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2022 Vol. 19, No. 20 Published: 2022-07-15

	5	Structure prediction and immune simulation of Brucella Omp2a-BtpB multi-epitope vaccine
		LI Min1 ZHU Yuejie2 HU Jinwei1 GU Ting1 YU Mingkai3 CHEN Zhiqiang3 DING Jianbing3 ZHANG Fengbo1
		Objective To predict and analyze T and B cell dominant epitopes of Omp2a and BtpB of Brucella by bioinformatics and construct a novel multi-epitope vaccine. Methods The amino acid sequences of the proteins, which were obtained from UniProt Database. Furthermore, the 3D structure of the proteins was builded by I-TASSER. Then being selected dominant epitopes and adjuvants to construct an multi-epitope vaccine and perform immune simulation. Results Two B cell dominant epitopes, five CTL cell dominant epitopes and three Th cell dominant epitopes were obtained in Omp2a. One B cell dominant epitope, five CTL cell dominant epitopes and one Th cell dominant epitope were obtained in BtpB. The constructed multi-epitope vaccine was a hydrophilic stable protein. Conclusion A novel Brucella multi-epitope vaccine is designed by using a bioinformatics approach, providing a theoretical basis for further research on Brucella vaccines.
		2022 Vol. 19 (20): 5-10 [Abstract] ( 21 ) HTML (1 KB) PDF (2241 KB) ( 160 )

	11	Visual analysis of the external treatment of hypertension in traditional Chinese medicine based on CiteSpace#br#
		WANG Ning1 WANG Ruixiang2 SONG Yongmei3
		Objective To visually analyze the literature in the field of external treatment of hypertension in traditional Chinese medicine based on CiteSpace. Methods The literatures in the field of external treatment of hypertension in traditional Chinese medicine from the inception to November 2021 of CNKI, VIP, and Wanfang database were research objects. CiteSpace was used to visually analyze the authors, institutions and keywords included in the literature. Results All of 504 literatures were included. The total number of literatures presented an upward trend. The researchers were represented by Guo Dong, and the research institution was represented by Shandong University of Traditional Chinese Medicine. The research hotpots mainly involved key external therapies, such as acupoint application, ear point bean, Chinese medicine foot bath; commonly used drugs, such as Euodiae Fructus, Prunellae Spica; commonly used acupoints, such as yǒngquán, shénquē; common symptoms, such as vertigo, dyslipidemia; key syndrome types, such as syndrome of hyperactivity of yang due to yin deficiency, syndrome of phlegm and dampness retain in the internal. The research trend was acupuncture, scraping, moxibustion and other characteristic therapies. Conclusion The visual atlas reveals the historical and development trend of external treatment of hypertension in traditional Chinese medicine, this field is in a period of rapid development. The cooperation between authors and institutions is not close. Current research hotpots are the observation of the curative effect of key external treatment, the law of acupoint selection, common symptoms and key syndrome types. The future research trend may still be key external therapies.
		2022 Vol. 19 (20): 11-15 [Abstract] ( 56 ) HTML (1 KB) PDF (2485 KB) ( 19 )

	16	Mechanism exploration of miRNA-205-3p in Kawasaki disease combined with giant coronary artery aneurysm#br#
		ZHENG Yang ZHANG Hui LI Xiaohui ZHANG Mingming LIN Yao SHI Lin
		Objective To explore the role and potential mechanism of human miRNA-205-3p in children with Kawasaki disease (KD) and KD combined with giant coronary artery aneurysm (GCAA). Methods Thirty-six children with KD were hospitalized in Department of Cardiology, Children’s Hospital Capital Institute of Pediatrics from November 2018 to February 2021, included 30 cases in KD group, and six cases in KD combined with GCAA group. There were 20 healthy children and 20 febrile children matched by age and sex in the same period (KD group and KD combined with GCAA group: healthy control group: fever control group = 1.8∶1∶1). The differentially expressed miRNA in KD group, KD combined with GCAA group, healthy control group, and fever control group were screened by microarray. Fluorescence quantitative polymerase chain reaction (qPCR) was used for verification. Possible related regulatory pathways were explored by bioinformatics analysis. Twelve C57BL/6 SPF male mice aged three to four weeks were divided into KD combined with coronary artery injury (CAL) group and control group according to random number table method, with six mice in each group. The animal model of KD combined with CAL was established by intraperitoneal injection of Lactobacillus casei cell wall components. Transforming growth factor-β1 (TGF-β1) and SMAD5 mRNA expressions in mice heart tissue were analyzed by fluorescence qPCR. Results Twelve miRNAs with more than 10 fold differential expression were screened by microarray. The expression of miRNA-205-3p in KD group was significantly higher than that in healthy control group and fever control group, and the difference was statistically significant (P ＜ 0.05). The expression of miRNA-205-3p in KD combined with GCAA group was significantly higher than that in healthy control group, fever control group, and KD group, and the differences were statistically significant (P ＜ 0.05). Bioinformatic analysis suggested miRNA-205-3p might regulate KD and GCAA formation through TGF-β/SMAD5 signaling pathway. TGF-β1 and SMAD5 mRNA expressions in mice heart tissue of KD combined with CAL group were higher than those in control group, the differences were statistically significant (P ＜ 0.05). Conclusion miRNA-205-3p can play a role in the formation of KD and KD combined with GCAA through TGF-β/SMAD5 signaling pathway. This research identifies a new target for clinical intervention in the formation of KD combined with GCAA.
		2022 Vol. 19 (20): 16-20,29 [Abstract] ( 53 ) HTML (1 KB) PDF (2232 KB) ( 22 )

	21	Relationship between the expression of lncRNA ADPGK-AS1 and miR-1301-3p and the prognosis of gastric cancer#br#
		WEI Haofei SUN Haibin WANG Chuan LI Xinjiang
		Objective To study the relationship between the expression of long non-coding RNA (lncRNA) ADPGK-AS1 and microRNA (miR)-1301-3p and the prognosis of gastric cancer. Methods One hundred and forty-two patients with gastric cancer treated in the Second Hospital of Hebei Medical University from May 2016 to May 2018 were selected. The expression levels of lncRNA ADPGK-AS1 and miR-1301-3p in cancer tissues and adjacent tissues were detected by real time quantitative PCR, according to the average value of the two groups, they were divided into lncRNA ADPGK-AS1 high expression group (69 cases), lncRNA ADPGK-AS1 low expression group (73 cases), miR-1301-3p high expression group (70 cases), and miR-1301-3p low expression group (72 cases). Pearson correlation was used to analyze the correlation between lncRNA ADPGK-AS1 and miR-1301-3p expression in cancer tissues. The binding sites between lncRNA ADPGK-AS1 and miR-1301-3p were predicted by online bioinformatics software. Kaplan-Meier survival was used to analyze the survival situation of patients with different lncRNA ADPGK-AS1 and miR-1301-3p expression levels. Results The expressions of lncRNA ADPGK-AS1 and miR-1301-3p in cancer tissues were higher than those in adjacent tissues (P ＜ 0.05). LncRNA ADPGK-AS1 was positively correlated with miR-1301-3p (r = 0.601, P ＜ 0.01). LncRNA ADPGK-AS1 had a binding site with miR-1301-3p at 2422-2443 bases. The median survival time of patients in lncRNA ADPGK-AS1 high expression group was 23.3 months (95%CI: 15.2-26.1), which was lower than that in lncRNA ADPGK-AS1 low expression group of 31.6 months (95%CI: 22.9-34.9) (P ＜ 0.05). The median survival time of patients in miR-1301-3p high expression group was 24.2 months (95%CI: 17.6-28.5), which was lower than that in miR-1301-3p low expression group of 30.5 months (95%CI: 21.6-34.5) (P ＜ 0.05). Conclusion The expressions of lncRNA ADPGK-AS1 and miR-1301-3p are increased in gastric cancer. There are binding sites between lncRNA ADPGK-AS1 and miR-1301-3p, they are potential molecular markers for predicting the prognosis of gastric cancer.
		2022 Vol. 19 (20): 21-24 [Abstract] ( 20 ) HTML (1 KB) PDF (824 KB) ( 23 )

	25	Expression of lncRNAs H19 and its significance in subchondral bone of diabetic mellitus osteoarthritis
		XUE Wei1 KANG Shaoying1 GUO Hongsheng1 WANG Peixia1 WANG Zhenxing1 ZHAN Jinhua1 ZHANG Yingmin1 WANG Huajun2
		Objective To investigate the expression of lncRNAs H19 in the subchondral bone of diabetic mellitus osteoarthritis (OA) and its significance. Methods Three patients with diabetes mellitus OA (DM-OA group), three patients with non diabetes OA (OA group) and, meanwhile, three physical examinees of the control group were selected. The expression of H19 in subchondral bone of each group was compared, H19 overexpression plasmid was constructed, and miR-141 and miR-22 mimic analogues were synthesized. The expression of β-catenin protein was detected. The differentiation function of osteoblasts was detected. Results The expression level of H19 in DM-OA group was higher than that in OA group and control group, and the expression levels of miR-141 and miR-22 in DM-OA group were lower than those in OA group and control group (P ＜ 0.05). The expression level of H19 in OA group was higher than that in control group, and the expression levels of miR-141 and miR-22 in OA group were lower than those in control group (P ＜ 0.05). After overexpression of H19 WT, miR-141, and miR-22 fragments, the fluorescence signal reported by luciferase decreased significantly (P ＜ 0.01). The miR-141 mimic and miR-22 mimic analogues had no effect on the fluorescence signal of mutant plasmids, and the difference was not statistically significant (P ＞ 0.05). The expression levels of β-catenin mRNA and Runx2 mRNA in DM-OA group were higher than those in OA group and control group (P ＜ 0.05). The expression levels of β-catenin mRNA and Runx2 mRNA in OA group were higher than those in control group (P ＜ 0.05). The expression levels of β-catenin protein and Runx2 protein in DM-OA group were higher than those in OA group and control group (P ＜ 0.05). The expression levels of β-catenin protein and Runx2 protein in OA group were higher than those in control group (P ＜ 0.05). Conclusion H19 is overexpressed in the subchondral bone of diabetes OA. H19 can activate Wnt/β-catenin signaling pathway by regulating miR-141 and miR-22 promotes subchondral bone hyperplasia and sclerosis.
		2022 Vol. 19 (20): 25-29 [Abstract] ( 19 ) HTML (1 KB) PDF (1366 KB) ( 28 )

	30	Research on the role of precision medical theory in the training of general practitioners in China
		ZHANG Ruiying1 WANG Jingzhang2 LIN Xian1 DU Jingfang1 WANG Yingying1 FAN Zhifang1
		Community and grass-roots health care is an important basis for the tiered diagnosis and treatment system, and high-quality and specialized general practitioners is the key to the first diagnosis at the grass-roots level. At present, precision medicine puts forward higher requirements for the diagnosis and treatment level of general practitioners. This paper gives some suggestions on how to strengthen the precise medical concepts, theories, and methods of general practitioners. In the new era, general practitioners should strengthen the studies on new theories, new technologies, and new methods of precision medicine, and apply them in clinical practice to promote the development of precision medicine care services. General practitioners shoulder the task of promoting the development of general practice and precision medicine, and should strive to promote their mutual coordination, integration, and synergistic development, with the aim of constructing a modern health service system of “grass-roots general practice and specialized precision medicine”.
		2022 Vol. 19 (20): 30-32 [Abstract] ( 31 ) HTML (1 KB) PDF (503 KB) ( 85 )

	33	Research progress of KISS-1 / KISS-1R system in regulating reproductive endocrine system
		HUANG Tiantian ZHANG Xuerong LIU Jianzhong
		As one of the tumor metastasis suppressors, KISS-1 is first discovered in human melanoma. KISS-1 has become a research hotspot in the medical field since its discovery. At present, KISS-1 has been proved to inhibit tumor metastasis, regulate gonadotrophin releasing hormone secretion, and regulate feeding behavior as an appetite regulator, so it has been included in the study of malignant tumors, reproductive system, endocrine, and metabolic diseases and other multi-system diseases. Therefore, this paper mainly discusses the effects of KISS-1 from the aspects of puberty initiation, reproductive function, energy metabolism, and other neuroendocrine functions.
		2022 Vol. 19 (20): 33-36 [Abstract] ( 22 ) HTML (1 KB) PDF (520 KB) ( 24 )

	37	Application progress of finite element analysis method in vertebroplasty
		QIAN Cheng JIANG Tao
		The application of finite element analysis method in the study of spinal biomechanics has been quite mature with the rapid development of computer technology. The use of finite element analysis method can accurately simulate the complex mechanical environment of osteoporotic vertebral compression fracture and provide theoretical basis for the selection of surgical treatment plans. This paper reviews the application progress of finite element analysis method in vertebroplasty in recent years, and focuses on how the finite element analysis method plays a role in the selection of surgical approach, determination of bone cement dosage, and evaluation of bone cement materials.
		2022 Vol. 19 (20): 37-40,57 [Abstract] ( 53 ) HTML (1 KB) PDF (696 KB) ( 154 )

	41	Investigation on the detection rate and risk factors of dyslipidemia in the physical examination population of the Zhuang nationality in Nanning City
		HUANG Yunhua1 GAN Min2 QIN Yuanyuan1 ZHAI Lujie2 CHEN Qingyun2 LIN Faquan1 SUN Zilin3 WANG Peng2▲
		Objective To study the detection rate and risk factors of dyslipidemia in the population of the Zhuang nationality in Nanning City, and provide a theoretical basis for the prevention and treatment of dyslipidemia. Methods The baseline data of urban and rural Zhuang residents aged 20-70 from Nanning in 2017 using the Guangxi project of National Key Research and Development Projects was analyzed. A random stratified cluster sampling method was used to enroll the research objects, a total of 2019 cases were enrolled for questionnaire surveys, physical examinations, and blood index tests. After excluding the invalid population, 1982 subjects were finally included. The subjects were divided into dyslipidemia group and non-dyslipidemia group according to the levels of blood lipids. The differences of various indexes between dyslipidemia group and non-dyslipidemia group were compared. The risk factors of dyslipidemia were analyzed by using the binary logistic regression. Results A total of 815 cases of abnormal lipids were examined, accounting for 41.1% of the total number. The detection rates of hypertriglyceridemia and low high-density lipoprotein cholesterol in men were higher than those in women, and the differences were statistically significant (P ＜ 0.05). The age, the ration of tea drinking, high fat intake, snoring, body mass index, diastolic blood pressure, systolic blood pressure, leukocyte, hemoglobin, 2-hour postprandial blood glucose, glycosylated hemoglobin, fasting blood glucose, creatinine, urea nitrogen, and uric acid in the dyslipidemia group were higher than those in the non-dyslipidemia group, and the percentage of neutrophils in the dyslipidemia group was lower than that in the non-dyslipidemia group, and the differences were statistically significant (P ＜ 0.05). The results of binary logistic regression analysis showed that age, body mass index, hemoglobin, 2-hour postprandial blood glucose, uric acid, and urea nitrogen were the independent risk factors for dyslipidemia (P ＜ 0.05), and the percentage of neutrophils was the protective factor for dyslipidemia (P ＜ 0.05). Conclusion The detection rate of dyslipidemia in the Zhuang nationality in Nanning is relatively high. The increased levels of age, body mass index, hemoglobin, 2-hour postprandial blood glucose, uric acid, and urea nitrogen are the risk factors for dyslipidemia.
		2022 Vol. 19 (20): 41-44,61 [Abstract] ( 56 ) HTML (1 KB) PDF (650 KB) ( 119 )

	45	Analysis on demand status and influencing factors of female breast cancer patients undergoing postoperative chemotherapy
		TANG Yao WAN Yonghui ZHOU Han YU Ying
		Objective To understand the demand status and influencing factors of female breast cancer patients undergoing postoperative chemotherapy. Methods By convenience sampling method, a total of 120 female breast cancer patients with postoperative chemotherapy and their spouses visited the Renmin Hospital of Wuhan University and Hubei Cancer Hospital from February to June 2021 were selected as the survey subjects. General information questionnaire, female breast cancer patient needs assessment scale, female breast cancer patients’ spouses needs assessment scale, and Anderson symptom assessment scale were used to conduct questionnaire surveys. Results Total needs of female breast cancer patients with postoperative chemotherapy was 101.50 (94.00, 107.75) points, which was above middle level. There were statistically significant differences in the demand scores of patients with different education levels, medical expense payment methods, and tumor metastasis (P ＜ 0.05). Patients’ needs were positively correlated with neuro-psychological symptom group (r = 0.196), gastrointestinal symptom group (r = 0.187), and spouse need (r = 0.238) (P ＜ 0.05). Medical expense payment mode, tumor metastasis, neuro-psychological symptom group, and spouse need were entered into the regression equation (P ＜ 0.05), which explained 33.2% of the total variation of patients’ needs score. Conclusion The needs of female breast cancer patients undergoing postoperative chemotherapy are above medium level, so provide targeted intervention measures, and promote patient needs satisfaction and the healing of the disease.
		2022 Vol. 19 (20): 45-48 [Abstract] ( 62 ) HTML (1 KB) PDF (579 KB) ( 76 )

	49	Research on construction of demand scale for the aging transformation in the home environment of rural disabled old people in the perspective of rural revitalization
		LI Laiyou1 YAN Junxin2 SUN Ning3 YU Libo1 LIU Baohua1 XU Zhenzhen1
		Objective To develop and establish a demand scale for the aging transformation in the home environment of rural disabled old people. Methods The validity and reliability of the scale for the aging transformation of home environment of rural disabled old people were analyzed and evaluated through evaluation of five experts and investigation of 300 rural disabled old people in five rural areas of Ningbo City, Zhejiang Province from July to December 2020. Results A total of 300 questionnaires were distributed in this survey, 275 valid questionnaires were recovered, and the effective recovery rate was 91.7%. The validity of demand scale for rural disabled old people in the home environment is good. The number of items in the scale “very relevant” was accounted for 88.4% (221/250) of the total number of items. The results showed that the scale had good surface validity. The content validity index was 0.952, it showed that the content validity was good. The cumulative contribution rate of principal components of the nine primary indicators was 89.5%, 50 items had large factor load (≥0.5) on their corresponding principal components, this showed good structural validity. The reliability of the aging transformation demand scale was good, there was a significant correlation between the whole scale and nine primary indicators (r = 0.752-0.981, P ＜ 0.01). Cronbach’s α coefficient of the whole scale and nine primary indicators and items was 0.925-0.986, the correlation between the nine primary indicators and their contents was more than 0.40 (P ＜ 0.01). Conclusion The validity and reliability of the scale for the aging transformation of home environment of rural disabled old people are good. It is applicable to the evaluation of aging transformation of rural disabled old people in the home environment in China.
		2022 Vol. 19 (20): 49-52 [Abstract] ( 20 ) HTML (1 KB) PDF (568 KB) ( 144 )

	53	Research analysis of the correlation between Alzheimer’s disease and type two diabetes mellitus
		ZHANG Shuyan SUN Shuning
		Objective To study the correlation between Alzheimer’s disease (AD) and type two diabetes mellitus (T2DM). Methods One hundred and fifty senile patients with AD first hospitalized in Department of Internal Neurology of Jinqiu Hospital of Liaoning Province from 2017 to 2020 were selected. According to whether combined with T2DM and the course of disease, they were divided into 84 cases in non-T2DM group, 29 cases in T2DM less than or equal to five years group and 37 cases in T2DM more than five years group. The basic data and cognitive function scores of each group were observed. The patients with AD complicated with T2DM were divided into 43 cases in group A and 23 cases in group B according to whether to control blood glucose or not, the course of AD and the score of cognitive function were observed. The effects of the course of T2DM and the level of fasting blood glucose (FBG) on the course of AD and cognitive function were analyzed. Results Body mass index, incidence of stroke, FBG and course of AD in non-T2DM group, T2DM less than or equal to five years group, and T2DM more than five years group were compared, and the differences were statistically significant (P ＜ 0.05). Mini-mental state scale (MMSE), activity of daily living scale (ADL) and AD pathological behavior scale (BEHAVE-AD) scores in non-T2DM group, T2DM less than or equal to five years group, and T2DM more than five years group were compared, the differences were statistically significant (P ＜ 0.05). Compared with group A, the course of AD in group B was prolonged, FBG levels and glycosylated hemoglobin increased, MMSE score decreased, Alzheimer’s disease assessment scale-congnitive score, BEHAVE-AD score, and ADL score increased, and the differences were statistically significant (P ＜ 0.05). The course of T2DM and FBG level were influencing factors of the course of AD, MMSE score, BEHAVE-AD, and ADL score (P ＜ 0.05). Conclusion Patients with AD complicated with T2DM have a long course of AD and a significant decline in cognitive function. Long course T2DM and hyperglycemia can promote the progress of AD. Therefore, if T2DM is found early in AD patients, blood glucose should be controlled in time, which may delay the progress of AD.
		2022 Vol. 19 (20): 53-57 [Abstract] ( 55 ) HTML (1 KB) PDF (597 KB) ( 26 )

	58	Study on correlation between occupational benefit and sleep quality of ICU nurses
		ZHANG Li ZHANG Zuoyan TANG Wenqi ZHENG Qingru QIAN Haiyong▲
		Objective To analyze the correlation between occupational benefit and sleep quality of intensive care unit (ICU) nurses. Methods One hundred and sixty nurses worked in ICU of two third class hospitals in Shanghai from October 2017 to October 2020 were selected as the research subjects by convenient sampling method, all study subjects were women. During the survey, occupational benefit of nurse was assessed by nurses’ sense of professional benefit questionnaire, sleep quality of nurse was assessed by Pittsburgh sleep quality index (PSQI). The baseline data of ICU nurses were collected. PSQI scores of ICU nurses with different data characteristics were compared. The correlation between occupational benefit and sleep quality of ICU nurses was analyzed, and the effect of occupational benefit on sleep quality of ICU nurses was analyzed. Results The score of occupational benefit of 160 included ICU nurses was (89.45±4.17) points and the score of PSQI was (10.28±0.88) points. PSQI score of low occupational benefit group was higher than that of high occupational benefit group, and the difference was statistically significant (P ＜ 0.05). There were no significant differences in PSQI scores among ICU nurses of different ages, working years, technical titles, education, staffing, marital status, and whether there was child care (P ＞ 0.05). By bivariate Pearson correlation test, the sense of professional benefit of ICU nurses was negatively correlated with PSQI score (r = -0.718, P ＜ 0.05). Multiple linear regression analysis showed that the decrease of ICU nurses’ occupational benefit score was a risk factor for the deterioration of sleep quality (P ＜ 0.05). The linear equation was Y = -1.882+0.239X (adjusted R2 = 0.777). Conclusion The sleep quality of ICU nurses is at a medium level, the sense of occupational benefit is negatively correlated with the PSQI score of ICU nurses, the decrease of occupational benefit score has a certain impact on the deterioration of sleep quality of ICU nurses.
		2022 Vol. 19 (20): 58-61 [Abstract] ( 27 ) HTML (1 KB) PDF (826 KB) ( 122 )

	62	Strategy discussion of sternal fixation and closure through median sternal incision in open heart surgery
		LIU Jianzhou MA Guotao LIU Xingrong LI Xiaofeng MIAO Qi ZHANG Chaoji
		Objective To explore the personalized treatment strategy of sternal fixation and closure through median sternal incision in open heart surgery. Methods Patients who underwent open heart surgery with median sternal incision in Peking Union Medical College Hospital, Chinese Academy of Medical Sciences from January 2019 to March 2021 were selected as the research objects. The characteristics of sternal fixation methods and chest incision complications were observed and analyzed retrospectively. Results Of the 293 patients, 169 cases were closed sternum with single steel wire fixation and 124 cases with double steel wire fixation. Robicsek braided sternum in 27 cases (19 cases with single steel wire and eight cases with double steel wire). Eight cases were fixed with sternal plate (five cases with single steel wire and three cases with double steel wire). Allogeneic cancellous bone sternum transplantation was performed in 40 cases (21 cases with single steel wire and 18 cases with double steel wire). Sternal instability occurred in five cases (four cases with single steel wire and one case with double steel wire). Superficial sternal wound infection in six cases (five cases with single steel wire and one case with double steel wire). Deep sternal wound infection in one case (one case with single steel wire and zero case with double steel wire). After active treatment of these complications, they were cured and discharged without related deaths. Conclusion Selecting the appropriate sternal fixation and closure method according to the characteristics of patients can reduce the incidence of sternal incision complications. A personalized selection strategy for sternal fixation and closure is proposed, which requires verification in clinical studies.
		2022 Vol. 19 (20): 62-65,74 [Abstract] ( 25 ) HTML (1 KB) PDF (592 KB) ( 38 )

	66	Effects of hyperbaric oxygen combined with cattle encephalon glycoside and ignotin in treating patients with traumatic brain injury and its effect on the expression of HIF-1α and miR-210
		CHEN Guiping LI Min TIAN Zhihua SHEN Jianbo CUI Jie DUAN Haifeng ZHANG Hao RU Xiaohong▲
		Objective To explore the effect of hyperbaric oxygen combined with cattle encephalon glycoside and ignotin in treating patients with traumatic brain injury and its effect on the expression of hypoxia inducible factor-1α (HIF-1α) and microRNA (miR-210). Methods A total of 110 patients with traumatic brain injury treated in Jincheng People’s Hospital of Shanxi Province from April 2018 to April 2020 were selected and divided into control group and observation group according to random number table method, with 55 cases in each group. Both groups were given conventional treatment, control group was treated with cattle encephalon glycoside and ignotin, and observation group was treated with hyperbaric oxygen combined with cattle encephalon glycoside and ignotin. Both groups were treated for 30 days. Glasgow coma scale (GCS) score, serum levels of neuron specific enolase (NSE), soluble factors associated suicide (sFas), HIF-1α, and miR-210 were compared between two groups before and after treatment. The incidence of secondary epilepsy was followed up for one and three months. Results A total of 102 patients were enrolled in this study, including 52 in the control group and 50 in the observation group. Thirty days after treatment, GCS scores of two groups were higher than those before treatment, and observation group was higher than control group (P < 0.05). Thirty days after treatment, serum levels of NSE, sFas, HIF-1α, and miR-210 of two groups were lower than those before treatment (P < 0.05), and observation group was lower than control group (P ＜ 0.05). Three months after treatment, the incidence of secondary epilepsy in observation group was lower than that in control group (P ＜ 0.05). Conclusion Hyperbaric oxygen combined with cattle encephalon glycoside and ignotin has a better clinical effect in the treatment of traumatic brain injury. It can significantly reduce nerve function injury, inhibit nerve cell apoptosis and regulate the expression of HIF-1α and miR-210, and can reduce the risk of short-term secondary epilepsy to a certain extent.
		2022 Vol. 19 (20): 66-69,91 [Abstract] ( 23 ) HTML (1 KB) PDF (672 KB) ( 59 )

	70	Meta analysis of efficacy and safety of Argatroban combined with Alteplase intravenous thrombolysis in the treatment of acute ischemic stroke
		WANG Ruolan1 HAN Zucheng2 YUAN Jie2 ZHANG Xiaole2 WANG Pei2
		Objective To systematically evaluate the effect of Argatroban combined with Alteplase intravenous thrombolysis in the treatment of acute ischemic stroke (AIS). Methods The databases of CBM, CNKI, Wanfang Data, and VIP were searched by computer, and the randomized controlled trials of Argatroban combined with Alteplase intravenous thrombolysis in the treatment of AIS from the establishment of the database to September 2021 were collected. The meta analysis was carried out with RevMan 5.3 software. Results A total of 1170 AIS patients were included in 13 randomized controlled trials. The results of meta analysis showed that total effective rate (RR = 1.21, 95%CI: 1.14-1.29, P < 0.000 01) and Barthel index score (MD = 7.63, 95%CI: 6.50-8.76, P < 0.000 01) in the experimental group were higher than those in the control group; NIHSS score (MD = -1.73, 95%CI: -1.94 to -1.52, P < 0.000 01), whole blood viscosity (MD = -0.50, 95%CI: -0.60 to -0.40, P < 0.000 01), and hematocrit (MD = -0.13, 95%CI: -0.15 to -0.12, P < 0.000 01) in the experimental group were lower than those in the control group. There was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Funnel plot results suggested that publication bias may exist. Conclusion Argatroban combined with Alteplase intravenous thrombolysis in the treatment of acute ischemic stroke is effective and safe.
		2022 Vol. 19 (20): 70-74 [Abstract] ( 19 ) HTML (1 KB) PDF (2005 KB) ( 35 )

	75	Meta analysis on the efficacy and safety of selective serotonin reuptake inhibitor in the treatment of Alzheimer’s disease with depression
		SONG Fan TANG Xinlong CHENG Fengxian TONG Qinghao
		Objective To systematically evaluate the efficacy and safety of serotonin-selective reuptake inhibitor (SSRIS) in the treatment of Alzheimer’s disease patients with depression. Methods The databases of PubMed, Embase, CNKI, Wanfang Data, VIP were electronically searched for relevant studies from inceptions to May 2021. Two reviewers independently screened the literature, extracted data and assessed the methodolgical quality. And meta analysis was performed by using RevMan 5.3. Results A total of seven studies with 438 patients were included. The results of meta analysis showed that there were no significant differences in the effective rate (OR = 2.33, 95%CI: 0.69-7.91, P = 0.17), the score of Cornell scale for depression in dementia (MD = -2.52, 95%CI: -6.19-1.15, P = 0.18), the score of simple mental state examination scale (MD = -0.30, 95%CI: -0.82-1.41, P = 0.60) and the incidence of adverse reactions (OR = 1.21, 95%CI: 0.65-2.26, P = 0.55) between two groups. Conclusion The efficacy and safety of SSRIS in the treatment of patients with AD concomitant depression are comparable to that of placebo.
		2022 Vol. 19 (20): 75-78 [Abstract] ( 27 ) HTML (1 KB) PDF (0 KB) ( 12 )

	79	Effect of microscope combined with endoscopy in the treatment of hypertensive cerebral hemorrhage
		CHENG Yang YE Xinxin MA Meng WU Kangjia ZHANG Changhao
		Objective To observe the effect of microscope combined with endoscopy in the treatment of hypertensive cerebral hemorrhage. Methods A total of 124 patients with hypertensive cerebral hemorrhage admitted to Department of Neurosurgery in Beijing Yanhua Hospital from January 2019 to December 2021 were selected. They were divided into observation group and control group by random number table method, with 62 cases in each group. The observation group was treated with small bone window craniotomy microscope combined with endoscopic hematoma removal, the control group was treated with small bone window craniotomy and hematoma removal under microscope. The hematoma volume, hematoma clearance rate, rebleeding rate, operation time, hospital stay, Glasgow coma scale (GCS), and activity of daily living (ADL) scores were compared between the two groups. Results The hematoma clearance rate of the observation group was higher than that of the control group, the rebleeding rate of the observation group was lower than that of the control group, and the operation time and hospital stay of the observation group were shorter than those of the control group, the differences were statistically significant (P ＜ 0.05). The GCS scores of the two groups after operation were higher than those before operation, and that of the observation group was higher than that of the control group, the differences were statistically significant (P ＜ 0.05). ADL score of the observation group was higher than that of the control group six months after operation, the difference was statistically significant (P ＜ 0.05). Conclusion Microscope combined with endoscopy in the treatment of hypertensive cerebral hemorrhage has more complete hematoma removal, lower rebleeding rate, shorter operation time and hospital stay. It can be used as a common means for clinical treatment of hypertensive cerebral hemorrhage.
		2022 Vol. 19 (20): 79-82 [Abstract] ( 16 ) HTML (1 KB) PDF (974 KB) ( 17 )

	83	Clinical significance of the expression of miR-590 and miR-16 in hysteromyoma tissue
		HUANG Yan1 ZHOU Yuzhen1 PAN Xiaohong2 ZHU Qianmeng1 ZHANG Yuying1▲
		Objective To explore clinical significance of the expression of microribonucleic acid-590 (miR-590) and miR-16 in hysteromyoma tissue. Methods One hundred and eighty-six patients with hysteromyoma treated in Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, Jiangsu Province from October 2018 to August 2020 were selected as study group, a total of 120 patients with uterine prolapse were selected as the control group. The expression levels of miR-590 and miR-16 in hysteromyoma tissue and normal uterine tissues were detected by real-time quantitative PCR. The influencing factors of hysteromyoma was explored by using multivariate logistic regression analysis. Pearson correlation was used to analyze the relationship between the expression levels of miR-590, miR-16 and the size, number of hysteromyoma. Results The expression level of miR-590 in study group was higher than that in control group, and the expression level of miR-16 was lower than that in control group (P < 0.05). The proportion of diabetes mellitus, menstrual disorders, and reproductive tract inflammation in study group were higher than those in control group, the number of miscarriages in study group was more than that in control group (P < 0.05). Logistic regression analysis showed that menstrual disorder, genital tract inflammation, and the expression levels of miR-590 and miR-16 in uterine tissue were the influencing factors of hysteromyoma (OR = 2.818, 2.751, 3.888, 3.476, P ＜ 0.05). The expression level of miR-590 was positively correlated with the size and number of hysteromyomas (r = 0.767, 0.795, P < 0.05). The expression level of miR-16 was negatively correlated with the size and number of hysteromyomas (r = -0.743, -0.792, P < 0.05). Conclusion MiR-590 is highly expressed in hysteromyoma tissue while miR-16 is low. The expression levels of miR-590 and miR-16 are related to the occurrence of hysteromyoma.
		2022 Vol. 19 (20): 83-86 [Abstract] ( 19 ) HTML (1 KB) PDF (507 KB) ( 14 )

	87	Meta analysis of the association between GBV-C virus infection and non-Hodgkin lymphoma and Hodgkin lymphoma
		XIE Wenrui1 FU Zhengqi1 DENG Chengwei1 ZHANG Zhidong2▲
		Objective To investigate the relationship between human GB virus type C (GBV-C) virus infection and non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL). Methods PubMed, Web of Science, Embase, CNKI, Wanfang database were searched for literatures on the relationship between GBV-C virus infection and NHL and HL. The search time was from January 1990 to July 2021. Two researchers independently screened the literature, extracted data and evaluated the literature. Data was analyzed by using Stata 14.0 software. Results Ten studies were included. Meta analysis showed that GBV-C infection increased the risk of NHL (RR = 2.36, 95%CI: 1.52-3.66, P = 0.0001). Subgroup analysis showed that GBV-C in North America (RR = 2.36, 95%CI: 1.51-3.68, P ＜ 0.001) and GBV-C in Europe (RR = 2.57, 95%CI: 1.41-4.68, P = 0.009) were associated with NHL. Matched GBV-C was associated with NHL (RR = 2.18, 95%CI: 1.23-3.83, P ＜ 0.001). GBV-C of NHL in B cells was related to NHL (RR = 2.12, 95%CI: 1.28-3.51, P ＜ 0.001). Meta analysis showed that GBV-C infection was related to follicular B-cell NHL (RR = 2.06, 95%CI: 1.58-2.67, P ＜ 0.001) and diffuse B-cell NHL (RR = 1.54, 95%CI: 1.16-2.03, P = 0.047). GBV-C infection was not associated with HL (RR = 1.43,95%CI:0.88-2.33, P = 0.15). Conclusion GBV-C infection is closely related to NHL and has nothing to do with HL, so it is suggested to focus on it in clinical work.
		2022 Vol. 19 (20): 87-91 [Abstract] ( 21 ) HTML (1 KB) PDF (1258 KB) ( 31 )

	92	Application value of Camrelizumab combined with GP chemotherapy in non-small cell lung cancer
		CHEN Lei1 CAO Qisheng1 WANG Yuqin1 HUANG Qi2
		Objective To investigate the effect of Camrelizumab combined with GP chemotherapy in the treatment of non-small cell lung cancer (NSCLC). Methods A total of 62 patients with NSCLC admitted to Maanshan People’s Hospital of Anhui Province from June 2019 to February 2021 were selected as the research subjects, and they were divided into single group and combined group according to random drawing, with 31 cases in each group. The single group was treated with GP chemotherapy, and the combined group was treated with Camrelizumab combined with GP chemotherapy. Clinical effects of two groups were compared. The indexes of pulmonary function (forced vital capacity [FVC], forced expiratory volume in the first second [FEV1], maximum ventilation volume [MVV], and immune function (CD4+, CD3+, CD8+) were compared between two groups before treatment and six cycles of treatment. Results Clinical effect of combined group was better than that of single group, and the difference was statistically significant (P ＜ 0.05). Six cycles of treatment, FVC, FEV1, and MVV in two groups were higher than those before treatment, and those in combined group were higher than those in single group, the differences were statistically significant (P ＜ 0.05). Six cycles of treatment, the levels of CD4+ and CD3+ in two groups were higher than those before treatment, and the levels of CD8+ in two groups were lower than those before treatment (P ＜ 0.05), and the levels of CD4+ and CD3+ in combined group were higher than those in single group, and the level of CD8+ in combined group was lower than that in single group, the differences were statistically significant (P < 0.05). Conclusion Camrelizumab combined with GP chemotherapy has a significant effect in the treatment of NSCLC, and can improve the lung function and immune function of patients.
		2022 Vol. 19 (20): 92-95 [Abstract] ( 31 ) HTML (1 KB) PDF (537 KB) ( 70 )

	96	Effect of laparoscopic radical resection of colorectal cancer through natural cavity on postoperative pain, inflammatory response, and intestinal barrier function in patients and health and economics evaluation
		XIE Wei WANG Xiangzhong ZHAO Ke CUI Suyang LI Fei
		Objective To evaluate the effects of trans-anal nature orifice specimen extraction (ta-NOSE) on postoperative pain, inflammatory response and intestinal barrier function in patients and health and economics. Methods Sixty patients underwent laparoscopic colorectal resection (LCR) in Jurong People Hospital, Jiangsu Province from June 2018 to March 2021 were selected, they were divided into two groups by random number table method, with 30 cases in each group. LCR group was treated with routine LCR, and ta-NOSE group was treated with ta-NOSE after LCR. The operation related indexes, pain, inflammation, intestinal barrier function indexes, complications, and health economic evaluation were compared between two groups. Results The amount of intraoperative bleeding in ta-NOSE group was less than that in LCR group, and the postoperative exhaust time and postoperative hospital stay in ta-NOSE group were shorter than those in LCR group (P < 0.05). At three days after operation, visual analogue scale (VAS) scores of two groups were higher than those at one day after operation (P < 0.05). At one day and three days after operation, VAS scores of ta-NOSE group was lower than those of LCR group (P < 0.05). There were statistically significant differences in serum C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), plasma D-lactic acid, and diamine oxidase (DAO) between two groups at different time points (P < 0.05). At one day and three days after operation, serum CRP and TNF-α, plasma D-lactic acid, and DAO between two groups were compared, and the differences were statistically significant (P < 0.05). There was no significant difference in total incidence of complication between two groups (P > 0.05). There was no significant difference in direct medical cost between two groups (P > 0.05); and the direct non-medical cost, indirect medical cost, and total cost in ta-NOSE group were lower than those in LCR group (P < 0.05). Conclusion Compared with conventional LCR, ta-NOSE in patients with colorectal cancer has less trauma, faster postoperative recovery, less stress and inflammation, and higher health and economic value.
		2022 Vol. 19 (20): 96-99 [Abstract] ( 16 ) HTML (1 KB) PDF (592 KB) ( 39 )

	100	Application of LAMβ1 combined with ARPC4 in the diagnosis of colorectal cancer
		XU Hao1 YANG Jie1 YUAN Yuan2▲
		Objective To explore the application value of laminin β1 (LAMβ1) combined with actin-related protein 2/3 complex 4 (ARPC4) in the diagnosis of colorectal cancer. Methods Cancer tissue samples and adjacent tissue samples from 74 patients with colorectal cancer in Rugao People’s Hospital of Jiangsu Province from March 2020 to March 2021 were collected. LAMβ1, ARPC4 mRNA expression levels in cancer tissues and adjacent tissues were detected by real-time fluorescence quantitative PCR; LAMβ1 and ARPC4 protein expression levels in cancer tissues and adjacent tissues were detected by Western blot; LAMβ1 combined with ARPC4 protein expression in the diagnosis of colorectal cancer was analyzed by receiver operating characteristic (ROC) curve. Results The mRNA and protein expression levels of colorectal cancer tissue LAMβ1, ARPC4 mRNA were higher than those in adjacent tissues (P < 0.05). The best cutoff point of cancer tissue LAMβ1, ARPC4 protein expression level in the diagnosis of colorectal cancer was 1.02 and 0.94 respectively; the sensitivity was 78.38% and 81.08% respectively; the specificity was 82.43% and 78.37% respectively; the area under curve (AUC) was 0.815 and 0.804 respectively, the Youden index was 0.608, 0.595, and the combined specificity, AUC and Youden index were 98.65%, 0.873, and 0.757, respectively. Conclusion The expression levels of LAMβ1 and ARPC4 protein in cancer tissues of patients with colorectal cancer are abnormally increased, both of which can be used as sensitive indicators for the diagnosis of colorectal cancer, and the combined diagnosis value of two indicators is higher.
		2022 Vol. 19 (20): 100-103 [Abstract] ( 29 ) HTML (1 KB) PDF (684 KB) ( 35 )

	104	Expression of lncRNA MAGI2-AS3 in tissues of patients with non-small cell lung cancer and the relationship with pathological parameters and prognosis
		YANG Guanghui1 PAN Huimin2 ZHA Lifen2 GU Jun1
		Objective To investigate the expression of long non-coding RNA (lncRNA) membrane associated guanylate kinase, WW, and PDZ domain containing two-antisense RNA three (MAGI2-AS3) in non-small cell lung cancer (NSCLC) patient tissues and the relationship with pathological parameters and prognosis. Methods One hundred and three patients with NSCLC admitted to Danyang People’s Hospital Affiliated to Nantong University from August 2016 to August 2018 were selected. The expressions of lncRNA MAGI2-AS3 in cancer tissues and adjacent tissues were detected. The relationship between lncRNA MAGI2-AS3 expression and pathological parameters of NSCLC patients was analyzed. According to lncRNA MAGI2-AS3 expression level, patients were divided into high lncRNA MAGI2-AS3 expression group (≥ mean lncRNA MAGI2-AS3 expression level) and low lncRNA MAGI2-AS3 expression group (< mean lncRNA MAGI2-AS3 expression level). The three-year survival curve of NSCLC patients was drawn by using Kaplan-Meier method. Prognostic factors of NSCLC patients were analyzed by using multi-factor Cox regression. Results The expression of lncRNA MAGI2-AS3 in NSCLC tissues was lower than that in adjacent tissues, the difference was statistically significant (P < 0.05). There were significant differences in the expression of lncRNA MAGI2-AS3 in patients with different TNM stages and lymph node metastasis (P < 0.05). The median survival time of high lncRNA MAGI2-AS3 expression group (51 cases) was longer than that of low lncRNA MAGI2-AS3 expression group (52 cases), the difference was statistically significant (P < 0.05). Multivariate Cox regression analysis showed that degree of tumor differentiation, TNM stage, lymph node metastasis, and expression level of lncRNA MAGI2-AS3 were influencing factors for poor prognosis in patients with NSCLC (P < 0.05). Conclusion The low expression of lncRNA MAGI2-AS3 in NSCLC tissues is related to TNM stage, lymph node metastasis, and poor prognosis, which can be used as a prognostic indicator for NSCLC patients.
		2022 Vol. 19 (20): 104-107 [Abstract] ( 22 ) HTML (1 KB) PDF (608 KB) ( 36 )

	108	Expression and clinical significance of miRNA-142-5p and RPN2 in glioma
		SU Jing ZHAO Jun LIANG Qiong
		Objective To study the expression and clinical significance of microRNA (miRNA)-142-5p and ribophorin 2 (RPN2) in glioma. Methods Eighty-five glioma patients treated in Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from January to December 2017 were selected. The expressions of miRNA-142-5p and RPN2 mRNA of cancer tissue and adjacent normal tissue were detected by qRT-PCR, the expression of RPN2 protein was detected by Western blot. Bioinformatics software and luciferase experiment were used to predict the interaction site between miRNA-142-5p and RPN2. The relationship between clinicopathological parameters and prognosis of patients with glioma and two indexes were analyzed. Results Compared with adjacent normal tissue, the expression of miRNA-142-5p was lower in cancer tissue, while the expressions of RPN2 mRNA and RPN2 protein were higher in cancer tissue (P < 0.05). There was negative correlation between miRNA-142-5p and RPN2 expression in cancer tissue (r = -0.604, P < 0.001). There were binding sites between miRNA-142-5p and RPN2 mRNA, compared with RPN2 WT group and RPN2 MUT+miRNA-142-5p mimic group, the luciferase activity of RPN2 WT+miRNA-142-5p mimic group was reduced (P < 0.05). The expressions of miRNA-142-5p and RPN2 mRNA were different in glioma patients with different Karnofsky performance status scores and World Health Organization grades (P < 0.05). In the cancer tissue group, patients with low expression of miRNA-142-5p and patients with high expression of RPN2 had a shorter median survival time than patients with high expression of miRNA-142-5p and patients with low expression of RPN2 (P < 0.05). Conclusion The expression of miRNA-142-5p is low and RPN2 is high in glioma. The expression of miRNA-142-5p and RPN2 is significantly negatively correlated, they are markers of poor survival and prognosis.
		2022 Vol. 19 (20): 108-111 [Abstract] ( 22 ) HTML (1 KB) PDF (618 KB) ( 32 )

	112	Short-term efficacy and safety of Anlotinib Hydrochloride in the treatment of advanced non-small cell lung cancer
		WAN Xin’an ZHOU Qin LI Zhuofang CHEN Hao DIAO Haixia
		Objective To explore the short-term efficacy and safety of Anlotinib Hydrochloride in the treatment of advanced non-small cell lung cancer (NSCLC). Methods Eighty patients with advanced NSCLC treated at the second line and above in the Second People’s Hospital of Wuhu City in Anhui Province from June 2018 to May 2021 were selected and they were divided into two groups according to random number table method, with 40 cases in each group. The observation group was treated with Anlotinib Hydrochloride, and the control group was given the best supportive treatment. After six weeks of treatment, the short-term curative effects (objective remission rate [ORR], disease control rate [DCR]), the levels of carcinoembryonic antigen (CEA) and cytokeratin 19 fragment (CYFRA21-1) were compared between two groups. Karnofsky performance status (KPS) score and adverse reactions were observed in two groups. Results After treatment, ORR and DCR of observation group were higher than those of control group (P ＜ 0.05). After treatment, the levels of CEA and CYFRA21-1 in two groups were lower than those before treatment (P < 0.05), and observation group was lower than control group (P < 0.05). After treatment, KPS scores of two groups were higher than those before treatment (P ＜ 0.05), and those of observation group were higher than control group (P ＜ 0.05). The incidence rates of hand foot syndrome, proteinuria, hypertension, and oral mucositis in observation group were higher than those in control group (P < 0.05). Conclusion Anlotinib Hydrochloride has significant short-term efficacy and good safety in the treatment of NSCLC, and it can provide a new treatment for NSCLC patients with treatment failure, which is worthy of popularization and application.
		2022 Vol. 19 (20): 112-115 [Abstract] ( 26 ) HTML (1 KB) PDF (547 KB) ( 33 )

	116	Clinicopathological characteristics of acquired immunodeficiency syndrome related Burkitt lymphoma#br#
		CHANG Jing1 XIE Jianlan2 YUE Zhujun1 ZHANG Yulin3 LYU Fudong1▲
		Objective To investigate the clinicopathological characteristics of acquired immunodeficiency syndrome (AIDS) related Burkitt lymphoma (BL). Methods A total of 29 AIDS related BL patients diagnosed in Beijing Youan Hospital, Capital Medical University from January 2017 to December 2021 were analyzed retrospectively. Clinical data were collected, and pathological features of tumor tissues were observed by hematoxylin-eosin staining, immunohistochemical staining, and fluorescence in situ hybridization. Results There were 28 males and one female in all patients. There were 16 patients aged ＜ 40 years and 13 patients aged ≥40 years. 18 patients were infected with human immunodeficiency virus ≤ one year, and 11 patients were infected with human immunodeficiency virus ＞one year. Lymph node enlargement occurred in 29 patients. Digestive system was involved in 19 patients, bone marrow in eight patients, and central system in six patients. There were 26 patients with Ann Arbor stage Ⅲ/Ⅳ and three patients with Ann Arbor stage Ⅰ/Ⅱ; 16 patients with elevated lactate dehydrogenase; β2 microglobulin was elevated in ten patients and normal in one patient. The copy number of epstein-barr virus was more than 500 in 13 patients and less than 500 in 16 patients. Hematoxylin-eosin staining showed loss of tissue inherent structure, background blue staining, diffuse infiltration of medium and large tumor cells in the shape of paving stones, accompanied by starry sky phenomenon, ten cases of local plasmacytoid differentiation, common nuclear mitosis, nuclear fragmentation, round nucleus, fine granular nuclear chromatin. All 29 patients were positive for CD20, CD10, and Bcl-6. > 90% of tumor cells were Ki-67 positive and > 50% of tumor cells were C-MYC positive in 29 patients, and fluorescence in situ hybridization showed MYC translocation in 29 patients. Twenty-seven patients were CD38 positive; 14 patients were MUM1 positive. EBER positive was found in 13 patients. Conclusion AIDS related BL patients are mostly middle-aged males, and tumor cell related indicators are mostly positive. Antiviral therapy and BL chemotherapy should be combined for treatment.
		2022 Vol. 19 (20): 116-118,135 [Abstract] ( 20 ) HTML (1 KB) PDF (1493 KB) ( 33 )

	119	Clinical observation on cluster needling of scalp points combined with repeated transcranial magnetic stimulation in treating balance disorder after cerebellar infarction
		SHAN Xiaochun ZHOU Peng ZHANG Yu WU Miao LIANG Xuesong
		Objective To discuss clinical effect of cluster needling of scalp points combined with repeated transcranial magnetic stimulation (rTMS) in treating balance disorder after cerebellar infarction. Methods Ninety patients with balance disorder after cerebellar infarction treated in outpatient and ward of Department of Acupuncture and Moxibustion, Shenzhen Baoan Hospital of Traditional Chinese Medicine (Group) from December 2019 to June 2020 were selected and they were divided into group A, group B, and group C according to the random number table method, with 30 cases in each group. Group A was treated with cluster needling of scalp points combined with low-frequency rTMS, group B was treated with pseudo cluster needling of scalp points combined with low-frequency rTMS, and group C was treated with cluster needling of scalp points combined with pseudo low-frequency rTMS. Berg balance scale (BBS) scores, Fugl-Meyer balance scale (FM-B) scores and motor evoked potential (MEP) threshold were observed before treatment and four weeks after treatment in each group. The curative effect of each group was compared. Results After treatment, BBS scores, FM-B scores and MEP threshold of each group were higher than those before treatment, and group A was higher than that of group B and group C (P ＜ 0.05). Four weeks after treatment, the overall efficacy of group A was higher than that of group B and group C (P ＜ 0.05). Conclusion The effect of cluster needling of scalp points combined with low-frequency rTMS in treating patients with balance disorder after cerebellar infarction is better than that of simple cluster needling of scalp points and simple low-frequency rTMS. It can effectively improve clinical effect of balance disorder after cerebellar infarction.
		2022 Vol. 19 (20): 119-122 [Abstract] ( 18 ) HTML (1 KB) PDF (600 KB) ( 107 )

	123	Short-term clinical effect of Minocycline in the treatment of peri-implantitis
		JIANG Liyu SUN Jingyang
		Objective To investigate the short-term clinical effect of Minocycline in the treatment of peri-implantitis. Methods A total of 98 patients with peri-implantitis admitted to Huaian First Hospital Affiliated to Nanjing Medical University from September 2020 to September 2021 were selected as the research objects, and they were divided into control group and study group according to random number table method, with 49 cases in each group. The control group was treated with Er, Cr: YSGG laser, the study group was treated with Minocycline on the basis of control group. Both groups were treated for four weeks. Clinical effects of two groups were compared. Gingival sulcus bleeding index and serum tumor necrosis factor-α (TNF-α) level and urinary deoxypyridinoline (DPD) level were compared between two groups before and after treatment. The adverse reactions of two groups during treatment were compared. Results The short-term effect of study group was better than that of control group, and the difference was statistically significant (P ＜ 0.05). Before treatment, there were no significant differences on gingival sulcus bleeding index, serum TNF-α level and urinary DPD level in two groups (P ＞ 0.05). After treatment, gingival sulcus bleeding index, serum TNF-α level and urinary DPD level in two groups were lower than those before treatment, and study group was lower than control group (P ＜ 0.05). There was no significant difference in the total incidence rate of adverse reactions between two groups (P ＞ 0.05). Conclusion Er, Cr: YSGG laser combined with Minocycline is effective in treating peri-implantitis, it can improve gingival sulcus bleeding index, reduce inflammation and inhibit bone resorption, and it is safe and reliable.
		2022 Vol. 19 (20): 123-126 [Abstract] ( 19 ) HTML (1 KB) PDF (565 KB) ( 23 )

	127	Clinical analysis on 14 cases of flexible hollow probe in the diagnosis and treatment of perianal hidradenitis suppurativa
		GUO Minghao DU Binglin LU Na CUI Guoce
		Objective To analyze the clinical efficacy of flexible hollow probe in the diagnosis and treatment of perianal hidradenitis suppurativa, and to explore the clinical value of flexible hollow probe in the diagnosis and treatment of perianal hidradenitis suppurativa. Methods The clinical characteristics, diagnosis and treatment methods of 14 patients with perianal hidradenitis suppurativa admitted to Department of Anorectal, the South District of Guanganmen Hospital, China Academy of Chinese Medical Sciences from January 2015 to April 2021 were analyzed retrospectively. Results All 14 patients underwent preoperative examination and surgical treatment with a flexible hollow probe. During the operation, the flexible hollow probe was used to locate and the lesion was extensively and thoroughly removed. After the operation, conventional anti-inflammatory and open wounds can be treated with flushing and dressing of the flexible hollow probe. The average operation time was (45±6) minutes, the average hospital stay was (15.6±3.7) days, and the average wound healing time was (38.7±4.5) days. Followed up for six to ten months, a toral of 14 patients were cured without recurrence. Conclusion The flexible hollow probe used in the diagnosis and treatment of perianal hidradenitis suppurativa can guide the accurate resection of the lesion, shorten the operation time, and reduce the pain of the patient, and improve the cure rate of one operation. It conforms to the concept of “precision medicine” and “individualized treatment” and is worthy of clinical promotion application.
		2022 Vol. 19 (20): 127-131 [Abstract] ( 26 ) HTML (1 KB) PDF (736 KB) ( 9 )

	132	Effect of exercise prescription guided by mirror image theory on the recovery of hand function after replantation and lysis of severed finger
		CHU Xiaoxin1 LU Fei1 ZHANG Juan1 LIU Fakun2 LIU Zhen1▲
		Objective To explore the effect of exercise prescription guided by mirror image theory on the recovery of hand function after replantation and lysis of severed fingers. Methods A total of 98 patients after replantation and lysis of severed fingers admitted to Lianyungang First People’s Hospital of Jiangsu Province from March 2016 to May 2021 were selected as the research objects. They were divided into control group of 49 cases and study group of 49 cases according to the random number table method. The control group received conventional rehabilitation treatment after operation, and the study group used exercise prescription training under the guidance of mirror theory after the operation on the basis of control group. The scores of finger replantation function, Michigan hand function assessment scale (MHQ) scores, Barthel index scale scores, total active range of motion (TAM) of finger joints were compared between two groups before and after intervention. Results Before intervention, there were no significant differences in the scores of finger replantation function, MHQ scores, Barthel index scale scores, and TAM between two groups (P > 0.05). After intervention, the scores of finger replantation function, MHQ, Barthel index scale, and TAM in two groups were higher than those before intervention, and those in study group were higher than control group (P < 0.05). Conclusion Exercise prescription training under the guidance of mirror image theory can improve the daily living ability of patients after replantation and release of severed fingers, and promote the recovery of hand function.
		2022 Vol. 19 (20): 132-135 [Abstract] ( 17 ) HTML (1 KB) PDF (569 KB) ( 25 )

	136	Clinical efficacy of transnasal high flow oxygen inhalation therapy in patients with acute exacerbation of chronic obstructive pulmonary disease
		WANG Lanlan LU Yang QIU Xia
		Objective To investigate the clinical effect of transnasal high flow oxygen inhalation therapy in the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods Sixty-six patients with AECOPD treated in Zhoushan Women and Children Hospital from February 2019 to August 2020 were selected and they were divided into control group and observation group according to random number table method, with 33 cases in each group. The control group was treated with noninvasive positive pressure ventilation therapy, and the observation group was treated with transnasal high flow oxygen inhalation therapy. The indexes of blood gas analysis, respiratory rate, heart rate, incidence of complications, reintubation and length of stay in ICU were compared between two groups. Results After treatment, the arterial partial pressure of oxygen and saturation of blood oxygen in two groups were higher than those before treatment, and observation group was higher than control group, the differences were statistically significant (P ＜ 0.05). The arterial partial pressure of carbon dioxide in two groups was lower than that before treatment, and observation group was lower than control group, the differences were statistically significant (P ＜ 0.05). After treatment, respiratory rate and heart rate of two groups were lower than those before treatment, and observation group was lower than control group, the differences were statistically significant (P ＜ 0.05). The incidence rates of bronchospasm, facial and nasal injury, and gastrointestinal flatulence in observation group were lower than those in control group, and the length of stay in ICU of observation group was shorter than that of control group, the differences were statistically significant (P ＜ 0.05). There was no significant difference on reintubation rate between two groups (P ＞ 0.05). Conclusion Transnasal high flow oxygen inhalation in the treatment of AECOPD patients can significantly improve the effect of blood gas indexes and symptoms, and reduce complications.
		2022 Vol. 19 (20): 136-139 [Abstract] ( 54 ) HTML (1 KB) PDF (567 KB) ( 47 )

	140	Experience summary of Professor An Haiyan in treating diabetic nephropathy with “xinrun tongluo method”
		ZHAO Jing1 AN Haiyan2 CAO Yunsong2 GUO Xiaoyuan2
		Diabetic nephropathy is the major microvascular complication of diabetes, and it is also the main cause of end-stage renal disease, the treatment is difficult. Professor An Haiyan believes that the disease always belongs to the syndrome of “deficiency of root cause and excess of manifestation”, and emphasizes that “blood stasis of kidney collaterals” is the core pathogenesis of the disease, which runs through the whole process. Pay attention to treatment by stages, give consideration to both manifestation and root cause, and develop both deficiency and excess. When the prescription is used, it should be flexibly combined with “xintong” and “rourun” Chinese medicine, and “xinrun tongluo method” should be skillfully used in the treatment of each stage, which should be determined according to the syndrome. Each clinical certificate is validated. This article summarizes and discusses Professor An Haiyan’s experience in treating diabetic nephropathy, and attaches a case of medical treatment to prove it, so as to broaden the train of thought for clinical treatment of this disease.
		2022 Vol. 19 (20): 140-143,147 [Abstract] ( 53 ) HTML (1 KB) PDF (842 KB) ( 32 )

	144	Clinical understand on Professor Wu Hong in treating chest bi with Fuling Xingren Gancao Decoction
		WANG Dicheng1 GE Luandie1 CAO Panxia1 HU Menghui1 WANG Kaixia1 WU Hong2
		Fuling Xingren Gancao Decoction is a classic formula created by Zhongjing in treating chest bi. Professor Wu Hong is good at using classic formula to treat heart disease, he believes that fluid retention and qi stagnation is the main pathological factor of chest bi. The application of Fuling Xingren Gancao Decoction in treating chest bi has achieved good results. Combined with the syndrome differentiation thought of six meridians, formula syndrome, qi and blood and fluid, he puts forward that the main pathogenesis of this formula is taiyin disease, water and dampness stagnate in the interior, and qi is not smooth. The key points of formula syndrome are: oppression in chest and panting are the main syndrome, and the syndrome of pale and fat tongue, white and thick greasy fur, and stringy and slippery pulse, which are caused by stopping fluid, dampness retention and qi stagnation. Clinical syndrome differentiation and treatment of chest bi following this context, it will be easier to achieve the purpose of corresponding formula and syndrome, and fast effect. This paper analyzes Professor Wu Hong’s experience in clinical application of this prescription by quoting ancient and modern medical classics, and introducing a case study.
		2022 Vol. 19 (20): 144-147 [Abstract] ( 29 ) HTML (1 KB) PDF (653 KB) ( 26 )

	148	Discussion on medication rule of non-alcoholic fatty liver disease based on national patent of traditional Chinese medicine compound
		SHI Xiaojun TAN Xiang ZHANG Xiaosi ZHANG Xiancui LI Junxiang
		Objective To explore medication rule of non-alcoholic fatty liver disease based on national patent of traditional Chinese medicine compound. Methods “Non-alcoholic fatty liver disease”, “traditional Chinese medicine” and “prescription” were the key words. The published patent compounds of traditional Chinese medicine in treating non-alcoholic fatty liver disease of patent database from database establishment to July 2021 were searched. Drug statistics, compatibility analysis, cluster analysis and complex network analysis were used to study patent compound based on ancient and modern medical records cloud platform. Results A total of 127 patents were included, involving 317 herbs. Salviae Miltiorrhizae Radix et Rhizoma was the most frequent herb. The medicine property was mostly warm. Herbal medicine mainly tasted bitter, sweet and pungent, which mostly belonged to liver and spleen meridians. Most of drug effects were clearing away heat and toxin, removing turbidity and reducing lipid, and promoting water and dampness. The drug compatibility of Crataegi Fructus-Alismatis Rhizoma, Salviae Miltiorrhizae Radix et Rhizoma-Crataegi Fructus appeared more. Three groups of traditional Chinese medicine cluster combinations and one core formula were obtained. Conclusion Traditional Chinese medicine patent compound is mainly used to treat non-alcoholic fatty liver disease, such as soothing liver and strengthening spleen, promoting blood circulation and removing blood stasis, clearing heat and detoxification, removing turbidity and reducing lipid. Medication is peaceful, treating both manifestation and root cause of disease. Its core drug composition can provide reference for clinical medication.
		2022 Vol. 19 (20): 148-151,156 [Abstract] ( 60 ) HTML (1 KB) PDF (996 KB) ( 27 )

	152	Experience of Chinese medicine master Xuan Guowei in treating psoriasis from blood
		ZENG Qiuju1 XUAN Guowei2 WU Meida1 LIAO Liehui2
		Psoriasis is a common and difficult skin disease in clinic. It has a long course, recurrent attacks and is not easy to cure. The understanding of physicians in all dynasties about the cause and pathogenesis is nothing more than blood stasis, blood dryness, blood heat, wind evil, dampness toxin, and so on. Chinese medicine master Xuan Guowei advocates making a point from dryness, toxin and blood stasis for clinical treatment of psoriasis, and starting from blood. According to different clinical manifestations, Professor Xuan divides patients with psoriasis into three types: blood-heat syndrome, blood-stasis syndrome and blood-deficiency syndrome, which are treated separately by cooling blood and detoxifying, promoting blood circulation and removing blood stasis, nourishing blood and moistening dryness. And Professor Xuan creates a basic prescription of psoriasis which originated from Pifu Jiedu Decoction. This paper summarizes Professor Xuan’s experience in treating psoriasis from blood, and lists a case for peer’s communication and reference.
		2022 Vol. 19 (20): 152-156 [Abstract] ( 32 ) HTML (1 KB) PDF (802 KB) ( 37 )

	157	Clinical effect of exercise acupuncture combined with rehabilitation training in treating increased muscle tension of upper limbs after stroke
		WU Chang YAN Jingyi TIAN Zhi
		Objective To analyze clinical effect of exercise acupuncture combined with rehabilitation training in treating increased muscle tension of upper limbs after stroke. Methods Eighty-two patients with increased muscle tension of upper limbs after stroke treated in Nanjing Tongren Hospital Affiliated to Medical College of Southeast University from March 2017 to March 2021 were selected and they were divided into routine group (rehabilitation training) and observation group (exercise acupuncture combined with rehabilitation training) according to random number table method, with 41 cases in each group. After three courses of treatment, total effective rate, Chinese medicine symptom score, upper limb motor function, activities of daily living, and adverse events were compared between two groups. Results After treatment, the total effective rate of observation group was higher than that of routine group (P < 0.05). After treatment, main symptom scores, secondary symptom scores, and total scores of two groups were lower than those before treatment, and observation group was lower than routine group (P < 0.05). After treatment, the scores of Fugl-Meyer motor function scale in two groups were higher than those before treatment, and observation group was higher than routine group (P < 0.05). After treatment, the scores of Barthel index scale in two groups were higher than those before treatment, and observation group was higher than routine group (P < 0.05). There were no significant adverse events in two groups. Conclusion Exercise acupuncture combined with rehabilitation training in the treatment of patients with increased muscle tension of upper limbs after stroke is helpful to reduce Chinese medicine symptoms, improve clinical efficacy, upper limb motor function, and activities of daily living, and has good safety.
		2022 Vol. 19 (20): 157-160 [Abstract] ( 48 ) HTML (1 KB) PDF (543 KB) ( 24 )

	161	Effect of nape acupuncture combined with superficial cervical skin acupuncture on dysphagia after stroke of blood stasis due to qi deficiency type
		XU Chen1 ZHU Yanyan1 WANG Lichun1 HUANG Fenghui2
		Objective To explore the effect of nape acupuncture combined with superficial cervical skin acupuncture on dysphagia after stroke of blood stasis due to qi deficiency type. Methods Sixty inpatients with dysphagia after stroke in Rehabilitation Hospital of Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine, Hebei Province from September 2019 to September 2020 were selected and they were divided into combined acupuncture group and traditional acupuncture group according to random number table method, with 30 cases in each group. On the basis of conventional treatment, combined acupuncture group was treated with nape acupuncture combined with superficial cervical skin acupuncture, traditional acupuncture group was treated with conventional acupuncture, six days one week, one day off, four weeks as a course of treatment. Clinical efficacy, Wata drinking water test grade, Ichiro Fujishima swallowing disorder score and video fluoroscopic swallowing study (VFSS) score were compared between two groups. Results After treatment, clinical effect of combined acupuncture group was better than that of traditional acupuncture group (P < 0.05). After treatment, Wata drinking water test grade in combined acupuncture group was better than that in traditional acupuncture group (P < 0.05). Four weeks after treatment, Ichiro Fujishima swallowing disorder scores in two groups were higher than those before treatment, and combined acupuncture group was higher than traditional acupuncture group (P < 0.05). Four weeks after treatment, VFSS scores of two groups were higher than those before treatment, and combined acupuncture group was higher than traditional acupuncture group (P < 0.05). Conclusion Nape acupuncture combined with superficial cervical skin acupuncture can improve curative effect of dysphagia after stroke, improve swallowing function of patients, and promote rehabilitation process, which is worthy of clinical promotion.
		2022 Vol. 19 (20): 161-164,188 [Abstract] ( 21 ) HTML (1 KB) PDF (686 KB) ( 148 )

	165	Effect of acupuncture at fēngchí acupoint combined with ultrasound-guided stellate ganglion block in the treatment of cervical vertigo
		GUO Hui1 ZHANG Zhijun1 YANG Liqiang2
		Objective To explore the effect of acupuncture at fēngchí acupoint combined with ultrasound-guided stellate ganglion block (SGB) in the treatment of cervical vertigo based on propensity score matching. Methods Clinical data of 150 patients with cervical vertigo diagnosed and treated in Wangjing Hospital of China Academy of Chinese Medical Sciences from January to December 2020 were retrospectively analyzed, among them, 80 cases were treated with ultrasound-guided SGB and included in control group, 70 cases were treated with acupuncture at fēngchí acupoint combined with ultrasound-guided SGB and included in observation group, Finally, 30 cases were included in the control group and the observation group after propensity score matching. After treatment of four weeks, clinical efficacy, clinical symptom score, basilar artery blood flow velocity and vertebral artery blood flow velocity of two groups were compared, and the safety of two groups was observed. Results After matching, clinical effect of observation group was better than that of control group (P < 0.05). After matching, there were no significant differences in clinical symptom scores between two groups before treatment (P > 0.05); clinical symptom scores of two groups after treatment of four weeks were lower than those before treatment, and observation group was lower than control group (P < 0.05). After matching, there were no significant differences in basilar artery blood flow velocity and vertebral artery blood flow velocity of two groups before treatment (P > 0.05); the basilar artery blood flow velocity and vertebral artery blood flow velocity of two groups after treatment of four weeks were faster than those before treatment, and observation group was faster than control group (P < 0.05). There were no risk events and adverse reactions in both groups during treatment. Conclusion Acupuncture at fēngchí acupoint combined with ultrasound-guided SGB in the treatment of cervical vertigo is more effective and safe than ultrasound-guided SGB alone.
		2022 Vol. 19 (20): 165-168 [Abstract] ( 23 ) HTML (1 KB) PDF (585 KB) ( 37 )

	169	Effect evaluation of mind map combined with nailing APP mode in teaching management of nursing students
		WANG Xiaojing DONG Huan XIE Xiaoning LI Aihua KE Jing
		Objective To evaluate the application effect of mind map combined with nailing APP mode in teaching management of nursing students. Methods From February to June 2021, convenience sampling was used to select students from two classes of nursing college of Grade 2017 in Beijing Health Vocational College, and they were divided into two groups according to the drawing method, 29 nursing students from Class One were selected as the control group, and 31 nursing students from Class Two were selected as the intervention group. The control group adopted the traditional teaching mode, and the intervention group adopted mind map combined with nailing APP mode on the basis of traditional teaching mode. The scores of theoretical assessment, teaching satisfaction, and self-regulated learning ability before and after intervention were compared between the two groups. Results The scores of theoretical assessment and teaching satisfaction of the intervention group were higher than those of the control group, and the differences were statistically significant (P < 0.05). After intervention, the learning consciousness, learning behavior, learning evaluation, interpersonal communication score, and total score of the control group were higher than those before intervention; the learning consciousness, learning strategy, learning behavior, learning evaluation, interpersonal communication score, and total score of the intervention group were higher than those before intervention; the learning awareness, learning strategies and total scores of the intervention group were higher than those of the control group, the differences were statistically significant (P < 0.05). Conclusion The teaching mode of mind map combined with nailing APP can fully improve the learning efficiency of nursing students, improve the teaching effect, and provide a scientific and effective teaching mode for nursing teaching.
		2022 Vol. 19 (20): 169-172 [Abstract] ( 22 ) HTML (1 KB) PDF (569 KB) ( 79 )

	173	The positive role of professional nursing guidance in the rehabilitation process of common peroneal nerve injury
		ZHANG Hongyuan1* YAO Xiaowei1* LIU Mengmeng1 ZHU Linyan2▲ ZHAO Meng1 XU Yinghua1 ZHANG Haosen2
		Objective To explore the professional nursing guidance method in the rehabilitation process of common peroneal nerve injury and its positive effect on nerve injury repair. Methods A total of 80 patients with incomplete common peroneal nerve injury who visited the Department of Neurology and Orthopedics of Hebei Chest Hospital and the Department of Neurology of the First Hospital of Hebei Medical University from July 2018 to July 2021 were collected. According to the simple random sampling method, they were divided into control group and professional nursing group, with 40 cases in each group. The control group was given routine nursing, including keeping the affected limb warm, instructed to walk independently, and brace protection; the professional nursing group received professional nursing guidance in addition to routine nursing, including knowledge about common peroneal nerve injury, video-guided functional exercise, nerve electrical stimulation therapy, and warm water foot bath. After three months, the degree of recovery of injured nerve function was evaluated by electromyography, and the differences of related indicators between the two groups were compared. Results After rehabilitation treatment, there were no significant differences in the percentage of spontaneous potential reduction and the percentage of increase in damaged nerve conduction velocity between the two groups (P ＞ 0.05). The increased percentage of motor unit potential recruitment frequency and the increased percentage of injured nerve compound muscle action potential amplitude in the professional nursing group were higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion The professional nursing instruction can help patients create favorable external conditions conducive to neurofunctional restoration in the process of peroneal nerve rehabilitation, so as to promote neurological function recovery faster and better.
		2022 Vol. 19 (20): 173-176 [Abstract] ( 23 ) HTML (1 KB) PDF (469 KB) ( 24 )

	177	Mediating effect of meaning in life between family care and post-traumatic growth in patients after craniocerebral injury surgery
		CHEN Wei1 SHEN Li2 ZHAO Li2
		Objective To analyze relationship between family care, meaning in life, and post-traumatic growth in patients after craniocerebral injury surgery, to explore mediating effect of meaning in life between family care and post-traumatic growth. Methods One hundred and thirty-four patients after craniocerebral injury surgery treated in Lu’an Hospital of Traditional Chinese Medicine of Anhui Province from January 2020 to May 2021 were selected and followed up for three months after discharge. At the end of follow up, family care, meaning in life and post-traumatic growth of patients were evaluated. Mediating effect of meaning in life between family care and post-traumatic growth in patients was mainly analyzed. Results In this study, 134 questionnaires were distributed and 120 valid questionnaires were recovered, and effective recovery rate was 89.55%. The average family APGAR index (APGAR) score was (4.10±1.49) points, as moderate family dysfunction, average meaning in life questionnaire (MLQ) score was (30.65±6.03) points, and average post-traumatic growth inventory (PTGI) score was (50.20±6.57) points. Meaning in life of patients after craniocerebral injury surgery was positively correlated with family care and post-traumatic growth, and family care was positively correlated with post-traumatic growth (r ＞ 0, P ＜ 0.05). The results of linear regression analysis showed that meaning of life played a partial mediating effect in the impact of family care on post-traumatic growth in patients after craniocerebral injury surgery, the contribution rate was 39.87%. Conclusion The post-traumatic growth level of patients after craniocerebral injury surgery needs to be improved, family care can not only affect the level of post-traumatic growth through intermediary of meaning of life, but also directly affect post-traumatic growth level of patients after craniocerebral injury surgery.
		2022 Vol. 19 (20): 177-180 [Abstract] ( 28 ) HTML (1 KB) PDF (884 KB) ( 31 )

	181	A case report on arthroscopic bone bridge resection combined with hemi-epiphyseal block in the treatment of ankle deformity caused by premature closure of distal tibial epiphysis
		HUANG Shunying1 HUANG Jiangfa2 GUAN Jianhao1 LIN Jinhao1 XU Yilang1 LIU Yan2
		Ankle deformity caused by premature closure of distal tibial epiphysis is a severe complication of fracture in children, and its treatment is still controversial currently. In order to explore the treatment of ankle deformity caused by premature closure of distal tibial epiphysis in children, reduce the difficulty of surgical skills and explore operational ideas, this paper retrospectively analyzes clinical data of a child with ankle deformity caused by premature closure of distal tibial epiphysis in Department of Orthopedics of Guangdong Provincial Hospital of Chinese Medicine. By analyzing the age, symptoms, and bone bridge types of children, reviewing relevant literature, discussing treatment scheme, and providing clinical diagnosis and treatment experience for arthroscopic resection of central bone bridge. The main cause of the deformity in this case is the formation of bone bridge. Since Langenski?觟ld applied bone bridge resection for the first time, this technology is famous for its high requirements for operation skills, especially the central bone bridge. There are deficiencies in the previous C-arm machine and navigation system guidance. Arthroscopic monitoring and guidance can provide better guarantee for the accuracy of bone bridge resection and deformity correction.
		2022 Vol. 19 (20): 181-184,193 [Abstract] ( 52 ) HTML (1 KB) PDF (1032 KB) ( 32 )

	185	One case of multiple myeloma with central nervous system infiltration in remission stage
		AN Wanhua WANG Wanli GUO Shuli WANG Songyun WANG Huirui
		One case of multiple myeloma (MM) with central nervous system (CNS) infiltration in remission stage is reported. The patient is a middle-aged female, who is diagnosed with MM and received PCD regimen (Bortezomib + Cyclophosphamide + Dexamethasone) for four courses of chemotherapy, and achieved complete remission. Consolidate one course of treatment, plan to carry out hematopoietic stem cell transplantation, sudden neurological symptoms, improve MRI, flow cytometry and other examinations, clearly diagnose MM complicated with CNS infiltration, and actively give systemic chemotherapy + intrathecal injection and other treatment. After reaching complete remission again, the condition deteriorated rapidly, multiple intracranial metastases, family members gave up treatment, continued to take Ibutinib orally after discharge, and died three months later. Based on the review of relevant literature at home and abroad, this paper expounds the incidence, clinical characteristics, diagnosis, treatment, and prognosis of this disease in detail. It is found that CNS invasion of MM is rare and progresses rapidly. The review, summary, and analysis of the treatment process of this patient shows that ibutinib single drug is an alternative treatment for this kind of patients.
		2022 Vol. 19 (20): 185-188 [Abstract] ( 25 ) HTML (1 KB) PDF (595 KB) ( 48 )

	189	Research on English translation standards of traditional Chinese medicine terms based on traditional Chinese medicine English corpus
		ZHANG Zhe XU Li MIN Ling YAO Qiuhui ZHANG Yue
		Objective To compare the application of two mainstream English translation standards of traditional Chinese medicine (TCM) terminologies in published research papers: International Standard Chinese-English Basic Nomenclature of Chinese Medicine (ISNTCM) by World Federation of Chinese Medicine Societies and WHO International Standard Terminologies on Traditional Medicine in the Western Pacific Region(ISTTM) by World Health Organization. Methods Terminologies from the two standards were collected and processed into Excel and Txt files to count their numbers of words and phrases. A total of 202 papers on TCM published by English edition of Journal of Traditional Chinese Medicine and American Journal of Chinese Medicine from its inception to September 2019 were collected, and a small TCM English corpus was built. The word frequency of two standard phrases and words in the corpus were retrieved. Results The shared words in the two major standards were more than their unique words, indicating that their core morphemes were basically the same, but due to the difference in collocations, there were more unique phrases than the common ones in the two standards. Besides, it was shown that for the terminologies corresponding to the same Chinese meaning, the word frequency of ISNTCM was generally higher than that of ISTTM, indicating that ISNTCM was more popular than ISTTM in published TCM research papers. Conclusion English translation standard of TCM terminology should not only conform to the rules of TCM, linguistics and other disciplines, but also follow the principle of “conventional practice”. Sampling the practical use of existing standards using corpus technology provides empirical evidence support for the related theoretical researches and functions as an effective way to resolve theoretical disputes. Besides, this study also shows that corpus technology might be applied to compile the English dictionary or to establish the English standard for TCM terminologies.
		2022 Vol. 19 (20): 189-193 [Abstract] ( 41 ) HTML (1 KB) PDF (584 KB) ( 143 )

	194	Construction of scientific and technological novelty search consulting service model based on the life cycle of medical scientific research projects
		LIU Yuhua YANG Zhenru ZHANG Xiuju ZHAO Xiaodong ZHAI Junxia
		Build a scientific and technological novelty search consulting service model covering the life cycle of medical scientific research projects, so as to provide reference for medical and health scientific and technological novelty search consulting service institutions. Based on the analysis of life cycle and project life cycle structure, the life cycle of medical scientific research projects is divided into four stages: embryonic stage, formation stage, development stage and mature stage, which respectively correspond to the application, project establishment, implementation and achievement transformation of scientific research projects, and provide corresponding scientific and technological novelty search and consulting services according to the information needs of each stage. It includes providing the direction and trend analysis report of novelty search projects over the years and the analysis report of fund supported projects over the years in the project application stage, providing the novelty search report in the project establishment stage, providing the literature search report of the fixed topic in the project implementation stage, and providing the contribution novelty search report, paper duplicate search report, paper novelty search report in the achievement transformation stage citation report and achievement appraisal and novelty search report are included in the paper.
		2022 Vol. 19 (20): 194-封三 [Abstract] ( 18 ) HTML (1 KB) PDF (825 KB) ( 23 )

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