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| Clinic value of serum Klotho protein for patients with traumatic brain injury complicated with acute kidney injury |
| REN Bin1 WANG Yonghong1 DING Xinmin1 LIANG Jifang2 |
1.Department of Neurosurgery, Shanxi Bethune Hospital (Shanxi Academy of Medical Sciences Tongji Shanxi Hospital) Third Hospital of Shanxi Medical University, Shanxi Province, Taiyuan 030032, China;
2.Department of Intensive Care Unit, Shanxi Bethune Hospital, (Shanxi Academy of Medical Sciences Tongji Shanxi Hospita) Third Hospital of Shanxi Medical University, Shanxi Province, Taiyuan 030032, China |
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Abstract Objective To investigate the value of serum Klotho protein level in the early diagnosis and prognosis of patients with traumatic brain injury complicated with acute kidney injury. Methods A total of 122 patients diagnosed with traumatic brain injury in the Department of Critical Care Medicine of Shanxi Bethune Hospital from July 2019 to September 2020 were selected as the research objects. According to the renal injury, they were divided into acute kidney injury group (37 cases) and non-acute kidney injury group (85 cases). The clinical data of the two groups were collected and compared. Logistic regression model was used to analyze the influencing factors of renal injury in patients with traumatic brain injury, and its diagnostic value was further analyzed. Results Body mass index, white blood cell count, neutrophil count, blood glucose, creatinine, and acute physiology and chronic health evaluationⅡ score of acute kidney injury group were higher than those in the non-acute kidney injury group, mean arterial pressure, platelet, lymphocyte count, albumin, and serum Klotho protein were lower than those in the non-acute kidney injury group, the differences were statistically significant (P ＜ 0.05). Multivariate analysis showed that high white blood cell count, platelet, and blood glucose levels were independent risk factors for acute kidney injury secondary to traumatic brain injury (OR ＞ 1, P ＜ 0.05), and high serum Klotho protein level was a protective factor (OR ＜ 1, P ＜ 0.05). The area under the receiver operating characteristic curve of serum Klotho protein in diagnosing acute kidney injury after craniocerebral injury was 0.897 (95%CI: 0.836-0.941) (P ＜ 0.05), and the cutoff value was 148.07 pg/ml. Conclusion Serum Klotho protein level can be used as an early diagnostic and predictive index for acute kidney injury secondary to craniocerebral injury.
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