Research progress of PD-1/PD-L1 inhibitors in the treatment of metastatic colorectal cancer
YIN Zhucheng LIANG Xinjun
Departments of Abdominal Oncology, Hubei Clinical Medical Research Center for Colorectal Cancer, Wuhan Colorectal Cancer Clinical Medical Research Center, Hubei Cancer Hospital, Hubei Province, Wuhan 430070, China
Abstract Colorectal cancer is one of the most common malignant tumors in the world. Most patients have metastases at diagnosis, the prognosis is poor. In recent years, immune checkpoint inhibitors have made a breakthrough progress in the treatment of a variety of malignant tumors, which is one of the current research hotspots. Monotherapy or combination therapy with programmed death-1 (PD-1)/programmed cell death ligand-1 (PD-L1) inhibitors may provide clinical benefit for patients with DNA mismatch repair defects/high microsatellite instability metastatic colorectal cancer (mCRC). The efficacy of monotherapy in patients with mismatch repair proficient/microsatellite stable mCRC is poor, and the feasibility of combination therapy with PD-1/PD-L1 inhibitors is being explored. This article reviews the application of PD-1/PD-L1 inhibitors in first-line, second-line, and posterior line treatment of mCRC patients, as well as the clinical research status and progress of PD-1/PD-L1 inhibitors monotherapy and combination therapy in different types of mCRC patients, so as to provide evidence for clinical application.
YIN Zhucheng LIANG Xinjun. Research progress of PD-1/PD-L1 inhibitors in the treatment of metastatic colorectal cancer[J]. 中国医药导报, 2022, 19(26): 39-42,57.
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