GBV-C病毒感染与非霍奇金淋巴瘤及霍奇金淋巴瘤关系的meta分析

Abstract
Figure/Table
References (32)
Related Citation (15)

Download: PDF (1258 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the relationship between human GB virus type C (GBV-C) virus infection and non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL). Methods PubMed, Web of Science, Embase, CNKI, Wanfang database were searched for literatures on the relationship between GBV-C virus infection and NHL and HL. The search time was from January 1990 to July 2021. Two researchers independently screened the literature, extracted data and evaluated the literature. Data was analyzed by using Stata 14.0 software. Results Ten studies were included. Meta analysis showed that GBV-C infection increased the risk of NHL (RR = 2.36, 95%CI: 1.52-3.66, P = 0.0001). Subgroup analysis showed that GBV-C in North America (RR = 2.36, 95%CI: 1.51-3.68, P ＜ 0.001) and GBV-C in Europe (RR = 2.57, 95%CI: 1.41-4.68, P = 0.009) were associated with NHL. Matched GBV-C was associated with NHL (RR = 2.18, 95%CI: 1.23-3.83, P ＜ 0.001). GBV-C of NHL in B cells was related to NHL (RR = 2.12, 95%CI: 1.28-3.51, P ＜ 0.001). Meta analysis showed that GBV-C infection was related to follicular B-cell NHL (RR = 2.06, 95%CI: 1.58-2.67, P ＜ 0.001) and diffuse B-cell NHL (RR = 1.54, 95%CI: 1.16-2.03, P = 0.047). GBV-C infection was not associated with HL (RR = 1.43,95%CI:0.88-2.33, P = 0.15). Conclusion GBV-C infection is closely related to NHL and has nothing to do with HL, so it is suggested to focus on it in clinical work.

Key words： GB virus type C Non-Hodgkin lymphoma Hodgkin lymphoma Meta analysis

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	XIE Wenrui1 FU Zhengqi1 DENG Chengwei1 ZHANG Zhidong2▲

Cite this article:

XIE Wenrui1 FU Zhengqi1 DENG Chengwei1 ZHANG Zhidong2▲. Meta analysis of the association between GBV-C virus infection and non-Hodgkin lymphoma and Hodgkin lymphoma[J]. 中国医药导报, 2022, 19(20): 87-91.

URL:

https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I20/87

[1] Adams MJ，Lefkowitz EJ，King AM，et al. Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses （2016） [J]. Arch Virol，2016，161（10）：2921-2949.
[2] Zimmerman J，Blackard JT. Human pegivirus type 1 infection in Asia—a review of the literature [J]. Rev Med Virol，2022，32（1）：e2257.
[3] Xie Y，Wang X，Feng J，et al. The prevalence，genetic characterization，and evolutionary analysis of porcine pegivirus in Guangdong，China [J]. Virol Sin，2021，36（1）：52-60.
[4] Reshetnyak VI，Karlovich TI，Ilchenko LU. Hepatitis G virus [J]. World J Gastroenterol，2008，14（30）：4725-4734.
[5] George SL，Varmaz D，Stapleton JT. GB virus C replicates in primary T and B lymphocytes [J]. J Infect Dis，2006， 193（3）：451-454.
[6] Kandathil AJ，Balagopal A. Human hepegivirus-1：innocent traveler，helpful symbiote，or insidious pathogen [J]. Clin Infect Dis，2020，71（5）：1229-1231.
[7] Barrington SF，Trotman J. The role of PET in the first-line treatment of the most common subtypes of non-Hodgkin lymphoma [J]. Lancet Haematol，2021，8（1）：e80-e93.
[8] Ernst D，Pischke S，Greer M，et al. No increased incidence for GB-virus C infection in a cohort of HIV-positive lymphoma patients [J]. Int J Cancer，2011，128（12）：3013.
[9] Nicolosi Guidicelli S，Lopez-Guillermo A，Falcone U，et al. Hepatitis C virus and GBV-C virus prevalence among patients with B-cell lymphoma in different European regions：a case-control study of the International Extranodal Lymphoma Study Group [J]. Hematol Oncol，2012，30（3）：137-142.
[10] Zignego AL，Giannini C，Gentilini P，et al. Could HGV infection be implicated in lymphomagenesis [J]. Br J Haematol，1997，98（3）：778-779.
[11] Fama A，Xiang J，Link BK，et al. Human pegivirus infection and lymphoma risk and prognosis：a North American study [J]. Br J Haematol，2018，182（5）：644-653.
[12] Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses [J]. Eur J Epidemiol，2010，25（9）：603-605.
[13] Normand SL. Meta-analysis：formulating，evaluating，combining，and reporting [J]. Stat Med，1999，18（3）：321-359.
[14] Collier JD，Zanke B，Moore M，et al. No association between hepatitis C and B-cell lymphoma [J]. Hepatology，1999，29（4）：1259-1261.
[15] Pavlova BG，Heinz R，Selim U，et al. Association of GB virus C （GBV-C）/hepatitis G virus （HGV） with haematological diseases of different malignant potential [J]. J Med Virol，1999，57（4）：361-366.
[16] De Renzo A，Persico E，de Marino F，et al. High prevalence of hepatitis G virus infection in Hodgkin’s disease and B-cell lymphoproliferative disorders：absence of correlation with hepatitis C virus infection [J]. Haematologica，2002，87（7）：714-718.
[17] Kaya H，Polat MF，Erdem F，et al. Prevalence of hepatitis C virus and hepatitis G virus in patients with non-Hodgkin’s lymphoma [J]. Clin Lab Haematol，2002，24（2）：107-110.
[18] Giannoulis E，Economopoulos T，Mandraveli K，et al. The prevalence of hepatitis C and hepatitis G virus infection in patients with B cell non-Hodgkin lymphomas in Greece：a Hellenic Cooperative Oncology Group Study [J]. Acta Haematol，2004，112（4）：189-193.
[19] Krajden M，Yu A，Braybrook H，et al. GBV-C/hepatitis G virus infection and non-Hodgkin lymphoma：a case control study [J]. Int J Cancer，2010，126（12）：2885-2892.
[20] Lanteri MC，Vahidnia F，Tan S，et al. Downregulation of cytokines and chemokines by GB virus C after transmission via blood transfusion in HIV-positive blood recipients [J]. J Infect Dis，2015，211（10）：1585-1596.
[21] Stapleton JT，Martinson JA，Klinzman D，et al. GB virus C infection and B-cell，natural killer cell，and monocyte activation markers in HIV-infected individuals [J]. AIDS，2013，27（11）：1829-1832.
[22] Wang T，Chen J，Zhang Q，et al. Prevalence of hepatitis G virus infection among 67，348 blood donors in mainland China [J]. BMC Public Health，2019，19（1）：685.
[23] Stapleton JT，Martinson JA，Klinzman D，et al. GB virus C infection and B-cell, natural killer cell, and monocyte activation markers in HIV-infected individuals [J]. AIDS（London，England），2013，27（1）：1829-1832.
[24] Lauck M，Bailey AL，Andersen KG，et al. GB virus C coinfections in west African Ebola patients [J]. J Virol，2015，89（4）：2425-2429.
[25] Chang CM，Stapleton JT，Klinzman D，et al. GBV-C infection and risk of NHL among U.S [J]. Cancer Res，2014，74（19）：5553-5560.
[26] Jordier F，Deligny ML，Barré R，et al. Human pegivirus isolates characterized by deep sequencing from hepatitis C virus-RNA and human immunodeficiency virus-RNA-positive blood donations，France [J]. J Med Virol，2019， 91（1）：38-44.
[27] Mota LDD，Finger-Jardim F，Silva CM，et al. Molecular and clinical profiles of human pegivirus type 1 infection in individuals living with HIV-1 in the Extreme South of Brazil [J]. Biomed Res Int，2019，2019：8048670.
[28] Slavov SN，Maraninchi Silveira R，Hespanhol MR，et al. Human pegivirus-1（HPgV-1）RNA prevalence and genotypes in volunteer blood donors from the Brazilian Amazon [J]. Transfus Clin Biol，2019，26（4）：234-239.
[29] Fama A，Larson MC，Link BK，et al. Human pegivirus infection and lymphoma risk：a systematic review and meta-analysis [J]. Clin Infect Dis，2020，71（5）：1221-1228.
[30] Liu Z，Zhang Y，Wei F，et al. Detection of GB virus C genomic sequence in the cerebrospinal fluid of a HIV-infected patient in China：a case report and literature review [J]. Epidemiol Infect，2016，144（1）：106-112.
[31] Bukowska-O■ko I，Perlejewski K，Pawe?覥czyk A，et al. Human pegivirus in patients with encephalitis of unclear etiology，poland [J]. Emerg Infect Dis，2018，24（10）：1785-1794.
[32] Balcom EF，Doan MAL，Branton WG，et al. Human pegivirus-1 associated leukoencephalitis：clinical and molecular features [J]. Ann Neurol，2018，84（5）：781-787.