血清血管生成素样蛋白8、白细胞介素-23水平与缺血性卒中患者颈动脉斑块易损风险的关系

doi:10.20047/j.issn1673-7210.2022.26.13

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Abstract Objective To investigate the relationship between serum angiopoietin-like protein 8 (ANGPTL8) and interleukin-23 (IL-23) levels and the risk of carotid plaque vulnerability in patients with ischemic stroke (IS). Methods A total of 197 patients with IS who were admitted to Shiyan Taihe Hospital, Hubei Province from January 2020 to September 2021 were selected. They were divided into vulnerable group (112 cases), stable group (46 cases), non-plaque (39 cases) according to the result of carotid ultrasound examination. The influencing factors of carotid plaque vulnerability risk in patients with IS were analyzed, and the receiver operating characteristic (ROC) curve was used to analyze the predictive value of serum ANGPTL8 and IL-23 levels on carotid plaque vulnerability risk in patients with IS. Results The serum levels of hypersensitivity C-reactive protein (hs-CRP), ANGPTL8, and IL-23 in vulnerable group were higher than those in stable group and non-plaque group, and the serum levels of ANGPTL8 and IL-23 in stable group were higher than those in non-plaque group (P < 0.05). The levels of low density lipoprotein cholesterol (LDL-C) in vulnerable group and stable group were higher than those in non-plaque group, and the levels of high density lipoprotein cholesterol were lower than those in non-plaque group (P < 0.05). LDL-C, hs-CRP, ANGPTL8, and IL-23 were independent risk factors for carotid plaque vulnerability risk in IS patients (OR > 1, P < 0.05). The area under the curve of ANGPTL8 and IL-23 combined to predict the carotid plaque vulnerability risk in patients with IS was higher than that of ANGPTL8 and IL-23 alone (P < 0.05). Conclusion Serum ANGPTL8 and IL-23 levels are independent risk factors for carotid plaque vulnerability risk in IS patients, and can be used as predictors of carotid plaque vulnerability risk.

Key words： Ischemic stroke Carotid plaque Plaque vulnerability Angiopoietin-like protein 8 Interleukin-23

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	AN Ran YANG Lu AI Zhibing

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AN Ran YANG Lu AI Zhibing. Relationship between serum angiopoietin-like protein 8, interleukin-23 levels and the risk of carotid plaque vulnerability in patients with ischemic stroke[J]. 中国医药导报, 2022, 19(26): 58-61,74.

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https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2022.26.13 OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I26/58

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