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| Analysis on the correlation between heart rate variability and total load of magnetic resonance imaging in cerebral small vessel disease |
| LIU Yuechen XU Hui BAI Hongying▲ |
| Department of Neurology, the Second Affiliated Hospital of Zhengzhou University, Henan Province, Zhengzhou 450000, China |
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Abstract Objective To analyze the correlation between heart rate variability (HRV) and the total load of magnetic resonance imaging (MRI) in cerebral small vessel disease (CSVD). Methods A total of 188 patients with CSVD admitted to the Department of Neurology, the Second Affiliated Hospital of Zhengzhou University from January 2019 to June 2021 were selected as the research objects. According to the imaging results of lacunae, microbleeds, white matter hyperintensity, and perivascular space, the total load score was evaluated. The score of 0-2 points was included in the low load group (132 cases), and the score of 3-4 points was included in the high load group (56 cases). The general data, HRV parameters, and imaging related indexes of the two groups were compared, and the correlation between HRV parameters and MRI total load score, as well as the influencing factors of MRI total load score in CSVD patients were further analyzed. Results The age of the high load group was higher than that of the low load group, the 24 h mean heart rate, standard deviation of the N-N intervals (SDNN), standard deviation of the averages of N-N intervals in all five minute segments of the entire recording (SDANN), root mean square value of the difference between adjacent N-N intervals (rMSSD), total power (TP), low frequency power (LF), and LF/high frequency power (HF) were all lower than those of the low load group, the differences were statistically significant (P ＜ 0.05). SDNN, SDANN, rMSSD, TP, LF, LF/HF were negatively correlated with the total MRI load score of CSVD patients (rs ＜ 0, P ＜ 0.05). Multivariate analysis showed that rMSSD were the influencing factors of MRI total load score of CSVD (P ＜ 0.05). Conclusion HRV parameters are correlated with the MRI total load score of CSVD patients, and autonomic nervous dysfunction may be related to the development of CSVD.
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