lncRNA ADPGK-AS1、miR-1301-3p的表达与胃腺癌预后的关系

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Abstract Objective To study the relationship between the expression of long non-coding RNA (lncRNA) ADPGK-AS1 and microRNA (miR)-1301-3p and the prognosis of gastric cancer. Methods One hundred and forty-two patients with gastric cancer treated in the Second Hospital of Hebei Medical University from May 2016 to May 2018 were selected. The expression levels of lncRNA ADPGK-AS1 and miR-1301-3p in cancer tissues and adjacent tissues were detected by real time quantitative PCR, according to the average value of the two groups, they were divided into lncRNA ADPGK-AS1 high expression group (69 cases), lncRNA ADPGK-AS1 low expression group (73 cases), miR-1301-3p high expression group (70 cases), and miR-1301-3p low expression group (72 cases). Pearson correlation was used to analyze the correlation between lncRNA ADPGK-AS1 and miR-1301-3p expression in cancer tissues. The binding sites between lncRNA ADPGK-AS1 and miR-1301-3p were predicted by online bioinformatics software. Kaplan-Meier survival was used to analyze the survival situation of patients with different lncRNA ADPGK-AS1 and miR-1301-3p expression levels. Results The expressions of lncRNA ADPGK-AS1 and miR-1301-3p in cancer tissues were higher than those in adjacent tissues (P ＜ 0.05). LncRNA ADPGK-AS1 was positively correlated with miR-1301-3p (r = 0.601, P ＜ 0.01). LncRNA ADPGK-AS1 had a binding site with miR-1301-3p at 2422-2443 bases. The median survival time of patients in lncRNA ADPGK-AS1 high expression group was 23.3 months (95%CI: 15.2-26.1), which was lower than that in lncRNA ADPGK-AS1 low expression group of 31.6 months (95%CI: 22.9-34.9) (P ＜ 0.05). The median survival time of patients in miR-1301-3p high expression group was 24.2 months (95%CI: 17.6-28.5), which was lower than that in miR-1301-3p low expression group of 30.5 months (95%CI: 21.6-34.5) (P ＜ 0.05). Conclusion The expressions of lncRNA ADPGK-AS1 and miR-1301-3p are increased in gastric cancer. There are binding sites between lncRNA ADPGK-AS1 and miR-1301-3p, they are potential molecular markers for predicting the prognosis of gastric cancer.

Key words： Gastric cancer LncRNA ADPGK-AS1 MiR-1301-3p Prognosis

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	WEI Haofei SUN Haibin WANG Chuan LI Xinjiang

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WEI Haofei SUN Haibin WANG Chuan LI Xinjiang. Relationship between the expression of lncRNA ADPGK-AS1 and miR-1301-3p and the prognosis of gastric cancer#br#[J]. 中国医药导报, 2022, 19(20): 21-24.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I20/21

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