盐酸安罗替尼治疗晚期非小细胞肺癌的近期效果及安全性

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Abstract Objective To explore the short-term efficacy and safety of Anlotinib Hydrochloride in the treatment of advanced non-small cell lung cancer (NSCLC). Methods Eighty patients with advanced NSCLC treated at the second line and above in the Second People’s Hospital of Wuhu City in Anhui Province from June 2018 to May 2021 were selected and they were divided into two groups according to random number table method, with 40 cases in each group. The observation group was treated with Anlotinib Hydrochloride, and the control group was given the best supportive treatment. After six weeks of treatment, the short-term curative effects (objective remission rate [ORR], disease control rate [DCR]), the levels of carcinoembryonic antigen (CEA) and cytokeratin 19 fragment (CYFRA21-1) were compared between two groups. Karnofsky performance status (KPS) score and adverse reactions were observed in two groups. Results After treatment, ORR and DCR of observation group were higher than those of control group (P ＜ 0.05). After treatment, the levels of CEA and CYFRA21-1 in two groups were lower than those before treatment (P < 0.05), and observation group was lower than control group (P < 0.05). After treatment, KPS scores of two groups were higher than those before treatment (P ＜ 0.05), and those of observation group were higher than control group (P ＜ 0.05). The incidence rates of hand foot syndrome, proteinuria, hypertension, and oral mucositis in observation group were higher than those in control group (P < 0.05). Conclusion Anlotinib Hydrochloride has significant short-term efficacy and good safety in the treatment of NSCLC, and it can provide a new treatment for NSCLC patients with treatment failure, which is worthy of popularization and application.

Key words： Advanced non-small cell lung cancer Anlotinib Short-term efficacy Adverse reaction

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	WAN Xin’an ZHOU Qin LI Zhuofang CHEN Hao DIAO Haixia

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WAN Xin’an ZHOU Qin LI Zhuofang CHEN Hao DIAO Haixia. Short-term efficacy and safety of Anlotinib Hydrochloride in the treatment of advanced non-small cell lung cancer[J]. 中国医药导报, 2022, 19(20): 112-115.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I20/112

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