5-羟色胺选择性重摄取抑制剂治疗阿尔茨海默病伴发抑郁症患者有效性和安全性的meta分析

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Abstract Objective To systematically evaluate the efficacy and safety of serotonin-selective reuptake inhibitor (SSRIS) in the treatment of Alzheimer’s disease patients with depression. Methods The databases of PubMed, Embase, CNKI, Wanfang Data, VIP were electronically searched for relevant studies from inceptions to May 2021. Two reviewers independently screened the literature, extracted data and assessed the methodolgical quality. And meta analysis was performed by using RevMan 5.3. Results A total of seven studies with 438 patients were included. The results of meta analysis showed that there were no significant differences in the effective rate (OR = 2.33, 95%CI: 0.69-7.91, P = 0.17), the score of Cornell scale for depression in dementia (MD = -2.52, 95%CI: -6.19-1.15, P = 0.18), the score of simple mental state examination scale (MD = -0.30, 95%CI: -0.82-1.41, P = 0.60) and the incidence of adverse reactions (OR = 1.21, 95%CI: 0.65-2.26, P = 0.55) between two groups. Conclusion The efficacy and safety of SSRIS in the treatment of patients with AD concomitant depression are comparable to that of placebo.

Key words： Serotonin-selective reuptake inhibitor Alzheimer’s disease Depression Efficacy Safety Meta analysis

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	SONG Fan TANG Xinlong CHENG Fengxian TONG Qinghao

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SONG Fan TANG Xinlong CHENG Fengxian TONG Qinghao. Meta analysis on the efficacy and safety of selective serotonin reuptake inhibitor in the treatment of Alzheimer’s disease with depression[J]. 中国医药导报, 2022, 19(20): 75-78.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I20/75

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