儿童传染性单核细胞增多症免疫功能变化与肝功能损害相关性研究

Abstract
Figure/Table
References (25)
Related Citation (15)

Download: PDF (496 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the relationship between changes of immune function and liver function damage in children with infectious mononucleosis (IM), so as to provide a theoretical basis for prevention and treatment of liver damage. Methods Clinical data of 85 children with IM caused by Epstein-Barr virus infection in the First People’s Hospital of Lianyungang, Jiangsu Province, from July 2017 to July 2019 were selected. They were divided into liver function damage group and no liver function damage group, according to whether the occurrence of liver function damage. The expression of IgA, IgM, IgG, CD19+B lymphocyte, complement component C3, natural killer (NK) cell, T lymphocyte subsets (CD4+, CD8+, and CD4+/CD8+) were compared between two groups; and the correlation between immune function and liver function damage in children with IM was analyzed. Results The incidence of IM children complicated with liver function damage was 40% (34/85). There were statistically significant differences in IgA, IgG, IgM, CD19+, CD8+, CD4+, CD4+/CD8+, and complement C3 between two groups (P < 0.05); there was no significant difference between two groups (P > 0.05). ALT level had no correlation with IgA, IgG, IgM, CD19+, CD8+, CD4+, CD4+/CD8+, and complement C3 (P > 0.05). CD8+ was an independent risk factor for liver function damage in IM children (OR = 1.104, P < 0.05). Conclusion The disorder of immune system in IM children is associated with liver function damage, so it is necessary to strengthen the monitoring of the disorder of immune function in IM children, and give liver protection and immunomodulatory therapy in early stage.

Key words： Children Infectious mononucleosis Immune function Liver function damage

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	LIU Jiangyan SUN Jun▲ MAO Kangwei LI Dalei

Cite this article:

LIU Jiangyan SUN Jun▲ MAO Kangwei LI Dalei. Correlation study on changes of immune function and liver damage in children with infectious mononucleosis#br#[J]. 中国医药导报, 2022, 19(3): 91-94.

URL:

https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I3/91

[1] 谢正德，申昆玲.重视儿童非肿瘤性EB病毒感染疾病的研究[J].首都医科大学学报，2010，31（2）：213-216.
[2] 欧阳文献，张慧，刘静，等.儿童传染性单核细胞增多症临床特征及治疗的单中心研究[J].中华实验和临床病毒学杂志，2018，32（1）：12-16.
[3] 樊亚楠，施逸怡，徐京杭，等.274例青少年和成人传染性单核细胞增多症患者肝损伤临床特征分析[J].临床肝胆病杂志，2021，37（3）：636-641.
[4] Odumade OA，Hogquist KA，Balfour HH Jr. Progress and problems in understanding and managing primary Epstein-Barr virus infections [J]. Clin Microbiol Rev，2011， 24（1）：193-209.
[5] Wu Y，Ma S，Zhang L，et al. Clinical manifestations and laboratory results of 61 children with infectious mononucleosis [J]. J Int Med Res，2020，48（10）：1-7.
[6] Forrest C，Hislop AD，Rickinson AB，et al. Proteome-wide analysis of CD8+ T cell responses to EBV reveals differences between primary and persistent infection [J]. PLoS Pathog，2018，14（9）：1-32.
[7] Lai JY，Choo JAL，Tan WJ，et al. TCR-like antibodies mediate complement and antibody-dependent cellular cytotoxicity against Epstein-Barr virus-transformed B lymphoblastoid cells expressing different HLA-A*02 microvariants [J]. Sci Rep，2017，7（1）：1-11.
[8] 王淙垲，刘汉嘉，黄永智，等.哮喘患儿外周血单核细胞中Toll样受体4表达及意义[J].中国实用诊断与治疗，2015，29（12）：1212-1214.
[9] Hagn M，Panikkar A，Smith C，et al. B Cell-Derived Circulating Granzyme B Is a Feature of Acute Infectious Mononucleosis [J]. Clin Trans Immunol，2015，4（6）：138-139.
[10] Klein G，Klein E，Kashuba E. Interaction of Epstein-Barr Virus（EBV）With Human B-lymphocytes [J]. Biochem Biophys Res Commun，2010，396（1）：69-73.
[11] Panikkar A，Smith C，Hislop A，et al. Impaired Epstein-Barr Virus-Specific Neutralizing Antibody Response During Acute Infectious Mononucleosis Is Coincident With Global B-Cell Dysfunction [J]. J Virol，2015，89（17）：9137-9141.
[12] 孙丹，李艳艳，田秀颖，等.IM患儿外周血单核细胞TLR2、TLR9及CD19+、CD23+表达水平及意义[J].国际检验医学，2019，40（6）：707-709.
[13] 张晓微，周思维，马振南.康艾注射液对结直肠癌肝转移介入术后肝功能的影响[J].中国当代医药，2020，27（11）：76-80.
[14] Liu H，Gemmell L，Lin R，et al. Development of an Improved Epstein-Barr Virus（EBV）Neutralizing Antibody Assay to Facilitate Development of a Prophylactic gp350-Subunit EBV Vaccine [J]. Mediterr J Hematol Infect Dis，2020，12（1）：e2020016.
[15] 韩红满，李四强.传染性单核细胞增多症相关免疫学研究进展[J].医学综述，2020，26（3）：443-447.
[16] 李博，郑欢伟，赵召霞，等.干扰素-1b序贯拉米夫定联合治疗对慢性乙型肝炎患儿T淋巴细胞亚群、补体水平及肝功能的影响[J].中国医药导报，2019，16（14）：148-151.
[17] 张东兰，王淑香，张志刚，等.传染性单核细胞增多症并发肝损害的相关因素分析[J].中国医师进修杂志，2012， 35（31）：32-34.
[18] Lai W，Wang Y，Wang J，et al. Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in adults and adolescents-a life-threatening disease：Analysis of 133 cases from a single center [J]. Hematol，2018，23（10）：810-816.
[19] Hadinoto V，Shapiro M，Greenough TC，et al. On the Dynamics of Acute EBV Infection and the Pathogenesis of Infectious Mononucleosis [J]. Blood，2008，111（3）：1420-1427.
[20] Long HM，Chagoury OL，Leese AM，et al. MHC Ⅱtetramers visualize human CD4+T cell responses to Epstein-Barr virus infection and demonstrate atypical kinetics of the nuclear antigen EBNA1 response [J]. J Exp Med，2013，210（5）：933-949.
[21] 杨嘉文.肝癌患者微创介入治疗对血清ALT水平、T细胞免疫功能的影响[J].中国现代医生，2021，59（1）：77-80.
[22] Parvaneh N，Filipovich AH，Borkhardt A. Primary immunodeficiencies predisposed to Epstein-Barr virus-driven haematological diseases [J]. Br J Haematol，2013， 162（5）：573-586.
[23] Chijioke O，Muller A，Feederle R，et al. Human natural killer cells prevent infectious mononucleosis features by targeting lytic Epstein-Barr virus infection [J]. Cell Rep，2013，5（6）：1489-1498.
[24] Pappworth IY，Wang EC，Rowe M. The switch from latent to productive infection in Epstein-Barr virus-infected B cells is associated with sensitization to NK cell killing [J]. J Virol，2007，81（2）：474-482.
[25] Williams H，McAulay K，Macsween KF，et al. The immune response to primary EBV infection：a role for natural killer cells [J]. Br J Haematol，2005，129（2）：266-274.