about consequences. Conclusion Based on the theoretical domain framework, the surgical team has insufficient knowledge and skills to implement perioperative thermal insulation; insufficient thermal insulation resources and management; lack of supervisory feedback and poor communication and collaboration obstacles.
		2022 Vol. 19 (26): 47-50 [Abstract] ( 25 ) HTML (1 KB) PDF (536 KB) ( 59 )

	51	Influencing factors of poor prognosis in patients with acute cerebral infarction
		CHENG Li
		DOI: 10.20047/j.issn1673-7210.2022.26.11
		Objective To investigate the influencing factors of poor prognosis in patients with acute cerebral infarction (ACI). Methods From January 2019 to September 2021, 80 ACI patients in Bozhou Hospital of Traditional Chinese Medicine, Anhui Province were selected as the study subjects. They were divided into good prognosis group (≤2 points, 47 cases) and poor prognosis group (＞2 points, 33 cases) according to modified Rankin score (mRS) after treatment. Clinical data were compared between the two groups, and logistic regression was used to analyze the influencing factors of poor prognosis in ACI patients. Results The levels of serum low density lipoprotein-cholesterol (LDL-C), homocysteine (Hcy), and National Institutes of Health stroke scale (NIHSS) score in the poor prognosis group were higher than those in the good prognosis group, and the differences were statistically significant (P ＜ 0.05). Logistic regression model analysis showed that high serum LDL-C and Hcy levels, and high NIHSS score were independent risk factors for poor prognosis in ACI patients (OR ＞ 1, P ＜ 0.05). Conclusion Serum LDL-C and Hcy levels and NIHSS score in patients with ACI are important factors influencing the poor prognosis, which should be paid attention to in clinical practice.
		2022 Vol. 19 (26): 51-53,70 [Abstract] ( 14 ) HTML (1 KB) PDF (525 KB) ( 27 )

	54	Difference analysis of cardiac structure in atrial fibrillation patients with different left atrial diameter
		YE Haitao LI Xiufen WANG Ziyi Zulipiye Ainaisi Ailifeire Parhati Parhati Tursun
		DOI: 10.20047/j.issn1673-7210.2022.26.12
		Objective To analyze the difference of cardiac structure in atrial fibrillation patients with different left atrial diameter (LAD). Methods From January 2020 to November 2021, 108 patients with atrial fibrillation who underwent radiofrency ablation in Xinjiang Uygur Autonomous Region Hospital of Traditional Chinese Medicine were selected. The LAD was measured by cardiac Doppler ultrasound and divided into group Ⅰ (< 38 mm), group Ⅱ (38-40 mm), and group Ⅲ (> 40 mm) according to the size of LAD. Cardiac output (CO) per minute, cardiac ejection fraction (EF), peak mitral orifice early diastolic flow velocity/peak mitral annulus early diastolic movement velocity (E/e’), E, septum and free wall e’, and the proportion of diastolic dysfunction were compared among three groups; left ventricular end diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD), and the proportion of ventricular structural abnormalities were compared among three groups. Results There were no significant differences in E/e’, septum e’, free wall e’, and the proportion of diastolic dysfunction among three groups (P > 0.05). There were significant differences in EF and CO among three groups (P < 0.05). EF in group Ⅲ was lower than that in groups Ⅰ and Ⅱ, CO was higher than that in group Ⅰ, and the differences were statistically significant (P < 0.05). There were significant differences in LVEDD, LVESD, and the proportion of ventricular structural abnormalities among three groups (P < 0.05). LVEDD, LVESD and the proportion of ventricular structural abnormalities in group Ⅲ was higher than that in group Ⅰ, LVESD and the proportion of ventricular structural abnormalities in group Ⅲ was higher than that in group Ⅱ, and the proportion of ventricular structural abnormalities in group Ⅱ was higher than that in group Ⅰ, and the differences were statistically significant (P < 0.05). Conclusion EF, CO, LVEDD, LVESD, and the proportion of ventricular structural abnormalities in different LAD patients are different, which can provide guidance for the treatment of AF patients.
		2022 Vol. 19 (26): 54-57 [Abstract] ( 16 ) HTML (1 KB) PDF (512 KB) ( 26 )

	58	Relationship between serum angiopoietin-like protein 8, interleukin-23 levels and the risk of carotid plaque vulnerability in patients with ischemic stroke
		AN Ran YANG Lu AI Zhibing
		DOI: 10.20047/j.issn1673-7210.2022.26.13
		Objective To investigate the relationship between serum angiopoietin-like protein 8 (ANGPTL8) and interleukin-23 (IL-23) levels and the risk of carotid plaque vulnerability in patients with ischemic stroke (IS). Methods A total of 197 patients with IS who were admitted to Shiyan Taihe Hospital, Hubei Province from January 2020 to September 2021 were selected. They were divided into vulnerable group (112 cases), stable group (46 cases), non-plaque (39 cases) according to the result of carotid ultrasound examination. The influencing factors of carotid plaque vulnerability risk in patients with IS were analyzed, and the receiver operating characteristic (ROC) curve was used to analyze the predictive value of serum ANGPTL8 and IL-23 levels on carotid plaque vulnerability risk in patients with IS. Results The serum levels of hypersensitivity C-reactive protein (hs-CRP), ANGPTL8, and IL-23 in vulnerable group were higher than those in stable group and non-plaque group, and the serum levels of ANGPTL8 and IL-23 in stable group were higher than those in non-plaque group (P < 0.05). The levels of low density lipoprotein cholesterol (LDL-C) in vulnerable group and stable group were higher than those in non-plaque group, and the levels of high density lipoprotein cholesterol were lower than those in non-plaque group (P < 0.05). LDL-C, hs-CRP, ANGPTL8, and IL-23 were independent risk factors for carotid plaque vulnerability risk in IS patients (OR > 1, P < 0.05). The area under the curve of ANGPTL8 and IL-23 combined to predict the carotid plaque vulnerability risk in patients with IS was higher than that of ANGPTL8 and IL-23 alone (P < 0.05). Conclusion Serum ANGPTL8 and IL-23 levels are independent risk factors for carotid plaque vulnerability risk in IS patients, and can be used as predictors of carotid plaque vulnerability risk.
		2022 Vol. 19 (26): 58-61,74 [Abstract] ( 21 ) HTML (1 KB) PDF (769 KB) ( 52 )

	62	Expression of serum lactic acid and NT-proBNP in patients with acute heart failure complicated with renal deterioration and its predictive value for renal deterioration
		SHEN Qingqing ZHANG Xinxin WANG Jiliang
		DOI: 10.20047/j.issn1673-7210.2022.26.14
		Objective To study the expression of serum lactic acid and N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with acute heart failure complicated with renal deterioration and its predictive value for renal deterioration. Methods A total of 122 patients with acute heart failure admitted to the Department of Cardiology, Xingtai Third Hospital, Hebei Province from April 2018 to November 2019 were selected. According to whether renal function deteriorated during hospitalization, they were divided into renal function deterioration group (39 cases) and non-renal function deterioration group (83 cases). Baseline data of two groups were collected, the serum lactic acid and NT-proBNP levels at admission and 72 h after admission were compared between two groups, and their predictive value for renal function deterioration was analyzed. Results The proportion of male, age >60 years old, hypertension, diabetes mellitus, history of chronic kidney disease, drinking history, taking norepinephrine, and taking furosemide in renal function deterioration group was higher than that in non-renal function deterioration group, while the hemoglobin level in renal function deterioration group was lower than that in non-renal function deterioration group (P < 0.05). At admission and 72 h after admission, the levels of blood lactic acid and NT-proBNP in renal function deterioration group were higher than those in non-renal function deterioration group (P < 0.05). Chronic kidney history, diabetes mellitus, blood lactate at admission, blood lactate at 72 h after admission, NT-proBNP at admission and NT-proBNP at 72 h after admission were independent influencing factors of renal function deterioration (OR > 1, P < 0.05). Area under the curves of blood lactate at admission, blood lactate 72 h after admission, NT-proBNP at admission, and NT-proBNP 72 h after admission in the diagnosis of renal function deterioration were 0.801, 0.760, 0.631, 0.708, respectively, which had good predictive value. Conclusion Chronic kidney history, diabetes mellitus, blood lactic acid and NT-proBNP at admission and 72 h after admission are independent risk factors for renal function deterioration in patients with acute heart failure, and blood lactate and NT-proBNP at admission and 72 h after admission can be used to predict renal function deterioration.
		2022 Vol. 19 (26): 62-66 [Abstract] ( 21 ) HTML (1 KB) PDF (783 KB) ( 102 )

	67	Predictive value of platelet/lymphocyte ratio combined with mean platelet volume detection in patients with ST-segment elevation myocardial infarction with no-reflow after percutaneous coronary intervention
		FAN Linglong ZHANG Yilin▲
		DOI: 10.20047/j.issn1673-7210.2022.26.15
		Objective To explore the predictive value of platelet/lymphocyte ratio (PLR) combined with mean platelet volume (MPV) detection in patients with ST-segment elevation myocardial infarction (STEMI) with no-reflow after percutaneous coronary intervention (PCI). Methods A total of 86 STEMI patients who underwent PCI in Hangzhou Ninth People’s Hospital from August 2019 to October 2021 were selected, and all patients underwent PCI. The incidence of no-reflow in STEMI patients after PCI was statistically analyzed, and they were divided into no-reflow group and reflow group. The clinical data of two groups were compared, and the risk factors of no-reflow in STEMI patients after PCI were analyzed; and the predictive efficacy of PLR combined with MPV in the occurrence of no-reflow in STEMI patients after PCI was analyzed. Results The incidence of no-reflow in STEMI patients after PCI was 24.42%. The low-density lipoprotein cholesterol, PLR, and MPV in no-reflow group were higher than those in reflow group (P < 0.05), while the left ventricular ejection fraction was lower than that in reflow group (P < 0.05). PLR and MPV were the influencing factors of no-reflow in STEMI patients after PCI (OR > 1, P < 0.05). The area under the curve of combined detection was higher than that of PLR and MPV alone. Conclusion The combination of PLR and MPV has high predictive performance for no-reflow in STEMI patients after PCI.
		2022 Vol. 19 (26): 67-70 [Abstract] ( 20 ) HTML (1 KB) PDF (698 KB) ( 41 )

	71	Predictive value of serum sTREM-1, MCP-1, and hs-CRP levels in restenosis after PCI in elderly patients with acute myocardial infarction
		TANG Ying HUANG Zehui JIANG Yu▲
		DOI: 10.20047/j.issn1673-7210.2022.26.16
		Objective To investigate the predictive value of serum soluble triggering receptor expresses on myeloid cells-1 (sTREM-1), monocytogenic protein 1 (MCP-1), and hypersensitivity C reactive protein (hs-CRP) levels after percutaneous coronary intervention (PCI) in elderly patients with acute myocardial infarction. Methods A total of 98 elderly patients with acute myocardial infarction admitted to Wuxi Second People’s Hospital of Jiangsu Province from March 2018 to March 2021 were selected. All subjects were followed up for six months. According to the incidence of restenosis, thy were divided into restenosis group and non-restenosis group. The risk factors of restenosis after PCI were analyzed; the receiver operating characteristic (ROC) curve was used to predict the diagnostic efficacy of different indicators for restenosis after PCI in elderly patients with acute myocardial infarction. Results Restenosis occurred in 11 of 98 patients, with an incidence of 11.22%. The levels of sTREM-1, MCP-1, and hs-CRP in restenosis group were higher than those in non-restenosis group (P < 0.05). sTREM-1, MCP-1, and hs-CRP were risk factors for restenosis after PCI in elderly patients with acute myocardial infarction (OR = 3.770, 5.376, 6.241, P < 0.05). The area under the curve of sTREM-1, MCP-1, and hs-CRP combined in predicting restenosis after PCI in elderly patients with acute myocardial infarction was higher than that predicted by each index alone (P < 0.05). Conclusion Serum sTREM-1, MCP-1, and hs-CRP are all associated with restenosis after PCI in elderly patients with acute myocardial infarction, and the predictive efficacy of the combination test is better.
		2022 Vol. 19 (26): 71-74 [Abstract] ( 17 ) HTML (1 KB) PDF (780 KB) ( 44 )

	75	Clinical efficacy of Melatonin on sleep disorder and mood disorder in patients with traumatic brain injury
		WU Chenrui WU Biying FUJiayuanyuan TAN Weilin ZHOU Qiang DU Mengran HUANG Xuekang LIAO Zhengbu
		DOI: 10.20047/j.issn1673-7210.2022.26.17
		Objective To observe the clinical efficacy of Melatonin on sleep disorder and mood disorder in patients with traumatic brain injury. Methods A total of 27 patients with mild to moderate traumatic brain injury treated in the Department of Neurosurgery, the First Affiliated Hospital of Chongqing Medical University from August 2019 to August 2021 were selected and divided into Melatonin group (13 cases) and control group (14 cases) by random number table method. The Melatonin group took Melatonin Capsules orally 30 minutes before falling asleep every night, while the control group took placebo orally 30 minutes before falling asleep every night. Both groups continued to take the drug for four weeks. After treatment, Pittsburgh sleep quality index (PSQI), Epworth sleepiness scale (ESS), hospital anxiety and depression scale (HADS), and Glasgow outcome scale-extended (GOS-E) were used to evaluate sleep disorder, mood disorder, and functional outcomes in the two groups. The incidence of adverse reactions during medication was recorded in both groups. Results After treatment, the PSQI, ESS, and HADS anxiety scores of Melatonin group were lower than those of control group, and the differences were statistically significant (P ＜ 0.05). There was no significant difference in HADS depression score and GOS-E score between the two groups (P ＞ 0.05). There was no significant difference in the incidence of fatigue, drowsiness, headache, dizziness, nausea, and vomiting between the two groups (P ＞ 0.05). Conclusion Melatonin can improve sleep disturbance and relieve anxiety after traumatic brain injury, with good safety.
		2022 Vol. 19 (26): 75-78 [Abstract] ( 15 ) HTML (1 KB) PDF (500 KB) ( 128 )

	79	Intervention effect of cognitive function training based on internet platform games on different types of elderly patients with mild cognitive impairment
		ZHANG Wei LI Yanling▲
		DOI: 10.20047/j.issn1673-7210.2022.26.18
		Objective To investigate the intervention effect and sustained effect of difficulty adaptive computer cognitive training based on internet platform games on different types in elderly patients with mild cognitive impairment (MCI). Methods From January 2019 to December 2020, 90 elderly patients with MCI were recruited from Liaoning Jinqiu Hospital, Liaoning Provincial People’s Hospital, the First Hospital of China Medical University, and Shengjing Hospital of China Medical University. They were divided into forgetting group (45 cases) and non-forgetting group (45 cases). Both groups were given difficulty adaptive computer cognitive training based on internet platform games, and the intervention lasted for eight weeks. The two groups received cognitive assessment before, at immediately after intervention, and three months after the intervention, and the differences of cognitive function related indicators were compared between the two groups. Results The total scores of Montreal cognitive assessment (MoCA) in the two groups at immediately after intervention were higher than those before intervention, and the total scores of MoCA in the non-forgetting group at three months after intervention were lower than those at immediately after intervention (P ＜ 0.05). The total score of auditory verbal learning test (AVLT), short-delay recall score, and recognition score in the non-forgetting group at immediately after intervention were higher than those before intervention, the short-delayed recall score, and recognition score at three months after intervention were higher than those before intervention, long-delayed recall score was lower than that at three months after trecdment, and the total AVLT score and long-delayed recall score at three months after intervention were lower than those at immediately after intervention (P ＜ 0.05). The long-delayed recall score and recognition score in the forgetting group at immediately after intervention were higher than those before intervention, and at three months after intervention were lower than those at immediately after intervention (P ＜ 0.05). The total AVLT score and long-delay recall score of the non-forgetting group before intervention were higher than those of the forgetting group at the same time, the total AVLT score and short-delay recall score at immediately after intervention were higher than those in the forgetting group at the same time, the short delayed recall score and recognition score at three months after intervention were higher than those in the forgetting group at the same time (P ＜ 0.05). The Stroop-B time in non-forgetting group at immediately after intervention was longer than that before intervention, and at three months after intervention was shorter than that at immediately after intervention, the Stroop-C time in both groups at three months after intervention was shorter than that at immediately after intervention (P ＜ 0.05). The shape trails test-A time in both groups at immediately after intervention and three months after intervention was shorter than that before intervention (P ＜ 0.05). The digital span test (DST) recite in reverse order scores of the two groups at three months after intervention were lower than those before intervention and immediately after intervention, and the DST recite in reverse order score of the forgetting group at immediately after intervention was higher than those before intervention (P ＜ 0.05). The DST recite in order score and recite in reverse order score in the non-forgetting group before intervention were higher than those in the forgetting group at the same time, and the DST recite in order score at immediately after intervention was lower than that in the forgetting group at the same time (P ＜ 0.05). Conclusion The short-term intervention effect of difficulty adaptive computer cognitive training on different types of elderly patients with MCI has been confirmed, but its durability and long-term benefits are still uncertain and need to be confirmed by further studies.
		2022 Vol. 19 (26): 79-85 [Abstract] ( 20 ) HTML (1 KB) PDF (842 KB) ( 98 )

	86	Analysis on the correlation between heart rate variability and total load of magnetic resonance imaging in cerebral small vessel disease
		LIU Yuechen XU Hui BAI Hongying▲
		DOI: 10.20047/j.issn1673-7210.2022.26.19
		Objective To analyze the correlation between heart rate variability (HRV) and the total load of magnetic resonance imaging (MRI) in cerebral small vessel disease (CSVD). Methods A total of 188 patients with CSVD admitted to the Department of Neurology, the Second Affiliated Hospital of Zhengzhou University from January 2019 to June 2021 were selected as the research objects. According to the imaging results of lacunae, microbleeds, white matter hyperintensity, and perivascular space, the total load score was evaluated. The score of 0-2 points was included in the low load group (132 cases), and the score of 3-4 points was included in the high load group (56 cases). The general data, HRV parameters, and imaging related indexes of the two groups were compared, and the correlation between HRV parameters and MRI total load score, as well as the influencing factors of MRI total load score in CSVD patients were further analyzed. Results The age of the high load group was higher than that of the low load group, the 24 h mean heart rate, standard deviation of the N-N intervals (SDNN), standard deviation of the averages of N-N intervals in all five minute segments of the entire recording (SDANN), root mean square value of the difference between adjacent N-N intervals (rMSSD), total power (TP), low frequency power (LF), and LF/high frequency power (HF) were all lower than those of the low load group, the differences were statistically significant (P ＜ 0.05). SDNN, SDANN, rMSSD, TP, LF, LF/HF were negatively correlated with the total MRI load score of CSVD patients (rs ＜ 0, P ＜ 0.05). Multivariate analysis showed that rMSSD were the influencing factors of MRI total load score of CSVD (P ＜ 0.05). Conclusion HRV parameters are correlated with the MRI total load score of CSVD patients, and autonomic nervous dysfunction may be related to the development of CSVD.
		2022 Vol. 19 (26): 86-89,98 [Abstract] ( 18 ) HTML (1 KB) PDF (606 KB) ( 38 )

	90	Effect of high-intensity repetitive transcranial magnetic stimulation on patients with major depression and suicidal ideation
		LI Songhua FU Kedeng HU Yuanyuan WANG Jianmei
		DOI: 10.20047/j.issn1673-7210.2022.26.20
		Objective To investigate the effect of high-intensity repetitive transcranial magnetic stimulation (rTMS) on patients with major depression and suicidal ideation. Methods A total of 90 patients with major depression and suicidal ideation admitted in Ningbo Mental Hospital of Zhejiang Province from May 2018 to May 2021 were selected and divided into high-intensity group, routine group, and control group by random number table method, with 30 cases in each group. On the basis of oral Venlafaxine, the high-intensity group was treated with rTMS (twice a day), and the routine group was treated with rTMS (once a day), each treatment in both groups was 6 000 pulses, and the control group was treated with sham stimulation. The scores of Beck suicidal ideation scale Chinese version (BSI-CV) and Hamilton depression rating scale-24 items (HAMD-24) at different time points before and after treatment were observed. The occurrence of adverse reactions in the two groups was recorded. Results A total of seven cases fell off in this study, including three cases in the high-intensity group, two cases in the conventional group, and two cases in the control group. The BSI-CV scores at the end of the 3rd day of treatment in the high-intensity group and the routine group were lower than those before treatment, the BSI-CV scores of the three groups at the end of the 7th day of treatment were lower than those at the end of the 3rd day of treatment, and the BSI-CV scores of the three groups at the end of the 14th day of treatment were lower than those at the end of the seventh day of treatment (P ＜ 0.05). The BSI-CV scores of the high-intensity group at the end of the 3rd, 7th, and 14th day of treatment were lower than those of the routine group and the control group at the same time, the BSI-CV scores of the routine group at the end of the 3rd, 7th and 14th day of treatment were lower than those of the control group at the same time (P ＜ 0.05). The HAMD-24 scores of the three groups at the end of the 7th and 14th days of treatment were lower than those before treatment, and at the end of the 14th day of treatment were lower than those at the end of the 7th day of treatment (P ＜ 0.05). The HAMD-24 scores of the high-intensity group at the end of the 7th and 14th day of treatment were lower than those of the routine group and the control group at the same time, and the HAMD-24 scores of the routine group at the end of the 7th and 14th day of treatment were lower than those of the control group at the same time (P ＜ 0.05). The incidence of headache in high intensity group and routine group were higher than those in control group (P ＜ 0.017). Conclusion High-intensity rTMS treatment can quickly reduce the depressive symptoms and suicidal ideation in patients with major depression, and the effect is better than the conventional treatment once a day, which is a relatively safe treatment measure.
		2022 Vol. 19 (26): 90-93 [Abstract] ( 21 ) HTML (1 KB) PDF (550 KB) ( 192 )

	94	Study on the correlation between rumination, post-traumatic growth, and quality of life in patients with ischemic stroke
		TAN Shiyun1 LIU Yanmei2 FENG Rui1 ZHANG Junling1 XUE Hua1
		DOI: 10.20047/j.issn1673-7210.2022.26.21
		Objective To understand the current status of rumination, post-traumatic growth, and quality of life in patients with ischemic stroke, and to explore the correlation between the three. Methods Convenience sampling method was used to select 281 ischemic stroke patients admitted to Shaanxi Provincial Hospital of Traditional Chinese Medicine from May to December 2020 as the research subjects. General information questionnaire, Chinese version of event related rumination inventory (C-ERRI), Chinese post-traumatic growth inventory (C-PTGI), and quality of life instruments for chronic disease-stroke (QLICD-ST V2.0) were used to investigate the current situation. Pearson correlation analysis was used to explore the correlation among them. Results A total of 292 questionnaires were distributed, and 281 questionnaires were recovered for statistical analysis, with an effective recovery rate of 96%. The scores of rumination, post-traumatic growth and quality of life in patients with ischemic stroke were (30.32±7.08), (51.21±15.33) points, and (54.78±17.18) points, respectively. The quality of life of patients with ischemic stroke was positively correlated with rumination and post-traumatic growth (r ＞ 0, P ＜ 0.05); it was negatively correlated with invasive rumination (r ＜ 0, P ＜ 0.05). Conclusion The rumination and post-traumatic growth of patients with ischemic stroke are at a moderate level, and the quality of life is at a moderately low level. Therefore, it is necessary to focus on improving the post-traumatic growth level of patients and guide their purposeful contemplation, so as to achieve the purpose of improving the quality of life of patients.
		2022 Vol. 19 (26): 94-98 [Abstract] ( 18 ) HTML (1 KB) PDF (657 KB) ( 174 )

	99	Clinic value of serum Klotho protein for patients with traumatic brain injury complicated with acute kidney injury
		REN Bin1 WANG Yonghong1 DING Xinmin1 LIANG Jifang2
		DOI: 10.20047/j.issn1673-7210.2022.26.22
		Objective To investigate the value of serum Klotho protein level in the early diagnosis and prognosis of patients with traumatic brain injury complicated with acute kidney injury. Methods A total of 122 patients diagnosed with traumatic brain injury in the Department of Critical Care Medicine of Shanxi Bethune Hospital from July 2019 to September 2020 were selected as the research objects. According to the renal injury, they were divided into acute kidney injury group (37 cases) and non-acute kidney injury group (85 cases). The clinical data of the two groups were collected and compared. Logistic regression model was used to analyze the influencing factors of renal injury in patients with traumatic brain injury, and its diagnostic value was further analyzed. Results Body mass index, white blood cell count, neutrophil count, blood glucose, creatinine, and acute physiology and chronic health evaluationⅡ score of acute kidney injury group were higher than those in the non-acute kidney injury group, mean arterial pressure, platelet, lymphocyte count, albumin, and serum Klotho protein were lower than those in the non-acute kidney injury group, the differences were statistically significant (P ＜ 0.05). Multivariate analysis showed that high white blood cell count, platelet, and blood glucose levels were independent risk factors for acute kidney injury secondary to traumatic brain injury (OR ＞ 1, P ＜ 0.05), and high serum Klotho protein level was a protective factor (OR ＜ 1, P ＜ 0.05). The area under the receiver operating characteristic curve of serum Klotho protein in diagnosing acute kidney injury after craniocerebral injury was 0.897 (95%CI: 0.836-0.941) (P ＜ 0.05), and the cutoff value was 148.07 pg/ml. Conclusion Serum Klotho protein level can be used as an early diagnostic and predictive index for acute kidney injury secondary to craniocerebral injury.
		2022 Vol. 19 (26): 99-102 [Abstract] ( 20 ) HTML (1 KB) PDF (680 KB) ( 21 )

	103	Clinical effect of high frequency oscillatory ventilation combined with calf pulmonary surfactant in the treatment of neonatal with acute respiratory distress syndrome
		LI Jie ZHANG Hehua LI Lei LI Shuai▲
		DOI: 10.20047/j.issn1673-7210.2022.26.23
		Objective To investigate the clinical effect of high frequency oscillatory ventilation (HFOV) combined with calf pulmonary surfactant in the treatment of neonatal acute respiratory distress syndrome (ARDS). Methods From January 2018 to June 2021, 80 cases of neonatal ARDS who received ventilator-assisted ventilation in Neonatal Intensive Care Unit of Fuyang Women’s and Children’s Hospital, Anhui Province were selected as the research subjects. They were divided into study group (48 cases, HFOV combined with calf pulmonary surfactant) and control group (32 cases, conventional mechanical ventilation combined with calf pulmonary surfactant) by coin toss method. The treatment effect (ventilator use time, oxygen days after weaning, and hospitalization days) were compared between the two groups; the improvement of blood gases (arterial partial pressure of oxygen [PaO2], arterial partial pressure of carbon dioxide [PaCO2], oxygenation index [OI], and respiratory index [RI]) during ventilation, ventilation lasted for 12, 24, 48, and 72 h were compared between two groups; the occurrence of complications was observed. Results The ventilator use time, oxygen days after weaning, and hospitalization days in study group were shorter than those in control group, and the differences were statistically significant (P < 0.05). Pairwise comparison of PaO2, PaCO2, OI, and RI at different time points between two groups showed statistical significance (P < 0.05). There were statistically significant differences in PaO2, PaCO2, OI, and RI between two groups at 12, 24 and 48 h after ventilation (P < 0.05). After 72 h ventilation, there were significant differences in OI and RI between two groups (P < 0.05). The complication rate of study group was lower than that of control group, and the difference was statistically significant (P < 0.05). Conclusion HFOV combined with calf pulmonary surfactant in the treatment of neonatal ARDS can significantly improve the blood oxygen status, shorten the mechanical ventilation and oxygen use time, and reduce the incidence of complications, which has good clinical efficacy.
		2022 Vol. 19 (26): 103-106 [Abstract] ( 18 ) HTML (1 KB) PDF (490 KB) ( 39 )

	107	Meta analysis of the relationship between L-type amino acid transporter 1 and solid tumor metastasis
		WU Sihui1 ZHOU Xulin1 HUANG Wenkang1 XU Min2
		DOI: 10.20047/j.issn1673-7210.2022.26.24
		Objective To investigate the correlation between L-type amino acid transporter 1(LAT1) and solid tumor metastasis. Methods Medline/PubMed, Embase, EBSCO, The Cochrane Library, Springerlink, Web of Science core collectior databas, Wiley Onlinelibary, China National Knowledge Infrastructure, and Cochrane Center for Controlled Clinical Trials (Cochrane) were used for literature search, two authors independently screened the literature, extracted data, and grouped the final materials Patients were divided into groups according to the relevant indexes to be studied, including lymph node metastasis positive group and negative group, lymphatic vessel invasion positive group and negative group, vascular invasion positive group and negative group. Patients with high LAT1 expression were screened out from each group for data analysis, and the differences between groups were compared. The literature search date was from the establishment of the database to May 2021, and the final meta analysis was performed using RevMan 5.4 software. Results After screening, 15 literatures were included. LAT1 expression was a risk factor for lymph node metastasis of most tumors, and there was a significant relationship between LAT1 expression and lymph node metastasis (OR = 2.03, 95%CI:1.44-2.86, P < 0.000 1). LAT1 expression was a significant risk factor for vascular invasion of most tumors (OR = 2.92, 95%CI:2.16-3.96, P < 0.000 01). Conclusion The expression of LAT1 is correlated with lymph node metastasis and vascular invasion, LAT1 is one of the promoting factors for metastasis of various solid tumors.
		2022 Vol. 19 (26): 107-111 [Abstract] ( 15 ) HTML (1 KB) PDF (1388 KB) ( 32 )

	112	Expression difference of TILs in Luminal B and Her-2 positive (HR positive) breast cancers and their relationship with prognosis
		MA Xiaoming1 LIU Bin2▲
		DOI: 10.20047/j.issn1673-7210.2022.26.25
		Objective To investigate the expression differences of tumor infiltrating lymphocytes (TILs) in LuminalB type and human epidermal growth factor receptor 2 (Her-2) positive (hormone receptor [HR] positive) breast cancers and their relationship with prognosis. Methods Specimens from 59 cases of LuminalB type and 46 cases of Her-2 positive (HR positive) type breast cancer patients who were diagnosed and received surgical treatment of breast cancer in the Affiliated Hospital of Xuzhou Medical University from January 2015 to February 2016 were collected, and the clinical data were retrospectively analyzed. The infiltration levels of TILs in patients with two types of breast cancer, including Luminal B type and Her-2 positive (HR positive) were compared, and the relationship between TILs and the prognosis of patients with two types of breast cancer was analyzed. Results The infiltration level of TILs in patients with Her-2 positive (HR positive) breast cancer was lower than that of LuminalB (P ＜ 0.05). LuminalB and Her-2 positive (HR positive) breast cancer recurrence groups had higher tumor staging rates from T3 to T4, and the proportion of low/moderate infiltration of TILs were higher than those in the non-recurring group (P ＜ 0.05). The 5-year recurrence of LuminalB and Her-2 positive (HR-positive) breast cancers was correlated with tumor stage and the degree of TILs infiltration by contingency correlation analysis (P ＜ 0.05). The recurrence curves of LuminalB and Her-2 positive (HR positive) breast cancer patients with low/moderate infiltration degree of TILs were compared with high infiltration patients, and the difference was statistically significant (P ＜ 0.05). Conclusion The level of TILs infiltration in patients with Luminal B breast cancer is higher than that in patients with Her-2 positive (HR positive), and the degree of TILs infiltration in patients with two types of breast cancer has a certain correlation with the prognosis.
		2022 Vol. 19 (26): 112-115,119 [Abstract] ( 18 ) HTML (1 KB) PDF (856 KB) ( 24 )

	116	Prognostic value of peripheral blood ALC / AMC combined with AGR in patients undergoing radical gastrectomy for gastric cancer
		WANG Hui1 MA Boheng1▲ XU Fangzheng2
		DOI: 10.20047/j.issn1673-7210.2022.26.26
		Objective To investigate the prognostic value of peripheral blood absolute lymphocyte count (ALC)/absolute monocyte count (AMC) combined with serum albumin globulin ratio (AGR) in patients undergoing radical gastrectomy for gastric cancer. Methods A total of 96 patients who planned to undergo radical gastrectomy in Rugao Hospital Affiliated to Nantong University from January 2018 to January 2020 were selected. The patients who underwent radical gastrectomy were divided into recurrence group and non-recurrence group according to their prognosis. The clinicopathological features including TNM stage, differentiation degree, and lymph node metastasis were compared between the two groups. Logistic regression analysis was used to explore the influencing factors of postoperative recurrence, and receiver operator characteristic curve was used to evaluate the predictive value of peripheral blood ALC/AMC and AGR levels on postoperative recurrence. Results The proportion of undifferentiated/poorly differentiated, TNM stage Ⅲ, lymph node metastasis, peripheral blood ALC/AMC, and AGR levels in the recurrence group were higher than those in the non-recurrence group (P < 0.05). Stage Ⅲ, undifferentiated/poorly differentiated, lymph node metastasis, ALC/AMC, and AGR levels were risk factors for recurrence after radical gastrectomy (OR = 2.768, 3.040, 3.083, 4.976, 4.235, P < 0.05). The area under the curve of ALC/AMC and AGR combined in predicting postoperative recurrence was higher than that of ALC/AMC and AGR alone (P < 0.05). Conclusion The stage, undifferentiated/poorly differentiated, having lymph node metastasis, ALC/AMC, and AGR levels were all risk factors affecting the relapse group. ALC/AMC and AGR can affect the prognosis of patients, and the combination of the two can be used as a reference index to predict the recurrence after radical gastrectomy.
		2022 Vol. 19 (26): 116-119 [Abstract] ( 26 ) HTML (1 KB) PDF (853 KB) ( 33 )

	120	Analysis of Professor Bai Yanping’s medication rules in the treatment of acne rosacea based on data mining
		LUO Sha1 BAI Yanping2 CHEN Jiaqi1 ZHUANG Mingyue1 LAI Lixia1 LIU Jiayi1
		DOI: 10.20047/j.issn1673-7210.2022.26.27
		Objective To analyze the Professor Bai Yanping’s medication rules in the treatment of acne rosacea based on data mining. Methods The traditional Chinese medicine prescriptions of Professor Bai Yanping in the treatment of acne rosacea in China-Japan Friendship Hospital from April 2010 to September 2020 were collected. The frequency, classification, efficacy, four nature, five flavour, and channel tropism of traditional Chinese medicine in the treatment of acne rosacea were analyzed descriptively. Association rules and cluster analysis were used to explore potential traditional Chinese medicine combinations, and the data were visualized through network graph. Results A total of 101 prescriptions and 156 traditional Chinese medicines were included in the study. Raw Glycyrrhizae Radix Et Rhizoma was the most frequently used traditional Chinese medicine, followed by Scutellariae Radix, Campsis Flos, Coptidis Rhizoma, Forsythiae Fructus, Angelicae Dahuricae Radix, Moutan Cortex, Atractylodis Macrocephalae Rhizoma, and Lonicerae Japonicae Flos. The four nature of drugs were mainly cold and warm, while the five flavours were mainly bitter, pungent, and sweet. The channel tropism were mainly lung, spleen, stomach, and liver channels. There were two traditional Chinese medicine combinations in the complex network diagram. The association rules were used to analyze 28 traditional Chinese medicine combinations. Two potential new prescriptions were identified by cluster analysis. Conclusion Professor Bai Yanping is good at treating acne rosacea with Wenqing Decoction, which is divided into three phases for treatment, using flowers skillfully to lightly propagating, guiding the channel affinity on the face to reach the disease.
		2022 Vol. 19 (26): 120-124 [Abstract] ( 19 ) HTML (1 KB) PDF (1372 KB) ( 42 )

	125	Pathogenesis of active rheumatoid arthritis induced by “overexertion leading to qi consumption”
		JIANG Wen JIANG Quan XU Haodong CHENG Zengyu TANG Xiaopo
		DOI: 10.20047/j.issn1673-7210.2022.26.28
		Rheumatoid arthritis (RA) is a crippling autoimmune disease with a high prevalence and disability rate, which seriously threatens the quality of life of patients. The clinical manifestation is that active stage and remission stage appear alternately. Repeated activity accelerates the process of bone destruction. How to stabilize the condition, avoid RA activity, and achieve continuous remission is the focus and difficulty of clinical treatment. That “overexertion leading to qi consumption” is an important cause of RA activity. Prevention of insufficient consumption of qi should be carried out throughout the treatment of RA. By explaining the connotation and extension of this classical theory of traditional Chinese medicine, this paper analyzes the pathogenesis characteristics of “overexertion leading to qi consumption” in the process of inducing RA activity from the point of view of five-zang fatigue and five-body arthralgia, expounds its close relationship with the turning point event of RA activity, and links it with the pathogenesis pathology of immune imbalance and inflammatory storm, so as to provide a theoretical basis for explaining the scientific connotation of RA activity caused by “overexertion leading to qi consumption”. In order to provide reference for RA activities of comprehensive prevention and preventive treatment in traditional Chinese medicine.
		2022 Vol. 19 (26): 125-128 [Abstract] ( 17 ) HTML (1 KB) PDF (555 KB) ( 206 )

	129	Wei Ni’s experience abstract in treating gouty arthritis in young people
		CHEN Xia WEI Ni
		DOI: 10.20047/j.issn1673-7210.2022.26.29
		Gout is a heterogeneous group of diseases caused by purine metabolism disorder and/or uric acid excretion disorder. Gouty arthritis is the main clinical manifestation. The prevalence of gouty arthritis is increasing year by year, showing a trend of younger onset. Associate chief physician Wei Ni thinks that compared with elderly patients, young patients with gouty arthritis have more congenital kidney qi deficiency and more frequent drinking and high-purine diets. In addition, bad emotions cause stagnation of liver qi, which affects the heart and lungs over time, and aggravates phlegm and dampness，blood stasis. These factors can cause frequent attacks of gouty arthritis, high blood uric acid levels, and a higher chance of tophi. Associate chief physician Wei Ni emphasizes that the five zang viscera should be coordinated to eliminate the source of phlegm, dampness, and blood stasis in the treatment of young patients with gouty arthritis. At the same time, the drug of dispelling stasis and removing obstruction in collaterals should be used as early as possible to prevent the formation of tophi.
		2022 Vol. 19 (26): 129-132 [Abstract] ( 23 ) HTML (1 KB) PDF (686 KB) ( 176 )

	133	Clinical effect of Yiqi Wenyang Decoction in the treatment of persistent moderate and severe allergic rhinitis of spleen qi weakness type
		CHEN Min LU Yawen SHI Jun
		DOI: 10.20047/j.issn1673-7210.2022.26.30
		Objective To observe the clinical effect of Yiqi Wenyang Decoction in the treatment of persistent moderate and severe allergic rhinitis (AR) of spleen qi weakness type. Methods One hundred and twenty-six patients with persistent moderate and severe AR treated in Jiangsu Province Hospital of Chinese Medicine from June 2020 to October 2021 were selected as the research objects. They were divided into control group and study group by envelope lottery, with 63 cases in each group. The control group was given routine treatment, and the study group was given Yiqi Wenyang Decoction on the basis of the control group, with 14 days as a course of treatment and two consecutive courses of treatment. The clinical efficacy, clinical symptoms and signs scores, serum cytokine levels and adverse reactions were compared between the two groups. Results The clinical efficacy of the study group was better than that of the control group, and the difference was statistically significant (P < 0.05). After treatment, the clinical symptoms, signs and total scores of the two groups were lower than those before treatment, and the study group was lower than the control group, the differences were statistically significant (P < 0.05). After treatment, the levels of interferon-γ (IFN-γ) and interleukin (IL)-1 in the two groups were higher than those before treatment, the levels of IL-13, IL-4, and IL-35 in the two groups were lower than those before treatment, and the levels of IFN-γ and IL-1 in the study group were higher than those in the control group, the levels of IL-13, IL-4, and IL-35 in the study group were lower than those in the control group, and the differences were statistically significant (P < 0.05). There were no obvious adverse reactions in both groups. Conclusion Yiqi Wenyang Decoction in the treatment of persistent moderate and severe allergic rhinitis AR patients can improve symptoms and reduce the level of inflammatory factors, with significant curative effect.
		2022 Vol. 19 (26): 133-136 [Abstract] ( 19 ) HTML (1 KB) PDF (565 KB) ( 42 )

	137	Meta analysis of Paroxetine combined with Olanzapine in the treatment of depression
		ZHAN Xiyou
		DOI: 10.20047/j.issn1673-7210.2022.26.31
		Objective To systematically evaluate the efficacy and safety of Paroxetine combined with Olanzapine in the treatment of depression. Methods The search formula was compiled with the search words “paroxetine”, “olanzapine”, and “depression”, the academic papers in the medical databases such as VIP, the Cochrane Library, CNKI, Web of Sciencecbm core collection database, PubMed, and Wanfang Data were searched and screened. The bias risk assessment and meta analysis of the included literature were carried out through the RevMan 5.3 software, the retrieval period is from the establishment of each database to May 2022. Results A total of 11 randomized controlled trials were included. The results of meta-analysis showed that the Hamilton depression scale of the observation group was lower than that of the control group (MD = -4.27, 95%CI:-5.73 to -2.80, P ＜ 0.000 01), and the total effective number was higher than that of the control group (RR = 1.13, 95%CI:1.03 to 1.24, P = 0.01). There was no significant difference in the total number of adverse reactions between the two groups (RR = 0.77, 95%CI: 0.27 to 2.23, P = 0.63). Conclusion Paroxetine combined with Olanzapine is effective and safe in the treatment of depression, which is worthy of clinical promotion.
		2022 Vol. 19 (26): 137-141 [Abstract] ( 22 ) HTML (1 KB) PDF (2685 KB) ( 15 )

	142	Application effect of perioperative dietary nursing program in laparoscopic cholecystectomy based on the concept of enhanced recovery after surgery
		LI Hui CHEN Xiaoling WANG Xin
		DOI: 10.20047/j.issn1673-7210.2022.26.32
		Objective To explore application effect of perioperative dietary nursing program in laparoscopic cholecystectomy based on the concept of enhanced recovery after surgery (ERAS). Methods A total of 80 patients who underwent laparoscopic cholecystectomy in Xuancheng People’s Hospital of Anhui Province from May 2019 to May 2021 were selected. According to the random number table method, they were divided into control group and experimental group, with 40 cases in each group. The control group received routine diet nursing during perioperative period, and the experiment adopted perioperative diet nursing program guided by ERAS concept, Including preoperative diet education, nutritional assessment, diet management, and early postoperative diet. The incidence of perioperative related discomfort was compared between the two groups. The postoperative recovery was recorded. Results The incidence of perioperative nausea, vomiting, abdominal distension, and hypoglycemia in the experimental group were lower than those in the control group, and the differences were statistically significant (P ＜ 0.05); the first time out of bed, recovery of bowel sounds, time of anal exhaust, and first defecation, and hospital stay in the experimental group were shorter than those in the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion For patients undergoing laparoscopic cholecystectomy, the perioperative dietary nursing plan based on ERAS concept can effectively reduce the occurrence of postoperative nausea, vomiting, abdominal distension, hypoglycemia and other uncomfortable symptoms, without increasing the risk of intraoperative reflux and aspiration, and can promote the recovery of patients and shorten the length of hospital stay.
		2022 Vol. 19 (26): 142-145,154 [Abstract] ( 17 ) HTML (1 KB) PDF (750 KB) ( 175 )

	146	Effect of behavior change theory nursing model on psychological emotion and cognitive function of patients with psychosomatic disorders
		TIAN Hong ZHANG Jianan XU Fangfang CHEN Junliang
		DOI: 10.20047/j.issn1673-7210.2022.26.33
		Objective To explore the effect of behavior change theory nursing model on psychological emotion and cognitive function of patients with psychosomatic disorders. Methods A total of 150 patients with psychosomatic disorders admitted to the Seventh People’s Hospital of Shaoxing, Zhejiang Province from December 2016 to December 2020 were selected, according to the random number table method, they were divided into control group and observation group, with 75 cases in each group. The control group was treated with routine nursing, while the observation group was treated with the nursing model of behavior change theory on the basis of the control group. The two groups were continuously intervened for eight weeks, and the scores of psychological emotion and cognitive ability were compared between the two groups, and the nursing satisfaction of the two groups was counted. Results Overall analysis showed that there were statistically significant differences in self-rating anxiety scale (SAS) and self-rating depression scale (SDS) scores between the two groups, time points and interaction (P ＜ 0.05); further pairwise comparison, intra-group comparison: SAS and SDS scores of the two groups at each time point (P ＜ 0.05); comparison between groups: at four and eight weeks after intervention, the SAS and SDS scores of the observation group were lower than those of the control group (P ＜ 0.05). Overall analysis showed that there were statistically significant differences in Montreal scale (MoCA) scores between groups, time points and interaction between the two groups (P ＜ 0.05); further pairwise comparison and intra-group comparison: the MoCA score of the two groups at each time point was statistically significant (P ＜ 0.05); comparison between groups: at four and eight weeks after intervention, the MoCA score of the observation group was higher than that of the control group (P ＜ 0.05). Eight weeks after intervention, the nursing satisfaction of the observation group was better than that of the control group (P ＜ 0.05). Conclusion The nursing model of behavioral change theory can effectively improve the psychological and emotional state of patients with psychosomatic disorders, improve their cognitive ability and nursing satisfaction.
		2022 Vol. 19 (26): 146-149 [Abstract] ( 28 ) HTML (1 KB) PDF (578 KB) ( 172 )

	150	Effect of Wechat supported diversified feedback guidance on the psychological state of breast cancer patients undergoing postoperative chemotherapy
		PU Jialin1 ZHANG Liuliu2 ZHU Fengying1 HUANG Liwen1 ZHU Liting1▲
		DOI: 10.20047/j.issn1673-7210.2022.26.34
		Objective To explore the effect of Wechat supported diversified feedback guidance on the psychological state of breast cancer patients undergoing postoperative chemotherapy. Methods A total of 110 breast cancer patients who received postoperative chemotherapy in the Department of Oncology, Jiangsu Cancer Hospital from January 2020 to December 2021 were selected as the research objects, according to the random number table method, they were divided into conventional group and feedback guidance group, with 55 cases in each group, the routine group was given routine guidance, while the feedback guidance group was given diversified feedback guidance supported by Wechat. Sense of coherence scale (SOC-13), death anxiety scale (C-T-DAS) and functional assessment of cancer the rapy-breast (FACT-B) were used to evaluate the effect of intervention. Results After intervention, the SOC-13 score of the two groups was higher than that before intervention, and the SOC-13 score of the feedback guidance group was higher than that of the conventional group, and the differences were statistically significant (P ＜ 0.05); the C-T-DAS score of the two groups was lower before intervention, and the C-T-DAS score of the feedback guidance group was lower than thoat of the conventional group, and the differences were statistically significant (P ＜ 0.05). The FACT-B score was higher than that before intervention, and the FACT-B score of the feedback guidance group was higher than that of the conventional group, and the differences were statistically significant (P ＜ 0.05). Conclusion The implementation of Wechat supported diversified feedback guidance for patients after radical mastectomy can significantly improve their sense of psychological coherence, reduce their sense of death anxiety, improve their psychological state and ehance their quality of life.
		2022 Vol. 19 (26): 150-154 [Abstract] ( 22 ) HTML (1 KB) PDF (644 KB) ( 46 )

	155	Intervention effect of standardized emergency nursing process in emergency nursing of children with bronchial asthma
		FANG Hua ZHAO Guangyun TAO Mei
		DOI: 10.20047/j.issn1673-7210.2022.26.35
		Objective To analyze the intervention effect of standardized emergency nursing process in emergency nursing of children with bronchial asthma. Methods A total of 110 children with bronchial asthma admitted to Lu’an People’s Hospital, Anhui Province from October 2019 to September 2021 were selected as the research subjects. According to the random number table, they were divided into the control group and the observation group, with 55 cases in each group. The control group received routine emergency nursing, the observation group adopted standardized emergency nursing process for nursing intervention. Both groups observed that the children were discharged from hospital. The lung function, psychological status, asthma control, and quality of life were compared between the two groups before intervention and at the time of discharge. Results At discharge, forced expiratory flow 25, forced expiratory flow 50 in the observation group were higher than those before intervention, and the observation group was higher than the control group (P ＜ 0.05). The scores of self-rating anxiety scale and self-rating depression scale in the two groups were lower than those before intervention, and the observation group was lower than the control group (P ＜ 0.05). At discharge, the scores of asthma control test, emotional function, symptoms, and activity in the observation group were higher than those before intervention and those in the control group (P ＜ 0.05). Conclusion Standardized emergency nursing process was used in emergency nursing of children with bronchial asthma, which could effectively improve their lung function, psychological status, and quality of life, help to control their illness, and had a better intervention effect.
		2022 Vol. 19 (26): 155-158 [Abstract] ( 19 ) HTML (1 KB) PDF (570 KB) ( 38 )

	159	Evaluation of clinical practice of patients’ demand-oriented nursing program for patients with diabetes
		YE Xiaojun1 CHEN Zhihua2 MA Xianghua3 DU Shanshan4▲
		DOI: 10.20047/j.issn1673-7210.2022.26.36
		Objective To evaluate the clinical practice evaluation of diabetic patients by a quantitative nursing plan based on patients’ demands. Methods A total of 90 patients with diabetes admitted to Lianyungang Second People’s Hospital, Jiangsu Province from June 2019 to March 2021 were selected as the research objects. The patients were divided into control group and observation group by parity method, with 45 cases in each group. The control group was given traditional nursing measures, while the observation group was given demand-oriented nursing mode. Blood glucose levels and quality of life were compared between the two groups. Results After the intervention, fasting blood glucose and 2-hour postprandial blood glucose in the observation group were lower than those before the intervention, and the observation group was lower than the control group, and the differences were statistically significant (P ＜ 0.05). The scores of all dimensions of quality of life in the two group were higher than those before intervention, and the observation group was higher than that in the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Demand-oriented nursing model for patients with diabetes has high clinical application value, which can stabilize the blood glucose index of patients, promote the self-care management ability of patients, and improve the quality of life of patients.
		2022 Vol. 19 (26): 159-162 [Abstract] ( 17 ) HTML (1 KB) PDF (541 KB) ( 27 )

	163	Application of extended follow-up service for high-risk infants from hospital to discharge in nursing management of premature infants
		GENG Qiuju YU Zhiqin HOU Jing TAN Guiling▲
		DOI: 10.20047/j.issn1673-7210.2022.26.37
		Objective To explore the measures and effects of the extended follow-up service for high-risk infants from in-hospital to discharge in the nursing management of premature infants. Methods A total of 100 premature infants admitted to the Department of Pediatrics of Qingdao Municipal Hospital from January to October 2020 were selected and divided into control group and observation group by random number table method, with 50 cases in each group. The control group was received routine nursing intervention, while the observation group was received extended follow-up services for high-risk children from in-hospital to discharge on the basis of routine nursing. The changes of physical indicators, neurodevelopmental status and the occurrence of neurological sequelae in the children after nursing intervention were observed. Results Six months after discharge, the height and weight of the two groups were higher than those at the time of discharge, while those of the observation group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). After the intervention, the behavioral ability, active muscle tone, passive muscle tone, general assessment, primitive reflex, and total score of the two groups were higher than those before the intervention, while those of the observation group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). The total incidence of neurological sequelae six months after discharge in the observation group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion The introduction of extended follow-up services for high-risk infants from in-hospital to discharge in the nursing management of preterm infants can promote the better physical and neurological development of preterm infants, thereby improving their overall rehabilitation effect.
		2022 Vol. 19 (26): 163-166,178 [Abstract] ( 15 ) HTML (1 KB) PDF (584 KB) ( 29 )

	167	Application effect of multidisciplinary cooperative rehabilitation intervention model in patients undergoing ectopic pregnancy surgery
		XI Jie LIU Dongmei ZHANG Yu LI Rong
		DOI: 10.20047/j.issn1673-7210.2022.26.38
		Objective To explore the effect of multidisciplinary cooperative rehabilitation intervention in the nursing of patients with ectopic pregnancy surgery. Methods A total of 200 patients with ectopic pregnancy who underwent surgical treatment in Urumqi Maternal and Child Health Hospital from January 2019 to December 2021 were selected, according to the random number table method, they were divided into routine group and intervention group, with 100 cases in each group. The conventional group received traditional single-discipline nursing intervention, and the intervention group received multidisciplinary cooperative rehabilitation intervention. The improvement of negative emotion, postoperative complications. and postoperative rehabilitation were observed. Results After intervention, the scores of Hamilton anxiety scale and Hamilton depression scale in the two groups were lower than those before intervention, and the intervention group was lower than the conventional group, and the differences were statistically significant (P ＜ 0.05). The total incidence of postoperative complications in intervention group was lower than that in routine group, and the difference was statistically significant (P ＜ 0.05). The average time of postoperative ambulation, anal exhaust, bowel sounds and gastrointestinal function recovery, and the average postoperative hospital stay in the intervention group were shorter than those in the conventional group, and the differences were statistically significant (P ＜ 0.05). Conclusion Multidisciplinary cooperative rehabilitation intervention in perioperative nursing of patients with ectopic pregnancy surgery can improve patients’ negative emotions, reduce complications and speed up postoperative rehabilitation.
		2022 Vol. 19 (26): 167-170 [Abstract] ( 16 ) HTML (1 KB) PDF (590 KB) ( 157 )

	171	Effects of psychological intervention combined with graphic communication and nursing on the negative emotions and health awareness of family members in children with severe pneumonia
		ZHOU Hairong NIU Dan WANG Simin LIANG Juan▲
		DOI: 10.20047/j.issn1673-7210.2022.26.39
		Objective To explore the effect of psychological intervention combined with graphic communication and nursing on the negative emotions and health awareness of family members in children with severe pneumonia, to provide a theoretical reference for clinical practice. Methods A total of 108 children with severe pneumonia and their families who were admitted to the Department of Pediatrics the First Affiliated Hospital of the Military Medical University of the Chinese People’s Liberation Army Air Force from January 2020 to December 2021 were selected as the research objects. They were divided into the control group and the observation group by random number table method, with 54 cases in each group. The control group was given routine psychological intervention, while the observation group was given graphic communication and nursing on the basis of the control group. The negative emotions, medical compliance behavior of children, and health awareness of family members of the two groups were compared. Results After one week of nursing, the proportions of externalizing behavior, internalizing behavior, disorder, and ability in the two groups were lower than those before nursing, while those of the observation group were lower than those of the control group, and the differences were statistically significant (P ＜ 0.05). The proportion of children following doctor’s instruction in taking medicine, diet, work and rest, and activities in the observation group were higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). The health awareness of family members in the observation group was better than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion The application of psychological intervention combined with graphic communication and nursing can relieve the negative emotions of children with severe pneumonia, improve the compliance of children with medical treatment, and enhance the health awareness of family members. It is worthy of widespread clinical promotion and application.
		2022 Vol. 19 (26): 171-174 [Abstract] ( 21 ) HTML (1 KB) PDF (565 KB) ( 34 )

	175	Application effect of nursing clinical decision support system in perioperative nursing of gynecological malignant tumor
		LI Chunchun SU Xiaohua ZHANG Ying▲
		DOI: 10.20047/j.issn1673-7210.2022.26.40
		Objective To explore the application effect of nursing clinical decision support system (CDSS) in perioperative nursing of gynecological malignant tumors. Methods A total of 128 patients with gynecological malignant tumors who were admitted to Tangdu Hospital of Air Force Military Medical University from November 2020 to November 2021 were selected. According to the random number table method, they were divided into CDSS nursing group (used CDSS-based nursing work mode) and routine nursing group (only received routine nursing), with 64 cases in each group. The quality of care, complications, and patients’ satisfaction were evaluated in the two groups. Results The compliance rate of nursing grade, the correct rate of nursing diagnosis, and the timely rate of nursing treatment in the CDSS nursing group were higher than those in the routine nursing group, and the differences were statistically significant (P ＜ 0.05). The total incidence of complications in the CDSS nursing group was lower than that in the routine nursing group, and the difference was statistically significant (P ＜ 0.05). The scores of nursing operation, service timeliness, nursing safety, and overall nursing quality satisfaction in the CDSS nursing group were higher than those in the routine nursing group, and the differences were statistically significant (P ＜ 0.05). Conclusion The CDSS nursing work mode can improve the nursing quality of gynecological malignant tumor patients, reduce postoperative complications, and improve patients’ satisfaction.
		2022 Vol. 19 (26): 175-178 [Abstract] ( 20 ) HTML (1 KB) PDF (590 KB) ( 44 )

	179	Study on the current situation and countermeasures of scientific and technological achievements of the tertiary medical institutions in Nanjing from 2010 to 2020#br#
		LU Tingting1 HU Dan2 WU Rong1 SHENG Wenqi3
		DOI: 10.20047/j.issn1673-7210.2022.26.41
		Objective To analyze the current situation of scientific and technological achievements of the tertiary medical institutions in Nanjing from 2010 to 2020, and to explore deficiencies and propose feasible countermeasures. Methods According to the names of 35 tertiary medical institutions published by Nanjing Municipal Health Commission, descriptive analysis of the outcomes was carried out based on the retrieval of China Hospital Knowledge Warehouse database. Results A total of 23 843 scientific and technological achievements, of which 84.7% were journal articles; there were five medical institutions with more than 1 000 achievements. Among the top 12 medical institutions, nine were located in Qinhuai District and Gulou District, all of which were tertiary medical institutions. The average output of general hospitals, traditional Chinese medicine (general) hospitals and integrated traditional Chinese and western medicine hospitals was 2.3 times that of specialized hospitals, 5.5 times that of tertiary medical institutions, and 12.8 times that of public medical institutions. Scientific and technological achievements were on the rise. Conclusion Achievements are mainly journal papers, with few patent. Medical and health institutions ignore the transformation of achievements. The uneven development of the institutions caused the gap in achievements. Measures including creating good institutional environment, building service platform, emphasizing the compound talents, and advocating collaboration and sharing can effectively improve the level of scientific and technological achievements.
		2022 Vol. 19 (26): 179-182 [Abstract] ( 12 ) HTML (1 KB) PDF (1351 KB) ( 18 )

	183	Development status and trend forecast analysis of resources and services in primary medical institutions
		HE Shuping1 YANG Haifeng2 XIE Yan2 HUANG Hao3 BIAN Li2
		DOI: 10.20047/j.issn1673-7210.2022.26.42
		Objective To research the resources and services of primary medical institutions in China, and to compare and analyze the overall situation of hospitals and medical service systems, so as to provide references for optimizing the allocation of medical resources and promoting the formation of a reasonable medical treatment pattern. Methods A descriptive analysis was made of the changes in resources and services of primary medical institutions from January 2010 to December 2018, and the proportion of resources and services of primary medical institutions and hospitals in the medical service system were compared and analyzed. The grey system model GM(1,1) was used to predict the number of consultations and general practitioners in primary medical institutions from 2019 to 2021. Results The resources and services of primary medical institutions were on the increase, but the development of hospitals was faster than that of primary medical institutions. The construction of general medicine talent team had achieved initial results, especially the proportion of general practitioners in township health centers had increased rapidly. Conclusion It is necessary to further regulate the total amount and scale of resources of primary medical institutions, strengthen the training and use of talents in primary medical institutions, strengthen the policy guidance and supporting measures for the implementation of the hierarchical diagnosis and treatment system, guide residents to realize the first diagnosis at the primary level, and gradually realize the optimization of the allocation of primary medical resources and the improvement of medical treatment. The order is more reasonable and orderly.
		2022 Vol. 19 (26): 183-188,193 [Abstract] ( 17 ) HTML (1 KB) PDF (1947 KB) ( 15 )

	189	Theoretical basis and innovation path of traditional Chinese medicine integrated community health management under active health
		LUO Guihua REN Jiarui OUYANG Jing JIA Lili LI Xiuqin ZHANG Yuan
		DOI: 10.20047/j.issn1673-7210.2022.26.43
		In view of the fact that the existing “passive health” medical service model in China is far from meeting the increasing demand for health, in order to further solve the problems of population aging, increasing chronic diseases and younger patients at the same time, this paper proposes the “active health” service model. The idea of “preventive treatment of disease” should be integrated into modern health management, and the appropriate techniques of traditional Chinese medicine should be fully tapped. The collaborative governance path should be realized with the participation of the government, universities, medical institutions, communities, and families, and the advantages of traditional Chinese medicine health intervention should be integrated. A “active health” model of health maintenance and health promotion based on the “nationwide system” has been formed, and traditional Chinese medicine has been promoted in communities to provide convenient access to the health of the whole people.
		2022 Vol. 19 (26): 189-193 [Abstract] ( 21 ) HTML (1 KB) PDF (801 KB) ( 171 )

	194	Construction and application exploration of public hospital online recruitment interview model
		ZHANG Yao1 LI Jun2 CAO Dongmei1 CUI Tongtong1
		DOI: 10.20047/j.issn1673-7210.2022.26.44
		This paper sorts out the problems and research limitations of online recruitment interviews with the method of literature review. Combined with the practical process of conducting online recruitment interviews in Beijing Tongren Hospital, Capital Medical University in 2021, the advantages and disadvantages of online interviews are summarized through interviews with experts and interviewers. Online recruitment effectively avoids aggregation and provides a new solution for talent recruitment evaluation in public hospitals, expands the scope of candidates, and ensures the number of hospital talent selection; the employment of graduates has been supported and the recruitment management has been promoted. This article suggests that the recruitment work can be further improved by improving the recruitment materials, improving the recruitment process, and confirming the identity of the candidates for online recruitment. Finally, the application of online recruitment under the multi-district management mode of the hospital was discussed.
		2022 Vol. 19 (26): 194-封三 [Abstract] ( 21 ) HTML (1 KB) PDF (619 KB) ( 174 )

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