高压氧联合脑苷肌肽治疗创伤性颅脑损伤患者的效果及其对HIF-1α及miR-210表达的影响

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Abstract Objective To explore the effect of hyperbaric oxygen combined with cattle encephalon glycoside and ignotin in treating patients with traumatic brain injury and its effect on the expression of hypoxia inducible factor-1α (HIF-1α) and microRNA (miR-210). Methods A total of 110 patients with traumatic brain injury treated in Jincheng People’s Hospital of Shanxi Province from April 2018 to April 2020 were selected and divided into control group and observation group according to random number table method, with 55 cases in each group. Both groups were given conventional treatment, control group was treated with cattle encephalon glycoside and ignotin, and observation group was treated with hyperbaric oxygen combined with cattle encephalon glycoside and ignotin. Both groups were treated for 30 days. Glasgow coma scale (GCS) score, serum levels of neuron specific enolase (NSE), soluble factors associated suicide (sFas), HIF-1α, and miR-210 were compared between two groups before and after treatment. The incidence of secondary epilepsy was followed up for one and three months. Results A total of 102 patients were enrolled in this study, including 52 in the control group and 50 in the observation group. Thirty days after treatment, GCS scores of two groups were higher than those before treatment, and observation group was higher than control group (P < 0.05). Thirty days after treatment, serum levels of NSE, sFas, HIF-1α, and miR-210 of two groups were lower than those before treatment (P < 0.05), and observation group was lower than control group (P ＜ 0.05). Three months after treatment, the incidence of secondary epilepsy in observation group was lower than that in control group (P ＜ 0.05). Conclusion Hyperbaric oxygen combined with cattle encephalon glycoside and ignotin has a better clinical effect in the treatment of traumatic brain injury. It can significantly reduce nerve function injury, inhibit nerve cell apoptosis and regulate the expression of HIF-1α and miR-210, and can reduce the risk of short-term secondary epilepsy to a certain extent.

Key words： Hyperbaric oxygen Cattle encephalon glycoside and ignotin Traumatic brain injury Hypoxia inducible factor-1α MicroRNA-210 Secondary epilepsy

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	CHEN Guiping LI Min TIAN Zhihua SHEN Jianbo CUI Jie DUAN Haifeng ZHANG Hao RU Xiaohong▲

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CHEN Guiping LI Min TIAN Zhihua SHEN Jianbo CUI Jie DUAN Haifeng ZHANG Hao RU Xiaohong▲. Effects of hyperbaric oxygen combined with cattle encephalon glycoside and ignotin in treating patients with traumatic brain injury and its effect on the expression of HIF-1α and miR-210[J]. 中国医药导报, 2022, 19(20): 66-69,91.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I20/66

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