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| Effect of high-intensity repetitive transcranial magnetic stimulation on patients with major depression and suicidal ideation |
| LI Songhua FU Kedeng HU Yuanyuan WANG Jianmei |
| Department of Psychiatry, Ningbo Mental Hospital, Zhejiang Province, Ningbo 315032, China |
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Abstract Objective To investigate the effect of high-intensity repetitive transcranial magnetic stimulation (rTMS) on patients with major depression and suicidal ideation. Methods A total of 90 patients with major depression and suicidal ideation admitted in Ningbo Mental Hospital of Zhejiang Province from May 2018 to May 2021 were selected and divided into high-intensity group, routine group, and control group by random number table method, with 30 cases in each group. On the basis of oral Venlafaxine, the high-intensity group was treated with rTMS (twice a day), and the routine group was treated with rTMS (once a day), each treatment in both groups was 6 000 pulses, and the control group was treated with sham stimulation. The scores of Beck suicidal ideation scale Chinese version (BSI-CV) and Hamilton depression rating scale-24 items (HAMD-24) at different time points before and after treatment were observed. The occurrence of adverse reactions in the two groups was recorded. Results A total of seven cases fell off in this study, including three cases in the high-intensity group, two cases in the conventional group, and two cases in the control group. The BSI-CV scores at the end of the 3rd day of treatment in the high-intensity group and the routine group were lower than those before treatment, the BSI-CV scores of the three groups at the end of the 7th day of treatment were lower than those at the end of the 3rd day of treatment, and the BSI-CV scores of the three groups at the end of the 14th day of treatment were lower than those at the end of the seventh day of treatment (P ＜ 0.05). The BSI-CV scores of the high-intensity group at the end of the 3rd, 7th, and 14th day of treatment were lower than those of the routine group and the control group at the same time, the BSI-CV scores of the routine group at the end of the 3rd, 7th and 14th day of treatment were lower than those of the control group at the same time (P ＜ 0.05). The HAMD-24 scores of the three groups at the end of the 7th and 14th days of treatment were lower than those before treatment, and at the end of the 14th day of treatment were lower than those at the end of the 7th day of treatment (P ＜ 0.05). The HAMD-24 scores of the high-intensity group at the end of the 7th and 14th day of treatment were lower than those of the routine group and the control group at the same time, and the HAMD-24 scores of the routine group at the end of the 7th and 14th day of treatment were lower than those of the control group at the same time (P ＜ 0.05). The incidence of headache in high intensity group and routine group were higher than those in control group (P ＜ 0.017). Conclusion High-intensity rTMS treatment can quickly reduce the depressive symptoms and suicidal ideation in patients with major depression, and the effect is better than the conventional treatment once a day, which is a relatively safe treatment measure.
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