多发性骨髓瘤缓解期并发中枢神经系统浸润1例报道

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Abstract One case of multiple myeloma (MM) with central nervous system (CNS) infiltration in remission stage is reported. The patient is a middle-aged female, who is diagnosed with MM and received PCD regimen (Bortezomib + Cyclophosphamide + Dexamethasone) for four courses of chemotherapy, and achieved complete remission. Consolidate one course of treatment, plan to carry out hematopoietic stem cell transplantation, sudden neurological symptoms, improve MRI, flow cytometry and other examinations, clearly diagnose MM complicated with CNS infiltration, and actively give systemic chemotherapy + intrathecal injection and other treatment. After reaching complete remission again, the condition deteriorated rapidly, multiple intracranial metastases, family members gave up treatment, continued to take Ibutinib orally after discharge, and died three months later. Based on the review of relevant literature at home and abroad, this paper expounds the incidence, clinical characteristics, diagnosis, treatment, and prognosis of this disease in detail. It is found that CNS invasion of MM is rare and progresses rapidly. The review, summary, and analysis of the treatment process of this patient shows that ibutinib single drug is an alternative treatment for this kind of patients.

Key words： Multiple myeloma Central nervous system infiltration in remission stage Cerebrospinal fluid Flowcytometry Prognosis

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	AN Wanhua WANG Wanli GUO Shuli WANG Songyun WANG Huirui

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AN Wanhua WANG Wanli GUO Shuli WANG Songyun WANG Huirui. One case of multiple myeloma with central nervous system infiltration in remission stage[J]. 中国医药导报, 2022, 19(20): 185-188.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I20/185

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