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| Clinicopathological characteristics of acquired immunodeficiency syndrome related Burkitt lymphoma#br# |
| CHANG Jing1 XIE Jianlan2 YUE Zhujun1 ZHANG Yulin3 LYU Fudong1▲ |
1.Department of Pathology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China;
2.Department of Pathology, Beijing Youyi Hospital, Capital Medical University, Beijing 100050, China;
3.Department of Respiratory and Infection, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China |
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Abstract Objective To investigate the clinicopathological characteristics of acquired immunodeficiency syndrome (AIDS) related Burkitt lymphoma (BL). Methods A total of 29 AIDS related BL patients diagnosed in Beijing Youan Hospital, Capital Medical University from January 2017 to December 2021 were analyzed retrospectively. Clinical data were collected, and pathological features of tumor tissues were observed by hematoxylin-eosin staining, immunohistochemical staining, and fluorescence in situ hybridization. Results There were 28 males and one female in all patients. There were 16 patients aged ＜ 40 years and 13 patients aged ≥40 years. 18 patients were infected with human immunodeficiency virus ≤ one year, and 11 patients were infected with human immunodeficiency virus ＞one year. Lymph node enlargement occurred in 29 patients. Digestive system was involved in 19 patients, bone marrow in eight patients, and central system in six patients. There were 26 patients with Ann Arbor stage Ⅲ/Ⅳ and three patients with Ann Arbor stage Ⅰ/Ⅱ; 16 patients with elevated lactate dehydrogenase; β2 microglobulin was elevated in ten patients and normal in one patient. The copy number of epstein-barr virus was more than 500 in 13 patients and less than 500 in 16 patients. Hematoxylin-eosin staining showed loss of tissue inherent structure, background blue staining, diffuse infiltration of medium and large tumor cells in the shape of paving stones, accompanied by starry sky phenomenon, ten cases of local plasmacytoid differentiation, common nuclear mitosis, nuclear fragmentation, round nucleus, fine granular nuclear chromatin. All 29 patients were positive for CD20, CD10, and Bcl-6. > 90% of tumor cells were Ki-67 positive and > 50% of tumor cells were C-MYC positive in 29 patients, and fluorescence in situ hybridization showed MYC translocation in 29 patients. Twenty-seven patients were CD38 positive; 14 patients were MUM1 positive. EBER positive was found in 13 patients. Conclusion AIDS related BL patients are mostly middle-aged males, and tumor cell related indicators are mostly positive. Antiviral therapy and BL chemotherapy should be combined for treatment.
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