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2022 Vol. 19, No. 3
Published: 2022-01-25
 
 
4 Discussion of effects of hot medicinal compress therapy on nerve cell structure and expression of autophagy factor in rats with cervical spondylotic radiculopathy based on Akt / mTOR pathway#br#
ZHAO Yuling HUANG Yi ZHOU Yanqiong JIANG Feifei CHEN Haiyan
Objective To explore the effects of hot medicinal compress therapy on neuronal ultrastructure and expression of autophagy factors in rats with cervical spondylotic radiculopathy (CSR) based on Akt / mTOR signaling pathway. Methods A total of 18 4-week-old SPF SD rats, weighing 150-200 g, and six of them were randomly selected as a blank group, and the rest were established as CSR models. After the molding was successful, they were divided into model group and hot medicinal compress group according to random number table method, with six rats in each group. Blank group and model group were fed normally without any treatment. In the hot medicinal compress group, the bladder channel, the governor channel, and the gallbladder channel were ironed for seven days. After the experiment, the structure of nerve cells was observed by HE staining. Transmission electron microscopy was used to observe the ultrastructure of nerve cells. The expression levels of p-Akt, p-mTOR, Beclin-1, and LC3-Ⅱ/LC3-Ⅰ proteins were detected by Western blot. Results HE staining showed that the tissue morphology of nerve root in the blank group was basically normal. In the model group, the tissue was severely damaged, the outer membrane of nerve root was incomplete, the fibers were disordered, and the axons of some fibers disappeared. The number of cell bodies decreased obviously, but nucleoli were not obvious. In the hot medicinal compress group, the tissue morphology was partially damaged, the nerve root outer membrane was more complete, the fibers were arranged more neatly, and the interstitium was infiltrated with mild inflammatory cells. Transmission electron microscopy showed that cells in blank group had abundant cytoplasm and normal organelles. In the model group, there were nuclear cavities, mitochondrial membrane was fuzzy and some cristae was broken, many lysosomes and autophagosomes were found in the cytoplasm. In the hot medicinal compress group, cytoplasm was abundant, part of mitochondrial membrane was broken, part of cristae was broken and dissolved, lysosomes and autophagosomes were found in cytoplasm. The expression levels of p-Akt and p-mTOR in the model group were lower than those in the blank group, while LC3-Ⅱ/LC3-Ⅰ and Beclin-1 were higher than those in the blank group, the differences were highly statistically significant (P < 0.01). The expression levels of p-Akt and p-mTOR in hot medicial compress group were higher than those in model group, while LC3-Ⅱ/LC3-Ⅰ and Beclin-1 were lower than those in model group, the differences were highly statistically significant (P ＜ 0.01). Conclusion Hot medicinal compress therapy may inhibit excessive autophagy, reduce apoptosis, and promote recovery of damaged nerve roots by enhancing p-Akt and p-mTOR protein expression, and activating Akt / mTOR pathway.
2022 Vol. 19 (3): 4-8 [Abstract] ( 79 ) HTML (1 KB)  PDF (2769 KB)  ( 214 )
9 Effects of different frequencies electro-acupuncture on cerebral ischemia reperfusion model rats#br#
LIAO Heng1 FAN Rongguo2 LI Youchun2 GAO Yujiao1 MU Jingping1
Objective To observe the effects of different frequencies electro-acupuncture on cerebral ischemia reperfusion model rats. Methods A total of 50 SPF male SD rats with the body weight of (235±5) g were selected, and ten of them were randomly selected as the sham operation group. The rest were established by middle cerebral artery occlusion to establish cerebral ischemia reperfusion model. After the molding was successful, they were divided into model group and high, medium, low frequency electro-acupuncture groups by random number table method, with ten rats in each group. High (100 Hz), medium (50 Hz), and low (2 Hz) frequency electro-acupuncture groups were treated with electro-acupuncture at bǎihuì, shéntíng, and shuǐgōu, a total of four weeks of intervention, sham operation group and model group did not intervene. After four weeks, regional cerebral blood flow (rCBF), hemorheological indexes, osmotic fragility of erythrocyte (EOF), blood-brain barrier permeability (Evans blue content in brain tissue), sugar water preference test, and Morris water maze test were compared among five groups. Results In the model group, the whole blood viscosity (high, medium, low cut), plasma viscosity, red blood cell aggregation index, Evans blue content of brain tissue were all higher than those in sham operation group, the sugar water preference rate, EOF (maximum and minimum) were lower than those in the sham operation group, and the escape latency was longer than that in the sham operation group, and the number of table crossing was lower than that in the sham operation group, and the differences were statistically significant (P ＜ 0.05). In high, medium, low frequency electro-acupuncture groups, whole blood viscosity (high, medium, low cut), plasma viscosity, red blood cell aggregation index, Evans blue content of brain tissue were all lower than those in model group, the sugar water preference rate, EOF (maximum and minimum) were higher than those in the model group, and the escape latency was shorter than that in the model group, and the number of table crossing was higher than that in the model group, and the differences were statistically significant (P ＜ 0.05). In the low frequency electro-acupuncture group, whole blood viscosity (high, medium, low cut), plasma viscosity, red blood cell aggregation index, Evans blue content of brain tissue were all lower than those in high and medium frequency electro-acupuncture groups, the sugar water preference rate, EOF (maximum and minimum) were higher than those in high and medium frequency electro-acupuncture groups, and the escape latency was shorter than that in the high and medium frequency electro-acupuncture groups, and the number of table crossing was higher than that in high and medium frequency electro-acupuncture groups, and the differences were statistically significant (P ＜ 0.05). There were statistically significant differences in rCBF among model group, high, medium, and low frequency electro-acupuncture groups at each time point (P ＜ 0.05). The rCBF of the model group was lower than that of the sham operation group at each same time point, the rCBF of high, medium, and low frequency electro-acupuncture groups from the first to the fourth week after intervention were higher than those of model group at the time point, the rCBF of low frequency electro-acupuncture group from the first to the fourth week after intervention were higher than those of high and medium frequency electro-acupuncture groups at the same time point, and the differences were statistically significant (P ＜ 0.05). Conclusion Low frequency electroacupuncture can improve the learning and memory ability of cerebral ischemia reperfusion rats. The mechanism may be related to maintaining the integrity of blood-brain barrier function and promoting the recovery of neural function.
2022 Vol. 19 (3): 9-12,23 [Abstract] ( 172 ) HTML (1 KB)  PDF (698 KB)  ( 60 )
13 Effects of Kujin Tablets on macrophages viral infection stimulated by Poly（I∶C）#br#
ZHU Chunxue HE Yanjie HE Meijuan LIU Qing LIU Chengyu WANG Yicheng HUANG Hanpeng▲
Objective To observe the antiviral action and mechanism of Kujin Tablets by stimulating RAW264.7 with Poly (I∶C) in vitro to simulate virus infection. Methods Cells were divided into control group, Poly (I∶C) group and Kujin Tablets group (1 mg/ml). The Poly (I∶C) group was stimulated with 20 μg/ml of Poly (I∶C) for 12 h, after Poly (I∶C) stimulation, the Kujin Tablets group was treated with the Kujin Tablets (1 mg/ml) for 6 h, while the control group received no special treatment. Antiviral factors (Toll-like receptor 3 [TLR3], interferon regulatory factor-3 [IRF3], interferon-β [IFN-β], interferon stimulated gene 15 [ISG15], oligosadenylate synthase 1[OAS1], myxovirus resistance 1 [MX1]), inflammatory factors (interleukin-6 [IL-6], tumor necrosis factor -α [TNF-α], transforming growth factor -β [TGF-β], endoplasmic reticulum stress gene (inositol-requiring enzyme 1α [IRE1α], spliced X-box binding protein 1 [xBP1s], and C/EBP homologous protein [CHOP]) mRNA levels; and IL-6, TNF-α, xBP1s, and caspase-3 protein levels were detected in all groups. Results The mRNA expression levels of TLR3, IRF3, IFN-β, ISG15, OAS1, MX1, IL-6, TNF-α, TGF-β, IRE1α, xBP1s, and CHOP in Poly (I∶C) group were higher than those in control group, and the differences were statistically significant (P ＜ 0.05). Compared with Poly (I∶C) group, the mRNA expression levels of TLR3, IRF3, IFN-β, ISG15, OAS1, and MX1 in Kujin Tablets group were up-regulated, while the mRNA expression levels of IL-6, TNF-α, TGF-β, IRE1α, xBP1s, and CHOP were down-regulated, and the differences were statistically significant (P ＜ 0.05). The protein expression levels of IL-6, TNF-α, xBP1s, and caspase-3 in Poly (I∶C) group were higher than those in control group, and the differences were statistically significant (P ＜ 0.05). The protein expression levels of IL-6, TNF-α, xBP1s, and caspase-3 in Kujin Tablets group were lower than those in Poly (I∶C) group, and the differences were statistically significant (P ＜ 0.05). Conclusion Kujin Tablets can reduce virus-induced apoptosis, and its mechanism is related to promoting intrinsic antiviral response, reducing the release of inflammatory mediators and regulating endoplasmic reticulum stress.
2022 Vol. 19 (3): 13-17 [Abstract] ( 113 ) HTML (1 KB)  PDF (791 KB)  ( 35 )
18 Analysis of components and targets of Ganjiang Huangqin Huanglian Renshen Decoction in the treatment of gastric adenocarcinoma based on WGCNA and molecular docking#br#
SUN Qian1 YANG Meizi2 LUAN Jixin3 LI Sen4 ZHANG Fan1
Objective To study the components and targets of Ganjiang Huangqin Huanglian Renshen Decoction in the treatment of gastric adenocarcinoma based on weighted gene co-expression network analysis (WGCNA) and molecular docking. Methods The drug-related components and targets were screened from the traditional Chinese medicine systems pharmacology database and analysis platform, and drug-compound-target interaction network was constructed. Gastric adenocarcinoma gene expression data were downloaded from TCGA database, and the key modules related to the risk level of gastric adenocarcinoma were screened. The biological functions of genes contained in the key modules were analyzed by GO and KEGG database. The module genes were uploaded to STRING database to screen key targets, and the semi-flexible docking reverse verification of key targets was carried out by molecular docking technology. Results Fifty-nine active components and 184 targets were screened, and 242 nodes and 676 edges were obtained from drug-compound-target interaction network. The key modules screened by WGCNA included 32 genes in total. The results of GO and KEGG enrichment mainly involve DNA integrity test points, reaction to metal ions, p53 signaling pathway, cell cycle, and cell senescence, etc. The key targets were VEGFA, CDK1, and CCND1. The molecular docking showed that quercetin, baicalein, baicalein, and other compounds had higher binding activities with key targets. Conclusion A variety of active ingredients can combine with the targets of gastric adenocarcinoma to play a regulatory role.
2022 Vol. 19 (3): 18-23 [Abstract] ( 93 ) HTML (1 KB)  PDF (3313 KB)  ( 75 )
24 Screening of key genes and bioinformatics analysis of sepsis-induced myocardial dysfunction#br#
JIANG Wanwei YANG Guohui
Objective To screen the key genes of sepsis-induced myocardial dysfunction (SIMD), and analyze the main biological processes. Methods Data sets of sepsis patients and SIMD mouse models were analyzed differentially by R software, genes related to SIMD were extracted, biological analysis, correlation analysis, and protein-protein interaction network analysis were carried out. Results There were 318 and 143 differential genes in sepsis patients and animal models respectively, including 84 SIMD genes, 54 down-regulated genes and 30 up-regulated genes. Sepsis and SIMD differential genes had similar biological functions in gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis. ANXA3, S100A8, LCN2, LTF, and KLHL2 were the key genes of SIMD; LTF, LCN2, and SOCS3 were the key proteins of SIMD. Conclusion Many key genes, such as LCN2, LTF, ANXA3, S100A8, KLHL2, and SOCS3 may involve in the pathophysiological process of SIMD, it is significant to further study the clinical diagnosis, prognosis, and treatment of SIMD.
2022 Vol. 19 (3): 24-28,33 [Abstract] ( 99 ) HTML (1 KB)  PDF (2803 KB)  ( 89 )
29 Study on quality standard of Yinqin Mixture#br#
OU Renhao ZENG Jin WEI Zuqiao LI Ping
Objective To develop a quality control method for Yinqin Mixture. Methods Artemisiae Scopariae Herba, Scutellareae Radix, and Rhei Radix et Rhizoma. were identified by microemulsion thin layer chromatography. Chlorogenic acid, caffeic acid, baicalin, and baicalein were simultaneously determined by high performance liquid chromatography, chromatographic column was Diamonsil C18 (2) column （250 mm×4.6 mm，5 μm）, the mobile phase consisted of acetonitrile-0.25% phosphoric acid solution with gradient elution at a flow rate of 1.0 ml/min, the detection wavelength was 310 nm and the column temperature was 30℃. Results The color of microemulsion thin layer chromatography was clear and the negative had no interference; the linear range of chlorogenic acid , caffeic acid, baicalin, and baicalein were 5.96-59.60 μg/ml (r = 0.9991), 0.60-6.00 μg/ml (r = 0.9992), 40.80-408.00 μg/ml (r = 0.9993), 1.98-19.84 μg/ml (r = 0.9994), respectively; average recovery rates of components were 96.56%, 101.84%, 98.77%, and 98.98%, respectively. Conclusion The method is simple， accurate, good reproducibility，and can be used for the quality control of Yinqin mixture.
2022 Vol. 19 (3): 29-33 [Abstract] ( 76 ) HTML (1 KB)  PDF (1072 KB)  ( 34 )
34 Research progress on influencing factors of acupuncture depth#br#
WANG Na ZHAO Zhuoting YAO Zeming GUO Xinrong
Acupuncture depth is one of the key factors of clinical efficacy of acupuncture and is affected by many factors. This study summarizes the discussion on the acupuncture depth in the comprehensive teaching materials and relevant literatures from the aspects of acupuncture tools, acupuncture technique, acupoints, diseases, individuals, and four seasons, in order to provide reference for the clinical practice of acupuncture. The clinical application of acupuncture in the treatment of diseases requires an overall grasp, comprehensive consideration, and treatment based on syndrome differentiation, so as to properly grasp the depth of acupuncture and better play the therapeutic effect of acupuncture.
2022 Vol. 19 (3): 34-37 [Abstract] ( 117 ) HTML (1 KB)  PDF (650 KB)  ( 163 )
38 Research progress on prevention and treatment of Alzheimer’s disease with traditional Chinese medicine based on gut microbiota#br#
WANG Yang1 ZHAO Jian2 WANG Di2 YANG Bo3 ZHENG Shijia4 ZHOU Zhongguang1
Intestinal microecology is a hotspot of research on life science in recent years. Gut microbiota and its metabolites regulate host’s behavior and cognitive function, and are closely related to the occurrence and development of Alzheimer’s disease (AD), gut microbiota has become a new target for the prevention and treatment of AD. Traditional Chinese medicine has advantages in regulating gut microbiota, and it is widely used in the prevention and treatment of AD. Targeting gut microbiota through traditional Chinese medicine has become a key breakthrough in anti-AD treatment. This paper describes the relationship between gut microbiota and AD, and summarizes the current situation of the research on the control of gut microbiota by traditional Chinese medicine, in order to provide research directions and ideas for strengthening the understanding of AD and the development of anti-AD drugs.
2022 Vol. 19 (3): 38-42 [Abstract] ( 142 ) HTML (1 KB)  PDF (684 KB)  ( 218 )
43 Correlation analysis of alexithymia and fatigue in HIV/AIDS patients
WAN Bin1 ZHAO Xia2▲ CHEN Xueyu1 LEI Limei1 FENG Shiping2 LIU Chunmei1 LYU Chunrong2 GUO Lihua2
Objective To investigate the status quo of alexithymia and fatigue in human immunodeficiency virus (HIV) carriers and acquired immune deficiency syndrome (AIDS) patients, and to understand the relationship between alexithymia and fatigue. Methods From September 2019 to June 2020, a total of 200 HIV/AIDS patients who were selected from a hospital in Chengdu by convenient sampling were surveyed using the alexithymia scale and the Chinese version of the multidimensional fatigue scale. Pearson correlation analysis was used to analyze the correlation between alexithymia and fatigue. Results A total of 186 questionnaires were returned, and the effective response rate was 93%. The scores of HIV/AIDS patients on alexithymia range were 20 to 82 points, with an average of (56.62±10.52) points; the total fatigue score were 20 to 92 points, with an average of (53.18±12.51) points. Pearson correlation analysis showed that the total score of patients with alexithymia and the difficulty in identifying their own emotional dimension, the difficulty in describing their own emotional dimension, and the dimension of extroverted thinking were positively correlated with the total fatigue score and each dimension scoring (r ＞ 0, P ＜ 0.01). Conclusion HIV/AIDS patients have a certain degree of alexithymia and fatigue, and the two are related. It is recommended that clinical medical staff pay attention to the patient’s alexithymia and fatigue in their work and take targeted measures.
2022 Vol. 19 (3): 43-45,50 [Abstract] ( 100 ) HTML (1 KB)  PDF (541 KB)  ( 57 )
46 Correlation analysis between mental health and sarcopenia of the elderly in Urumqi community#br#
CHE Yajie Rezivanguli Eniva JIANG Xin YANG Xuanxuan ZHENG Shuangfeng YAN Ping
Objective To study the correlation between the status of depression and anxiety of the elderly in Urumqi community and sarcopenia and its influencing factors, and to provide a basis for formulating corresponding intervention measures in the later period. Methods The convenience sampling method was adopted to select community elderly people aged 60 and above in Shuimogou District, Urumqi City from July to December 2019. The Ishii score was used to screen and diagnose sarcopenia, nine patient health questionnaires, seven generalized anxiety disorder scales to assess the mental state of the elderly. Results Among the 447 elderly in the community, they were 60 to 94 years old, with an average of (73.14±7.53) years old, and the number of patients with sarcopenia was 178 cases (39.8%). Among the elderly with sarcopenia, 63 cases (35.39%) had depression symptoms, and 55 cases (30.90%) had anxiety symptoms. Whether depression or anxiety occurs in elderly people with sarcopenia in the community was related to gender and housing status, and the differences were statistically significant (P ＜ 0.05). There was a statistically significant difference in the incidence of depression and anxiety between the two groups (P ＜ 0.05). There was a statistically significant difference in the degree of depression and anxiety symptoms between the two groups (P ＜ 0.05). Correlation analysis of the status of depression and anxiety in elderly people with sarcopenia in the community showed that depression scores (r = 0.105), depression severity (r = 0.126), and anxiety scores (r = 0.096) were positively correlated with sarcopenia (P ＜ 0.05). Conclusion Poor mental state will have a negative impact on sleep, diet, and activities of daily living in the elderly with sarcopenia. It is suggested that community health care personnel should find out the psychological problems of the elderly with sarcopenia in time, and give early intervention. Through the change of mental state, some bad lifestyles can also be improved and the occurrence of bad outcomes can be reduced.
2022 Vol. 19 (3): 46-50 [Abstract] ( 217 ) HTML (1 KB)  PDF (632 KB)  ( 89 )
51 Influencing factors of nurses’ nursing behavior in blood collection room of outpatient department#br#
ZHANG Hui CHEN Hong HUANG Jing
Objective To analyze the influencing factors of nurses’ nursing behavior in the blood collection room of the outpatient department. Methods A random sampling method was used to select 100 outpatient blood sampling nurses from April 2018 to September 2019 in West China Hospital of Sichuan University. The hospital self-made nursing behavior scale was used to evaluate the nursing behavior of nurses in the outpatient blood collection room, the baseline data filling form was designed, and the relevant baseline data of the nurses were asked and recorded. The nursing behavior scores of nurses in the blood collection room with different data characteristics were comparecl, and the relevant factors that might affect the nursing behavior of the nurses in the blood collection room in the outpatient department were analyzed. Results The nursing behavior of 100 nurses in the blood collection room of the outpatient department was average, and the average score of the self-made nursing behavior scale was (10.02±1.31) points. There was a statistically significant difference in the scores of nurses’ nursing behavior scale in the blood collection room of different working years, social support, and coping styles (P ＜ 0.05). Multiple linear regression analysis showed that working years ≥ five years (X1), low social support(X2), and negative coping (X3) were the general influencing factors of nurses’ nursing behavior in the blood collection room of the outpatient department (P ＜ 0.05). The regression equation was obtained: Y = 13.842-1.732X1-2.014X2-0.819X3. Conclusion The nursing behavior of nurses in the blood collection room of the outpatient department is generally affected by factors such as nurses’ working years ≥ five years, low social support, and negative coping.
2022 Vol. 19 (3): 51-54 [Abstract] ( 215 ) HTML (1 KB)  PDF (535 KB)  ( 31 )
55 Influencing factors of coping style in young and middle-aged patients with essential hypertension#br#
ZHANG Xiaoyan1 JIANG Yanyan2 SHEN Xin1▲
Objective To analyze the influencing factors of the coping style of young and middle-aged patients with essential hypertension (EHT). Methods A total of 100 young and middle-aged EHT patients who were treated from April 2018 to December 2020 in the Third Clinical College of China Three Gorges University were selected. The simplified coping style questionnaire (SCSQ) was used to evaluate the patient’s coping style, design the baseline data filling form, and inquire and record the relevant baseline data of the patient. Logistic regression analysis was used to find out the relevant factors affecting the coping style of young and middle-aged EHT patients. Results Among 100 patients, 47 cases responded negatively, accounting for 47.00%; 53 cases responded positively, accounting for 53.00%. EHT patients with different coping styles had statistically significant differences in education level, perceived stress score, psychological resilience score, and self-feeling burden score (P ＜ 0.05). Logistic regression analysis showed that college degree or below, heavier perceived pressure, self-perceived burden, and sleep quality were generally influential factors for the negative coping of young and middle-aged EHT patients (OR ＞ 1, P ＜ 0.05). Conclusion The negative coping of young and middle-aged EHT patients may be affected by their low education level, heavy perceived pressure, self perceived burden and general sleep quality.
2022 Vol. 19 (3): 55-58 [Abstract] ( 246 ) HTML (1 KB)  PDF (537 KB)  ( 86 )
59 Discussion on the measurement management medical equipment under the background of precision medicine#br#
YUAN Hong1 MU Wuyun2 DONG Yongli3▲
The accuracy and safety of medical equipment directly affect the results of clinical diagnosis and treatment, in the context of precision medicine, attention should be paid to the importance of measurement management of medical equipment to ensure the accuracy and reliability of medical measuring instruments and fully protect the health and safety of the masses. At first, this paper discusses the measurement under the background of precision medicine equipment management, medical metrology management system is not perfect, people died as a result of mistakes, medical equipment using the environment and supporting facilities for the influence of the metrological management, as well as medical equipment measurement test scope limitation, this paper discusses the measurement should attach importance to management, and medical measurement professional personnel training, at the same time, the third-party supervision and management should be strengthened, the whole process measurement management should be emphasized, and the improvement of the medical measurement management system under the background of precision medicine.
2022 Vol. 19 (3): 59-62 [Abstract] ( 81 ) HTML (1 KB)  PDF (588 KB)  ( 39 )
63 Effect of flax lignans on the blood glucose and blood lipid in diabetic patients#br#
GONG Liya WANG Yan▲ SHI Jian
Objective To study the effect of flax lignans  on blood glucose and blood lipids in diabetic patients. Methods In this study, 118 patients with diabetes admitted in the Second Hospital of Hebei Medical University were selected from March 2016 to February 2017 and they were divided into control group (55 cases) and intervention group (56 cases) by random number table method. The control group was given placebo starch 300 mg per time, twice a day, and the intervention group was given oral administration secoisolarici-resinol diglucoside 300 mg and starch 300 mg per time, twice a day. The diet changes of the two groups of patients before and after the intervention were investigated. Fasting blood glucose (FBG), 2 h postprandial plasma glucose (2hPG), glycosylated hemoglobin (HbA1c), triglyceride (TG), total cholestero (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), and C-reactive protein (CRP) level were detected before and after the intervention. Results There were no significant differences in weight, dietary energy intake and energy supply ratio of three nutrients between the two groups before and after intervention (P ＞ 0.05). Before intervention, there was no significant difference in FBG, 2hPG and HbA1c between the two groups (P ＞ 0.05). After intervention, FBG, 2hPG and HbA1c in the intervention group were lower than before intervention, and the intervention group were lower than those in the control group, the differences were statistically significant (P ＜ 0.05). Before intervention, there was no significant difference in the levels of TG, TC, HDL-C, LDL-C, and CRP between the two groups (P ＞ 0.05). After intervention, TC, LDL-C was lower than before intervention, TC level in the control group was higher than before intervention, the difference was statistically significant (P ＜ 0.05), and TC and LDL-C in the intervention group were lower than the control group, the differences were statistically significant (P ＜ 0.05). Conclusion flax lignans has a significant effect on improving blood glucose and blood lipids in diabetic patients.
2022 Vol. 19 (3): 63-66 [Abstract] ( 85 ) HTML (1 KB)  PDF (506 KB)  ( 26 )
67 Clinical efficacy of Mudan Granules combined with Thioctic Acid Injection in the treatment of diabetic foot#br#
FU Fangying1 CHEN Ling1 WENG Yucai1 CHEN Jinyi2
Objective To study the clinical effect of Mudan Granules combined with Thioctic Acid Injection in the treatment of diabetic foot. Methods A total of 98 patients with diabetic foot treated in the Second Affiliated Hospital of Hainan Medical College from April 2019 to October 2020 were selected. The patients were divided into control group (treated with Thioctic Acid Injection) and experimental group (treated with Mudan Granules on the basis of control group) by random number table method, with 49 cases in each group. The two groups were treated for 4 weeks. The curative effect, blood glucose index (glycosylated hemoglobin [HbA1c], fasting blood glucose [FBG], 2 h postprandial blood glucose [2hPG]), hemodynamic index of dorsalis pedis artery (vessel diameter, resistance index [RI], blood flow velocity, pulsatility index [PI]), inflammatory factor index (high sensitivity C-reactive protein [hs-CRP], interleukin-6 [IL-6], procalcitonin [PCT]) before and after treatment, and the incidence of adverse reactions were compared between the two groups. Results The clinical efficacy of the experimental group was higher than that of the control group (P ＜ 0.05). After four weeks of treatment, the levels of HbA1c, FBG, 2hPG, hs-CRP, IL-6, and PCT decreased compared with before treatment in both groups, and those in the experimental group were lower than the control group (P ＜ 0.05). After four weeks of treatment, the vascular diameter, RI, blood flow velocity, and PI increased compared with before treatment in both groups, and those in the experimental group were higher than the control group (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion It is effective to treat diabetic foot with Mudan Granules and Thioctic Acid Injection. It can effectively control blood sugar, improve inflammatory reaction and hemodynamics of dorsal artery of foot, and is safe and reliable.
2022 Vol. 19 (3): 67-70 [Abstract] ( 97 ) HTML (1 KB)  PDF (534 KB)  ( 46 )
71 Summary of the best evidence for self-management in patients with urinary incontinence#br#
WANG Xiaojing1,2 ZHANG Liya1,2 WANG Qing1,3 TANG Ailing2 XU Fanglei2▲
Objective To retrieve, evaluate, and summarize the evidence of self-management in patients with urinary incontinence. Methods The Cochrane Library, JBI Evidence-based Health Care Database, UK National Institute for Healthcare Excellence, European Urological Association, Canadian Association of Obstetricians and Gynaecologists, Japan Urological Association, Women’s Preventive Services Initiative, PubMed, Web of Science, China Biomedical Literature Database, CNKI, Wanfang Data were searchered. The retrieval time was from the establishment of the database to March, 2021. The quality of the included literatures was evaluated, and evidence was extracted from the literatures. Results A total of 12 literatures meeting the quality standards were included, and 21 pieces of best evidence were finally collected, including screening assessment, lifestyle, functional exercise, drug therapy, and follow-up. Conclusion Clinical medical staff should selectively apply the best evidence of the self-management of patients with urinary incontinence to implement self-management intervention for patients with urinary incontinence on the basis of evidence and in combination with the actual situation and patients’ wishes.
2022 Vol. 19 (3): 71-74 [Abstract] ( 145 ) HTML (1 KB)  PDF (564 KB)  ( 17 )
75 Clinical observation of combined external fixator combined with Fuyuan Huoxue Decoction in the treatment of elderly high-risk patients with proximal humerus fractures#br#
ZHANG Yili1 TIAN Yafeng2 DONG Junge2 YANG Mingshuai2 DONG Shaoyang1 XUE Pengyu1 CHEN Baosheng1 FAN Jinrui1
Objective To investigate the clinical effects of combined external fixator combined with Fuyuan Huoxue Decoction on the treatment of high-risk elderly patients with proximal humerus fractures. Methods A total of 60 elderly high risk patients with proximus humeraus fractures admitted to the First Department of Orthopedics, Hebei Hospital of Traditional Chinese Medicine from October 2019 to October 2020 were selected as the research subjects, and they were divided into control group and experimental group according to random number table method, with 30 cases in each group. Both groups were treated with combined external fixator. The experimental group was treated with Fuyuan Huoxue Decoction on the basis of combined external fixator treatment. After six months, the fixation device in both groups were removed, and the experimental group stopped taking medication. The fracture healing time, swelling degree, visual analogue scale (VAS) score, Neer shoulder function score, and D-dimer level of the two groups were observed. Results The fracture healing time of the experimental group was shorter than that of the control group, and the difference was statistically significant (P ＜ 0.05). In both two groups, VAS scores at three weeks, three months, and six months after surgery were lower than those at one day before surgery and one day after surgery, and Neer shoulder function scores were higher than those at one day before surgery and one day after surgery; VAS scores at three and six months after surgery were lower than those at three weeks after surgery, and Neer shoulder function scores were higher than those at three weeks after surgery; VAS scores at six months after surgery were lower than those at three months after surgery, and Neer shoulder function scores were higher than those at three months after surgery, the differences were statistically significant (P ＜ 0.05). VAS scores of the experimental group were lower than those of the control group at three weeks, three months, and six months after surgery, and Neer shoulder function scores were higher than those of the control group at the same period, the differences were statistically significant (P ＜ 0.05). The D-dimer levels of both groups were lower at 3, 7, and 14 d after surgery than those at one day before surgery and one day after surgery, the D-dimer levels at 7, 14 d after surgery were lower than those at 3 d after surgery, the D-dimer levels at 14 d after surgery were lower than those at 7 d after surgery, the differences were statistically significant (P ＜ 0.05). The D-dimer levels of the experimental group were lower than those of the control group at 3, 7, and 14 d after surgery, the differences were statistically significant (P ＜ 0.05). The degree of swelling in the experimental group three weeks after surgery was lighter than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Combined external fixator combined with Fuyuan Huoxue Decoction for the treatment of elderly high-risk patients with proximal humerus fractures can help to accelerate local blood circulation, relieve postoperative swelling, promote fracture healing, relieve postoperative pain, and shorten postoperative functional recovery time.
2022 Vol. 19 (3): 75-78,86 [Abstract] ( 62 ) HTML (1 KB)  PDF (739 KB)  ( 44 )
79 Application effects of joints continuous passive motion machine training combined with comprehensive rehabilitation therapy in patients with knee joint mobility dysfunction after lower limb fracture#br#
BI Fei CAI Zhenyuan▲
Objective To observe the application effects of joints continuous passive motion (CPM) machine training combined with comprehensive rehabilitation therapy in patients with knee joint mobility dysfunction after lower limb fracture. Methods A total of 80 patients with with knee joint mobility dysfunction after lower limb fracture admitted to Huaian First Hospital Affiliated to Nanjing Medical University from January 2019 to January 2021, they were divided into rehabilitation group (40 cases, the comprehensive rehabilitation therapy), the combined group (40 cases, the comprehensive rehabilitation therapy combined joint CPM machine) by random number table method. Three weeks as a course of treatment, the two groups were treated for three courses. Visual analogue scale (VAS) score, range of motion, and knee Lysholm score were compared between the two groups before and after treatment. The clinical efficacy of the two groups was compared. The incidence of adverse reactions in the two groups was recorded. Results After treatment, VAS scores of the two groups were lower than those before treatment, ranges of motion were higher than those before treatment, knee Lysholm scores were higher than those before treatment, and VAS scores of the combined group were lower than those of the rehabilitation group, ranges of motion were higher than those of the rehabilitation group, knee Lysholm scores were higher than those of the rehabilitation group, the differences were statistically significant (P ＜ 0.05). The clinical efficacy of combined group was better than that of rehabilitation group, and the difference was statistically significant (P ＜ 0.05). There were no adverse reactions in both groups during treatment. Conclusion In patients with knee mobility dysfunction after lower limb fracture, comprehensive rehabilitation combines with joints CPM machine can relieve pain and improve knee mobility and function, with accurate, safe, and reliable effect.
2022 Vol. 19 (3): 79-82 [Abstract] ( 108 ) HTML (1 KB)  PDF (540 KB)  ( 73 )
83 Influencing factors of posttraumatic growth in middle-aged and elderly patients with intertrochanteric fractures of femur#br#
PEI Hongxue SONG Huifang LI Manman WANG Yan▲
Objective To evaluate the level of posttraumatic growth in middle-aged and elderly patients with intertrochanteric fracture of femur (IFF), and to analyze the influencing factors of posttraumatic growth in IFF patients. Methods Data of 105 middle-aged and elderly IFF patients admitted to Fuyang Second People’s Hospital, Anhui Province from January 2017 to February 2021 were retrospectively collected and analyzed. The level of posttraumatic growth was assessed by the posttraumatic growth inventory (PTGI). Patients with PTGI score ＜ 70 points were included in the low posttraumatic growth group (39 cases), and patients with PTGI score ≥ 70 points were included in the normal posttraumatic growth group (66 cases). The baseline data of two groups were collected and compared to analyze the influencing factors of posttraumatic growth in middle-aged and elderly IFF patients. Results The scores of social support rating scale (SSRS), compliance behavior score, and Connor-Davidson resilience scale (CD-RISC) in the low posttraumatic growth group were lower than those in the normal posttraumatic growth group, and the differences were statistically significant (P ＜ 0.05). Multivariate analysis showed that high SSRS score, high compliance behavior score, and high CD-RISC score were protective factors for low level of posttraumatic growth in middle-aged and elderly IFF patients (OR ＜ 1, P ＜ 0.05). Conclusion The posttraumatic growth level of middle-aged and elderly IFF patients may be affected by social support, medical compliance behavior, psychological resilience, and other factors.
2022 Vol. 19 (3): 83-86 [Abstract] ( 134 ) HTML (1 KB)  PDF (562 KB)  ( 154 )
87 Relationship between miR-138 expression and Th1/Th2 balance in peripheral blood of children with bronchial asthma#br#
LIAO Quanhui1 WANG Shuirong1 HUANG Long1 CAI Xue1 FU Tianming2 LI Kexing3
of Paediatrics, Longquanyi District of Chengdu Maternity and Child Health Care Hospital, Sichuan Province, Chengdu   610100, China; 2.Department of Obstetrics and Gynecology, Longquanyi District of Chengdu Maternity and Child Health Care Hospital, Sichuan Province, Chengdu   610100, China; 3.Division of Neonatology, Longquanyi District of Chengdu Maternity and Child Health Care Hospital, Sichuan Province, Chengdu   610100, China
[Abstract] Objective To investigate the relationship between microRNA (miRNA)-138 expression and T helper cell (Th)1/Th2 balance in peripheral blood of children with bronchial asthma (BA). Methods A total of 103 children with BA admitted to Longquanyi District of Chengdu Maternity and Child Health Care Hospital from January 2020 to March 2021 were selected. According to clinical manifestations, they were divided into acute attack group (42 cases) and clinical remission group (61 cases), and 82 healthy children with physical examination were selected as control group during the same period. Peripheral blood miR-138, T-bet, GATA binding protein 3 (GATA3) detected by qRT-PCR, peripheral blood Th1 percentage and Th2 percentage detected by flow cytometry, and peripheral blood interleukin-2 (IL-2), IL-4, IL-10, and interferon-γ (INF-γ) levels were detected by enzyme linked immunosorbent assay. Results MiR-138 expression and Th2 percentage in peripheral blood of acute attack group were higher than those of clinical remission group and control group, while Th1 percentage and Th1/Th2 were lower than those of clinical remission group and control group (P < 0.05); MiR-138 expression and Th2 percentage in peripheral blood in clinical remission group were higher than those in control group, while Th1 percentage and Th1/Th2 were lower than those in control group (P < 0.05). T-bet level in peripheral blood of acute attack group was lower than that of clinical remission group and control group, while GATA3 level was higher than that of clinical remission group and control group (P < 0.05); T-bet level in peripheral blood of clinical remission group was lower than that of control group, and GATA3 was higher than that of control group (P < 0.05). The levels of IL-2 and IFN-γ in peripheral blood of acute attack group were lower than those of clinical remission group and control group, while the levels of IL-4 and IL-10 were higher than those of clinical remission group and control group (P < 0.05); the levels of IL-2 and IFN-γ in peripheral blood in clinical remission group were lower than those in control group, while the levels of IL-4 and IL-10 were higher than those in control group (P < 0.05). There were negative correlation between miR-138 expression and T-bet, Th1/Th2, IL-2, and IFN-γ in peripheral blood of children with BA (r = -0.498, -0.515, -0.464, -0.428, P < 0.01); it was positively correlated with GATA3, IL-4, and IL-10 (r = 0.595, 0.518, 0.386, P < 0.01). Conclusion Peripheral blood miR-138 expression is significantly upregulated in children with BA, which may mediate the inflammatory response by regulating the Th1/Th2 balance, participate in the development of BA occurs.
2022 Vol. 19 (3): 87-90,98 [Abstract] ( 57 ) HTML (1 KB)  PDF (649 KB)  ( 48 )
91 Correlation study on changes of immune function and liver damage in children with infectious mononucleosis#br#
LIU Jiangyan SUN Jun▲ MAO Kangwei LI Dalei
Objective To investigate the relationship between changes of immune function and liver function damage in children with infectious mononucleosis (IM), so as to provide a theoretical basis for prevention and treatment of liver damage. Methods Clinical data of 85 children with IM caused by Epstein-Barr virus infection in the First People’s Hospital of Lianyungang, Jiangsu Province, from July 2017 to July 2019 were selected. They were divided into liver function damage group and no liver function damage group, according to whether the occurrence of liver function damage. The expression of IgA, IgM, IgG, CD19+B lymphocyte, complement component C3, natural killer (NK) cell, T lymphocyte subsets (CD4+, CD8+, and CD4+/CD8+) were compared between two groups; and the correlation between immune function and liver function damage in children with IM was analyzed. Results The incidence of IM children complicated with liver function damage was 40% (34/85). There were statistically significant differences in IgA, IgG, IgM, CD19+, CD8+, CD4+, CD4+/CD8+, and complement C3 between two groups (P < 0.05); there was no significant difference between two groups (P > 0.05). ALT level had no correlation with IgA, IgG, IgM, CD19+, CD8+, CD4+, CD4+/CD8+, and complement C3 (P > 0.05). CD8+ was an independent risk factor for liver function damage in IM children (OR = 1.104, P < 0.05). Conclusion The disorder of immune system in IM children is associated with liver function damage, so it is necessary to strengthen the monitoring of the disorder of immune function in IM children, and give liver protection and immunomodulatory therapy in early stage.
2022 Vol. 19 (3): 91-94 [Abstract] ( 117 ) HTML (1 KB)  PDF (496 KB)  ( 28 )
95 Protective effect of different doses of recombinant human interferon on central nervous system of children with severe hand-foot-mouth disease#br#
SONG Mingmei1 SUN Zhiwei1 LU Jiayun2▲
Objective To explore the protective effect of different doses of recombinant human interferon (hIFN) on central nervous system of children with severe hand foot mouth disease (HFMD). Methods The clinical data of 82 children with severe HFMD admitted to the 904th Hospital of the People’s Liberation Army Joint Logistic Support Force were retrospectively analyzed from March 2015 to October 2019. According to the treatment methods, they were divided into group A (conventional antiviral therapy, 20 cases), group B (2 μg/kg hIFN-α16 combined with conventional antiviral therapy, 31 cases), and group C (4 μg/kg hIFN-α16 combined with conventional antiviral therapy, 31 cases). The clinical symptoms, efficacy, immune function, and serological indexes of three groups were compared, and the incidence of adverse reactions during treatment were recorded. Results The time of rash resolution and fever resolution in group C were shorter than those in group A and B, and the time of rash resolution and fever resolution in group B were shorter than those in group A, and the differences were statistically significant (P ＜ 0.05). The total effective rate of group B and C were higher than those of group A, and the differences were statistically significant (P ＜ 0.05); there was no significant difference in total effective rate between group B and group C (P > 0.05). After treatment, CD3+ and CD4+ in three groups were higher than before treatment, group C was higher than group A and B, and group B was higher than group A, and the differences were statistically significant (P < 0.05); CD8+ in three groups were lower than before treatment, group C was lower than group A and B, and group B was lower than group A, and the differences were statistically significant (P < 0.05). After treatment, CRP, NSE, and S-100P levels in three groups were lower than those before treatment, and group C was lower than group A and B, and group B was lower than group A, and the differences were statistically significant (P < 0.05). Conclusion High-dose hIFN can significantly improve the clinical symptoms and immune function of children with severe HFMD, and has more significant protection on the central nervous system, with good safety.
2022 Vol. 19 (3): 95-98 [Abstract] ( 71 ) HTML (1 KB)  PDF (524 KB)  ( 33 )
99 Effect of Pidotimod combined with recombinant human interferon α1b and Ganciclovir in the treatment of children with EB virus associated infectious mononucleosis#br#
ZHANG Hui1 LI Hongyuan2 ZHANG Jianming1▲
Objective To investigate the effect of Pidotimod combined with recombinant human interferon α1b and Ganciclovir in the treatment of children with Epstein-Barr virus (EBV） associated infectious mononucleosis. Methods A total of 80 children with EBV associated infectious mononucleosis admitted to Department of Pediatrics, Fuyang Women and Children’s Hospital, Anhui Province from January 2018 to March 2021 were selected, and they were divided into observation group and control group by random number table method, with 40 cases in each group. Control group was treated with recombinant human interferon α1b and Ganciclovir, and observation group was treated with Pidotimod on the basis of control group, two groups were treated for ten days. Clinical symptoms improved conditions, CD4+, CD8+, CD4+/CD8+, tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), interleukin-6 (IL-6), creatine kinase (CK), creatine kinase MB (CK-MB), lactate dehydrogenase (LDH), and aspartate aminotransferase (AST) levels were compared, the occurrence of adverse reactions during treatment were recorded. Results The disappearance time of pharyngeal pain, antipyretic time, and relief time of tonsil and lymph node enlargement in observation group were shorter than those in control group, and the differences were statistically significant (P < 0.05). After treatment, CD4+, CD8+, and CD4+/CD8+ in both groups were higher than those before treatment, and observation group was higher than control group, and the differences were statistically significant (P < 0.05). After treatment, the levels of TNF-α, CRP, and IL-6 in two groups were lower than those before treatment, and observation group was lower than control group, and the differences were statistically significant (P < 0.05). After treatment, the levels of CK, CK-MB, LDH, and AST in two groups were lower than those before treatment, and observation group was lower than control group, and the differences were statistically significant (P < 0.05). During the treatment, no obvious adverse reactions occurred in two groups. Conclusion Pidomord combined with recombinant human interferon α1b and Ganciclovir in the treatment of children with EBV associated infectious mononucleosis have obvious effect, it’s worthy of promotion and application.
2022 Vol. 19 (3): 99-102 [Abstract] ( 90 ) HTML (1 KB)  PDF (573 KB)  ( 49 )
103 Effect of glass fiber post combined with all-ceramic crown in repairing large-area defects of anterior teeth and its influence on chewing ability#br#
XUE Lufeng XUE Qiubo LU Wei▲
Objective To explore the effect of glass fiber post combined with all-ceramic crowns in repairing large-area defects of anterior teeth and its influence on chewing ability. Methods A total of 82 (112 teeth) with large anterior teeth defects admitted to the 904th Hospital, Joint Logistic Support Force of the Chinese People’s Liberation Army from August 2018 to August 2020 were selected, they were divided into control group (41 cases, 54 teeth) and study group (41 cases, 58 teeth) according to the random number table method. The control group was repaired metal post cobalt-chromium porcelain crowns, while the study group was repaired glass fiber post combined with all-ceramic crowns. Patients in both groups were followed up for six months, the repair effect, repair success rate, chewing efficiency, and gingival crevicular fluid metalloproteinase 2 (MMP2), intercellular adhesion molecule 1 (ICAM1), alkaline phosphatase (ALP) levels were compared, the incidence of complications during follow-up was recorded. Results The repair integrity, color matching, and edge fitness of study group were better than those of control group, and the differences were statistically significant (P < 0.05). The repair success rate of study group was higher than that of control group, and the difference was statistically significant (P < 0.05). Six months after restoration, the chewing efficiency of two groups were higher than that before restoration, and study group was higher than control group, and the differences were statistically significant (P < 0.05). Six months after restoration, the levels of gingival crevicular fluid MMP2, ICAM1, and ALP were higher than those before restoration, and study group was lower than control group, and the differences were statistically significant (P < 0.05). There was no significant difference in the incidence of complications between two groups (P > 0.05). Conclusion The glass fiber post combined with all-ceramic crown has a good effect in repairing large-area defects of anterior teeth, and high success rate, at the same time, the periodontal tissue stimulation is less, so it is a safe and reliable repair method.
2022 Vol. 19 (3): 103-106 [Abstract] ( 37 ) HTML (1 KB)  PDF (512 KB)  ( 48 )
107 Effect of modified suspension intramuscular injection on the effect of octreotide Acetate Microsphere injection#br#
WU Jing SHI Yanping WANG Lijun BAO Xinjie XING Bing ZHANG Yi▲
Objective To analyze the effect of modified suspension intramuscular injection on the effect of Octreotide Acetate Microsphere injection, and to provide a reference for clinical medication. Methods A total of 79 patients from the Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences were selected as the research objects. They were divided into two groups by random number table method, a total of 39 cases in the traditional group (196 injections of Octreotide Acetate Microspheres) and a total of 40 cases in the modified group (201 injections of Octreotide Acetate Microspheres). The traditional group referred to the drug instructions and administerd according to the conventional method, while the modified group adopted the improved configuration method and injection procedure. The injection success rate, the patient’s skin induration and the occurrence of pain between the two groups were compared. Results The injection success rate and the incidence of induration in the modified group were lower than those in the traditional group, and the differences were highly statistically significant (P ＜ 0.01); there was no statistically significant difference in the pain degree scores between the two groups (P ＞ 0.05). Conclusion The modified suspension intramuscular injection method can effectively improve the injection effect of Octreotide Acetate Microspheres.
2022 Vol. 19 (3): 107-110 [Abstract] ( 46 ) HTML (1 KB)  PDF (643 KB)  ( 124 )
111 Discussion on the participation of traditional Chinese medicine in the clinical management of pulmonary nodules#br#
LI Yaoyuan HUA Baojin ZHENG Honggang
In recent years, the detection rate of pulmonary nodules has been significantly improved, and its reasonable clinical management has great practical value. Traditional Chinese medicine can cut off and reverse the development trend of isolated and incompletely resected pulmonary nodules, eliminate or control their growth and reduce the incidence of lung cancer; combining disease differentiation, constitution differentiation and imaging characteristics, we can provide characteristic treatment scheme of traditional Chinese medicine for patients with asymptomatic pulmonary nodules. Traditional Chinese medicine can reduce the postoperative clinical symptoms of patients with pulmonary nodules and prevent recurrence and metastasis. Comprehensive therapy of traditional Chinese medicine can reduce the incidence of pulmonary nodules / lung cancer by intervening relevant risk factors in advance. Therefore, traditional Chinese medicine can be applied to the prevention and treatment of pulmonary nodules in all stages of the whole cycle to improve the efficiency of clinical management, which is an effective supplement to the current diagnosis and treatment norms.
2022 Vol. 19 (3): 111-114 [Abstract] ( 108 ) HTML (1 KB)  PDF (623 KB)  ( 172 )
115 Professor Liu Ying’s differentiation and treatment experience of Sj?觟gren syndrome based on “theory of latent toxin”#br#
LUO Yawen1 LIU Ying2
Sj?觟gren syndrome is a common clinical rheumatic immune disease, which can lead to multi-system damage in addition to exocrine gland damage, seriously affecting patientsem damacal and mental health and quality of life. Modern medicine shows no specific therapeutic drugs for this disease, while Chinese medicine provides a reliable cure. This disease, which comes under the category of “zaobi” in Chinese medicine, characterized by pathologically insidious and severe onset, and clinically prolonged course, increasingly severer condition, and not responding to treatment, matches “latent toxin” in the pathogenic characteristics. Based on years of clinical experience, Professor Liu Ying concludes that the key pathogenic factor of this disease is “hidden toxicity due to vital qi deficiency”, and proposes the treatment method of “clearing dryness to relieve toxins, resolving stasis to remove toxins, and nourishing yin to benefit qi”. This method focuses on “regulation of body and spirit together” and the combination of regulation and nourishment in the treatment. In the meantime, removing toxins and reinforcing vital qi have their own emphasis in different stages of the disease. All of these combine to reflect the concept of “people-oriented” in Chinese medicine. This paper is intended to elaborate the treatment experience of the “theory of latent toxin” on Sj?觟gren syndrome in order to broaden our mind on the treatment of this disease.
2022 Vol. 19 (3): 115-118 [Abstract] ( 160 ) HTML (1 KB)  PDF (1111 KB)  ( 35 )
119 Thoughts on differentiation and treatment of three yin-meridian in fundus macular edema#br#
SONG Haijiao1 JIN Ming2
Fundus macular edema can be caused by various eye diseases, it could result in central vision loss and visual distortion. At present, Western medicine treatment is not satisfactory, however Chinese medicine shows unique advantages. This paper discusses the pathogenesis and treatment of fundus macular edema by Chinese medicine from the viewpoint of “three yin-meridian obstruction can lead to water disease” in Huangdi Neijing. The auther thinks that chill obstruction in hand taiyin lung, foot taiyin spleen or foot shaoyin kidney meridian could lead to fundus macular edema, so the treatment is first to recognize the organ which is lack of vital energy, then to tonify them, and at the same time, to eliminate damp by freeing lung-qi, activating spleen, promoting diuresis and activating blood circulation. To cure both the symptoms and root causes is effective.
2022 Vol. 19 (3): 119-122 [Abstract] ( 110 ) HTML (1 KB)  PDF (656 KB)  ( 73 )
123 A long-term case of Professor Zhang Yu’s application of supplementing spleen and kidney in the treatment of gouty nephropathy#br#
CHANG Meiying ZHAO Mingming YU Yi WANG Rumeng MA Sijia ZHANG Yu
Gouty nephropathy is one of the most common complications of gout, its incidence rate is gradually increasing. Gouty nephropathy has a serious impact on the life quality in patients with acute attack. At present, Western medicine is still lack specific drugs for the treatment of this disease, and symptomatic treatment is the main principle. Traditional Chinese medicine has certain advantages in the treatment of gouty nephropathy. This paper systematically analyzes one long-term medical case of professor Zhang Yu in treating gouty nephropathy by supplementing spleen and kidney, and analyzes his traditional Chinese medicine syndrome differentiation ideas and clinical treatment experience. This paper summarizes Professor Zhang Yu’s clinical experience in treating gouty nephropathy on the basis of supplementing spleen and kidney, according to the different stages of disease development, combined with the clinical experience of treating gout nephropathy by invigorating dampness and removing turbidity, activating blood and resolving stasis.
2022 Vol. 19 (3): 123-126,130 [Abstract] ( 71 ) HTML (1 KB)  PDF (767 KB)  ( 38 )
127 Curative effect of low and medium frequency combined with massage therapy on postpartum lumbago#br#
SHI Wenjing1 CHEN Wei2▲ CHENG Fang3 LI Xiaowei3 ZHANG Cheng3 ZHU Liaoyuan3
Objective To explore the curative effect of low and medium frequency combined with massage therapy on postpartum lumbago. Methods A total of 80 patients with postpartum lumbago were selected as the research objects who visited the Department of Postpartum Health Care, Huaian Maternal and Child Health Hospital of Jiangsu Province from November 2019 to June 2020 were selected as the study subjects. They were divided into control group and observation group by random number method, with 40 cases in each group. The control group was treated with conventional massage, the observation group was treated with low and medium frequency therapy on the basis of the control group. The two groups were compared in terms of clinical efficacy, pain numerical rating scale (NRS) score, Roland-Morris dysfunction survey (RMDQ) score, abdominal and dorsal muscle endurance, lumbar mobility and postpartum depression degree. Results The total effective rate of observation group was better than that of control group (P ＜ 0.05); the NRS and RMDQ scores of the two groups after treatment were lower than those before treatment, and observation group were lower than control group (P ＜ 0.05); the lumbar and dorsal muscle endurance time of the two groups after treatment were longer than those before treatment, and the observation group was longer than control group (P ＜ 0.05); the anterior flexion angle, posterior extension angle, lateral flexion angle, and rotation angle of the two groups after treatment were larger than those before treatment, and the observation group were larger than the control group (P ＜ 0.05); the scores of Edinburgh postpartum depression scale (EPDS) of the two groups were lower than those before treatment, and the observation group was lower than the control group. Conclusion Low and medium frequency combined with massage therapy can effectively improve the pain of patients with postpartum lumbago, increase the effective rate of treatment, improve the endurance of abdominal muscle, and reduce postpartum depression.
2022 Vol. 19 (3): 127-130 [Abstract] ( 194 ) HTML (1 KB)  PDF (583 KB)  ( 21 )
131 Effect of milli fire needle combined with divergent extracorporeal shock wave in the treatment of lumbar muscle strain with syndrome of cold-damp#br#
WANG Cheng LYU Yanan GAO Xin LIAN Zhanxiong LIANG Shufen DENG Xiangqiang HUANG Woning XIE Yantong
Objective To observe the effect of milli fire needle combined with divergent extracorporeal shock wave in the treatment of lumbar muscle strain with syndrome of cold-damp. Methods A total of 180 lumbar muscle strain patients with syndrome of cold-damp in outpatients of the People’s Hospital of Guangxi Zhuang Autonomous Region from January 2017 to June 2019 were selected as the research objects. They were divide into two groups by random number table method, with 90 cases in each group. Under the guidance of tendon theory and meridians theory, the observation group was treated with milli fire needle combined with divergent extracorporeal shock wave, the control group was treated with conventional acupuncture combined with divergent extracorporeal shock wave, once every 3 days, and the course of treatment was ended after 10 times. Visual analogue scale (VAS) scores of the two groups before treatment, at the end of treatment, three months after the end of treatment and six months after the end of treatment were evaluated, the current perception threshold (CPT) of T11 and T12 before and after the treatment was measured, respectively, and the short-term and long-term clinical efficacy were evaluated objectively. Results Overall analysis showed: there were statistically significant differences in comparison among groups comparison, time point comparison, and interaction between groups (P ＜ 0.05), further pairwise comparison, intra-group comparison: compared with before treatment, VAS scores in both groups decreased at the end of treatment, and compared with the end of treatment, VAS scores in both groups increased three months after the end of treatment, and compared with three months after the end of treatment, VAS scores in both groups increased six months after the end of treatment, with statistically significant differences (P ＜ 0.05); comparison between groups: there was no statistical significance in VAS scores between the two groups before treatment (P ＞ 0.05), VAS scores of the observation group at each time point after treatment was lower than those of the control group, the difference were statistically significant (P ＜ 0.05). There was no significant difference in the CPT values of T11 and T12 between the two groups before treatment (P ＞ 0.05), the CPT values of T11 and T12 in both groups decreased after treatment, and the observation group was lower than the control group, the difference was statistically significant (P ＜ 0.05). Conclusion The analgesic and long-term effect of milli fire needle combined with divergent extracorporeal shock wave in the treatment of lumbar muscle strain with syndrome of cold-damp are better.
2022 Vol. 19 (3): 131-134,142 [Abstract] ( 54 ) HTML (1 KB)  PDF (761 KB)  ( 133 )
135 Clinical effect of external application of traditional Chinese medicine combined with ultrashort wave in the treatment of meniscus injury#br#
CHU Xiaowei1 DENG Haipeng2 JIAO Daiyan2 SHEN Rongrong3▲
Objective To explore the clinical value of external application of traditional Chinese medicine combined with ultrashort wave in the treatment of meniscus injury. Methods A total of 80 patients of meniscus injury admitted to Haian People’s Hospital of Jiangsu Province from September 2019 to March 2020 were selected as the research objects. According to the random number table method, they were divided into control group and observation group, with 40 cases in each group. The control group was given conventional treatment, and the observation group was treated with external application of traditional Chinese medicine combined with ultrashort wave on the basis of control group. The clinical efficacy of the two groups were compared, and the knee joint pain scores, knee joint movement degree, knee joint swelling degree, and knee joint atrophy degree of the two groups were compared before and after treatment. Results The total effective rate of observation group was better than that of control group, and the difference was statistically significant (P ＜ 0.05). Overall analysis showed that there were statistically significant differences in time point comparison, between groups comparison, and interaction (P ＜ 0.05). Further pial comparison, intra-group comparison: visual analogue scale (VAS) scores, knee joint swelling degree, and knee joint atrophy degree at the 2nd and 4th weeks after treatment were lower than those before treatment, and the 4th week was lower than the 2nd week (P ＜ 0.05), knee joint activity degree of the two groups in the 2nd and 4th week after treatment were bigger than those before treatment, and the 4th week was bigger than that in the 2nd week (P ＜ 0.05); Comparison between groups: there was no statistically significant difference in VAS scores, knee joint activity degree, knee joint swelling degree, and knee joint atrophy degree before treatment (P ＜ 0.05), VAS scores, knee joint swelling degree, and knee joint atrophy degree of observation group at the 2nd and 4th week after treatment were lower than those of control group (P ＜ 0.05), the knee joint activity of observation group at the 2nd and 4th week after treatmentcwas were bigger than those of the control group. Conclusion External application of traditional Chinese medicine combined with ultrashort wave can effectively promote the functional recovery of the affected limb in patients with meniscus injury, and the clinical effect is significant.
2022 Vol. 19 (3): 135-138 [Abstract] ( 146 ) HTML (1 KB)  PDF (537 KB)  ( 26 )
139 Effect of acupoint application of Dinggui Powder combined with Jianpi Bazhen cake in the treatment of infantile diarrhea with syndrome of spleen deficiency and its influence on immune function#br#
YANG Yingying LIU Quansheng TANG Xuexiao QIAN Chenjia ZHAO Changjiang▲
Objective To explore the effect of acupoint application of Dinggui Powder combined with Jianpi Bazhen Gao in the treatment of infantile diarrhea with spleen deficiency and its influence on immune function. Methods A total of 98 children with spleen deficiency diarrhea who were admitted to Jiangyin Hospital of Traditional Chinese Medicine from June 2017 to May 2020 were selected as the research subjects. They were divided into study group (49 cases) and control group (49 cases) according to different treatment options. The control group was given the basic treatment at the same time with Jianpi Bazhen Gao, and the study group was treated with Dinggui Powder acupoint application on the basis of the control group. Both groups were treated for seven days. The clinical efficacy were compared between the two groups, traditional Chinese medicine syndrome score, immune function index, and safety before and after treatment were compared between the two groups. Results The clinical efficacy of the study group was better than that of the control group. There was no significant difference in traditional Chinese medicine syndrome scores between the two groups before treatment (P ＞ 0.05), Chinese medicine syndrome scores of the two groups after treatment were lower than those before treatment, and the study group was lower than the control group (P ＜ 0.05); there was no significant difference in CD4+/CD8+ between the two groups before treatment (P ＞ 0.05), CD4+/CD8+ in the two groups after treatment were higher than those before treatment, and the study group was higher than the control group (P ＜ 0.05); there was no significant difference in the incidence of adverse drug reactions between the two groups (P ＞ 0.05). Conclusion Dinggui powder acupoint application combined with Jianpi Bazhen cake is used to treat infantile diarrhea with syndrome of spleen deficiency, which has definite curative effect, can improve immune function, safe and reliable.
2022 Vol. 19 (3): 139-142 [Abstract] ( 222 ) HTML (1 KB)  PDF (587 KB)  ( 140 )
143 Rehabilitation effect of hospital-community-family transitional care on stroke patients after discharge: a meta-analysis#br#
LOU Jiaao1 XIAO Li2 XIAO Yanling3 HE Fang3 JIANG Fang1 JIANG Ping3 CHEN Qiuxia3
Objective To evaluate the rehabilitation effect of hospital-community-family continuing care for stroke patients after discharge. Methods CNKI, Wanfang Database, VIP, China Biomedical Literature Database, Web of Science, the Cochrane Library, PubMed, and EMbase databases were searched by computer, and the retrieval time from established to March 2021. The control group used hospital-led routine transitional care for stroke, and the experimental group used a randomized controlled trial (RCT) of transitional care for stroke in hospital-community-family mode. Literature screening, quality evaluation and data extraction were carried out by two researchers independently, and meta-analysis was performed by Stata 16 statistical software. Results A total of 21 RCTs involving 1968 patients were included. The results of meta-analysis showed that: compared with the control group, the daily living ability (SMD = 1.26, 95%CI [0.84, 1.69], P ＜ 0.01) of patients in the experimental group were improved, and the motor function (SMD = 1.40, 95%CI [1.03, 1.77], P ＜ 0.01), and neurological deficits (WMD = -2.14, 95%CI [-2.48, -1.81], P ＜ 0.01), anxiety (SMD = -1.33, 95%CI [-1.73, -0.92], P ＜ 0.01), and depression (SMD = -1.12, 95%CI [-1.45,-0.79], P ＜ 0.01) were decreased. Conclusion Hospital-community-family transitional nursing has positive and significant effect on improving the daily living ability and motor function of discharged patients with stroke, and alleviating the neurological deficit, anxiety and depression.
2022 Vol. 19 (3): 143-149,173 [Abstract] ( 221 ) HTML (1 KB)  PDF (3058 KB)  ( 180 )
150 Effect of follow-up extended nursing on rehabilitation effect and disease knowledge of children with Kawasaki disease based on knowledge, belief and action#br#
DUAN Suxian FENG Dongling SU Meiyan ZHANG Yingqian▲
Objective To explore the effect of follow-up extended nursing based on knowledge, belief and action on the rehabilitation effect and disease knowledge of children with Kawasaki disease. Methods A retrospective study was conducted to study 92 children with Kawasaki disease and 92 children’s family members who were admitted and discharged from Children’ Hospital of Hebei Province from February 2019 to January 2021, according to random number table method, the patients were divided into control group and study group, with 46 children and 46 family members in each group, basic nursing was used in the control group, and follow-up extended nursing was used in the research group on the basis of knowledge, belief and action. The outcomes of the two groups were compared and analyzed. Results The score of family members’ knowledge of disease in study group was higher than that in control group (P ＜ 0.05). The total incidence of complications in study group was lower than that in control group (P ＜ 0.05). The symptom disappeared time in the study group was significantly shorter than that in the control group (P ＜ 0.05). The nursing satisfaction of family members in the study group was higher than that in the control group (P ＜ 0.05). Conclusion Children with Kawasaki disease can shorten the time for symptoms to disappear by taking follow-up extened care based on knowledge, belief and action, it can effectively reduce the incidence of complications, improve the family members’ knowledge of the disease and nursing satisfaction, which has certain reference value in clinical practice.
2022 Vol. 19 (3): 150-153 [Abstract] ( 199 ) HTML (1 KB)  PDF (562 KB)  ( 26 )
154 Effect of mindfulness decompression training on coping styles and psychosomatic symptoms of breast cancer patients undergoing chemotherapy#br#
REN Xuan XIE Lijuan▲
Objective To analyze the effect of mindfulness decompression training on coping styles and psychosomatic symptoms of breast cancer patients undergoing chemotherapy. Methods A total of 82 patients receiving breast cancer chemotherapy from January 2018 to January 2020 were selected from the Jiangsu Provincial People’s Hospital. They were divided into control group and intervention group by random number table rnethod, with 41 cases each group. The control group received routine intervention and the intervention group received mindfulness stress reduction training intervention. Followed up for six months, the scores of coping style, psychosomatic symptoms and cancer-related fatigue were compared between the two groups. Results After six months of follow-up, three cases fell off in the intervention group and one case fell off in the control group. The yield and avoidance scores of the two groups were lower than those before intervention, and the face score was higher than that before intervention, and the yield and avoidance scores of the intervention group were lower than those of the control group, and the face score was higher than that of the control group (P ＜ 0.05). The scores of psychosomatic symptoms in both groups were lower than those before intervention, and the core symptoms, impact on life and total psychosomatic symptoms in intervention group were lower than those in control group (P ＜ 0.05); the scores of cancer-related fatigue in the two groups were lower than those before intervention, and the scores of physical fatigue, psychological fatigue, the impact of fatigue on life and cancer-related fatigue in the intervention group were lower than those in the control group (P ＜ 0.05). Conclusion Mindfulness decompression training can promote the development of positive coping style, avoid negative coping behavior, improve psychosomatic symptoms and cancer-related fatigue degree of breast cancer patients after chemotherapy.
2022 Vol. 19 (3): 154-157 [Abstract] ( 179 ) HTML (1 KB)  PDF (532 KB)  ( 338 )
158 Application of multidisciplinary collaborative health education model in joint perfusion therapy of elderly outpatients with knee osteoarthritis#br#
WANG Jing1 MEI Shencong1 JIANG Chaolai2 XUE Jiafeng1 YANG Lina1▲
Objective To analyze the application effect of multidisciplinary collaborative health education model in the joint perfusion therapy of elderly outpatients with knee osteoarthritis (KOA). Methods A total of 200 elderly patients with KOA who received joint perfusion therapy in Department of Outpatient, Shanghai Sixth People’s Hospital from December 2019 to October 2020 were selected, they were divided into control group and observation group by a random number table method, with 100 cases in each group, the control group received routine health education, while the observation group received multidisciplinary collaborative health education, all patients were followed up for six months; the severity of illness (assessed by Lequesne index of severity for osteroarthritis [ISOA], Western Ontario and McMaster University [WOMAC] index) and mental state (assessed by self-rating anxiety scale [SAS], self-rating depression scale [SDS]) and quality of life (assessed by WHO’s quality of life scale [WHOQOL-100]) before intervention, one month, three months and six months after intervention were compared between the two groups. Results The scores of ISOA, WOMAC, SAS, and SDS of both groups at each time point after intervention were significantly lower than the previous time point, and the score of WHOQOL-100 was significantly higher than the previous time point (P ＜ 0.05); the scores of ISOA, WOMAC, SAS, and SDS in the observation group at each time point after intervention were lower than those in the control group, and the scores of WHOQOL-100 were higher than those in the control group (P ＜ 0.05). Conclusion The multidisciplinary collaborative health education model can effectively reduce the severity of knee joint, relieve anxiety and depression in joint perfusion therapy of elderly outpatients with KOA, which is beneficial to improve the quality of life of patients.
2022 Vol. 19 (3): 158-161 [Abstract] ( 271 ) HTML (1 KB)  PDF (571 KB)  ( 15 )
162 Application of incremental resistance exercise training combined with WeChat health education platform in the nursing of patients with chronic renal failure after maintenance hemodialysis#br#
LIU Fang WU Han ZHANG Yingying CHENG Li
Objective To explore the application effect of incremental resistance exercise training combined with WeChat health education platform in the nursing of patients with chronic renal failure after maintenance hemodialysis (MHD). Methods A total of 100 MHD patients with chronic renal failure admitted to Bozhou People’s Hospital from January 2019 to January 2021 were selected, according to the random number table method, they were divided into control group and  observation group, with 50 cases in each group. The control group received routine intervention, and the observation group received incremental resistance exercise training combined with WeChat health education platform intervention. Cardiopulmonary endurance and fatigue were measured and compared before and three months after intervention. The self-made knowledge questionnaire was used to evaluate and compare the knowledge of disease between the two groups. General self-efficacy scale (GSES) and chronic kidney disease patients self-management scale were used to evaluate and compare the self-efficacy and self-management ability of the two groups. Results After three months of intervention, the scores of maximal oxygen uptake, metabolic equivalent, and fatigue scale 14 in both groups were lower than before intervention (P ＜ 0.05). The scores of each dimension of disease knowledge, medication knowledge, diet knowledge, and related behavior knowledge and total scores of both groups were increased than before intervention, and the observation group was higher than the control group (P ＜ 0.05). The general self-efficacy scale score and self-management scale score of both groups were increased than before intervention, and the observation group was higher than the control group (P ＜ 0.05). Conclusion Incremental resistance exercise training combined with WeChat health education platform is more conducive to improving the cardiopulmonary endurance and fatigue of MHD patients with chronic renal failure, and improving their disease cognition and self-management ability.
2022 Vol. 19 (3): 162-165，181 [Abstract] ( 166 ) HTML (1 KB)  PDF (695 KB)  ( 195 )
166 Meta analysis of the intervention effect of vibration expectoration nursing on elderly patients with chronic obstructive pulmonary disease#br#
CAO Jingdi WANG Yanxia XIA Wenlan
Objective To systematically evaluate the intervention effect of vibration expectoration nursing on elderly chronic obstructive pulmonary disease (COPD) by meta method. Methods Randomized controlled trials of vibration expectoration and artificial backbuckling expectoration in the care of elderly COPD were collected by searching CNKI.com, Wanfang Data, VIP, China Biomedical Literature Database and PubMed. The search period was from self-built database to July 2021. Meta-analysis was performed by RevMan 5.3 software. Results A total of nine literatures were included. The results of meta-analysis showed that vibration sputum excretion nursing was significantly higher than manual sputum excretion nursing in improving 24-hour sputum excretion (WMD = 8.87, 95%CI [5.62,12.12], P ＜ 0.000 01), arterial oxygen partial pressure (WMD = 11.56, 95%CI [6.60,16.52], P ＜ 0.000 01) and hospital stay [WMD = -6.10, 95%CI (-10.65, -1.54), P = 0.009] was shorter than manual sputum excretion nursing. Conclusion The intervention effect of vibration sputum drainage nursing on elderly patients with COPD is better than that of artificial back buckle sputum drainage nursing, which has clinical popularization value.
2022 Vol. 19 (3): 166-169 [Abstract] ( 186 ) HTML (1 KB)  PDF (1981 KB)  ( 19 )
170 Prevention effect of acupoint massage combined with whole seamless nursing mode in the prevention of artificial abortion syndrome in colposcopy cervical biopsy in outpatient clinic#br#
LIU Sa1 YANG Hong2▲ YU Qiaoping1 ZHAO Jingwei1 ZHU Jun1 GU Wenzhu1
Objective To investigate the prevention effect of acupoint massage combined with whole seamless nursing mode of patients in artificial abortion syndrome in cervical biopsy. Methods From January 2020 to January 2021, 5078 patients underwent colposcopic biopsy in Cervical Clinic, Wuxi Maternal and Child Health Hospital of Jiangsu Province were collected. They were divided into the control group received routine nursing mode (2539 cases) and the intervention group received acupoint massage combined with seamless nursing mode (2539 cases) by the random drawing method. The incidence of induced abortion syndrome, self-rating anxiety scale score, visual analogue scale (VAS) score of pain and hospital satisfaction were compared between the two groups. Results Finally, 2388 cases were enrolled in the control group, and 2432 cases were enrolled in the intervention group. The incidence of induced abortion syndrome in intervention group was lower than that in control group (P ＜ 0.05). The scores of VAS and self-rating anxiety scale in the intervention group were lower than those in the control group (P ＜ 0.05). The satisfaction of intervention group was significantly higher than that of control group (P ＜ 0.05). Conclusion The application effect of acupoint massage combined with whole seamless nursing mode in reducing the incidence of artificial abortion syndrome in colposcopy cervical biopsy, reducing patients’ pain, relieving patients’ anxiety and improving patients’ satisfaction is significant, which is worth to promote.
2022 Vol. 19 (3): 170-173 [Abstract] ( 135 ) HTML (1 KB)  PDF (621 KB)  ( 22 )
174 A case of gastric adenocarcinoma of the fundic gland type and literature review#br#
KOU Mengjia1 GONG Yucheng1 WANG Zhibin2
Gastric adenocarcinoma of the fundic gland type （GA-FG） is a rare tumor that belongs to the new gastric cancer subtype. However, its pathogenesis is not clear, the submucosal infiltration rate is high, but the degree of malignancy is low, lymphatic and venous metastases are less common, and the prognosis is good. In previous reports, GA-FG was mostly submucosal bulge, and the tumor surface was whitish or faded. One case of GA-FG patient reported in this article was admitted to the Department of Spleen, Stomach and Hepatobiliary, Dongfang Hospital, Beijing University of Chinese Medicine on July 30, 2020. The shape of the lesion is a rare flat type, the surface of the tumor is reddish, and there are fundus gland polyps around the lesion. The clinical manifestations were acid reflux heartburn, history of proton pump inhibitor drugs, and endoscopic submucosal dissection treatment. There was no obvious abnormality after the operation. This article reports on the diagnosis and treatment process of patients, reviews and reviews relevant literature, and concludes that the endoscopic diagnosis of GA-FG has not yet formed a consensus and has limitations, and it is very easy to misdiagnose and miss diagnosis. However, it has unique clinicopathological characteristics, combined with morphology and immunophenotype, it can be diagnosed clearly. In terms of etiology, whether proton pump inhibitor is related to the occurrence of GA-FG requires more reports for research and demonstration.
2022 Vol. 19 (3): 174-177 [Abstract] ( 271 ) HTML (1 KB)  PDF (996 KB)  ( 194 )
178 Clinical characteristics of one case of taurodontism and its family and literature review#br#
ZHANG Jing LI Wuli JIN Jie SUN Cheng WANG Lu ZHAO Chunhui
Taurodontism is a rare morphological anomaly of teeth, which is characterized by an enlarged body and pulp chamber, as well as apical displacement of the pulpal floor and shortened roots. It occurs alone or accompanies with other abnormal tooth development, or as a symptom of the syndrome. Taurodontism frequently occur in sporadic cases, and it is rare reported in families. In this paper, reported a family with taurodontism. The proband was a 15-year-old male, and his parents were consanguineous marriage. In November 2020, the patient and his parents visited the Stomatological Hospital Affiliated to Anhui Medical University with “chief complaint of recurrent pain in the left maxillary posterior teeth for half a year”. With X ray and cone-beam computed tomography examination, the proband and his mother were diagnosed with multiple taurodontism with pulp stones. Besides, the genetic examination failed to identify taurodontism-related mutations. Base on this reported case, the article reviews the etiology, clinical manifestations, diagnosis and genetic characteristics of taurodontism, aiming to improve clinicians’ understanding of taurodontism.
2022 Vol. 19 (3): 178-181 [Abstract] ( 45 ) HTML (1 KB)  PDF (932 KB)  ( 92 )
182 Renal papillary adenoma: a case report and literature review#br#
ZHANG Lefei YI Faxian YAN Nuo
This paper retrospectively analyzes the clinical data of a case of renal papillary adenoma admitted by the Department of Urology Surgery, Affiliated Hospital of Inner Mongolia Medical University, and discusses its clinical features, diagnosis, treatment, and prognosis. In this paper, the patient underwent laparoscopic partial right nephrectomy with good postoperative outcome. The clinical presentation and imaging examination of renal papillary adenoma lack specificity, and the diagnosis of this disease needs to rely on pathological examination. In this paper, report the clinical course and data of this patient and review the relevant literature, so that can better understand the diagnosis and treatment of renal papillary adenoma, as well as the long-term prognosis, in order to improve the understanding of this disease and achieve early diagnosis and timely treatment.
2022 Vol. 19 (3): 182-184,192 [Abstract] ( 91 ) HTML (1 KB)  PDF (995 KB)  ( 34 )
185 Discussion on employment mode of traditional Chinese medicine colleges and universities from the perspective of “Three-all Education”#br#
XU Kai1 LI Qinglin2 CHE Zhiyuan3 LI Hewei4 ZHANG Rongxing1
The employment of traditional Chinese medicine colleges and universities has always been concerned by the academic circle. Firstly, this paper analyzes the employment dilemma of traditional Chinese medicine colleges and universities from the macro, medium, micro, and individual levels. Then, it explains the development of the concept of “Three-all Education” and the necessity of applying it to the employment mode of traditional Chinese medicine colleges and universities. Based on this, under the guidance of national policies and with the help of network information platform, it is proposed to build a “Three-all Education” pattern in which traditional Chinese medicine colleges and universities are the main body, and the society, employers, families, and individual students participate, cooperate, full plan and develop comprehensively. Finally, the application prospect, possible obstacles, and countermeasures of this mode are briefly discussed in order to solve the employment dilemma of traditional Chinese medicine colleges and universities.
2022 Vol. 19 (3): 185-188 [Abstract] ( 93 ) HTML (1 KB)  PDF (651 KB)  ( 52 )
189 Analysis on the operating efficiency of traditional Chinese medicine hospitals in poverty-stricken counties in China based on DEA method#br#
LI Yuan1 JIANG Yan1 DONG Shi2 XU Xunhang1 AN Xuzhao1 LOU Cuidi1 CHENG Wei1
Objective To analyze the input and output of traditional Chinese medicine hospitals in 680 poverty-stricken counties in China in 2018, and to analyze the operating efficiency of hospitals in each province, and to propose efficiency improvement measures. Methods This study was carried out in December 2019. Data envelopment analysis was conducted to calculate the efficiency of 680 traditional Chinese medicine hospitals in poverty-stricken counties in China (from 22 provinces) in 2018 by collecting the number of health technicians, beds available, revenue from financial subsidies, total expenditure, total number of patients, and the number of discharged patients. Results Traditional Chinese medicine hospitals in poverty-stricken counties were mainly secondary hospitals. There were great differences in hospital quantity, input-output between eastern, central and western regions. According to data envelopment analysis, 8 of the 22 provinces had comprehensive technical efficiency of 1, and 10 provinces had pure technical efficiency of 1. Among 14 provinces with scale efficiency < 1, 9 provinces showed decreasing returns to scale, while the other 5 provinces showed increasing returns to scale. Conclusion The overall operating efficiency of provincial hospitals is not high, and the technical efficiency and scale efficiency need to be further improved. The state should strengthen technical training for grass-roots health personnel, adopt differentiated strategies for targeted poverty alleviation, increase investment in hospitals in areas with increasing returns to scale, and pay attention to improving the technical management level of hospitals in areas with decreasing returns to scale.
2022 Vol. 19 (3): 189-192 [Abstract] ( 76 ) HTML (1 KB)  PDF (520 KB)  ( 29 )
193 Construction and practical experience summary of training mode of the team of rural doctors in Beijing#br#
LU Dongmei1 LI Yufeng2 WANG Shaobin1 HE Yulan1 LIU Xinying1
In order to solve the shortage of human resources in rural health institutions in Beijing, the training mode of the team of rural doctors is studied. Finally, it is determined to adopt the mode of directed entrusting training, which combines academic learning with standardized training, and develops basic courses, professional courses and clinical practice in a “1+2” mode. “1” is completed in school and “2” is completed in teaching hospital. The government and schools work together. The government makes enrollment plans, and schools make training plans, in order to educate students and train the team of doctors for village-level health institutions and retain health professionals. This training mode of the team of rural doctors has been supported by local governments and schools, which further promotes the construction of grassroots rural doctors. Through this training mode, the team of rural doctors have been effectively expanded, and a feasible way has been explored for rural grassroots institutions in Beijing.
2022 Vol. 19 (3): 193-196 [Abstract] ( 100 ) HTML (1 KB)  PDF (593 KB)  ( 36 )
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